ATE251624T1 - Granulatimide-derivate zur behandlung von krebs - Google Patents

Granulatimide-derivate zur behandlung von krebs

Info

Publication number: ATE251624T1
Authority: AT; Austria
Prior art keywords: granulatimide; cancer; derivatives; treatment; iii
Prior art date: 1998-03-13

Application number

AT99908706T

Other languages

English (en)

Inventor

Raymond J Andersen

Michel Roberge

Jasbinder Sanghera

Danny Leung

Roberto G S Berlinck

Sao Paulo De

Edward Piers

Robert Britton

Original Assignee

Univ British Columbia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-13

Filing date

1999-03-11

Publication date

2003-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27170646&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE251624(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-03-13 Priority claimed from CA 2232074 external-priority patent/CA2232074A1/en

1998-08-14 Priority claimed from CA002245029A external-priority patent/CA2245029A1/en

1999-03-11 Application filed by Univ British Columbia filed Critical Univ British Columbia

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE251624T1 publication Critical patent/ATE251624T1/de

Links

LBTREMHIJGMYQN-UHFFFAOYSA-N ctk1a7209 Chemical class N1C2=CC=CC=C2C2=C1C(N=CN1)=C1C1=C2C(=O)NC1=O LBTREMHIJGMYQN-UHFFFAOYSA-N 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT99908706T 1998-03-13 1999-03-11 Granulatimide-derivate zur behandlung von krebs ATE251624T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CA 2232074 CA2232074A1 (en)	1998-03-13	1998-03-13	Granulatimide compounds as g2 checkpoint inhibitors
CA002245029A CA2245029A1 (en)	1998-03-13	1998-08-14	Granulatimide compounds as g2 checkpoint inhibitors
US09/258,991 US6291447B1 (en)	1998-03-13	1999-02-26	Granulatimide compounds and uses thereof
PCT/CA1999/000224 WO1999047522A1 (en)	1998-03-13	1999-03-11	Granulatimide derivatives for use in cancer treatment

Publications (1)

Publication Number	Publication Date
ATE251624T1 true ATE251624T1 (de)	2003-10-15

Family

ID=27170646

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99908706T ATE251624T1 (de)	1998-03-13	1999-03-11	Granulatimide-derivate zur behandlung von krebs

Country Status (6)

Country	Link
EP (1)	EP1070068B2 (de)
JP (1)	JP2002506868A (de)
AT (1)	ATE251624T1 (de)
AU (1)	AU758241B2 (de)
DE (1)	DE69911935T3 (de)
WO (1)	WO1999047522A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1126855B1 (de)	1998-09-25	2007-05-09	Cephalon, Inc.	Methoden zur prophylaxe und behandlung von schäden der wahrnehmungshärchenzellen und der cochlearen neuronen
US6841567B1 (en)	1999-02-12	2005-01-11	Cephalon, Inc.	Cyclic substituted fused pyrrolocarbazoles and isoindolones
AU2337601A (en) *	1999-12-23	2001-07-09	Ontario Cancer Institute, The	Inhibition of gsk-3beta
GB0008264D0 (en) *	2000-04-04	2000-05-24	Smithkline Beecham Plc	Novel method and compounds
US7122679B2 (en)	2000-05-09	2006-10-17	Cephalon, Inc.	Multicyclic compounds and the use thereof
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) *	2000-05-19	2001-11-19	Aegera Therapeutics Inc.	Neuroprotective compounds
AUPR500201A0 (en)	2001-05-14	2001-06-07	Commonwealth Scientific And Industrial Research Organisation	Recovery of minerals by flotation
AU2003247044B8 (en)	2002-06-06	2009-04-09	Canbas Co. Ltd.	Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA-damaging treatments
FR2845995A1 (fr) *	2002-10-16	2004-04-23	Servier Lab	Nouveaux derives de pyrrolo[3,4-c]carbazole et de pyrido[2,3-b]pyrrolo[3,4-e]indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2258358A3 (de)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenese mit Acetylcholinesterasehemmer
EP2275095A3 (de)	2005-08-26	2011-08-17	Braincells, Inc.	Neurogenese durch modulation des Muscarinrezeptors
EP1940389A2 (de)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation von neurogenese durch pde-hemmung
AU2006308889A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2382975A3 (de)	2006-05-09	2012-02-29	Braincells, Inc.	Neurogenese mittels Angiotensin-Modulation
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2009127059A1 (en) *	2008-04-15	2009-10-22	Alethia Biotherapeutics Inc.	Complexes of isogranulatimide and granulatimide with a cyclodextrm, formulations and their use for the treatment of cancer
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
CN103864890B (zh) *	2012-12-12	2016-09-14	浙江医药股份有限公司新昌制药厂	咪唑异丙乙酰茶氨酸苄酯并吡啶并吲哚、其制备、纳米结构及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
AU7035991A (en) *	1989-12-14	1991-07-18	Schering Corporation	Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
DE3942296A1 (de) *	1989-12-21	1991-06-27	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
CA2140653A1 (en) *	1992-08-12	1994-03-03	Irene Abraham	Protein kinase inhibitors and related compounds combined with taxol
WO1994007895A1 (en) *	1992-09-25	1994-04-14	Schering Corporation	Diindolo compounds and pharmaceutical compositions containing them
PT657458E (pt) *	1993-12-07	2002-02-28	Lilly Co Eli	Inibidores de proteina cinase c
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5604219A (en) *	1994-03-18	1997-02-18	Kyowa Hakko Kogyo Co., Ltd.	Indolocarbazole derivatives that stimulate platelet production
AU2565795A (en) *	1994-06-01	1995-12-21	Ciba-Geigy Ag	Carbazole derivatives as agents against multi-drug resistance
WO1995032975A1 (en) *	1994-06-01	1995-12-07	Ciba-Geigy Ag	Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents
EP0763042A1 (de) *	1994-06-01	1997-03-19	Novartis AG	Polycyclische lactamderivate zur sensibilisierung resistenter zellen gegen antitumormittel
US5705511A (en) *	1994-10-14	1998-01-06	Cephalon, Inc.	Fused pyrrolocarbazoles
PL184728B1 (pl) *	1995-11-20	2002-12-31	Lilly Co Eli	Nowe pochodne bisindolilomaleimidu z mostkiem N,N'i środek farmaceutyczny
SI0776895T1 (en) *	1995-11-20	1999-04-30	Eli Lilly And Company	Protein kinase C inhibitor
FR2755691B1 (fr) *	1996-11-08	1998-12-04	Adir	Nouveaux derives 7,12-dioxa-benzo[a]anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1999
- 1999-03-11 AT AT99908706T patent/ATE251624T1/de not_active IP Right Cessation
- 1999-03-11 DE DE69911935T patent/DE69911935T3/de not_active Expired - Lifetime
- 1999-03-11 AU AU28219/99A patent/AU758241B2/en not_active Ceased
- 1999-03-11 JP JP2000536717A patent/JP2002506868A/ja not_active Ceased
- 1999-03-11 WO PCT/CA1999/000224 patent/WO1999047522A1/en not_active Ceased
- 1999-03-11 EP EP99908706A patent/EP1070068B2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU758241B2 (en)	2003-03-20
EP1070068A1 (de)	2001-01-24
WO1999047522A1 (en)	1999-09-23
DE69911935T2 (de)	2004-09-09
EP1070068B2 (de)	2007-01-17
DE69911935T3 (de)	2008-02-07
DE69911935D1 (de)	2003-11-13
EP1070068B1 (de)	2003-10-08
JP2002506868A (ja)	2002-03-05
AU2821999A (en)	1999-10-11

Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE251624T1 (de)	2003-10-15	Granulatimide-derivate zur behandlung von krebs
ATE264846T1 (de)	2004-05-15	Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen
ATE383339T1 (de)	2008-01-15	Amin-derivate zur behandlung von apoptosis
ATE296826T1 (de)	2005-06-15	Pyrazolo(1,5)pyridinderivate
EA200000592A1 (ru)	2000-12-25	Азаполициклические соединения, конденсированные с арилом
BR0007589A (pt)	2002-10-15	Inibidores da proliferação de células
TR199800924T2 (xx)	1998-08-21	Quinoline t�revleri.
ES2191208T3 (es)	2003-09-01	Oxiimino-pregnano-carbolactonas.
DE69716810D1 (de)	2002-12-12	2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one
ES2243579T3 (es)	2005-12-01	Derivados de pirazolopirideno.
DK0665834T3 (da)	2001-09-10	Quinolon- og acridinonderivater til behandling af urininkontinens
EE04777B1 (et)	2007-02-15	Kasvajavastased ühendid, neid sisaldavad farmatseutilised kompositsioonid ning nende kasutamine
EA200000431A3 (ru)	2001-02-26	Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их
EE03771B1 (et)	2002-06-17	Tetrahüdropüridoühendid, neid sisaldav ravim ja nende kasutamine
ATE170852T1 (de)	1998-09-15	Benzolsulfonamid-derivate zur behandlung der blaseninstabilität
EA200000996A1 (ru)	2001-06-25	Конденсированные с арилом азаполициклические соединения
ATE237585T1 (de)	2003-05-15	Substituierte 3,3-diamino-2-propennitrile, ihre herstellung und verwendung
DE69127976D1 (de)	1997-11-20	Tropolonderivate und pharmazeutische zubereitungen davon zur vorbeugung und behandlung von ischämischen krankheiten
TR199802044T2 (xx)	1999-02-22	Yeni karbon asidi t�revleri, �retilmeleri ve kullan�mlar�.
ES2019840A6 (es)	1991-07-01	Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina.
EA199900534A1 (ru)	2000-02-28	Имидазопиридазины
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
DE69307674D1 (de)	1997-03-06	HIV-Proteaseinhibitoren und ihre Verwendung zur Behandlung von AIDS
SE9604582D0 (sv)	1996-12-13	Novel compounds
ES2104174T3 (es)	1997-10-01	Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.