ATE250576T1 - Substituierte pyrrolylverbindungen zur behandlung von entzündungen - Google Patents
Substituierte pyrrolylverbindungen zur behandlung von entzündungenInfo
- Publication number
- ATE250576T1 ATE250576T1 AT97950891T AT97950891T ATE250576T1 AT E250576 T1 ATE250576 T1 AT E250576T1 AT 97950891 T AT97950891 T AT 97950891T AT 97950891 T AT97950891 T AT 97950891T AT E250576 T1 ATE250576 T1 AT E250576T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammation
- treatment
- substituted pyrrolyl
- compounds
- pyrrolyl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3268896P | 1996-12-10 | 1996-12-10 | |
| PCT/US1997/022488 WO1998025896A1 (en) | 1996-12-10 | 1997-12-09 | Substituted pyrrolyl compounds for the treatment of inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250576T1 true ATE250576T1 (de) | 2003-10-15 |
Family
ID=21866300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97950891T ATE250576T1 (de) | 1996-12-10 | 1997-12-09 | Substituierte pyrrolylverbindungen zur behandlung von entzündungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5935990A (de) |
| EP (1) | EP0946507B1 (de) |
| AT (1) | ATE250576T1 (de) |
| AU (1) | AU5377698A (de) |
| CA (1) | CA2273836A1 (de) |
| DE (1) | DE69725171T2 (de) |
| DK (1) | DK0946507T3 (de) |
| ES (1) | ES2208964T3 (de) |
| PT (1) | PT946507E (de) |
| WO (1) | WO1998025896A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100485642B1 (ko) * | 1996-03-18 | 2005-09-30 | 에자이 가부시키가이샤 | 축합고리함유카르복실산유도체 |
| US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
| US6887893B1 (en) | 1997-12-24 | 2005-05-03 | Sankyo Company, Limited | Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia |
| US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| DE19953025A1 (de) | 1999-11-04 | 2001-05-10 | Merck Patent Gmbh | Pyrrolderivate als Phosphodiesterase VII-Hemmer |
| ATE283048T1 (de) * | 1999-12-08 | 2004-12-15 | Pharmacia Corp | Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt |
| CA2393724A1 (en) * | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| DE19963174A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Pyrrol-Mannichbasen |
| AU3653301A (en) | 2000-01-28 | 2001-08-07 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
| AU2001255600A1 (en) * | 2000-04-25 | 2001-11-07 | Pharmacia Corporation | Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes |
| WO2002005848A2 (en) * | 2000-07-13 | 2002-01-24 | Pharmacia Corporation | Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| MY137736A (en) | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
| US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| KR20050033546A (ko) | 2002-04-08 | 2005-04-12 | 글락소 그룹 리미티드 | (2-((2-알콕시)-페닐)-시클로펜트-1-에닐) 방향족 카르보및 헤테로시클릭산 및 유도체 |
| US7622117B2 (en) * | 2002-04-17 | 2009-11-24 | Dynamis Therapeutics, Inc. | 3-deoxyglucosone and skin |
| GB0212785D0 (en) * | 2002-05-31 | 2002-07-10 | Glaxo Group Ltd | Compounds |
| CA2496225C (en) | 2002-08-20 | 2012-08-07 | Sankyo Company Limited | Process for the production of .gamma.-keto acetals |
| JP4601274B2 (ja) * | 2002-08-20 | 2010-12-22 | 第一三共株式会社 | γ−ケトアセタール類の製造方法 |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| ATE479683T1 (de) | 2002-11-05 | 2010-09-15 | Glaxo Group Ltd | Antibakterielle mittel |
| DE10261130A1 (de) * | 2002-12-20 | 2004-07-01 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole |
| EP1745791B1 (de) * | 2003-05-07 | 2013-06-26 | Osteologix A/S | Behandlung von Knorpel/Knochen-Erkrankungen mit wasserlöslichen Strontiumsalzen |
| ES2394782T3 (es) * | 2003-05-07 | 2013-02-05 | Osteologix A/S | Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos |
| US20050131028A1 (en) * | 2003-09-11 | 2005-06-16 | Pharmacia Corporation | Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| GB0328024D0 (en) * | 2003-12-03 | 2004-01-07 | Glaxo Group Ltd | Compounds |
| MX2007008227A (es) * | 2005-01-05 | 2007-09-11 | Novacea Inc | Prevencion de trastornos tromboticos con compuestos de vitamina d activa o mimeticos de los mismos. |
| FR2887548B1 (fr) * | 2005-06-27 | 2007-09-21 | Sanofi Aventis Sa | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique |
| KR20080064956A (ko) * | 2005-09-27 | 2008-07-10 | 미리어드 제네틱스, 인크. | 치료학적 화합물로서의 피롤 유도체 |
| PT1975158E (pt) * | 2005-12-27 | 2011-09-23 | Ct Nac Investigaciones Oncologicas Cnio | Novos derivados de pirrole com actividade inibidora de histona desacetilase |
| MX2008016336A (es) * | 2006-06-27 | 2009-01-16 | Abbott Lab | Derivados de tiazolina y oxazolina y sus metodos de uso. |
| EP2059504B1 (de) | 2006-08-03 | 2015-09-09 | Rottapharm Biotech S.r.l. | 3-substituierte 1,5-diaryl-2-alkylpyrrole als hochselektive und oral wirksame cox-2-inhibitoren |
| CA2662870A1 (en) * | 2006-09-07 | 2008-03-13 | Myriad Genetics, Inc. | Therapeutic compounds for diseases and disorders |
| EP2170062A4 (de) | 2007-07-12 | 2010-12-29 | Tragara Pharmaceuticals Inc | Verfahren und zusammensetzungen zur behandlung von krebserkrankungen, tumoren und tumorvermittelten erkrankungen |
| DK2315590T3 (da) | 2008-08-15 | 2012-11-19 | N30 Pharmaceuticals Inc | Pyrrolinhibitorer af S-nitrosoglutathionreduktase |
| WO2010019910A1 (en) | 2008-08-15 | 2010-02-18 | N30 Pharmaceuticals, Llc | Novel pyrrole inhibitors of s-nitrosoglutathione reductase as therapeutic agents |
| DK2318007T3 (da) | 2008-08-15 | 2013-03-25 | N30 Pharmaceuticals Inc | Nye pyrrol-inhibitorer af s-nitrosoglutathion-reduktase som terapeutiske midler |
| US10500178B2 (en) | 2015-03-13 | 2019-12-10 | The Board Of Trustees Of The Leland Stanford Junior University | LTB4 inhibition to prevent and treat human lymphedema |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3168531A (en) * | 1963-06-12 | 1965-02-02 | Parke Davis & Co | 1-aryl-5-(p-lower alkoxyphenyl)-pyrrole-2-propionic acid compounds |
| BE633582A (de) * | 1963-06-13 | |||
| US3427305A (en) * | 1966-11-01 | 1969-02-11 | Searle & Co | 5 - ((halo/alkoxy)phenyl) - 1 - (p - sulfonamido(phenyl/benzyl)) - 2 - pyrrolepropionic acids |
| US3531497A (en) * | 1967-02-21 | 1970-09-29 | Upjohn Co | 2,4,5 - triphenyl - (and substituted triphenyl) - 3 - acetonitriles of pyrrole |
| DE1938904A1 (de) * | 1968-08-02 | 1970-02-05 | Innothera Lab Sa | 1-Phenylpyrrole |
| US5187185A (en) * | 1988-12-09 | 1993-02-16 | Rhone-Poulenc Ag Company | Pesticidal 1-arylpyrroles |
| DE2261965A1 (de) * | 1971-12-23 | 1973-06-28 | Continental Pharma | Derivate der pyrrolessigsaeure und deren salze sowie von pyrrolacetonitril, verfahren zur herstellung dieser verbindungen, diese verbindungen enthaltende pharmazeutische produkte und verwendung dieser verbindungen und produkte |
| US4267184A (en) * | 1979-02-08 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones |
| US4267190A (en) * | 1980-04-18 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α,α-bis(polyfluoromethyl)-1H-pyrrole-2-methanethiols |
| US4335136A (en) * | 1980-04-18 | 1982-06-15 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines |
| US4652582A (en) * | 1985-01-09 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Antiinflammatory-2-halo-4,5-diarylpyrroles |
| US4694018A (en) * | 1985-11-29 | 1987-09-15 | G. D. Serale & Co. | Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives |
| DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
| AU641905B2 (en) * | 1988-12-09 | 1993-10-07 | Rhone-Poulenc Agrochimie | 1-substituted-phenyl pyrrole derivatives as insecticides and methods for their production |
| US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
| DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
| US5128485A (en) * | 1990-12-17 | 1992-07-07 | American Cyanamid Company | Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents |
| EP0492093B1 (de) * | 1990-12-26 | 1999-03-17 | American Cyanamid Company | Verfahren zur Herstellung von 2-Aryl-1-substituierten-5-(Trifluormethyl)-Pyrrolen als Insektizide, Akarizide und Nematizide Wirkstoffe sowie als Zwischenprodukte zur Herstellung dieser Wirkstoffe |
| US5144041A (en) * | 1990-12-26 | 1992-09-01 | American Cyanamid Company | Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| EP0764644A1 (de) * | 1993-01-15 | 1997-03-26 | G.D. Searle & Co. | Verwendung von 3,4-Diarylfurane und deren Analoga enthaltende Medikamente zur Behandlung von Magen-Darm-Erkrankungen |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
-
1997
- 1997-12-09 US US08/987,356 patent/US5935990A/en not_active Expired - Fee Related
- 1997-12-09 DE DE69725171T patent/DE69725171T2/de not_active Expired - Fee Related
- 1997-12-09 AT AT97950891T patent/ATE250576T1/de not_active IP Right Cessation
- 1997-12-09 CA CA002273836A patent/CA2273836A1/en not_active Abandoned
- 1997-12-09 ES ES97950891T patent/ES2208964T3/es not_active Expired - Lifetime
- 1997-12-09 DK DK97950891T patent/DK0946507T3/da active
- 1997-12-09 EP EP97950891A patent/EP0946507B1/de not_active Expired - Lifetime
- 1997-12-09 PT PT97950891T patent/PT946507E/pt unknown
- 1997-12-09 WO PCT/US1997/022488 patent/WO1998025896A1/en not_active Ceased
- 1997-12-09 AU AU53776/98A patent/AU5377698A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU5377698A (en) | 1998-07-03 |
| DE69725171D1 (de) | 2003-10-30 |
| PT946507E (pt) | 2004-02-27 |
| EP0946507A1 (de) | 1999-10-06 |
| EP0946507B1 (de) | 2003-09-24 |
| DE69725171T2 (de) | 2004-07-15 |
| CA2273836A1 (en) | 1998-06-18 |
| DK0946507T3 (da) | 2004-01-26 |
| ES2208964T3 (es) | 2004-06-16 |
| WO1998025896A1 (en) | 1998-06-18 |
| US5935990A (en) | 1999-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0946507 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |