ATE252080T1 - Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel - Google Patents

Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel

Info

Publication number: ATE252080T1
Authority: AT; Austria
Prior art keywords: indolin; derivatives; production; products containing; pct
Prior art date: 1996-12-13

Application number

AT97951307T

Other languages

English (en)

Inventor

Loic Foulon

Gal Claudine Serradeil-Le

Gerard Valette

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1997-12-11

Publication date

2003-11-15

1997-12-11 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE252080T1 publication Critical patent/ATE252080T1/de

Links

229940126601 medicinal product Drugs 0.000 title 1
150000005623 oxindoles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
101800000989 Oxytocin Proteins 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
108010004977 Vasopressins Proteins 0.000 abstract 1
102000002852 Vasopressins Human genes 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229960003726 vasopressin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97951307T 1996-12-13 1997-12-11 Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel ATE252080T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615384A FR2757157B1 (fr)	1996-12-13	1996-12-13	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR1997/002270 WO1998025901A1 (fr)	1996-12-13	1997-12-11	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number	Publication Date
ATE252080T1 true ATE252080T1 (de)	2003-11-15

Family

ID=9498678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97951307T ATE252080T1 (de)	1996-12-13	1997-12-11	Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel

Country Status (11)

Country	Link
US (1)	US6090818A (de)
EP (1)	EP0950047B1 (de)
JP (1)	JP3330958B2 (de)
AT (1)	ATE252080T1 (de)
AU (1)	AU5488498A (de)
BR (1)	BR9713925A (de)
CA (1)	CA2274898A1 (de)
DE (1)	DE69725608T2 (de)
FR (1)	FR2757157B1 (de)
NO (1)	NO313551B1 (de)
WO (1)	WO1998025901A1 (de)

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HUP9902374A3 (en) *	1999-07-15	2002-11-28	Sanofi Aventis	Process for producing spiro[(4-cyclohexanone)-[3h]indol-2'[1'h]-on derivatives and intermediates
HU225150B1 (en) *	1999-07-15	2006-07-28	Sanofi Aventis	Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride
FR2804115B1 (fr)	2000-01-25	2002-03-08	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
US20030103983A1 (en) *	2002-05-09	2003-06-05	Pressler Milton Lethan	Ace inhibitor-vasopressin antagonist combinations
US20030008860A1 (en)	2002-05-09	2003-01-09	Bakker-Arkema Rebecca Guggemos	Treatment of congestive heart failure
IL145684A (en) *	2000-10-04	2007-06-17	Warner Lambert Co	Medications for the treatment of pulmonary hypertension
BR0211030A (pt) *	2001-06-18	2004-06-22	Applied Research Systems	Derivado de pirrolidina oxadiazole, uso de um derivado de pirrolidina oxadiazole, composição farmacêutica contendo pelo menos um derivado de pirrolidina oxadiazole, método para preparação de um composto de pirrolidina oxadiazole
DE10229777A1 (de) *	2002-07-03	2004-01-29	Bayer Ag	Indolin-Phenylsulfonamid-Derivate
US8580842B2 (en) *	2003-09-30	2013-11-12	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050070718A1 (en)	2003-09-30	2005-03-31	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7414052B2 (en)	2004-03-30	2008-08-19	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7517899B2 (en)	2004-03-30	2009-04-14	Wyeth	Phenylaminopropanol derivatives and methods of their use
WO2005118166A2 (en)	2004-06-04	2005-12-15	Teva Pharmaceutical Industries, Ltd.	Pharmaceutical composition containing irbesartan
FR2874921B1 (fr) *	2004-09-09	2006-10-20	Sanofi Aventis Sa	Derives de 3-spiro-indolin-2-one, leur preparation et leur application en therapeutique
CA2589363A1 (en) *	2004-12-13	2006-06-22	Eli Lilly And Company	Spiro derivatives as lipoxygenase inhibitors
WO2006101937A1 (en) *	2005-03-18	2006-09-28	Janssen Pharmaceutica N.V.	Acylhydrazones as kinase modulators
US7803834B2 (en)	2005-03-24	2010-09-28	Abbott Gmbh & Co. Kg	Substituted oxindole derivatives, drugs containing said derivatives and the use thereof
DE102005014936A1 (de)	2005-03-24	2006-12-14	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
DE102005014904A1 (de) *	2005-03-26	2007-02-01	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
AR053710A1 (es) *	2005-04-11	2007-05-16	Xenon Pharmaceuticals Inc	Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en)	2005-04-11	2011-11-30	Xenon Pharmaceuticals Inc	Spiro-oxindole compounds and their uses as therapeutic agents
AR056317A1 (es) *	2005-04-20	2007-10-03	Xenon Pharmaceuticals Inc	Compuestos de oxindol y composicion farmaceutica
JP2009517444A (ja)	2005-12-02	2009-04-30	アボットゲーエムベーハーウントカンパニーカーゲー	置換オキシインドール誘導体、それを含む医薬およびそれの使用
DE102006040915A1 (de) *	2006-08-26	2008-03-20	Abbott Gmbh & Co. Kg	Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung
US8119676B2 (en) *	2006-08-26	2012-02-21	Abbott GmbH & Co. HG	Substituted benzimidazolone derivatives, medicaments comprising them and their use
TWI315304B (en) *	2006-08-31	2009-10-01	Univ Taipei Medical	Indoline-sulfonamides compounds
EP2073806B1 (de)	2006-10-12	2012-02-15	Xenon Pharmaceuticals Inc.	Verwendung von spiro-oxindol-verbindungen als therapeutika
BRPI0719166A2 (pt) *	2006-10-12	2014-06-03	Xenon Pharmaceuticals Inc	Derivados de espiro-oxindol tricíclicos e seus usos como agentes terapêuticos
WO2008046049A1 (en) *	2006-10-12	2008-04-17	Xenon Pharmaceuticals Inc.	Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
US20080167286A1 (en) *	2006-12-12	2008-07-10	Abbott Laboratories	Pharmaceutical compositions and their methods of use
US8486979B2 (en) *	2006-12-12	2013-07-16	Abbvie Inc.	1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es) *	2006-12-30	2008-07-31	Abbott Gmbh & Amp	Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
ES2398676T3 (es)	2007-12-07	2013-03-20	Abbott Gmbh & Co. Kg	Derivados de oxindol sustituidos con amidometilo y su uso para la producción de un medicamento para el tratamiento de enfermedades dependientes de la vasopresina
EP2231644B1 (de)	2007-12-07	2014-01-15	AbbVie Deutschland GmbH & Co KG	5,6-Disubstitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen
NZ586651A (en) *	2007-12-07	2012-06-29	Abbott Gmbh & Co Kg	5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
US8703774B2 (en) *	2007-12-07	2014-04-22	AbbVie Deutschland GmbH & Co. KG	Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
BRPI0821431A8 (pt)	2007-12-27	2015-09-22	Abbott Gmbh & Co Kg	derivados de oxindol substituídos e o seu uso para o tratamento de doenças dependentes de vasopressina.
FR2927625B1 (fr)	2008-02-19	2010-03-12	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
FR2930249B1 (fr)	2008-04-21	2010-05-14	Sanofi Aventis	Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
WO2010045197A1 (en)	2008-10-17	2010-04-22	Xenon Pharmaceuticals, Inc.	Spiro-oxindole compounds and their use as therapeutic agents
HRP20150882T1 (hr) *	2008-10-17	2015-09-25	Xenon Pharmaceuticals Inc.	Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva
US9040568B2 (en)	2009-05-29	2015-05-26	Abbvie Inc.	Pharmaceutical compositions for the treatment of pain
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PE20170202A1 (es)	2009-10-14	2017-03-24	Xenon Pharmaceuticals Inc	Metodos sinteticos para compuestos espiro-oxoindol
US20110086899A1 (en) *	2009-10-14	2011-04-14	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions for oral administration
RU2596488C2 (ru)	2010-02-26	2016-09-10	Ксенон Фармасьютикалз Инк.	Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов
DE102010021637A1 (de)	2010-05-26	2011-12-01	Bayer Schering Pharma Aktiengesellschaft	Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
AR103636A1 (es)	2015-02-05	2017-05-24	Teva Pharmaceuticals Int Gmbh	Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
EP3371174B1 (de)	2015-11-06	2021-03-17	H. Hoffnabb-La Roche Ag	Indolin-2-on-derivate
HUE050083T2 (hu)	2015-11-06	2020-11-30	Hoffmann La Roche	Indolin-2-on származékok
JP6857653B2 (ja)	2015-11-06	2021-04-14	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体
JP6857651B2 (ja)	2015-11-06	2021-04-14	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ｃｎｓ疾患の処置に有用なインドリン−２−オン誘導体
CN120518581B (zh) *	2025-05-15	2025-12-02	广东医科大学	一种螺环丁烷吲哚酮衍生物及其制备方法和应用

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US4226860A (en) *	1979-08-06	1980-10-07	American Home Products Corporation	Spiroindolones
GR75187B (de) *	1981-01-29	1984-07-13	Delalande Sa
FR2708605A1 (fr) *	1993-07-30	1995-02-10	Sanofi Sa	Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
US5663431A (en) *	1992-01-30	1997-09-02	Sanofi	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708606B1 (fr) *	1993-07-30	1995-10-27	Sanofi Sa	Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
FR2740136B1 (fr) *	1995-10-24	1998-01-09	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
US5776969A (en) *	1997-02-27	1998-07-07	Eli Lilly And Company	Treatment of sleep disorders

1996
- 1996-12-13 FR FR9615384A patent/FR2757157B1/fr not_active Expired - Fee Related
1997
- 1997-12-11 US US09/331,007 patent/US6090818A/en not_active Expired - Lifetime
- 1997-12-11 CA CA002274898A patent/CA2274898A1/en not_active Abandoned
- 1997-12-11 AT AT97951307T patent/ATE252080T1/de not_active IP Right Cessation
- 1997-12-11 WO PCT/FR1997/002270 patent/WO1998025901A1/fr not_active Ceased
- 1997-12-11 AU AU54884/98A patent/AU5488498A/en not_active Abandoned
- 1997-12-11 EP EP97951307A patent/EP0950047B1/de not_active Expired - Lifetime
- 1997-12-11 JP JP52630898A patent/JP3330958B2/ja not_active Expired - Fee Related
- 1997-12-11 BR BR9713925A patent/BR9713925A/pt not_active Application Discontinuation
- 1997-12-11 DE DE69725608T patent/DE69725608T2/de not_active Expired - Lifetime
1999
- 1999-06-11 NO NO19992878A patent/NO313551B1/no unknown

Also Published As

Publication number	Publication date
US6090818A (en)	2000-07-18
DE69725608D1 (de)	2003-11-20
WO1998025901A1 (fr)	1998-06-18
FR2757157B1 (fr)	1999-12-31
EP0950047B1 (de)	2003-10-15
FR2757157A1 (fr)	1998-06-19
NO992878D0 (no)	1999-06-11
DE69725608T2 (de)	2004-07-29
JP3330958B2 (ja)	2002-10-07
CA2274898A1 (en)	1998-06-18
NO992878L (no)	1999-08-10
EP0950047A1 (de)	1999-10-20
BR9713925A (pt)	2000-03-21
JP2000509723A (ja)	2000-08-02
AU5488498A (en)	1998-07-03
NO313551B1 (no)	2002-10-21

Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69725608D1 (de)	2003-11-20	Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel
UA34428C2 (uk)	2001-03-15	Заміщені фенілімідазолідини, спосіб їх одержання, фармацевтична композиція, проміжні сполуки
NL980012I2 (nl)	2004-11-01	Mometasonfuroaat-monohydraat, werkwijze om zulks te bereiden en farmaceutische samenstellingen.
MY133647A (en)	2007-11-30	Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
UA32543C2 (uk)	2001-02-15	Арилацетаміди, що мають анальгетичну дію, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
TR200101961T2 (tr)	2001-12-21	1,2-halkalı kinolin türevleri
IL117091A0 (en)	1996-06-18	Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
EE05091B1 (et)	2008-10-15	Oligosahhariidid, nende valmistamismeetod ja kasutamine ning farmatseutilised kompositsioonid
AU2001235596A1 (en)	2001-08-07	Novel 1,3-dihydro-2h-indol-2-one derivatives, preparation method and pharmaceutical compositions containing them
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