ATE253918T1 - Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel - Google Patents
Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittelInfo
- Publication number
- ATE253918T1 ATE253918T1 AT99403077T AT99403077T ATE253918T1 AT E253918 T1 ATE253918 T1 AT E253918T1 AT 99403077 T AT99403077 T AT 99403077T AT 99403077 T AT99403077 T AT 99403077T AT E253918 T1 ATE253918 T1 AT E253918T1
- Authority
- AT
- Austria
- Prior art keywords
- hymenialdisine
- derivatives
- production
- therapeutic agents
- gsk
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- QPCBNXNDVYOBIP-WHFBIAKZSA-N hymenialdisine Chemical compound NC1=NC(=O)C([C@@H]2[C@@H]3C=C(Br)N=C3C(=O)NCC2)=N1 QPCBNXNDVYOBIP-WHFBIAKZSA-N 0.000 title abstract 2
- ATBAETXFFCOZOY-UHFFFAOYSA-N hymenialdisine Natural products N1C(N)=NC(=O)C1=C1C(C=C(Br)N2)=C2C(=O)NCC1 ATBAETXFFCOZOY-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 108091007914 CDKs Proteins 0.000 abstract 1
- 102000008122 Casein Kinase I Human genes 0.000 abstract 1
- 108010049812 Casein Kinase I Proteins 0.000 abstract 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 abstract 1
- 102100038104 Glycogen synthase kinase-3 beta Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99403077A EP1106180B1 (de) | 1999-12-08 | 1999-12-08 | Verwendung von Hymenialdisin und dessen Derivaten zur Herstellung therapeutischer Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253918T1 true ATE253918T1 (de) | 2003-11-15 |
Family
ID=8242210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99403077T ATE253918T1 (de) | 1999-12-08 | 1999-12-08 | Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7098204B2 (de) |
| EP (2) | EP1106180B1 (de) |
| JP (1) | JP2004500356A (de) |
| AT (1) | ATE253918T1 (de) |
| AU (1) | AU2365701A (de) |
| CA (1) | CA2384982A1 (de) |
| DE (1) | DE69912808T2 (de) |
| ES (1) | ES2213996T3 (de) |
| WO (1) | WO2001041768A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1250137B1 (de) * | 2000-01-24 | 2007-08-15 | Genzyme Corporation | Inhibitoren des jak/stat-weges und deren verwendung zur behandlung von allgemeiner primärer osteoarthritis |
| US6756385B2 (en) * | 2000-07-31 | 2004-06-29 | Pfizer Inc. | Imidazole derivatives |
| GT200100147A (es) * | 2000-07-31 | 2002-06-25 | Derivados de imidazol | |
| TW201041580A (en) * | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| US7521230B2 (en) * | 2002-10-16 | 2009-04-21 | Board Of Regents Of The University Of Nebraska | Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof |
| EP1585523B1 (de) * | 2002-12-17 | 2008-10-01 | Centre National De La Recherche Scientifique (Cnrs) | Verwendung von purinderivaten zur induktion der differenzierung überzähliger haarzellen und deiter-zellen im entwickelnden corti-organ zur behandlung von taubheit |
| WO2004098520A2 (en) * | 2003-05-01 | 2004-11-18 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| BRPI0410071A (pt) * | 2003-05-08 | 2006-05-23 | Wyeth Corp | métodos para usar no diagnóstico e prognóstico da artrite em um paciente, para usar no monitoramento do curso da artrite em um paciente, para avaliar a eficácia de um tratamento para artrite em um paciente, para triar um composto capaz de inibir a artrite em um paciente e para tratar artrite em um paciente, e, molécula de sirna |
| US7385055B2 (en) | 2003-05-19 | 2008-06-10 | Board Of Trustees Of Michigan State University | Preparation of hymenialdisine derivatives and use thereof |
| DE102004002885B4 (de) * | 2004-01-20 | 2007-03-15 | Johannes-Gutenberg-Universität Mainz | Neue medizinisch einsetzbare Pyrrolalkaloide: Verfahren zu ihrer Isolierung, Synthese, sie enthaltende Arzneimittel und deren Verwendung |
| EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| EP2275095A3 (de) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
| EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| FR2899107B1 (fr) * | 2006-03-30 | 2008-06-13 | Neurokin Entpr Unipersonnelle | Utilisation de la (s)-roscovitine pour la fabrication d'un medicament |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| EP2382975A3 (de) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
| JP2009537532A (ja) * | 2006-05-15 | 2009-10-29 | セネックス バイオテクノロジー，インク． | 腫瘍細胞増殖の選択的阻害剤としてのｃｄｋｉ経路阻害剤 |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| ES2425179T3 (es) * | 2006-10-25 | 2013-10-11 | The Rockefeller University | Métodos para el tratamiento de trastornos relacionados con beta-amiloide y composiciones para los mismos |
| WO2008147713A1 (en) * | 2007-05-24 | 2008-12-04 | The Regents Of The University Of California | Wnt signaling inhibitors, and methods for making and using them |
| ES2799897T3 (es) | 2007-08-31 | 2020-12-22 | Whitehead Inst Biomedical Res | Estimulación de la vía wnt en la reprogramación de células somáticas |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| SG10201510665WA (en) * | 2009-12-04 | 2016-01-28 | Sunovion Pharmaceuticals Inc | Multicycle Compounds And Pharmaceutical Compositions Useful For The Treatment Of Neurological Disorders |
| ES2728932T3 (es) | 2014-01-09 | 2019-10-29 | Intra Cellular Therapies Inc | Compuestos orgánicos |
| EP3210017B1 (de) | 2014-10-26 | 2021-10-06 | King Abdullah University Of Science And Technology | Alkaloide aus schwamm, gerüste zur hemmung des humanen immunschwächevirus (hiv) |
| WO2016130969A1 (en) | 2015-02-13 | 2016-08-18 | George Robert Pettit | Silstatin compounds |
| WO2019094709A1 (en) | 2017-11-09 | 2019-05-16 | Pettit George R | Betulastatin compounds |
| KR102858286B1 (ko) * | 2023-01-26 | 2025-09-10 | 경희대학교 산학협력단 | 항생효과를 가지는 신규 유기-금속 복합체, 이를 포함하는 항생용 조성물 및 이의 제조방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69323185T2 (de) * | 1992-02-24 | 1999-07-08 | Smithkline Beecham Corp., Philadelphia, Pa. 19101 | Proteinkinase c-inhibitor |
| JP3714685B2 (ja) * | 1994-05-18 | 2005-11-09 | 第一サントリーファーマ株式会社 | ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体 |
| DE19500851A1 (de) | 1995-01-13 | 1996-07-18 | Werner & Pfleiderer Lebensmitt | Teigteil- und Wirk-Maschine |
| US5591740A (en) * | 1995-06-07 | 1997-01-07 | Osteoarthritis Sciences, Incorporated | Use of debromohymenialdisine for treating osteoarthritis |
| CA2216559A1 (en) * | 1997-09-25 | 1999-03-25 | Michel Roberge | G2 checkpoint inhibitors and assay |
| IL129178A0 (en) | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Induction of nerve generation |
| WO2001010445A1 (fr) | 1999-08-05 | 2001-02-15 | Teijin Limited | Remedes contre la neuropathie |
| FR2798065B1 (fr) | 1999-09-02 | 2003-09-05 | Assist Publ Hopitaux De Paris | Utilisation de la nicotine ou de ses derives dans un medicament pour le traitement des maladies neurologiques, notamment la maladie de parkinson |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| US20050009876A1 (en) | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
| CA2423192C (en) | 2000-09-20 | 2010-11-23 | Karolinska Innovations Ab | 1-azabicyclo[2.2.2]octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors |
| TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
-
1999
- 1999-12-08 ES ES99403077T patent/ES2213996T3/es not_active Expired - Lifetime
- 1999-12-08 AT AT99403077T patent/ATE253918T1/de not_active IP Right Cessation
- 1999-12-08 DE DE69912808T patent/DE69912808T2/de not_active Expired - Lifetime
- 1999-12-08 EP EP99403077A patent/EP1106180B1/de not_active Expired - Lifetime
-
2000
- 2000-12-07 US US10/149,115 patent/US7098204B2/en not_active Expired - Fee Related
- 2000-12-07 EP EP00987404A patent/EP1235578A2/de not_active Ceased
- 2000-12-07 CA CA002384982A patent/CA2384982A1/en not_active Abandoned
- 2000-12-07 AU AU23657/01A patent/AU2365701A/en not_active Abandoned
- 2000-12-07 JP JP2001543113A patent/JP2004500356A/ja active Pending
- 2000-12-07 WO PCT/EP2000/012791 patent/WO2001041768A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1235578A2 (de) | 2002-09-04 |
| DE69912808D1 (de) | 2003-12-18 |
| WO2001041768A3 (en) | 2002-05-10 |
| US7098204B2 (en) | 2006-08-29 |
| ES2213996T3 (es) | 2004-09-01 |
| DE69912808T2 (de) | 2004-09-30 |
| US20030105075A1 (en) | 2003-06-05 |
| EP1106180A1 (de) | 2001-06-13 |
| WO2001041768A9 (en) | 2002-09-12 |
| JP2004500356A (ja) | 2004-01-08 |
| AU2365701A (en) | 2001-06-18 |
| WO2001041768A2 (en) | 2001-06-14 |
| EP1106180B1 (de) | 2003-11-12 |
| CA2384982A1 (en) | 2001-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |