IT1277466B1 - Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi - Google Patents

Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi

Info

Publication number
IT1277466B1
IT1277466B1 IT95MI001764A ITMI951764A IT1277466B1 IT 1277466 B1 IT1277466 B1 IT 1277466B1 IT 95MI001764 A IT95MI001764 A IT 95MI001764A IT MI951764 A ITMI951764 A IT MI951764A IT 1277466 B1 IT1277466 B1 IT 1277466B1
Authority
IT
Italy
Prior art keywords
peptides
engineered peptide
peptide synthetases
ribosomal
production
Prior art date
Application number
IT95MI001764A
Other languages
English (en)
Inventor
Ferra Francesca De
Francesco Rodriguez
Guido Grandi
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Priority to IT95MI001764A priority Critical patent/IT1277466B1/it
Publication of ITMI951764A0 publication Critical patent/ITMI951764A0/it
Priority to EP96109937A priority patent/EP0789078B1/en
Priority to AT96109937T priority patent/ATE250129T1/de
Priority to DE69630010T priority patent/DE69630010D1/de
Priority to US08/670,901 priority patent/US5795738A/en
Publication of ITMI951764A1 publication Critical patent/ITMI951764A1/it
Application granted granted Critical
Publication of IT1277466B1 publication Critical patent/IT1277466B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT95MI001764A 1995-08-09 1995-08-09 Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi IT1277466B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT95MI001764A IT1277466B1 (it) 1995-08-09 1995-08-09 Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi
EP96109937A EP0789078B1 (en) 1995-08-09 1996-06-20 Engineered peptide synthetases and their use for the non-ribosomal production of peptides
AT96109937T ATE250129T1 (de) 1995-08-09 1996-06-20 Modifizierte peptidsynthetasen, und deren verwendung in der nicht-ribosomalen herstellung von peptiden
DE69630010T DE69630010D1 (de) 1995-08-09 1996-06-20 Modifizierte Peptidsynthetasen, und deren Verwendung in der nicht-ribosomalen Herstellung von Peptiden
US08/670,901 US5795738A (en) 1995-08-09 1996-06-26 Engineered peptide synthetases and their use for the non-ribosomal production of peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001764A IT1277466B1 (it) 1995-08-09 1995-08-09 Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi

Publications (3)

Publication Number Publication Date
ITMI951764A0 ITMI951764A0 (it) 1995-08-09
ITMI951764A1 ITMI951764A1 (it) 1997-02-09
IT1277466B1 true IT1277466B1 (it) 1997-11-10

Family

ID=11372167

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001764A IT1277466B1 (it) 1995-08-09 1995-08-09 Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi

Country Status (5)

Country Link
US (1) US5795738A (it)
EP (1) EP0789078B1 (it)
AT (1) ATE250129T1 (it)
DE (1) DE69630010D1 (it)
IT (1) IT1277466B1 (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537762A (ja) * 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
DE19909146A1 (de) * 1999-03-03 2000-09-28 Mohamed A Marahiel Verfahren zur gezielten biologischen Synthese von Peptiden
EP1096011A1 (en) * 1999-05-10 2001-05-02 Holland Sweetener Company V.o.F. Microbiological production method for alpha-l-aspartyl-l-phenylalanine
DE19928313A1 (de) * 1999-06-16 2000-12-21 Ullrich Keller Verfahren zur Veränderung von Peptidsynthefasen in der Weise, daß sie ihre Substrataminosäuren N-methylieren können
FR2796465B1 (fr) * 1999-07-16 2001-11-23 Suisse Electronique Microtech Systeme capteur biochimique a sensibilite accrue par amplification moleculaire du signal
IL160169A0 (en) * 2001-08-06 2004-07-25 Cubist Pharm Inc Nucleic acid molecules that encode a daptomycin non-ribosomal peptide synthetase and methods for the production thereof
JP4447467B2 (ja) 2002-12-26 2010-04-07 協和発酵バイオ株式会社 ジペプチドの製造法
US20080051326A1 (en) * 2004-11-12 2008-02-28 Alexander Dylan C Antiinfective Lipopeptides
CN101142315B (zh) * 2005-03-18 2010-10-27 协和发酵生化株式会社 二肽的制备方法
EP1924699A4 (en) * 2005-08-26 2009-11-11 Aureogen Biosciences Aureobasidin-A-SYNTHETASE
WO2007074858A1 (ja) * 2005-12-27 2007-07-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
WO2008131014A1 (en) * 2007-04-16 2008-10-30 Modular Genetics, Inc. Lipopeptides and lipopeptide synthetases
WO2008131002A2 (en) 2007-04-16 2008-10-30 Modular Genetics, Inc. Generation of acyl amino acids
US20100248307A1 (en) * 2007-08-31 2010-09-30 Kyowa Hakko Bio Co., Ltd. Peptide production method
RU2012129311A (ru) 2012-07-11 2014-01-20 Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием
EP2970928A4 (en) 2013-03-15 2017-02-15 Modular Genetics, Inc. Generation of acyl amino acids
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
US12123004B2 (en) 2018-07-18 2024-10-22 Modular Genetics, Inc. Generation of acyl amino acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0540074A1 (en) * 1991-10-09 1993-05-05 ENIRICERCHE S.p.A. Cloning and sequencing of that chromosomal DNA region of bacillus subtilis comprising the SRFA operon which encodes the multienzymatic complex surfactin synthetase
IT1264712B1 (it) * 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi

Also Published As

Publication number Publication date
EP0789078A2 (en) 1997-08-13
EP0789078A3 (en) 1999-10-27
ATE250129T1 (de) 2003-10-15
ITMI951764A0 (it) 1995-08-09
US5795738A (en) 1998-08-18
DE69630010D1 (de) 2003-10-23
ITMI951764A1 (it) 1997-02-09
EP0789078B1 (en) 2003-09-17

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