ATE297372T1 - 4-nitroxybutylester von naproxen - Google Patents

4-nitroxybutylester von naproxen

Info

Publication number: ATE297372T1
Authority: AT; Austria
Prior art keywords: naproxen; nitroxybutyl ester; nitroxybutyl; ester; naphthyl
Prior art date: 1999-08-04

Application number

AT03102132T

Other languages

English (en)

Inventor

Francesca Benedini

Erminio Oldani

Graziano Castaldi

Antonio Tarquini

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-04

Filing date

2000-07-27

Publication date

2005-06-15

2000-07-27 Application filed by Nicox Sa filed Critical Nicox Sa

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297372T1 publication Critical patent/ATE297372T1/de

Links

-1 4-NITROXYBUTYL Chemical class 0.000 title abstract 2
CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 title abstract 2
CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 title 1
229960002009 naproxen Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT03102132T 1999-08-04 2000-07-27 4-nitroxybutylester von naproxen ATE297372T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1999MI001753A IT1313596B1 (it)	1999-08-04	1999-08-04	Processo per la preparazione di nitrossialchil esteri del naproxene

Publications (1)

Publication Number	Publication Date
ATE297372T1 true ATE297372T1 (de)	2005-06-15

Family

ID=11383500

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT00951456T ATE251109T1 (de)	1999-08-04	2000-07-27	Verfahren zur herstellung von naproxennitroxyalkylestern
AT03102132T ATE297372T1 (de)	1999-08-04	2000-07-27	4-nitroxybutylester von naproxen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT00951456T ATE251109T1 (de)	1999-08-04	2000-07-27	Verfahren zur herstellung von naproxennitroxyalkylestern

Country Status (23)

Country	Link
US (2)	US6700011B1 (de)
EP (2)	EP1200386B1 (de)
JP (2)	JP4667691B2 (de)
KR (1)	KR100687820B1 (de)
CN (1)	CN1198786C (de)
AT (2)	ATE251109T1 (de)
AU (1)	AU778694B2 (de)
BR (1)	BRPI0012915B1 (de)
CA (1)	CA2380116C (de)
DE (2)	DE60005682T2 (de)
DK (2)	DK1200386T3 (de)
ES (2)	ES2243859T3 (de)
HU (1)	HU227109B1 (de)
IL (1)	IL147639A0 (de)
IT (1)	IT1313596B1 (de)
MX (1)	MXPA02001256A (de)
NO (1)	NO327669B1 (de)
PL (1)	PL200165B1 (de)
PT (2)	PT1384707E (de)
RU (1)	RU2248348C2 (de)
TR (1)	TR200200290T2 (de)
WO (1)	WO2001010814A1 (de)
ZA (2)	ZA200200478B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6297260B1 (en)	1998-10-30	2001-10-02	Nitromed, Inc.	Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
AP2002002582A0 (en)	1999-12-23	2002-09-30	Nitromed Inc	Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
DE60122939T2 (de)	2000-12-21	2007-01-11	Nitromed, Inc., Bedford	Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
AU2002365372A1 (en) *	2001-11-27	2003-06-10	Astrazeneca Ab	New process
CA2487414A1 (en)	2002-06-11	2003-12-18	Nitromed, Inc.	Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en)	2002-07-03	2009-09-24	Nicox S.A.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en)	2002-07-29	2007-07-17	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it)	2002-08-29	2004-02-29	Nicox Sa	Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) *	2002-11-14	2004-05-15	Dinamite Dipharma S P A	Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
NZ569396A (en) *	2006-02-03	2011-06-30	Nicox Sa	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
CN100427475C (zh) *	2006-11-30	2008-10-22	华南理工大学	萘普生-2-芳基吗啉乙酯及其制备方法与应用
JP2010531324A (ja) *	2007-06-28	2010-09-24	ニコックスエスエイ	１，４−ブタンジオールモノナイトレートの製造方法
WO2009149053A2 (en) *	2008-06-02	2009-12-10	Dr. Reddy's Laboratories Ltd.	Naproxcinod process and solid dispersion
ITRM20080325A1 (it) *	2008-06-20	2009-12-21	Nicox Sa	Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en)	2010-03-31	2011-11-16	Lonza Ag	Process for the production of esters of nitric acid
TWI417276B (zh)	2011-03-01	2013-12-01	Everlight Chem Ind Corp	２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en)	2013-01-21	2018-12-18	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CA3167343A1 (en)	2020-02-10	2021-08-19	Brigitte DUQUESROIX-CHAKROUN	Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57145841A (en) *	1981-03-05	1982-09-09	Nissan Chem Ind Ltd	L-menthyl naphthylpropionate and its preparation
IT1243367B (it) *	1990-07-26	1994-06-10	Italfarmaco Spa	Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
EP0722434B1 (de) *	1993-10-06	1998-07-29	Nicox S.A.	Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
WO1995030641A1 (en) *	1994-05-10	1995-11-16	Nicox S.A.	Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) *	1995-08-25	1997-03-05	蔡雄	可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) *	1995-10-09	1997-04-17	Russinsky Limited	Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it)	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr)	1996-12-12	1999-12-17	Hoechst Marion Roussel Inc	Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

1999
- 1999-08-04 IT IT1999MI001753A patent/IT1313596B1/it active
2000
- 2000-07-27 KR KR1020027000946A patent/KR100687820B1/ko not_active Expired - Fee Related
- 2000-07-27 JP JP2001515282A patent/JP4667691B2/ja not_active Expired - Lifetime
- 2000-07-27 RU RU2002102860/04A patent/RU2248348C2/ru active
- 2000-07-27 DK DK00951456T patent/DK1200386T3/da active
- 2000-07-27 US US10/031,412 patent/US6700011B1/en not_active Expired - Lifetime
- 2000-07-27 BR BRPI0012915-1A patent/BRPI0012915B1/pt not_active IP Right Cessation
- 2000-07-27 DE DE60005682T patent/DE60005682T2/de not_active Expired - Lifetime
- 2000-07-27 PL PL353092A patent/PL200165B1/pl unknown
- 2000-07-27 DK DK03102132T patent/DK1384707T3/da active
- 2000-07-27 AU AU64385/00A patent/AU778694B2/en not_active Ceased
- 2000-07-27 DE DE60020753T patent/DE60020753T2/de not_active Expired - Lifetime
- 2000-07-27 EP EP00951456A patent/EP1200386B1/de not_active Expired - Lifetime
- 2000-07-27 PT PT03102132T patent/PT1384707E/pt unknown
- 2000-07-27 PT PT00951456T patent/PT1200386E/pt unknown
- 2000-07-27 CA CA2380116A patent/CA2380116C/en not_active Expired - Lifetime
- 2000-07-27 EP EP03102132A patent/EP1384707B1/de not_active Expired - Lifetime
- 2000-07-27 TR TR2002/00290T patent/TR200200290T2/xx unknown
- 2000-07-27 IL IL14763900A patent/IL147639A0/xx not_active IP Right Cessation
- 2000-07-27 CN CNB008111588A patent/CN1198786C/zh not_active Expired - Fee Related
- 2000-07-27 WO PCT/EP2000/007222 patent/WO2001010814A1/en not_active Ceased
- 2000-07-27 HU HU0202435A patent/HU227109B1/hu not_active IP Right Cessation
- 2000-07-27 ES ES03102132T patent/ES2243859T3/es not_active Expired - Lifetime
- 2000-07-27 AT AT00951456T patent/ATE251109T1/de active
- 2000-07-27 ES ES00951456T patent/ES2208390T3/es not_active Expired - Lifetime
- 2000-07-27 AT AT03102132T patent/ATE297372T1/de active
- 2000-07-27 MX MXPA02001256A patent/MXPA02001256A/es active IP Right Grant
2002
- 2002-01-18 ZA ZA200200478A patent/ZA200200478B/en unknown
- 2002-02-01 NO NO20020515A patent/NO327669B1/no not_active IP Right Cessation
2003
- 2003-06-10 ZA ZA200304525A patent/ZA200304525B/xx unknown
- 2003-07-24 US US10/625,558 patent/US7238829B2/en not_active Expired - Lifetime
2010
- 2010-11-30 JP JP2010266860A patent/JP2011042690A/ja active Pending

Also Published As

Publication number	Publication date
DE60020753T2 (de)	2006-03-16
JP2003506425A (ja)	2003-02-18
CA2380116C (en)	2011-07-05
CN1198786C (zh)	2005-04-27
MXPA02001256A (es)	2005-06-06
EP1384707A1 (de)	2004-01-28
DE60020753D1 (de)	2005-07-14
HUP0202435A2 (hu)	2002-11-28
EP1200386A1 (de)	2002-05-02
ATE251109T1 (de)	2003-10-15
PL200165B1 (pl)	2008-12-31
RU2248348C2 (ru)	2005-03-20
JP4667691B2 (ja)	2011-04-13
KR100687820B1 (ko)	2007-02-28
DE60005682T2 (de)	2004-09-16
CA2380116A1 (en)	2001-02-15
HU227109B1 (en)	2010-07-28
IT1313596B1 (it)	2002-09-09
WO2001010814A1 (en)	2001-02-15
US7238829B2 (en)	2007-07-03
NO20020515D0 (no)	2002-02-01
DE60005682D1 (de)	2003-11-06
ITMI991753A0 (it)	1999-08-04
PT1384707E (pt)	2005-08-31
CN1367773A (zh)	2002-09-04
ES2208390T3 (es)	2004-06-16
ES2243859T3 (es)	2005-12-01
NO327669B1 (no)	2009-09-07
HUP0202435A3 (en)	2004-03-01
ITMI991753A1 (it)	2001-02-04
IL147639A0 (en)	2002-08-14
EP1200386B1 (de)	2003-10-01
BR0012915A (pt)	2002-06-04
EP1384707B1 (de)	2005-06-08
JP2011042690A (ja)	2011-03-03
BRPI0012915B1 (pt)	2015-09-01
ZA200304525B (en)	2004-04-28
KR20020013974A (ko)	2002-02-21
DK1384707T3 (da)	2005-08-15
DK1200386T3 (da)	2003-12-22
PT1200386E (pt)	2004-02-27
US20050119339A1 (en)	2005-06-02
PL353092A1 (en)	2003-10-06
ZA200200478B (en)	2003-10-29
NO20020515L (no)	2002-02-01
TR200200290T2 (tr)	2002-05-21
AU778694B2 (en)	2004-12-16
US6700011B1 (en)	2004-03-02
AU6438500A (en)	2001-03-05

Legal Events

Date

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Title

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2005-12-15

UEP

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Publication	Publication Date	Title
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