ATE250601T1 - Prozess zur herstellung der kristallinen form i von cabergolin - Google Patents

Prozess zur herstellung der kristallinen form i von cabergolin

Info

Publication number: ATE250601T1
Authority: AT; Austria
Prior art keywords: cabergoline; producing; crystalline form; crystalline
Prior art date: 2000-03-24

Application number

AT01936098T

Other languages

English (en)

Inventor

Attilio Tomasi

Stefania Magenes

Mario Ungari

Giuliano Ramella

Gianfranco Pallanza

Original Assignee

Pharmacia Italia Spa

Attilio Tomasi

Stefania Magenes

Mario Ungari

Giuliano Ramella

Gianfranco Pallanza

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-24

Filing date

2001-03-19

Publication date

2003-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9888433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE250601(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-03-19 Application filed by Pharmacia Italia Spa, Attilio Tomasi, Stefania Magenes, Mario Ungari, Giuliano Ramella, Gianfranco Pallanza filed Critical Pharmacia Italia Spa

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE250601T1 publication Critical patent/ATE250601T1/de

Links

KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 title 1
229960004596 cabergoline Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT01936098T 2000-03-24 2001-03-19 Prozess zur herstellung der kristallinen form i von cabergolin ATE250601T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0007308.0A GB0007308D0 (en)	2000-03-24	2000-03-24	Process for preparing crystalline form \| of cabergoline
PCT/EP2001/003099 WO2001070740A1 (en)	2000-03-24	2001-03-19	Process for preparing crystalline form i of cabergoline

Publications (1)

Publication Number	Publication Date
ATE250601T1 true ATE250601T1 (de)	2003-10-15

Family

ID=9888433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01936098T ATE250601T1 (de)	2000-03-24	2001-03-19	Prozess zur herstellung der kristallinen form i von cabergolin

Country Status (31)

Country	Link
US (2)	US6727363B2 (de)
EP (1)	EP1272489B1 (de)
JP (1)	JP4184666B2 (de)
KR (1)	KR100827558B1 (de)
CN (1)	CN1188412C (de)
AR (1)	AR032449A1 (de)
AT (1)	ATE250601T1 (de)
AU (2)	AU780747B2 (de)
BR (1)	BR0109507A (de)
CA (1)	CA2402836A1 (de)
CZ (1)	CZ20023176A3 (de)
DE (1)	DE60100858T2 (de)
DK (1)	DK1272489T3 (de)
EA (1)	EA005928B1 (de)
EE (1)	EE05088B1 (de)
ES (1)	ES2208602T3 (de)
GB (1)	GB0007308D0 (de)
HK (1)	HK1052348B (de)
HU (1)	HUP0300591A3 (de)
IL (2)	IL150985A0 (de)
MX (1)	MXPA02009283A (de)
MY (1)	MY134189A (de)
NO (1)	NO20024321L (de)
NZ (1)	NZ521316A (de)
PE (1)	PE20011140A1 (de)
PL (1)	PL358253A1 (de)
PT (1)	PT1272489E (de)
SI (1)	SI1272489T1 (de)
SK (1)	SK13582002A3 (de)
WO (1)	WO2001070740A1 (de)
ZA (1)	ZA200206045B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0007308D0 (en)	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Process for preparing crystalline form \| of cabergoline
GB0007307D0 (en)	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Crystalline form \|\| of cabergoline
DE10053397A1 (de) *	2000-10-20	2002-05-02	Schering Ag	Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10043321B4 (de) *	2000-08-24	2005-07-28	Neurobiotec Gmbh	Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10064453A1 (de) *	2000-12-16	2002-07-04	Schering Ag	Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
MXPA04008915A (es) *	2002-03-15	2005-06-20	Pharmacia Corp	Proceso para la preparacion de la forma cristalina 1 de la cabergolina.
KR100605794B1 (ko) *	2002-03-15	2006-08-01	파마시아 코포레이션	카베르골린의 제1형 결정을 제조하는 방법
IL155545A (en)	2003-04-21	2009-12-24	Finetech Pharmaceutical Ltd	Solvate form of cabergoline
EP1620101A4 (de) *	2003-05-08	2008-07-09	Ivax Pharmaceuticals Sro	Polymorphe von cabergolin
GB0409785D0 (en) *	2004-04-30	2004-06-09	Resolution Chemicals Ltd	Preparation of cabergoline
US7339060B2 (en)	2005-03-23	2008-03-04	Resolution Chemicals, Ltd.	Preparation of cabergoline
GB0515430D0 (en) *	2005-07-27	2005-08-31	Resolution Chemicals Ltd	Preparation of cabergoline
GB0505965D0 (en)	2005-03-23	2005-04-27	Resolution Chemicals Ltd	Preparation of cabergoline
EP1925616A1 (de) *	2006-10-26	2008-05-28	LEK Pharmaceuticals D.D.	Verfahren zur Herstellung kristalliner Formen des Cabergolins via stabile Solvate des Cabergolins
EP1953157A1 (de)	2007-01-31	2008-08-06	LEK Pharmaceuticals D.D.	Neue Kristallform von Cabergolin
EP2185169A2 (de) *	2007-08-29	2010-05-19	Max Zeller Söhne AG	Verwendung von extrakten von vitex agnus castus zur herstellung eines medikaments
EP4074552B1 (de) *	2021-04-16	2024-04-03	Thermo King LLC	Elektrische verbindungseinheit

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3019322A1 (de)	1980-05-21	1981-12-03	Merck Patent Gmbh, 6100 Darmstadt	Psychopharmakon sowie verwendung von adenosinderivaten
US4526892A (en)	1981-03-03	1985-07-02	Farmitalia Carlo Erba, S.P.A.	Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
GB2103603B (en) *	1981-08-11	1985-04-11	Erba Farmitalia	Ergoline derivatives
GB9205439D0 (en) *	1992-03-12	1992-04-22	Erba Carlo Spa	Process for the synthesis of ergoline derivatives
WO1995005176A1 (en)	1993-08-18	1995-02-23	Alcon Laboratories, Inc.	Use of ergoline derivatives for the treatment of glaucoma
EP1075278A1 (de)	1998-01-13	2001-02-14	AstraZeneca UK Limited	Pharmazeutische zusammenstellungen die eine verbindung mit dopamin d2rezeptor agonistaktivität und eine verbindung (b) mit beta2-adrenergischer aktivität enthalten
SK13312000A3 (sk)	1998-03-27	2001-05-10	Pharmacia And Upjohn Company	Použitie kabergolínu pri liečbe syndrómu nepokojných nôh
GB0007308D0 (en)	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Process for preparing crystalline form \| of cabergoline
GB0007307D0 (en)	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Crystalline form \|\| of cabergoline
GB0007309D0 (en)	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Crystalline form V\|\| of cabergoline

2000
- 2000-03-24 GB GBGB0007308.0A patent/GB0007308D0/en not_active Ceased
2001
- 2001-03-13 PE PE2001000237A patent/PE20011140A1/es not_active Application Discontinuation
- 2001-03-19 EA EA200201016A patent/EA005928B1/ru unknown
- 2001-03-19 SK SK1358-2002A patent/SK13582002A3/sk unknown
- 2001-03-19 DK DK01936098T patent/DK1272489T3/da active
- 2001-03-19 NZ NZ521316A patent/NZ521316A/en unknown
- 2001-03-19 CA CA002402836A patent/CA2402836A1/en not_active Withdrawn
- 2001-03-19 AR ARP010101263A patent/AR032449A1/es unknown
- 2001-03-19 AU AU62110/01A patent/AU780747B2/en not_active Ceased
- 2001-03-19 HK HK03104554.7A patent/HK1052348B/zh not_active IP Right Cessation
- 2001-03-19 BR BR0109507-2A patent/BR0109507A/pt not_active Application Discontinuation
- 2001-03-19 CZ CZ20023176A patent/CZ20023176A3/cs unknown
- 2001-03-19 ES ES01936098T patent/ES2208602T3/es not_active Expired - Lifetime
- 2001-03-19 WO PCT/EP2001/003099 patent/WO2001070740A1/en not_active Ceased
- 2001-03-19 EP EP01936098A patent/EP1272489B1/de not_active Expired - Lifetime
- 2001-03-19 PT PT01936098T patent/PT1272489E/pt unknown
- 2001-03-19 CN CNB018070051A patent/CN1188412C/zh not_active Expired - Fee Related
- 2001-03-19 DE DE60100858T patent/DE60100858T2/de not_active Expired - Fee Related
- 2001-03-19 IL IL15098501A patent/IL150985A0/xx active IP Right Grant
- 2001-03-19 EE EEP200200545A patent/EE05088B1/xx not_active IP Right Cessation
- 2001-03-19 HU HU0300591A patent/HUP0300591A3/hu unknown
- 2001-03-19 US US10/239,636 patent/US6727363B2/en not_active Expired - Fee Related
- 2001-03-19 PL PL01358253A patent/PL358253A1/xx not_active Application Discontinuation
- 2001-03-19 AT AT01936098T patent/ATE250601T1/de not_active IP Right Cessation
- 2001-03-19 MX MXPA02009283A patent/MXPA02009283A/es active IP Right Grant
- 2001-03-19 SI SI200130045T patent/SI1272489T1/xx unknown
- 2001-03-19 KR KR1020027012590A patent/KR100827558B1/ko not_active Expired - Fee Related
- 2001-03-19 JP JP2001568941A patent/JP4184666B2/ja not_active Expired - Fee Related
- 2001-03-22 MY MYPI20011364A patent/MY134189A/en unknown
2002
- 2002-07-29 ZA ZA200206045A patent/ZA200206045B/xx unknown
- 2002-07-30 IL IL150985A patent/IL150985A/en not_active IP Right Cessation
- 2002-09-10 NO NO20024321A patent/NO20024321L/no not_active Application Discontinuation
2003
- 2003-10-31 US US10/698,737 patent/US6953854B2/en not_active Expired - Fee Related
2005
- 2005-07-14 AU AU2005203071A patent/AU2005203071B2/en not_active Ceased

Also Published As

Publication number	Publication date
SK13582002A3 (sk)	2003-04-01
US6953854B2 (en)	2005-10-11
AU2005203071B2 (en)	2007-10-18
KR20020081587A (ko)	2002-10-28
MY134189A (en)	2007-11-30
EE200200545A (et)	2004-04-15
PT1272489E (pt)	2004-02-27
DK1272489T3 (da)	2003-12-15
US6727363B2 (en)	2004-04-27
EA005928B1 (ru)	2005-08-25
NZ521316A (en)	2004-05-28
US20030149067A1 (en)	2003-08-07
SI1272489T1 (en)	2004-02-29
MXPA02009283A (es)	2003-03-12
PE20011140A1 (es)	2001-11-01
NO20024321D0 (no)	2002-09-10
EE05088B1 (et)	2008-10-15
ZA200206045B (en)	2003-07-29
CN1419554A (zh)	2003-05-21
IL150985A0 (en)	2003-02-12
GB0007308D0 (en)	2000-05-17
HK1052348B (zh)	2005-09-16
DE60100858T2 (de)	2004-07-29
CN1188412C (zh)	2005-02-09
AU780747B2 (en)	2005-04-14
AR032449A1 (es)	2003-11-12
IL150985A (en)	2007-03-08
PL358253A1 (en)	2004-08-09
JP4184666B2 (ja)	2008-11-19
JP2003528100A (ja)	2003-09-24
AU2005203071A1 (en)	2005-08-11
EP1272489A1 (de)	2003-01-08
CZ20023176A3 (cs)	2003-02-12
WO2001070740A1 (en)	2001-09-27
EP1272489B1 (de)	2003-09-24
KR100827558B1 (ko)	2008-05-07
HK1052348A1 (en)	2003-09-11
DE60100858D1 (de)	2003-10-30
US20040092744A1 (en)	2004-05-13
NO20024321L (no)	2002-09-10
HUP0300591A3 (en)	2009-01-28
HUP0300591A2 (hu)	2003-07-28
EA200201016A1 (ru)	2003-02-27
AU6211001A (en)	2001-10-03
ES2208602T3 (es)	2004-06-16
BR0109507A (pt)	2002-12-10
CA2402836A1 (en)	2001-09-27

Legal Events

Date

Code

Title

Description

2004-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1272489

Country of ref document: EP

2010-12-15

REN

Ceased due to non-payment of the annual fee

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