ATE297372T1 - 4-nitroxybutylester von naproxen - Google Patents

4-nitroxybutylester von naproxen

Info

Publication number
ATE297372T1
ATE297372T1 AT03102132T AT03102132T ATE297372T1 AT E297372 T1 ATE297372 T1 AT E297372T1 AT 03102132 T AT03102132 T AT 03102132T AT 03102132 T AT03102132 T AT 03102132T AT E297372 T1 ATE297372 T1 AT E297372T1
Authority
AT
Austria
Prior art keywords
naproxen
nitroxybutyl ester
nitroxybutyl
ester
naphthyl
Prior art date
Application number
AT03102132T
Other languages
English (en)
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of ATE297372T1 publication Critical patent/ATE297372T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT03102132T 1999-08-04 2000-07-27 4-nitroxybutylester von naproxen ATE297372T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene

Publications (1)

Publication Number Publication Date
ATE297372T1 true ATE297372T1 (de) 2005-06-15

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03102132T ATE297372T1 (de) 1999-08-04 2000-07-27 4-nitroxybutylester von naproxen
AT00951456T ATE251109T1 (de) 1999-08-04 2000-07-27 Verfahren zur herstellung von naproxennitroxyalkylestern

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00951456T ATE251109T1 (de) 1999-08-04 2000-07-27 Verfahren zur herstellung von naproxennitroxyalkylestern

Country Status (23)

Country Link
US (2) US6700011B1 (de)
EP (2) EP1384707B1 (de)
JP (2) JP4667691B2 (de)
KR (1) KR100687820B1 (de)
CN (1) CN1198786C (de)
AT (2) ATE297372T1 (de)
AU (1) AU778694B2 (de)
BR (1) BRPI0012915B1 (de)
CA (1) CA2380116C (de)
DE (2) DE60020753T2 (de)
DK (2) DK1200386T3 (de)
ES (2) ES2208390T3 (de)
HU (1) HU227109B1 (de)
IL (1) IL147639A0 (de)
IT (1) IT1313596B1 (de)
MX (1) MXPA02001256A (de)
NO (1) NO327669B1 (de)
PL (1) PL200165B1 (de)
PT (2) PT1200386E (de)
RU (1) RU2248348C2 (de)
TR (1) TR200200290T2 (de)
WO (1) WO2001010814A1 (de)
ZA (2) ZA200200478B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
US6649629B2 (en) 1999-12-23 2003-11-18 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
AU2002365372A1 (en) * 2001-11-27 2003-06-10 Astrazeneca Ab New process
US7220749B2 (en) 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004004648A2 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
DK1978947T3 (da) * 2006-02-03 2014-11-03 Nicox Science Ireland Nitrooxyderivater til anvendelse ved behandling af muskeldystrofier
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
CN101730676A (zh) 2007-06-28 2010-06-09 尼科克斯公司 1,4-丁二醇单硝酸酯的制备方法
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
US11660282B2 (en) 2020-02-10 2023-05-30 Nicox Sa Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
JP4043046B2 (ja) * 1994-05-10 2008-02-06 ニコックス エス エイ 消炎、鎮痛および抗血栓活性を有するニトロ化合物およびそれらの組成物
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
CN1198786C (zh) 2005-04-27
JP2003506425A (ja) 2003-02-18
US6700011B1 (en) 2004-03-02
NO20020515D0 (no) 2002-02-01
ZA200304525B (en) 2004-04-28
JP4667691B2 (ja) 2011-04-13
EP1384707B1 (de) 2005-06-08
EP1200386B1 (de) 2003-10-01
PL200165B1 (pl) 2008-12-31
TR200200290T2 (tr) 2002-05-21
KR20020013974A (ko) 2002-02-21
JP2011042690A (ja) 2011-03-03
ES2243859T3 (es) 2005-12-01
HU227109B1 (en) 2010-07-28
ITMI991753A0 (it) 1999-08-04
HUP0202435A3 (en) 2004-03-01
EP1200386A1 (de) 2002-05-02
ZA200200478B (en) 2003-10-29
DK1384707T3 (da) 2005-08-15
MXPA02001256A (es) 2005-06-06
US20050119339A1 (en) 2005-06-02
ES2208390T3 (es) 2004-06-16
CA2380116A1 (en) 2001-02-15
IL147639A0 (en) 2002-08-14
BRPI0012915B1 (pt) 2015-09-01
KR100687820B1 (ko) 2007-02-28
US7238829B2 (en) 2007-07-03
AU778694B2 (en) 2004-12-16
PT1200386E (pt) 2004-02-27
RU2248348C2 (ru) 2005-03-20
ITMI991753A1 (it) 2001-02-04
PL353092A1 (en) 2003-10-06
NO20020515L (no) 2002-02-01
EP1384707A1 (de) 2004-01-28
ATE251109T1 (de) 2003-10-15
CN1367773A (zh) 2002-09-04
DK1200386T3 (da) 2003-12-22
NO327669B1 (no) 2009-09-07
BR0012915A (pt) 2002-06-04
DE60005682D1 (de) 2003-11-06
DE60005682T2 (de) 2004-09-16
WO2001010814A1 (en) 2001-02-15
DE60020753D1 (de) 2005-07-14
PT1384707E (pt) 2005-08-31
HUP0202435A2 (hu) 2002-11-28
DE60020753T2 (de) 2006-03-16
CA2380116C (en) 2011-07-05
IT1313596B1 (it) 2002-09-09
AU6438500A (en) 2001-03-05

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