DK1103546T3 - Fremgangsmåde til fremstilling af pyridinderivater - Google Patents

Fremgangsmåde til fremstilling af pyridinderivater

Info

Publication number
DK1103546T3
DK1103546T3 DK00125665T DK00125665T DK1103546T3 DK 1103546 T3 DK1103546 T3 DK 1103546T3 DK 00125665 T DK00125665 T DK 00125665T DK 00125665 T DK00125665 T DK 00125665T DK 1103546 T3 DK1103546 T3 DK 1103546T3
Authority
DK
Denmark
Prior art keywords
compound
formula
chem
reacting
substituents
Prior art date
Application number
DK00125665T
Other languages
English (en)
Inventor
Hans Hilpert
Fabienne Hoffmann-Emery
Goesta Rimmler
Mark Rogers-Evans
Helmut Werner Stahr
Pius Waldmeier
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1103546T3 publication Critical patent/DK1103546T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00125665T 1999-11-29 2000-11-23 Fremgangsmåde til fremstilling af pyridinderivater DK1103546T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123686 1999-11-29

Publications (1)

Publication Number Publication Date
DK1103546T3 true DK1103546T3 (da) 2004-02-23

Family

ID=8239482

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00125665T DK1103546T3 (da) 1999-11-29 2000-11-23 Fremgangsmåde til fremstilling af pyridinderivater

Country Status (12)

Country Link
US (1) US6303790B1 (da)
EP (1) EP1103546B1 (da)
JP (1) JP3403164B2 (da)
KR (1) KR100371121B1 (da)
CN (1) CN1176908C (da)
AT (1) ATE252559T1 (da)
CA (1) CA2326815C (da)
DE (1) DE60006054T2 (da)
DK (1) DK1103546T3 (da)
ES (1) ES2208206T3 (da)
JO (1) JO2252B1 (da)
MX (1) MXPA00011670A (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
EP1103545B1 (en) * 1999-11-29 2003-11-05 F. Hoffmann-La Roche Ag 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
BRPI0307351B8 (pt) * 2002-02-12 2021-05-25 Smithkline Beecham Corp composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto
US7288658B2 (en) * 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
MX2007000198A (es) 2004-07-06 2007-03-15 Hoffmann La Roche Proceso para la preparacion de derivados de carboxamida-piridina utilizados como intermediarios en la sintesis de antagonistas del receptor nk-1.
NZ560232A (en) 2005-02-25 2010-11-26 Hoffmann La Roche Tablets with improved drug substance dispersibility
SI1928427T1 (sl) 2005-09-23 2010-03-31 Hoffmann La Roche Nove formulacije za doziranje
GB0808747D0 (en) 2008-05-14 2008-06-18 Glaxo Wellcome Mfg Pte Ltd Novel compounds
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
NZ714708A (en) 2013-07-02 2019-06-28 Eustralis Pharmaceuticals Ltd Trading As Pressura Neuro Method for preventing and/or treating chronic traumatic encephalopathy-ii
CN104003933A (zh) * 2014-05-14 2014-08-27 上海应用技术学院 一种含氟基团的3-（吡啶基-2-亚胺）丙酸乙酯类似物的制备方法
CN105061303A (zh) * 2015-08-03 2015-11-18 成都欣捷高新技术开发有限公司 一种制备奈妥吡坦关键中间体n-甲基-4-(2-甲基苯基)-6-(4-甲基-1-哌嗪基)-3-吡啶胺的新方法
CN105732488B (zh) * 2016-03-28 2018-02-16 大连理工大学 一种吡啶‑2‑甲酸脱羧合成2‑(2‑氯乙氧基)乙氧基吡啶醚化合物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745123A (en) 1986-02-18 1988-05-17 Warner-Lambert Company Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister

Also Published As

Publication number Publication date
MXPA00011670A (es) 2002-08-20
CA2326815C (en) 2009-08-25
DE60006054T2 (de) 2004-07-22
JO2252B1 (en) 2004-10-07
CN1297887A (zh) 2001-06-06
JP2001151755A (ja) 2001-06-05
EP1103546B1 (en) 2003-10-22
EP1103546A1 (en) 2001-05-30
KR100371121B1 (ko) 2003-02-06
US6303790B1 (en) 2001-10-16
CA2326815A1 (en) 2001-05-29
JP3403164B2 (ja) 2003-05-06
ES2208206T3 (es) 2004-06-16
CN1176908C (zh) 2004-11-24
DE60006054D1 (de) 2003-11-27
KR20010051922A (ko) 2001-06-25
ATE252559T1 (de) 2003-11-15

Similar Documents

Publication Publication Date Title
DE60006054D1 (de) Herstellungsverfahren für Pyridinderivate
ATE82966T1 (de) Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel.
BR9910326A (pt) Processo para preeparar isoxazóis, composto, processo para preparar compostos, uso de compostos, e, processo para preparar tioéteres
ATE334654T1 (de) Vor uv-strahlen schützende zusammensetzungen
DE60208364D1 (de) Chinolinderivate mit einer azolylgruppe und chinazolinderivate
DE69201058D1 (de) Perhydroisoindol derivate und ihre herstellung.
DK0703902T3 (da) Fremgangsmåde til fremstilling af piperidinderivater
ATE430563T1 (de) Cyano-substituierte oleanolsäure als inhibitor der no-produktion
ATE119774T1 (de) Imidazopyridinderivate und ihre verwendung.
FI931067A0 (fi) Antitumoera foereningar
ATE268767T1 (de) N-aryl-piperidinderivate und ihre verwendung als 5-ht1b-rezeptorliganden
ATE239708T1 (de) Huperzin-derivate, ihre herstellung und ihre verwendung
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
ATE137220T1 (de) Benzen-, pyridin-, pyrimidinderivat
DE60014043D1 (de) Flouride von 4-substituierten piperidin-derivaten
NO971384L (no) Pyrimidinylpyrazol-derivat
NZ221699A (en) Pyridazinone derivatives; pharmaceutical compositions and intermediates
ATE143354T1 (de) N-alkoxymethylbenzamid-derivate und verfahren zu ihrer herstellung und ihre verwendung zur herstellung von benzamid-derivaten
DK1209151T3 (da) 4-substituerede piperidinderivativer
DK0806413T3 (da) 2-substituerede viatmin D3-derivater
DE69612611D1 (de) Triazin-derivate
DK0873327T3 (da) Fremgangsmåde til fremstilling af 2-chlor-5-chlormethyl-thiazol
ATE245147T1 (de) Substituierte aminochinazolinon (thion) derivate
DE69626624D1 (de) Medikamente gegen trhombocytopenie
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.