ATE252080T1 - Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel - Google Patents

Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel

Info

Publication number: ATE252080T1
Authority: AT; Austria
Prior art keywords: indolin; derivatives; production; products containing; pct
Prior art date: 1996-12-13

Application number

AT97951307T

Other languages

English (en)

Inventor

Loic Foulon

Gal Claudine Serradeil-Le

Gerard Valette

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1997-12-11

Publication date

2003-11-15

1997-12-11 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE252080T1 publication Critical patent/ATE252080T1/de

Links

229940126601 medicinal product Drugs 0.000 title 1
150000005623 oxindoles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
101800000989 Oxytocin Proteins 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
108010004977 Vasopressins Proteins 0.000 abstract 1
102000002852 Vasopressins Human genes 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229960003726 vasopressin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT97951307T 1996-12-13 1997-12-11 Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel ATE252080T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615384A FR2757157B1 (fr)	1996-12-13	1996-12-13	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1997/002270 WO1998025901A1 (fr)	1996-12-13	1997-12-11	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number	Publication Date
ATE252080T1 true ATE252080T1 (de)	2003-11-15

Family

ID=9498678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97951307T ATE252080T1 (de)	1996-12-13	1997-12-11	Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel

Country Status (11)

Country	Link
US (1)	US6090818A (de)
EP (1)	EP0950047B1 (de)
JP (1)	JP3330958B2 (de)
AT (1)	ATE252080T1 (de)
AU (1)	AU5488498A (de)
BR (1)	BR9713925A (de)
CA (1)	CA2274898A1 (de)
DE (1)	DE69725608T2 (de)
FR (1)	FR2757157B1 (de)
NO (1)	NO313551B1 (de)
WO (1)	WO1998025901A1 (de)

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HUP9902376A3 (en) *	1999-07-15	2002-11-28	Sanofi Aventis	Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts
HUP9902374A3 (en) *	1999-07-15	2002-11-28	Sanofi Aventis	Process for producing spiro[(4-cyclohexanone)-[3h]indol-2'[1'h]-on derivatives and intermediates
FR2804115B1 (fr) *	2000-01-25	2002-03-08	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
US20030103983A1 (en) *	2002-05-09	2003-06-05	Pressler Milton Lethan	Ace inhibitor-vasopressin antagonist combinations
US20030008860A1 (en)	2002-05-09	2003-01-09	Bakker-Arkema Rebecca Guggemos	Treatment of congestive heart failure
EP1195166B1 (de) *	2000-10-04	2007-07-25	Astellas Pharma Inc.	Verwendung von einem Vasopressin-Antagonisten wie Conivaptan zur Herstellung eines Medikaments für die Behandlung der pulmonalen Hypertension
EP1444225B1 (de) *	2001-06-18	2012-10-10	Merck Serono SA	Pyrrolidin oxadiazol- und thiadiazol oxim derivate als oxytozin rezeptor antagonisten
DE10229777A1 (de) *	2002-07-03	2004-01-29	Bayer Ag	Indolin-Phenylsulfonamid-Derivate
US20050070718A1 (en)	2003-09-30	2005-03-31	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8580842B2 (en)	2003-09-30	2013-11-12	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7517899B2 (en)	2004-03-30	2009-04-14	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en)	2004-03-30	2008-08-19	Wyeth	Phenylaminopropanol derivatives and methods of their use
CA2568640C (en)	2004-06-04	2011-08-09	Teva Pharmaceutical Industries Ltd.	Pharmaceutical composition containing irbesartan
FR2874921B1 (fr) *	2004-09-09	2006-10-20	Sanofi Aventis Sa	Derives de 3-spiro-indolin-2-one, leur preparation et leur application en therapeutique
US7576094B2 (en) *	2004-12-13	2009-08-18	Eli Lilly And Company	Spiro derivatives as lipoxygenase inhibitors
WO2006101937A1 (en) *	2005-03-18	2006-09-28	Janssen Pharmaceutica N.V.	Acylhydrazones as kinase modulators
DE102005014904A1 (de) *	2005-03-26	2007-02-01	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
DE102005014936A1 (de)	2005-03-24	2006-12-14	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
CA2602194A1 (en)	2005-03-24	2006-09-28	Abbott Gmbh & Co. Kg	Substituted oxindol derivatives, drugs containing said derivatives and the use thereof
AR056968A1 (es)	2005-04-11	2007-11-07	Xenon Pharmaceuticals Inc	Compuestos espiro-oxindol y composiciones farmacéuticas
MY145694A (en)	2005-04-11	2012-03-30	Xenon Pharmaceuticals Inc	Spiroheterocyclic compounds and their uses as therapeutic agents
AR056317A1 (es) *	2005-04-20	2007-10-03	Xenon Pharmaceuticals Inc	Compuestos de oxindol y composicion farmaceutica
WO2007063123A1 (de)	2005-12-02	2007-06-07	Abbott Gmbh & Co. Kg	Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
CN101528712B (zh) *	2006-08-26	2013-10-30	Abbvie德国有限责任两合公司	取代的苯并咪唑酮衍生物、包含它们的药物以及其用途
DE102006040915A1 (de) *	2006-08-26	2008-03-20	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
TWI315304B (en) *	2006-08-31	2009-10-01	Univ Taipei Medical	Indoline-sulfonamides compounds
CA2666143A1 (en) *	2006-10-12	2008-04-17	Xenon Pharmaceuticals Inc.	Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
WO2008046046A1 (en) *	2006-10-12	2008-04-17	Xenon Pharmaceuticals Inc.	Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
AR063280A1 (es)	2006-10-12	2009-01-21	Xenon Pharmaceuticals Inc	Uso de compuestos de espiro-oxindol como agentes terapeuticos
US8486979B2 (en) *	2006-12-12	2013-07-16	Abbvie Inc.	1,2,4 oxadiazole compounds and methods of use thereof
US20080167286A1 (en)	2006-12-12	2008-07-10	Abbott Laboratories	Pharmaceutical compositions and their methods of use
UY30846A1 (es)	2006-12-30	2008-07-31	Abbott Gmbh & Amp	Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
EP2231643B1 (de)	2007-12-07	2012-10-31	Abbott GmbH & Co. KG	Amidomethyl-substitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen
CN102026995B (zh)	2007-12-07	2014-10-29	Abbvie德国有限责任两合公司	5，6-二取代的羟吲哚衍生物和其用途
US8703774B2 (en)	2007-12-07	2014-04-22	AbbVie Deutschland GmbH & Co. KG	Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
CN101952276B (zh)	2007-12-07	2014-10-22	Abbvie德国有限责任两合公司	5-卤素取代的羟吲哚衍生物和其用于治疗加压素依赖性疾病的用途
RU2487872C2 (ru)	2007-12-27	2013-07-20	Эбботт Гмбх Унд Ко.Кг	Замещенные производные оксиндола и их применение для лечения заболеваний, зависимых от вазопрессина
FR2927625B1 (fr)	2008-02-19	2010-03-12	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
FR2930249B1 (fr)	2008-04-21	2010-05-14	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
CN105218565A (zh)	2008-10-17	2016-01-06	泽农医药公司	螺羟吲哚化合物及其作为治疗剂的用途
WO2010045197A1 (en)	2008-10-17	2010-04-22	Xenon Pharmaceuticals, Inc.	Spiro-oxindole compounds and their use as therapeutic agents
WO2010138600A2 (en)	2009-05-29	2010-12-02	Abbott Laboratories	Pharmaceutical compositions for the treatment of pain
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) *	2009-10-14	2011-04-14	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions for oral administration
CN102753556B (zh)	2009-10-14	2015-05-13	泽农医药公司	螺-羟吲哚化合物的合成方法
NZ601667A (en)	2010-02-26	2014-10-31	Xenon Pharmaceuticals Inc	Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
DE102010021637A1 (de)	2010-05-26	2011-12-01	Bayer Schering Pharma Aktiengesellschaft	Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
TW201636017A (zh)	2015-02-05	2016-10-16	梯瓦製藥國際有限責任公司	以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
WO2017076931A1 (en)	2015-11-06	2017-05-11	F. Hoffmann-La Roche Ag	Indolin-2-one derivatives for use in the treatment of cns and related disorders
RU2727179C2 (ru) *	2015-11-06	2020-07-21	Ф. Хоффманн-Ля Рош Аг	Производные индолин-2-она
CN108137561B (zh)	2015-11-06	2021-03-26	豪夫迈·罗氏有限公司	二氢吲哚-2-酮衍生物
EP3371170B1 (de) *	2015-11-06	2019-07-31	H. Hoffnabb-La Roche Ag	Indolin-2-on-derivate zur behandlung von erkrankungen des zentralen nervensystems (zns)
CN120518581B (zh) *	2025-05-15	2025-12-02	广东医科大学	一种螺环丁烷吲哚酮衍生物及其制备方法和应用

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US4395416A (en) *	1981-01-29	1983-07-26	Delalande S.A.	1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the process for preparing the same and their use in therapeutics
FR2708605A1 (fr) *	1993-07-30	1995-02-10	Sanofi Sa	Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
US5663431A (en) *	1992-01-30	1997-09-02	Sanofi	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708606B1 (fr) *	1993-07-30	1995-10-27	Sanofi Sa	Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
FR2740136B1 (fr) *	1995-10-24	1998-01-09	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
US5776969A (en) *	1997-02-27	1998-07-07	Eli Lilly And Company	Treatment of sleep disorders

1996
- 1996-12-13 FR FR9615384A patent/FR2757157B1/fr not_active Expired - Fee Related
1997
- 1997-12-11 AU AU54884/98A patent/AU5488498A/en not_active Abandoned
- 1997-12-11 BR BR9713925A patent/BR9713925A/pt not_active Application Discontinuation
- 1997-12-11 AT AT97951307T patent/ATE252080T1/de not_active IP Right Cessation
- 1997-12-11 US US09/331,007 patent/US6090818A/en not_active Expired - Lifetime
- 1997-12-11 JP JP52630898A patent/JP3330958B2/ja not_active Expired - Fee Related
- 1997-12-11 EP EP97951307A patent/EP0950047B1/de not_active Expired - Lifetime
- 1997-12-11 WO PCT/FR1997/002270 patent/WO1998025901A1/fr not_active Ceased
- 1997-12-11 CA CA002274898A patent/CA2274898A1/en not_active Abandoned
- 1997-12-11 DE DE69725608T patent/DE69725608T2/de not_active Expired - Lifetime
1999
- 1999-06-11 NO NO19992878A patent/NO313551B1/no unknown

Also Published As

Publication number	Publication date
CA2274898A1 (en)	1998-06-18
WO1998025901A1 (fr)	1998-06-18
JP2000509723A (ja)	2000-08-02
EP0950047A1 (de)	1999-10-20
FR2757157A1 (fr)	1998-06-19
NO992878L (no)	1999-08-10
NO992878D0 (no)	1999-06-11
NO313551B1 (no)	2002-10-21
DE69725608D1 (de)	2003-11-20
DE69725608T2 (de)	2004-07-29
BR9713925A (pt)	2000-03-21
JP3330958B2 (ja)	2002-10-07
EP0950047B1 (de)	2003-10-15
AU5488498A (en)	1998-07-03
US6090818A (en)	2000-07-18
FR2757157B1 (fr)	1999-12-31

Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69725608D1 (de)	2003-11-20	Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel
UA34428C2 (uk)	2001-03-15	Заміщені фенілімідазолідини, спосіб їх одержання, фармацевтична композиція, проміжні сполуки
NL980012I2 (nl)	2004-11-01	Mometasonfuroaat-monohydraat, werkwijze om zulks te bereiden en farmaceutische samenstellingen.
MY133647A (en)	2007-11-30	Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
UA32543C2 (uk)	2001-02-15	Арилацетаміди, що мають анальгетичну дію, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
TR200101961T2 (tr)	2001-12-21	1,2-halkalı kinolin türevleri
IL117091A0 (en)	1996-06-18	Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
EE05091B1 (et)	2008-10-15	Oligosahhariidid, nende valmistamismeetod ja kasutamine ning farmatseutilised kompositsioonid
AU2001235596A1 (en)	2001-08-07	Novel 1,3-dihydro-2h-indol-2-one derivatives, preparation method and pharmaceutical compositions containing them
NZ300942A (en)	1998-12-23	1-aryl-2-acylamino-ethane derivatives as neurokinin 1 antagonists
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ATE217616T1 (de)	2002-06-15	Tetrasubstituierte imidazolderivate, verfahren zu ihrer herstellung, ihre anwendung als medikamente und diese enthaltende pharmazeutischen zusammensetzungen
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