BRPI0412993A - inibidores da atividade da akt - Google Patents

inibidores da atividade da akt

Info

Publication number
BRPI0412993A
BRPI0412993A BRPI0412993-8A BRPI0412993A BRPI0412993A BR PI0412993 A BRPI0412993 A BR PI0412993A BR PI0412993 A BRPI0412993 A BR PI0412993A BR PI0412993 A BRPI0412993 A BR PI0412993A
Authority
BR
Brazil
Prior art keywords
akt activity
activity inhibitors
inhibitors
compounds
akt
Prior art date
Application number
BRPI0412993-8A
Other languages
English (en)
Inventor
Dirk A Heerding
Tammy J Clark
David H Drewry
Jack Dale Leber
Igor Safonov
Dennis S Yamashita
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BRPI0412993A publication Critical patent/BRPI0412993A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"INIBIDORES DA ATIVIDADE DA Akt". São inventados novos compostos 1H-imidazo ¢4,5-c! piridin-2-il, o uso de tais compostos como inibidores da atividade da proteína quinase B e no tratamento de câncer e artrite.
BRPI0412993-8A 2003-07-29 2004-07-28 inibidores da atividade da akt BRPI0412993A (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US49085103P 2003-07-29 2003-07-29
US49105503P 2003-07-30 2003-07-30
US49310103P 2003-08-06 2003-08-06
US49475203P 2003-08-13 2003-08-13
US50701403P 2003-09-29 2003-09-29
US53084703P 2003-12-18 2003-12-18
PCT/US2004/024340 WO2005011700A1 (en) 2003-07-29 2004-07-28 INHIBITORS OF Akt ACTIVITY

Publications (1)

Publication Number Publication Date
BRPI0412993A true BRPI0412993A (pt) 2006-10-03

Family

ID=34120170

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412993-8A BRPI0412993A (pt) 2003-07-29 2004-07-28 inibidores da atividade da akt

Country Status (16)

Country Link
US (1) US20080255143A1 (pt)
EP (1) EP1653961A4 (pt)
JP (1) JP2007500709A (pt)
KR (1) KR20060066714A (pt)
AR (1) AR045134A1 (pt)
AU (1) AU2004261214A1 (pt)
BR (1) BRPI0412993A (pt)
CA (1) CA2534038A1 (pt)
CO (1) CO5640140A2 (pt)
IL (1) IL173174A0 (pt)
IS (1) IS8322A (pt)
MA (1) MA27933A1 (pt)
MX (1) MXPA06001134A (pt)
NO (1) NO20060985L (pt)
TW (1) TW200523262A (pt)
WO (1) WO2005011700A1 (pt)

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AU2004261214A1 (en) 2005-02-10
EP1653961A1 (en) 2006-05-10
CO5640140A2 (es) 2006-05-31
JP2007500709A (ja) 2007-01-18
MXPA06001134A (es) 2006-04-11
US20080255143A1 (en) 2008-10-16
IS8322A (is) 2006-02-22
WO2005011700A1 (en) 2005-02-10
MA27933A1 (fr) 2006-06-01
IL173174A0 (en) 2006-06-11
AR045134A1 (es) 2005-10-19
CA2534038A1 (en) 2005-02-10
EP1653961A4 (en) 2009-04-01

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