ATE251109T1 - Verfahren zur herstellung von naproxennitroxyalkylestern - Google Patents

Verfahren zur herstellung von naproxennitroxyalkylestern

Info

Publication number
ATE251109T1
ATE251109T1 AT00951456T AT00951456T ATE251109T1 AT E251109 T1 ATE251109 T1 AT E251109T1 AT 00951456 T AT00951456 T AT 00951456T AT 00951456 T AT00951456 T AT 00951456T AT E251109 T1 ATE251109 T1 AT E251109T1
Authority
AT
Austria
Prior art keywords
naproxennitroxyalkyl
esters
producing
naphthyl
methoxy
Prior art date
Application number
AT00951456T
Other languages
English (en)
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of ATE251109T1 publication Critical patent/ATE251109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00951456T 1999-08-04 2000-07-27 Verfahren zur herstellung von naproxennitroxyalkylestern ATE251109T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Publications (1)

Publication Number Publication Date
ATE251109T1 true ATE251109T1 (de) 2003-10-15

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00951456T ATE251109T1 (de) 1999-08-04 2000-07-27 Verfahren zur herstellung von naproxennitroxyalkylestern
AT03102132T ATE297372T1 (de) 1999-08-04 2000-07-27 4-nitroxybutylester von naproxen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03102132T ATE297372T1 (de) 1999-08-04 2000-07-27 4-nitroxybutylester von naproxen

Country Status (23)

Country Link
US (2) US6700011B1 (de)
EP (2) EP1200386B1 (de)
JP (2) JP4667691B2 (de)
KR (1) KR100687820B1 (de)
CN (1) CN1198786C (de)
AT (2) ATE251109T1 (de)
AU (1) AU778694B2 (de)
BR (1) BRPI0012915B1 (de)
CA (1) CA2380116C (de)
DE (2) DE60020753T2 (de)
DK (2) DK1200386T3 (de)
ES (2) ES2243859T3 (de)
HU (1) HU227109B1 (de)
IL (1) IL147639A0 (de)
IT (1) IT1313596B1 (de)
MX (1) MXPA02001256A (de)
NO (1) NO327669B1 (de)
PL (1) PL200165B1 (de)
PT (2) PT1200386E (de)
RU (1) RU2248348C2 (de)
TR (1) TR200200290T2 (de)
WO (1) WO2001010814A1 (de)
ZA (2) ZA200200478B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126838A4 (de) 1998-10-30 2005-02-16 Nitromed Inc Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden
JP2003523958A (ja) 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法
CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2003045896A1 (en) * 2001-11-27 2003-06-05 Astrazeneca Ab New process
US7220749B2 (en) 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
JP5745210B2 (ja) * 2006-02-03 2015-07-08 ニコックス サイエンス アイルランド 筋ジストロフィーの治療用薬剤のニトロオキシ誘導体の使用
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
BRPI0813438A2 (pt) 2007-06-28 2014-12-23 Nicox Sa Processo para preparar um composto, uso de um composto, e, composto.
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
CA3167343A1 (en) 2020-02-10 2021-08-19 Brigitte DUQUESROIX-CHAKROUN Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
JP3775796B2 (ja) * 1993-10-06 2006-05-17 ニコックス エス エイ 抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法
RU2145595C1 (ru) * 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
AU6835696A (en) * 1995-10-09 1997-04-30 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
PL200165B1 (pl) 2008-12-31
DE60005682D1 (de) 2003-11-06
CA2380116C (en) 2011-07-05
CN1198786C (zh) 2005-04-27
IT1313596B1 (it) 2002-09-09
WO2001010814A1 (en) 2001-02-15
ZA200304525B (en) 2004-04-28
JP2003506425A (ja) 2003-02-18
HUP0202435A3 (en) 2004-03-01
NO20020515L (no) 2002-02-01
JP2011042690A (ja) 2011-03-03
ITMI991753A0 (it) 1999-08-04
CN1367773A (zh) 2002-09-04
PT1200386E (pt) 2004-02-27
AU6438500A (en) 2001-03-05
JP4667691B2 (ja) 2011-04-13
KR20020013974A (ko) 2002-02-21
EP1200386A1 (de) 2002-05-02
HU227109B1 (en) 2010-07-28
NO20020515D0 (no) 2002-02-01
ES2243859T3 (es) 2005-12-01
DK1200386T3 (da) 2003-12-22
US6700011B1 (en) 2004-03-02
US20050119339A1 (en) 2005-06-02
DK1384707T3 (da) 2005-08-15
EP1384707B1 (de) 2005-06-08
DE60020753T2 (de) 2006-03-16
BR0012915A (pt) 2002-06-04
MXPA02001256A (es) 2005-06-06
EP1200386B1 (de) 2003-10-01
BRPI0012915B1 (pt) 2015-09-01
ITMI991753A1 (it) 2001-02-04
PL353092A1 (en) 2003-10-06
US7238829B2 (en) 2007-07-03
NO327669B1 (no) 2009-09-07
ES2208390T3 (es) 2004-06-16
TR200200290T2 (tr) 2002-05-21
ATE297372T1 (de) 2005-06-15
CA2380116A1 (en) 2001-02-15
AU778694B2 (en) 2004-12-16
RU2248348C2 (ru) 2005-03-20
DE60005682T2 (de) 2004-09-16
IL147639A0 (en) 2002-08-14
KR100687820B1 (ko) 2007-02-28
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
ZA200200478B (en) 2003-10-29
PT1384707E (pt) 2005-08-31
EP1384707A1 (de) 2004-01-28

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