ATE250603T1 - 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung - Google Patents

1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung

Info

Publication number: ATE250603T1
Authority: AT; Austria
Prior art keywords: compounds; acridone; naphthalimide; imidazo; antitumor effect
Prior art date: 2000-03-07

Application number

AT01914696T

Other languages

English (en)

Inventor

Wieslaw M Cholody

Teresa Kosakowska-Cholody

Christopher J Michejda

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-07

Filing date

2001-03-05

Publication date

2003-10-15

2001-03-05 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE250603T1 publication Critical patent/ATE250603T1/de

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 title 1
FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title 1
XJHABGPPCLHLLV-UHFFFAOYSA-N benzo[de]isoquinoline-1,3-dione Chemical compound C1=CC(C(=O)NC2=O)=C3C2=CC=CC3=C1 XJHABGPPCLHLLV-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
JPASRFGVACYSJG-UHFFFAOYSA-N 8,10-dihydroimidazo[4,5-a]acridin-9-one Chemical class N1=C2C=CC3=NC=NC3=C2C=C2C1=CCC(=O)C2 JPASRFGVACYSJG-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT01914696T 2000-03-07 2001-03-05 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung ATE250603T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18799100P	2000-03-07	2000-03-07
PCT/US2001/007087 WO2001066545A2 (en)	2000-03-07	2001-03-05	1,8-NAPHTHALIMIDE IMIDAZO[4,5,1-de]ACRIDONES WITH ANTI-TUMOR ACTIVITY

Publications (1)

Publication Number	Publication Date
ATE250603T1 true ATE250603T1 (de)	2003-10-15

Family

ID=22691331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01914696T ATE250603T1 (de)	2000-03-07	2001-03-05	1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung

Country Status (8)

Country	Link
US (1)	US6664263B2 (de)
EP (1)	EP1265898B1 (de)
JP (1)	JP2003525940A (de)
AT (1)	ATE250603T1 (de)
AU (2)	AU2001240054B2 (de)
CA (1)	CA2402446C (de)
DE (1)	DE60100855T2 (de)
WO (1)	WO2001066545A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1519939T5 (da)	2002-07-05	2011-01-24	Targacept Inc	N-Aryl-diazaspirocykliske forbindelser og fremgangsmåder til fremstilling og anvendelse deraf
CA2586320A1 (en) *	2003-11-05	2005-05-19	Photobiomed Corporation	Bonding tissues and cross-linking proteins with naphthalimide compounds
EP1761537B1 (de) *	2004-06-30	2011-08-03	Council of Scientific and Industrial Research	Über die piperazineinheit gebundene pyrrolo[2,1-c][1,4]benzodiazepin-napthalimid-konjugate und verfahren zu deren herstellung
US6979684B1 (en)	2004-06-30	2005-12-27	Council Of Scientific And Industrial Research	Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof
WO2007092436A2 (en) *	2006-02-08	2007-08-16	Xanthus Pharmaceuticals, Inc.	Compounds for treating inflammatory disorders, demyelinating disorders and cancers
US20080108641A1 (en) *	2006-02-08	2008-05-08	Ajami Alfred M	Compounds for treating inflammatory disorders, demyelinating disdorders and cancers
CN100364536C (zh) *	2006-03-03	2008-01-30	大连理工大学	甲基异硫脲阳离子作为连接基的脱氧核糖核酸双嵌入剂
US20100016300A1 (en) *	2006-08-02	2010-01-21	Ajami Alfred M	Imidazoacridine Compounds for Treating FLT3-Mediated Disorders
WO2008016660A2 (en) *	2006-08-02	2008-02-07	Xanthus Pharmaceuticals, Inc.	Imidazoacridine compounds for treating leukemias
WO2008016661A2 (en) *	2006-08-02	2008-02-07	Xanthus Pharmaceuticals, Inc.	Morpholino compounds for treating inflammatory and demyelinating diseases and cancers
EP2086521A2 (de) *	2006-11-07	2009-08-12	Government of the United States of America, Represented by the Secretary, Department of Health and Human Services	Aus transmembranpeptiden zusammengesetzte selbstanordnende nanopartikel und ihre anwendung zur spezifischen verabreichung von anti-krebs-wirkstoffen in einen tumor
CN112898301B (zh) *	2021-01-29	2022-03-08	河南大学	一种萘酰亚胺吲哚杂环化合物、其制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9104548D0 (en)	1991-03-05	1991-04-17	Cholody Wienlaw M	Antineoplastic modified imidazoacridines
IL110460A (en)	1993-08-18	2001-01-11	Basf Ag	Bis-naphthalimides, their preparation and pharmaceutical compositions containing them
ATE211471T1 (de) *	1996-04-12	2002-01-15	Us Gov Health & Human Serv	Acridonderivate als antineoplastische-und antiretrovirale mittel

2001
- 2001-03-05 AU AU2001240054A patent/AU2001240054B2/en not_active Ceased
- 2001-03-05 WO PCT/US2001/007087 patent/WO2001066545A2/en not_active Ceased
- 2001-03-05 EP EP01914696A patent/EP1265898B1/de not_active Expired - Lifetime
- 2001-03-05 CA CA2402446A patent/CA2402446C/en not_active Expired - Fee Related
- 2001-03-05 JP JP2001565361A patent/JP2003525940A/ja active Pending
- 2001-03-05 DE DE60100855T patent/DE60100855T2/de not_active Expired - Lifetime
- 2001-03-05 AU AU4005401A patent/AU4005401A/xx active Pending
- 2001-03-05 US US10/221,236 patent/US6664263B2/en not_active Expired - Lifetime
- 2001-03-05 AT AT01914696T patent/ATE250603T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2402446A1 (en)	2001-09-13
US6664263B2 (en)	2003-12-16
DE60100855T2 (de)	2004-07-15
JP2003525940A (ja)	2003-09-02
EP1265898B1 (de)	2003-09-24
DE60100855D1 (de)	2003-10-30
AU2001240054B2 (en)	2005-08-11
WO2001066545A2 (en)	2001-09-13
CA2402446C (en)	2011-05-17
US20030203916A1 (en)	2003-10-30
EP1265898A2 (de)	2002-12-18
WO2001066545A3 (en)	2002-02-28
AU4005401A (en)	2001-09-17

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Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties