ATE251158T1 - Indolizin spal2 inhibitoren - Google Patents
Indolizin spal2 inhibitorenInfo
- Publication number
- ATE251158T1 ATE251158T1 AT95927422T AT95927422T ATE251158T1 AT E251158 T1 ATE251158 T1 AT E251158T1 AT 95927422 T AT95927422 T AT 95927422T AT 95927422 T AT95927422 T AT 95927422T AT E251158 T1 ATE251158 T1 AT E251158T1
- Authority
- AT
- Austria
- Prior art keywords
- indolizine
- compounds
- spal2
- indolizin
- inhibitors
- Prior art date
Links
- HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical compound C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UKVDMENMUORDKW-UHFFFAOYSA-N 2-indolizin-1-yl-2-oxoacetamide Chemical class C1=CC=CC2=C(C(=O)C(=O)N)C=CN21 UKVDMENMUORDKW-UHFFFAOYSA-N 0.000 abstract 1
- LRSNLLOKLZWSTC-UHFFFAOYSA-N 2-indolizin-1-ylacetamide Chemical class C1=CC=CC2=C(CC(=O)N)C=CN21 LRSNLLOKLZWSTC-UHFFFAOYSA-N 0.000 abstract 1
- REHUXAUXLDYKHW-UHFFFAOYSA-N 2-indolizin-1-ylacetohydrazide Chemical class C1=CC=CC2=C(CC(=O)NN)C=CN21 REHUXAUXLDYKHW-UHFFFAOYSA-N 0.000 abstract 1
- LRBVPNDTTFHDIX-UHFFFAOYSA-N 2-indolizin-3-ylacetamide Chemical class C1=CC=CN2C(CC(=O)N)=CC=C21 LRBVPNDTTFHDIX-UHFFFAOYSA-N 0.000 abstract 1
- MPWVHKXRHZZZDM-UHFFFAOYSA-N 2-indolizin-3-ylacetic acid Chemical compound C1=CC=CN2C(CC(=O)O)=CC=C21 MPWVHKXRHZZZDM-UHFFFAOYSA-N 0.000 abstract 1
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 abstract 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002478 indolizines Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27844594A | 1994-07-21 | 1994-07-21 | |
| PCT/US1995/009381 WO1996003383A1 (en) | 1994-07-21 | 1995-07-20 | INDOLIZINE sPLA2 INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE251158T1 true ATE251158T1 (de) | 2003-10-15 |
Family
ID=23065002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95927422T ATE251158T1 (de) | 1994-07-21 | 1995-07-20 | Indolizin spal2 inhibitoren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6645976B1 (de) |
| EP (1) | EP0772596B1 (de) |
| JP (1) | JPH10505584A (de) |
| KR (1) | KR970704695A (de) |
| CN (1) | CN1158121A (de) |
| AT (1) | ATE251158T1 (de) |
| AU (1) | AU3145995A (de) |
| BR (1) | BR9508298A (de) |
| CA (1) | CA2195570A1 (de) |
| DE (1) | DE69531864T2 (de) |
| ES (1) | ES2208685T3 (de) |
| HU (1) | HUT77867A (de) |
| MX (1) | MX9700511A (de) |
| WO (1) | WO1996003383A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177440B1 (en) | 1996-10-30 | 2001-01-23 | Eli Lilly And Company | Substituted tricyclics |
| US6713645B1 (en) * | 1996-10-30 | 2004-03-30 | Eli Lilly And Company | Substituted tricyclics |
| WO1998047507A1 (en) | 1997-04-24 | 1998-10-29 | Shionogi & Co., Ltd. | Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds |
| JP2001513555A (ja) * | 1997-08-28 | 2001-09-04 | イーライ・リリー・アンド・カンパニー | 非リウマチ様関節炎の処置方法 |
| WO1999024033A1 (en) * | 1997-11-12 | 1999-05-20 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds |
| AU3054399A (en) | 1998-03-31 | 1999-10-25 | Shionogi & Co., Ltd. | Pyrrolo(1,2-a)pyrazine sPLA2 inhibitor |
| IL129484A0 (en) * | 1998-04-17 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
| CN1302300A (zh) | 1998-05-21 | 2001-07-04 | 盐野义制药株式会社 | 吡咯并[1,2－b]哒嗪sPLA2抑制剂 |
| CA2346334A1 (en) | 1998-10-14 | 2000-04-20 | Shionogi & Co., Ltd. | Composition for treating or preventing ischemia reperfusion injury |
| JP4636521B2 (ja) * | 1999-07-19 | 2011-02-23 | 塩野義製薬株式会社 | ｓＰＬＡ２阻害作用を有する三環系化合物 |
| JP4636522B2 (ja) * | 1999-08-02 | 2011-02-23 | 塩野義製薬株式会社 | ｓＰＬＡ２阻害作用を有する三環式化合物 |
| US6787545B1 (en) | 1999-08-23 | 2004-09-07 | Shiongi & Co., Ltd. | Pyrrolotriazine derivatives having spla2-inhibitory activities |
| AU7559600A (en) * | 1999-10-15 | 2001-04-23 | Shionogi & Co., Ltd. | V type and/or x type spla2 inhibitors |
| US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
| AU2001267823A1 (en) | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
| AU2001267825A1 (en) | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cirrhosis |
| TWI314457B (de) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| US20040116462A1 (en) * | 2002-12-12 | 2004-06-17 | Mitsunori Ono | Indolizine compounds |
| AU2003267071A1 (en) * | 2002-09-13 | 2004-04-30 | Synta Pharmaceuticals Corp. | Synthesis of indolizines |
| WO2005079805A1 (en) * | 2004-02-20 | 2005-09-01 | Astrazeneca Ab | Pyrrole derivatives as gonadotropin releasing hormone (gnrh) antagonists |
| JP5172661B2 (ja) * | 2005-05-18 | 2013-03-27 | エフ２ジー リミテッド | 抗真菌剤 |
| GB0518783D0 (en) * | 2005-09-14 | 2005-10-26 | Argenta Discovery Ltd | Indolizine compounds |
| GB0623209D0 (en) * | 2006-11-21 | 2007-01-03 | F2G Ltd | Antifungal agents |
| AU2009239778B2 (en) | 2008-04-24 | 2014-03-13 | F2G Ltd | Pyrrole antifungal agents |
| GB0809773D0 (en) * | 2008-05-29 | 2008-07-09 | F2G Ltd | Antifungal combination therapy |
| US20150025105A1 (en) * | 2012-02-09 | 2015-01-22 | Praveen Rao Perampalli Nekkar | Indolizine derivatives |
| DK3221308T3 (en) | 2014-11-21 | 2018-12-10 | F2G Ltd | Antifungals |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| CN111440165B (zh) * | 2020-04-13 | 2023-06-16 | 深圳职业技术学院 | 取代吲嗪类衍生物及其制备方法 |
| CN111393437B (zh) * | 2020-04-13 | 2022-11-22 | 深圳职业技术学院 | 三取代吲嗪类化合物及其制备方法 |
| TW202412770A (zh) * | 2022-05-25 | 2024-04-01 | 天主教魯汶大學 | 用於治療ｔｒｐｍ３介導之病症的吲口巾衍生物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1174124A (en) * | 1967-06-30 | 1969-12-10 | Beecham Group Ltd | Pharmacologically Active Indolizine Compounds |
| US3717644A (en) * | 1970-06-01 | 1973-02-20 | L Walter | 1-(di-lower alkyl amino lower alkyl)-2-phenyl-5,6,7,8-tetrahydroindolizines |
-
1995
- 1995-07-20 JP JP8505935A patent/JPH10505584A/ja not_active Ceased
- 1995-07-20 CA CA002195570A patent/CA2195570A1/en not_active Abandoned
- 1995-07-20 AU AU31459/95A patent/AU3145995A/en not_active Abandoned
- 1995-07-20 WO PCT/US1995/009381 patent/WO1996003383A1/en not_active Ceased
- 1995-07-20 MX MX9700511A patent/MX9700511A/es unknown
- 1995-07-20 ES ES95927422T patent/ES2208685T3/es not_active Expired - Lifetime
- 1995-07-20 DE DE69531864T patent/DE69531864T2/de not_active Expired - Fee Related
- 1995-07-20 EP EP95927422A patent/EP0772596B1/de not_active Expired - Lifetime
- 1995-07-20 BR BR9508298A patent/BR9508298A/pt not_active IP Right Cessation
- 1995-07-20 US US08/765,566 patent/US6645976B1/en not_active Expired - Fee Related
- 1995-07-20 AT AT95927422T patent/ATE251158T1/de not_active IP Right Cessation
- 1995-07-20 HU HU9700179A patent/HUT77867A/hu unknown
- 1995-07-20 CN CN95195129A patent/CN1158121A/zh active Pending
-
1997
- 1997-01-20 KR KR1019970700373A patent/KR970704695A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR970704695A (ko) | 1997-09-06 |
| EP0772596A4 (de) | 1999-01-13 |
| CN1158121A (zh) | 1997-08-27 |
| CA2195570A1 (en) | 1996-02-08 |
| HUT77867A (hu) | 1998-09-28 |
| BR9508298A (pt) | 1998-11-03 |
| US6645976B1 (en) | 2003-11-11 |
| EP0772596A1 (de) | 1997-05-14 |
| HU9700179D0 (en) | 1997-03-28 |
| AU3145995A (en) | 1996-02-22 |
| EP0772596B1 (de) | 2003-10-01 |
| ES2208685T3 (es) | 2004-06-16 |
| DE69531864D1 (de) | 2003-11-06 |
| WO1996003383A1 (en) | 1996-02-08 |
| JPH10505584A (ja) | 1998-06-02 |
| MX9700511A (es) | 1997-04-30 |
| DE69531864T2 (de) | 2004-07-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE251158T1 (de) | Indolizin spal2 inhibitoren | |
| MY112897A (en) | Ih-indole-3-glyoxylamide spla2 inhibitors | |
| IL130338A0 (en) | Pyrroles as sPLA2 inhibitors | |
| MX9804751A (es) | Naftil acetamidas como inhibidores de la spla2. | |
| IL130201A0 (en) | Phenyl glyoxamides as spla2 inhibitors | |
| EP1100492A4 (de) | INDOLVERBINDUNGEN ALS sPLA 2? INHIBITOREN | |
| MX9804750A (es) | Naftil glioxamidas como inhibidores de la spla2. | |
| ATE247119T1 (de) | Substituierte pyrroloindole | |
| ATE350367T1 (de) | Spla2 inhibitoren | |
| WO2002012249A3 (en) | Substituted pyrrole compounds and their use as spla2 inhibitors | |
| AU7053700A (en) | Novel spla2 inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |