ATE251133T1 - Neue strukturelle vitamin d derivate - Google Patents

Neue strukturelle vitamin d derivate

Info

Publication number
ATE251133T1
ATE251133T1 AT99203513T AT99203513T ATE251133T1 AT E251133 T1 ATE251133 T1 AT E251133T1 AT 99203513 T AT99203513 T AT 99203513T AT 99203513 T AT99203513 T AT 99203513T AT E251133 T1 ATE251133 T1 AT E251133T1
Authority
AT
Austria
Prior art keywords
vitamin
ring
derivatives
analogue
membered
Prior art date
Application number
AT99203513T
Other languages
English (en)
Inventor
Roger Bouillon
Maurits Vandewalle
Clercq Pierre Jean De
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Application granted granted Critical
Publication of ATE251133T1 publication Critical patent/ATE251133T1/de

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    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/198—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing ether groups, groups, groups, or groups
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    • A61P13/00—Drugs for disorders of the urinary system
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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
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    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
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    • C07C47/37—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
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    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
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    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Endocrinology (AREA)
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  • Oncology (AREA)
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  • Hematology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
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  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99203513T 1993-07-09 1994-07-07 Neue strukturelle vitamin d derivate ATE251133T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93202037 1993-07-09

Publications (1)

Publication Number Publication Date
ATE251133T1 true ATE251133T1 (de) 2003-10-15

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ID=8213977

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94924749T ATE191712T1 (de) 1993-07-09 1994-07-07 Neue strukturelle vitamin d derivate
AT99203513T ATE251133T1 (de) 1993-07-09 1994-07-07 Neue strukturelle vitamin d derivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94924749T ATE191712T1 (de) 1993-07-09 1994-07-07 Neue strukturelle vitamin d derivate

Country Status (16)

Country Link
US (2) US6017907A (de)
EP (2) EP0972762B1 (de)
JP (2) JP4235256B2 (de)
CN (1) CN1103755C (de)
AT (2) ATE191712T1 (de)
AU (1) AU699200B2 (de)
CA (1) CA2166898C (de)
DE (2) DE69423966T2 (de)
DK (2) DK0707566T3 (de)
ES (2) ES2147238T3 (de)
GR (1) GR3033856T3 (de)
NO (1) NO314142B1 (de)
NZ (1) NZ271332A (de)
PT (2) PT972762E (de)
RU (1) RU2153491C2 (de)
WO (1) WO1995001960A1 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT972762E (pt) * 1993-07-09 2004-02-27 Theramex Novos analogos estruturais da vitamina d
EP0793649B1 (de) * 1994-11-21 1999-02-03 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin-d-derivate
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
DE69606680T2 (de) * 1995-10-30 2000-08-17 F. Hoffmann-La Roche Ag, Basel 1-Alpha, 26-dihydroxy-D-homo-vitamin D3
EP0874813A1 (de) * 1995-10-31 1998-11-04 F. Hoffmann-La Roche Ag 24-homo-26,27-hexafluoro-cholecalciferol derivate
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
ES2173586T3 (es) * 1997-05-23 2002-10-16 Basilea Pharmaceutica Ag Derivados de ciclohexandiol.
AU735676B2 (en) * 1997-06-10 2001-07-12 Mrc Holdings Pty Limited Method of treatment of liver tumours and pharmaceutical compositions for use therein
AUPO727097A0 (en) 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
JP4357114B2 (ja) * 1998-02-24 2009-11-04 中外製薬株式会社 ２４−ヒドロキシビタミンｄ誘導体
US6184422B1 (en) * 1998-02-26 2001-02-06 Hoffman-La Roche Inc. Cyclohexanediol derivatives
ES2368824T3 (es) * 1998-03-27 2011-11-22 Oregon Health & Science University Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos.
US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6310262B1 (en) * 1999-10-18 2001-10-30 Basilea Pharmaceutica Ag Process for preparing retiferol derivatives
US6191292B1 (en) * 1999-12-08 2001-02-20 Laboratoire Theramex Precursors of the A-ring of vitamin D and method and intermediates for the preparation thereof
KR100732271B1 (ko) 1999-12-08 2007-06-25 라보라뚜와르 떼라멕스 비타민 디 전구체, 제조방법 및 중간체
US7632518B2 (en) * 2002-01-15 2009-12-15 Dsm Ip Assets B.V. 25-hydroxy vitamin D3 compositions
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
CA2528378A1 (en) * 2003-06-11 2004-12-23 Novacea, Inc. Treatment of immune-mediated disorders with active vitamin d compounds alone or in combination with other therapeutic agents
US20050074443A1 (en) * 2003-10-03 2005-04-07 Treadwell Benjamin V. Methods of attenuating autoimmune disease and compositions useful therefor
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US7713951B2 (en) * 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
GB0423091D0 (en) * 2004-10-19 2004-11-17 Leuven K U Res & Dev Bioactive vitamin d analogues
US20080069814A1 (en) * 2005-01-05 2008-03-20 Novacea, Inc. Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof
US20090069276A1 (en) * 2005-04-22 2009-03-12 Novacea, Inc. Treatment, prevention and amelioration of pulmonary disorders associated with chemotherapy or radiotherapy with active vitamin D compounds or mimics thereof
JP2011510088A (ja) * 2008-01-22 2011-03-31 ウイスコンシン アラムニ リサーチ ファンデーション １α，２５−ジヒドロキシ−１９−ノル−ビタミンＤ３化合物の１３，１３−ジメチル−ｄｅｓ−Ｃ，Ｄ類似体並びにその局所組成物剤形及びそれによる皮膚状態の治療方法
US8109466B2 (en) * 2008-06-23 2012-02-07 Rohr, Inc. Thrust reverser cascade assembly and AFT cascade ring with flow deflector portion
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
DE602010000019D1 (de) * 2009-05-20 2011-05-26 Hybrigenics Sa Neue therapeutische Verwendungen von Inecalcitol
CN106265695B (zh) 2009-08-14 2021-05-07 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
ATE550318T1 (de) * 2010-01-26 2012-04-15 Hybrigenics Sa Neues verfahren zur isomerisierung kondensierter bicyclischer strukturen und herstellung von diese enthaltenden vitamin d analoga
WO2011144661A1 (en) * 2010-05-20 2011-11-24 Roche Diagnostics Gmbh Release reagent for vitamin d compounds
US20120015913A1 (en) 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
EP2407152A1 (de) 2010-07-15 2012-01-18 Hybrigenics S.A. Formulierungen von 14-epi-Analoga von Vitamin D
EP2407155B1 (de) 2010-07-15 2012-12-26 Hybrigenics S.A. Formulierungen des Inecalcitols
AU2012338908B2 (en) 2011-11-18 2018-03-22 F. Hoffmann-La Roche Ag Release reagent for vitamin D compounds
WO2013078559A1 (en) * 2011-11-30 2013-06-06 Alphora Research Inc. Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
JP2015501818A (ja) 2011-12-16 2015-01-19 アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法
CA2860446C (en) 2011-12-29 2017-01-10 Alphora Research Inc. 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
US9278979B2 (en) 2012-03-30 2016-03-08 Alphora Research Inc. Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
JP6407950B2 (ja) 2013-03-14 2018-10-17 アクイノックス ファーマシューティカルズ （カナダ） インコーポレイテッド Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法
ES2740779T3 (es) 2013-03-14 2020-02-06 Aquinox Pharmaceuticals Canada Inc Moduladores de SHIP1
CN112156097A (zh) 2013-05-29 2021-01-01 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
GB2515128B (en) 2013-06-10 2015-05-27 Givaudan Sa Improvements in or relating to organic compounds
WO2015106293A1 (en) 2014-01-13 2015-07-16 P2 Science, Inc. Terpene-derived acids and esters and methods for preparing and using same
US10071944B2 (en) 2014-06-20 2018-09-11 P2 Science, Inc. Film ozonolysis in a tubular or multitubular reactor
WO2016022803A2 (en) * 2014-08-06 2016-02-11 P2 Science, Inc. Fragrances from the esters of fatty acids
GB201421855D0 (en) * 2014-12-09 2015-01-21 Givaudan Sa Improvements in or relating to organic compounds
CA2986790A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
JP7028457B2 (ja) 2016-06-21 2022-03-02 ピー２・サイエンス・インコーポレイテッド 過酸化物混合物の連続クエンチのためのフロースルー反応器およびそれを含む方法
EP3512631B1 (de) 2016-09-16 2022-03-23 P2 Science, Inc. Verwendung von vanadium zum oxidieren von aldehyden und ozoniden
EP3866968A4 (de) 2018-10-19 2022-07-27 P2 Science, Inc. Neue verfahren zur disproportionierungsabschreckungvon ozoniden
CN110330522A (zh) * 2019-07-29 2019-10-15 南京海融医药科技股份有限公司 一种帕立骨化醇异构体杂质py5的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985003299A1 (en) * 1984-01-30 1985-08-01 Wisconsin Alumni Research Foundation Side-chain unsaturated 1-hydroxyvitamin d compounds
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
DE3913310A1 (de) * 1989-04-20 1990-10-25 Schering Ag Spirocyclopropane in der vitamin d-reihe
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
PT972762E (pt) * 1993-07-09 2004-02-27 Theramex Novos analogos estruturais da vitamina d

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JP4312183B2 (ja) 2009-08-12
WO1995001960A1 (en) 1995-01-19
EP0972762A2 (de) 2000-01-19
EP0972762B1 (de) 2003-10-01
DE69433220T2 (de) 2004-08-19
JPH09500117A (ja) 1997-01-07
DK0707566T3 (da) 2000-09-04
ES2209327T3 (es) 2004-06-16
ES2147238T3 (es) 2000-09-01
EP0707566A1 (de) 1996-04-24
EP0707566B1 (de) 2000-04-12
DE69433220D1 (de) 2003-11-06
JP2006001944A (ja) 2006-01-05
CN1103755C (zh) 2003-03-26
NO314142B1 (no) 2003-02-03
EP0972762A3 (de) 2000-02-23
RU2153491C2 (ru) 2000-07-27
DE69423966D1 (de) 2000-05-18
PT972762E (pt) 2004-02-27
CA2166898A1 (en) 1995-01-19
ATE191712T1 (de) 2000-04-15
NO960099D0 (no) 1996-01-09
JP4235256B2 (ja) 2009-03-11
NZ271332A (en) 2001-03-30
US6017907A (en) 2000-01-25
PT707566E (pt) 2000-09-29
AU7492794A (en) 1995-02-06
GR3033856T3 (en) 2000-10-31
AU699200B2 (en) 1998-11-26
CN1130899A (zh) 1996-09-11
CA2166898C (en) 2004-09-07
DK0972762T3 (da) 2004-02-09
DE69423966T2 (de) 2000-11-16
NO960099L (no) 1996-03-08
US6548715B1 (en) 2003-04-15

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