ATE252109T1 - Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davon - Google Patents

Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davon

Info

Publication number
ATE252109T1
ATE252109T1 AT96940965T AT96940965T ATE252109T1 AT E252109 T1 ATE252109 T1 AT E252109T1 AT 96940965 T AT96940965 T AT 96940965T AT 96940965 T AT96940965 T AT 96940965T AT E252109 T1 ATE252109 T1 AT E252109T1
Authority
AT
Austria
Prior art keywords
group
unsubstituted
substituted
hydrogen
linker arm
Prior art date
Application number
AT96940965T
Other languages
English (en)
Inventor
Richard T Pon
Shuyuan Yu
Original Assignee
Univ Technologies Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Technologies Int filed Critical Univ Technologies Int
Application granted granted Critical
Publication of ATE252109T1 publication Critical patent/ATE252109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Handcart (AREA)
  • Forklifts And Lifting Vehicles (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96940965T 1995-12-22 1996-12-13 Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davon ATE252109T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US920895P 1995-12-22 1995-12-22
PCT/CA1996/000837 WO1997023497A1 (en) 1995-12-22 1996-12-13 Linker arm for solid support oligonucleotide synthesis and process for production thereof

Publications (1)

Publication Number Publication Date
ATE252109T1 true ATE252109T1 (de) 2003-11-15

Family

ID=21736236

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96940964T ATE219098T1 (de) 1995-12-22 1996-12-13 Wiederverwendbarer festtäger für oligonukleotid- synthese, verfahren zur herstellung davon und verfahren zur verwendung davon
AT96940965T ATE252109T1 (de) 1995-12-22 1996-12-13 Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT96940964T ATE219098T1 (de) 1995-12-22 1996-12-13 Wiederverwendbarer festtäger für oligonukleotid- synthese, verfahren zur herstellung davon und verfahren zur verwendung davon

Country Status (8)

Country Link
US (1) US6015895A (de)
EP (2) EP0877751B1 (de)
JP (2) JP2000502342A (de)
AT (2) ATE219098T1 (de)
AU (2) AU725690B2 (de)
CA (2) CA2241222C (de)
DE (2) DE69630400T2 (de)
WO (2) WO1997023496A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043353A (en) * 1995-12-22 2000-03-28 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
AU765387B2 (en) * 1998-02-09 2003-09-18 Toyo Kohan Co. Ltd. Substrates for immobilizing and amplifying DNA, DNA-immobilized chips having DNA immobilized on the substrates, and method for amplifying DNA
CA2319587C (en) * 1998-02-11 2004-09-21 University Of Houston Method and apparatus for chemical and biochemical reactions using photo-generated reagents
AU4494099A (en) * 1998-07-02 2000-01-24 University Technologies International Inc. Reusable solid support for oligonucleotide synthesis
US7135564B1 (en) * 1998-07-02 2006-11-14 University Technologies International Inc. Reusable solid support for oligonucleotide synthesis
US6924359B1 (en) * 1999-07-01 2005-08-02 Yale University Neovascular-targeted immunoconjugates
JP3786248B2 (ja) * 1999-11-11 2006-06-14 東洋鋼鈑株式会社 化学修飾を施した基体およびその製造方法
CA2424716A1 (en) * 2000-09-05 2002-03-14 Shuyuan Yu Process for producing multiple oligonucleotides on a solid support
US20030036066A1 (en) * 2000-09-08 2003-02-20 University Technologies International Inc. Linker phosphoramidites for oligonucleotide synthesis
JP2004248503A (ja) * 2000-10-18 2004-09-09 Takara Holdings Inc 核酸固定化用担体
JP2002199881A (ja) * 2000-12-28 2002-07-16 Toyo Kohan Co Ltd Ｄｎａ固定化基体の再使用法
US7211654B2 (en) * 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
JP4012145B2 (ja) 2001-06-25 2007-11-21 独立行政法人科学技術振興機構 ピロール−イミダゾールポリアミドの固相合成法
FR2826957B1 (fr) * 2001-07-09 2005-09-30 Centre Nat Rech Scient Procede de fonctionnalisation de supports solides, supports solides fonctionnalises et leurs utilisations
US20030092062A1 (en) * 2001-10-24 2003-05-15 Reddy M. Parameswara Immobilizing biological molecules
US20030162160A1 (en) * 2002-02-27 2003-08-28 Jack Horchler Interactive puzzle
US7202264B2 (en) 2003-01-31 2007-04-10 Isis Pharmaceuticals, Inc. Supports for oligomer synthesis
EP2708541B1 (de) * 2003-11-13 2015-01-28 Isis Pharmaceuticals, Inc. 5,6-Dihydroxy-Isoindol-Derivate als Linker für Oligomer-Festphasensynthese
GB0428020D0 (en) 2004-12-22 2005-01-26 Amersham Health As Stabilisation of radiopharmaceutical precursors
EP2346883B1 (de) 2008-09-23 2016-03-23 Scott G. Petersen Selbstfreisetzende biolabile phosphatgeschützte pro-oligos für therapeutika auf oligonukleotidbasis und vermittlung von rna-interferenz
JP7783822B2 (ja) 2020-02-24 2025-12-10 インテグレーティッド ディーエヌエイ テクノロジーズ インコーポレーティッド 固体支持体上でのオリゴヌクレオチド合成

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides
ATE239484T1 (de) * 1991-10-24 2003-05-15 Isis Pharmaceuticals Inc Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen
US5476925A (en) * 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
EP0623626B1 (de) * 1993-04-05 1999-09-01 Perseptive Biosystems, Inc. Automatisierte Allyl-Deprotektion bei der Festphasesynthese
US5817751A (en) * 1994-06-23 1998-10-06 Affymax Technologies N.V. Method for synthesis of diketopiperazine and diketomorpholine derivatives
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US5798276A (en) * 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
DE19532553A1 (de) * 1995-09-04 1997-03-06 Hoechst Ag Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate
US5736626A (en) * 1996-01-29 1998-04-07 The Perkin-Elmer Corporation Solid support reagents for the direct synthesis of 3'-labeled polynucleotides

Also Published As

Publication number Publication date
US6015895A (en) 2000-01-18
DE69621836D1 (de) 2002-07-18
WO1997023496A1 (en) 1997-07-03
DE69630400T2 (de) 2005-04-14
EP0877751A1 (de) 1998-11-18
JP2000502341A (ja) 2000-02-29
AU1027797A (en) 1997-07-17
EP0876390B1 (de) 2002-06-12
WO1997023497A1 (en) 1997-07-03
CA2241331A1 (en) 1997-07-03
CA2241222A1 (en) 1997-07-03
DE69621836T2 (de) 2003-02-20
ATE219098T1 (de) 2002-06-15
EP0877751B1 (de) 2003-10-15
AU725690B2 (en) 2000-10-19
DE69630400D1 (de) 2003-11-20
AU725627B2 (en) 2000-10-19
CA2241331C (en) 2003-06-17
EP0876390A1 (de) 1998-11-11
AU1027897A (en) 1997-07-17
CA2241222C (en) 2003-07-22
JP2000502342A (ja) 2000-02-29

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