ATE252559T1 - Herstellungsverfahren für pyridinderivate - Google Patents
Herstellungsverfahren für pyridinderivateInfo
- Publication number
- ATE252559T1 ATE252559T1 AT00125665T AT00125665T ATE252559T1 AT E252559 T1 ATE252559 T1 AT E252559T1 AT 00125665 T AT00125665 T AT 00125665T AT 00125665 T AT00125665 T AT 00125665T AT E252559 T1 ATE252559 T1 AT E252559T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- formula
- chem
- reacting
- substituents
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 25
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001131 transforming effect Effects 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99123686 | 1999-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252559T1 true ATE252559T1 (de) | 2003-11-15 |
Family
ID=8239482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00125665T ATE252559T1 (de) | 1999-11-29 | 2000-11-23 | Herstellungsverfahren für pyridinderivate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6303790B1 (de) |
| EP (1) | EP1103546B1 (de) |
| JP (1) | JP3403164B2 (de) |
| KR (1) | KR100371121B1 (de) |
| CN (1) | CN1176908C (de) |
| AT (1) | ATE252559T1 (de) |
| CA (1) | CA2326815C (de) |
| DE (1) | DE60006054T2 (de) |
| DK (1) | DK1103546T3 (de) |
| ES (1) | ES2208206T3 (de) |
| JO (1) | JO2252B1 (de) |
| MX (1) | MXPA00011670A (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1035115B1 (de) * | 1999-02-24 | 2004-09-29 | F. Hoffmann-La Roche Ag | 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten |
| DE60006340T2 (de) * | 1999-11-29 | 2004-09-09 | F. Hoffmann-La Roche Ag | 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramid |
| TWI287003B (en) * | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
| US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
| CN100369898C (zh) * | 2002-02-12 | 2008-02-20 | 史密丝克莱恩比彻姆公司 | 用作p38抑制剂的烟酰胺衍生物 |
| US7288658B2 (en) * | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
| CN1984891B (zh) | 2004-07-06 | 2012-08-08 | 弗·哈夫曼-拉罗切有限公司 | 用作合成nk-1受体拮抗剂的中间体的甲酰胺吡啶衍生物的制备方法 |
| CA2598762A1 (en) | 2005-02-25 | 2006-08-31 | F. Hoffmann-La Roche Ag | Tablets with improved drug substance dispersibility |
| ATE453384T1 (de) | 2005-09-23 | 2010-01-15 | Hoffmann La Roche | Neue dosierformulierung |
| GB0808747D0 (en) | 2008-05-14 | 2008-06-18 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
| US8426450B1 (en) | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| JP6464421B2 (ja) | 2013-07-02 | 2019-02-06 | ユーストラリス ファーマシューティカルズ リミテッド （トレーディング アズ プレススラ ニューロ） | 慢性外傷性脳障害ｉｉを予防及び／又は治療する方法 |
| CN104003933A (zh) * | 2014-05-14 | 2014-08-27 | 上海应用技术学院 | 一种含氟基团的3-（吡啶基-2-亚胺）丙酸乙酯类似物的制备方法 |
| CN105061303A (zh) * | 2015-08-03 | 2015-11-18 | 成都欣捷高新技术开发有限公司 | 一种制备奈妥吡坦关键中间体n-甲基-4-(2-甲基苯基)-6-(4-甲基-1-哌嗪基)-3-吡啶胺的新方法 |
| CN105732488B (zh) * | 2016-03-28 | 2018-02-16 | 大连理工大学 | 一种吡啶‑2‑甲酸脱羧合成2‑(2‑氯乙氧基)乙氧基吡啶醚化合物的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745123A (en) | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
| EP1035115B1 (de) | 1999-02-24 | 2004-09-29 | F. Hoffmann-La Roche Ag | 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten |
-
2000
- 2000-11-20 US US09/716,538 patent/US6303790B1/en not_active Expired - Lifetime
- 2000-11-23 EP EP00125665A patent/EP1103546B1/de not_active Expired - Lifetime
- 2000-11-23 ES ES00125665T patent/ES2208206T3/es not_active Expired - Lifetime
- 2000-11-23 JO JO2000186A patent/JO2252B1/en active
- 2000-11-23 AT AT00125665T patent/ATE252559T1/de active
- 2000-11-23 DK DK00125665T patent/DK1103546T3/da active
- 2000-11-23 CA CA002326815A patent/CA2326815C/en not_active Expired - Lifetime
- 2000-11-23 DE DE60006054T patent/DE60006054T2/de not_active Expired - Lifetime
- 2000-11-24 KR KR10-2000-0070272A patent/KR100371121B1/ko not_active Expired - Lifetime
- 2000-11-27 MX MXPA00011670A patent/MXPA00011670A/es active IP Right Grant
- 2000-11-28 JP JP2000360682A patent/JP3403164B2/ja not_active Expired - Lifetime
- 2000-11-28 CN CNB001283839A patent/CN1176908C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3403164B2 (ja) | 2003-05-06 |
| CN1297887A (zh) | 2001-06-06 |
| JP2001151755A (ja) | 2001-06-05 |
| DE60006054T2 (de) | 2004-07-22 |
| JO2252B1 (en) | 2004-10-07 |
| EP1103546A1 (de) | 2001-05-30 |
| KR20010051922A (ko) | 2001-06-25 |
| MXPA00011670A (es) | 2002-08-20 |
| CA2326815A1 (en) | 2001-05-29 |
| KR100371121B1 (ko) | 2003-02-06 |
| DK1103546T3 (da) | 2004-02-23 |
| ES2208206T3 (es) | 2004-06-16 |
| CA2326815C (en) | 2009-08-25 |
| CN1176908C (zh) | 2004-11-24 |
| EP1103546B1 (de) | 2003-10-22 |
| US6303790B1 (en) | 2001-10-16 |
| DE60006054D1 (de) | 2003-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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