ATE251624T1 - Granulatimide-derivate zur behandlung von krebs - Google Patents
Granulatimide-derivate zur behandlung von krebsInfo
- Publication number
- ATE251624T1 ATE251624T1 AT99908706T AT99908706T ATE251624T1 AT E251624 T1 ATE251624 T1 AT E251624T1 AT 99908706 T AT99908706 T AT 99908706T AT 99908706 T AT99908706 T AT 99908706T AT E251624 T1 ATE251624 T1 AT E251624T1
- Authority
- AT
- Austria
- Prior art keywords
- granulatimide
- cancer
- derivatives
- treatment
- iii
- Prior art date
Links
- LBTREMHIJGMYQN-UHFFFAOYSA-N ctk1a7209 Chemical class N1C2=CC=CC=C2C2=C1C(N=CN1)=C1C1=C2C(=O)NC1=O LBTREMHIJGMYQN-UHFFFAOYSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2232074 CA2232074A1 (en) | 1998-03-13 | 1998-03-13 | Granulatimide compounds as g2 checkpoint inhibitors |
| CA002245029A CA2245029A1 (en) | 1998-03-13 | 1998-08-14 | Granulatimide compounds as g2 checkpoint inhibitors |
| US09/258,991 US6291447B1 (en) | 1998-03-13 | 1999-02-26 | Granulatimide compounds and uses thereof |
| PCT/CA1999/000224 WO1999047522A1 (en) | 1998-03-13 | 1999-03-11 | Granulatimide derivatives for use in cancer treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE251624T1 true ATE251624T1 (de) | 2003-10-15 |
Family
ID=27170646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99908706T ATE251624T1 (de) | 1998-03-13 | 1999-03-11 | Granulatimide-derivate zur behandlung von krebs |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1070068B2 (de) |
| JP (1) | JP2002506868A (de) |
| AT (1) | ATE251624T1 (de) |
| AU (1) | AU758241B2 (de) |
| DE (1) | DE69911935T3 (de) |
| WO (1) | WO1999047522A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1040053B (en) | 1998-09-25 | 2007-09-21 | Cephalon, Inc. | Use of fused pyrrolocarbazoles for preventing/treating damage to sensory hair cells and cochlear neurons |
| US6841567B1 (en) | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
| AU2337601A (en) * | 1999-12-23 | 2001-07-09 | Ontario Cancer Institute, The | Inhibition of gsk-3beta |
| GB0008264D0 (en) * | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
| US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| AUPR500201A0 (en) | 2001-05-14 | 2001-06-07 | Commonwealth Scientific And Industrial Research Organisation | Recovery of minerals by flotation |
| CA2487388C (en) | 2002-06-06 | 2011-05-10 | Canbas Co., Ltd. | Compounds that abrogate dna-damage-induced cell cycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
| FR2845995A1 (fr) * | 2002-10-16 | 2004-04-23 | Servier Lab | Nouveaux derives de pyrrolo[3,4-c]carbazole et de pyrido[2,3-b]pyrrolo[3,4-e]indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP2258357A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| EP2275096A3 (de) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (de) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2021000A2 (de) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenese mittels angiotensin-modulation |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2009127059A1 (en) * | 2008-04-15 | 2009-10-22 | Alethia Biotherapeutics Inc. | Complexes of isogranulatimide and granulatimide with a cyclodextrm, formulations and their use for the treatment of cancer |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| CN103864890B (zh) * | 2012-12-12 | 2016-09-14 | 浙江医药股份有限公司新昌制药厂 | 咪唑异丙乙酰茶氨酸苄酯并吡啶并吲哚、其制备、纳米结构及应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| DE3835842A1 (de) * | 1988-10-21 | 1990-04-26 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| WO1991009034A1 (en) * | 1989-12-14 | 1991-06-27 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856 |
| DE3942296A1 (de) * | 1989-12-21 | 1991-06-27 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung |
| JPH08500112A (ja) * | 1992-08-12 | 1996-01-09 | ジ・アップジョン・カンパニー | タキソールと組み合わせるプロテインキナーゼ阻害剤および関連化合物 |
| WO1994007895A1 (en) * | 1992-09-25 | 1994-04-14 | Schering Corporation | Diindolo compounds and pharmaceutical compositions containing them |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| KR100340159B1 (ko) * | 1993-12-07 | 2002-11-23 | 일라이 릴리 앤드 캄파니 | 단백질키나제c억제제 |
| US5604219A (en) * | 1994-03-18 | 1997-02-18 | Kyowa Hakko Kogyo Co., Ltd. | Indolocarbazole derivatives that stimulate platelet production |
| WO1995032975A1 (en) * | 1994-06-01 | 1995-12-07 | Ciba-Geigy Ag | Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents |
| JPH10501526A (ja) * | 1994-06-01 | 1998-02-10 | チバ−ガイギー アクチェンゲゼルシャフト | 多薬物耐性に対する作用物質としてのカルバゾール誘導体 |
| EP0763042A1 (de) * | 1994-06-01 | 1997-03-19 | Novartis AG | Polycyclische lactamderivate zur sensibilisierung resistenter zellen gegen antitumormittel |
| US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| CA2237401C (en) * | 1995-11-20 | 2003-10-21 | Eli Lilly And Company | Novel intermediates and their use to prepare n,n'-bridged bisindolylmaleimides |
| ES2122764T3 (es) * | 1995-11-20 | 1998-12-16 | Lilly Co Eli | Inhibidor de la proteina quinasa c. |
| FR2755691B1 (fr) * | 1996-11-08 | 1998-12-04 | Adir | Nouveaux derives 7,12-dioxa-benzo[a]anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
1999
- 1999-03-11 AU AU28219/99A patent/AU758241B2/en not_active Ceased
- 1999-03-11 EP EP99908706A patent/EP1070068B2/de not_active Expired - Lifetime
- 1999-03-11 WO PCT/CA1999/000224 patent/WO1999047522A1/en not_active Ceased
- 1999-03-11 DE DE69911935T patent/DE69911935T3/de not_active Expired - Lifetime
- 1999-03-11 AT AT99908706T patent/ATE251624T1/de not_active IP Right Cessation
- 1999-03-11 JP JP2000536717A patent/JP2002506868A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1070068A1 (de) | 2001-01-24 |
| EP1070068B2 (de) | 2007-01-17 |
| AU758241B2 (en) | 2003-03-20 |
| WO1999047522A1 (en) | 1999-09-23 |
| DE69911935D1 (de) | 2003-11-13 |
| DE69911935T2 (de) | 2004-09-09 |
| DE69911935T3 (de) | 2008-02-07 |
| AU2821999A (en) | 1999-10-11 |
| JP2002506868A (ja) | 2002-03-05 |
| EP1070068B1 (de) | 2003-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |