ATE253940T1 - Stabile lösung von calcitriol zum verpacken in phiolen - Google Patents

Stabile lösung von calcitriol zum verpacken in phiolen

Info

Publication number: ATE253940T1
Authority: AT; Austria
Prior art keywords: packaging; calcitriol; vials; stable solution; solution
Prior art date: 1999-09-29

Application number

AT00965443T

Other languages

English (en)

Inventor

Edward C Shinal

Original Assignee

Aaipharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-29

Filing date

2000-09-26

Publication date

2003-11-15

2000-09-26 Application filed by Aaipharma Inc filed Critical Aaipharma Inc

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253940T1 publication Critical patent/ATE253940T1/de

Links

GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 title abstract 2
229960005084 calcitriol Drugs 0.000 title abstract 2
235000020964 calcitriol Nutrition 0.000 title abstract 2
239000011612 calcitriol Substances 0.000 title abstract 2
238000004806 packaging method and process Methods 0.000 title abstract 2
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
238000002845 discoloration Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oil, Petroleum & Natural Gas (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Endocrinology (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

AT00965443T 1999-09-29 2000-09-26 Stabile lösung von calcitriol zum verpacken in phiolen ATE253940T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/408,970 US6211169B1 (en)	1999-09-29	1999-09-29	Stable calcitriol solution for packaging into vials
PCT/US2000/026417 WO2001022998A1 (en)	1999-09-29	2000-09-26	Stable calcitriol solution for packaging in vials

Publications (1)

Publication Number	Publication Date
ATE253940T1 true ATE253940T1 (de)	2003-11-15

Family

ID=23618517

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00965443T ATE253940T1 (de)	1999-09-29	2000-09-26	Stabile lösung von calcitriol zum verpacken in phiolen

Country Status (12)

Country	Link
US (1)	US6211169B1 (de)
EP (1)	EP1216057B1 (de)
JP (1)	JP2003510293A (de)
AT (1)	ATE253940T1 (de)
AU (1)	AU7616200A (de)
CA (1)	CA2388438A1 (de)
DE (1)	DE60006558T2 (de)
ES (1)	ES2204692T3 (de)
MX (1)	MXPA02003162A (de)
NO (1)	NO20021402L (de)
PT (1)	PT1216057E (de)
WO (1)	WO2001022998A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1441674A (zh) *	2000-09-18	2003-09-10	福荷福尔丁和考有限公司	二磷酸盐溶液
JP2005515996A (ja) *	2001-12-03	2005-06-02	ノバセアインコーポレイティッド	活性型ビタミンｄ化合物を含む薬学的組成物
US20040058895A1 (en) *	2002-09-18	2004-03-25	Bone Care International, Inc.	Multi-use vessels for vitamin D formulations
US20040053895A1 (en) *	2002-09-18	2004-03-18	Bone Care International, Inc.	Multi-use vessels for vitamin D formulations
US7148211B2 (en) *	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US20050026877A1 (en) *	2002-12-03	2005-02-03	Novacea, Inc.	Pharmaceutical compositions comprising active vitamin D compounds
WO2004087190A1 (en) *	2003-04-02	2004-10-14	Genix Therapeutics Inc.	Method for the treatment of prostate cancer
US20050020546A1 (en) *	2003-06-11	2005-01-27	Novacea, Inc.	Pharmaceutical compositions comprising active vitamin D compounds
PL2601105T3 (pl) *	2010-08-06	2018-03-30	Hospira Australia Pty Ltd	Sposób i system przygotowania fiolki
MX388963B (es)	2011-03-04	2025-03-20	Gruenenthal Gmbh	Formulacion farmaceutica acuosa de tapentadol para administracion oral
WO2013114003A1 (fr) *	2012-01-30	2013-08-08	Laboratoires Urgo	Procede de preparation d'un produit sirupeux comprenant des vitamines
WO2015119183A1 (ja) *	2014-02-05	2015-08-13	協和発酵キリン株式会社	活性型ビタミンｄ３またはその誘導体を含有する液剤
PE20171651A1 (es)	2015-03-27	2017-11-13	Gruenenthal Chemie	Formulacion estable para administracion parenteral de tapentadol
EP3515412B1 (de)	2016-09-23	2025-04-23	Grünenthal GmbH	Stabile formulierungen zur parenteralen verabreichung von tapentadol
CN116077432B (zh) *	2023-02-21	2023-09-08	正大制药（青岛）有限公司	一种骨化三醇口服溶液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4308264A (en) *	1981-01-28	1981-12-29	Abbott Laboratories	Stabilized, dilute aqueous preparation of 1α,25-dihydroxycholecalciferol for neonatal administration
US4420092A (en)	1982-09-01	1983-12-13	Mpl Inc.	Tamper-resistant pharmaceutical vial and cap assembly
JP2545540B2 (ja) *	1987-05-29	1996-10-23	株式会社大協精工	両面ラミネ−トゴム栓
US5230429A (en)	1990-12-13	1993-07-27	Etheredge Iii Robert W	Tamper-evident injectable drug vial
JPH05238936A (ja) *	1992-02-27	1993-09-17	Dainippon Pharmaceut Co Ltd	カルシトリオールの水性液剤
AU5861396A (en)	1995-05-19	1996-11-29	Abbott Laboratories	Stable aqueous formulations of 1alpha,25-dihydroxycholecalci ferol for parenteral administration
US6051567A (en) *	1999-08-02	2000-04-18	Abbott Laboratories	Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol

1999
- 1999-09-29 US US09/408,970 patent/US6211169B1/en not_active Expired - Fee Related
2000
- 2000-09-26 ES ES00965443T patent/ES2204692T3/es not_active Expired - Lifetime
- 2000-09-26 EP EP00965443A patent/EP1216057B1/de not_active Expired - Lifetime
- 2000-09-26 CA CA002388438A patent/CA2388438A1/en not_active Abandoned
- 2000-09-26 MX MXPA02003162A patent/MXPA02003162A/es active IP Right Grant
- 2000-09-26 DE DE60006558T patent/DE60006558T2/de not_active Expired - Fee Related
- 2000-09-26 AT AT00965443T patent/ATE253940T1/de not_active IP Right Cessation
- 2000-09-26 PT PT00965443T patent/PT1216057E/pt unknown
- 2000-09-26 JP JP2001526207A patent/JP2003510293A/ja active Pending
- 2000-09-26 AU AU76162/00A patent/AU7616200A/en not_active Abandoned
- 2000-09-26 WO PCT/US2000/026417 patent/WO2001022998A1/en not_active Ceased
2002
- 2002-03-20 NO NO20021402A patent/NO20021402L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20021402D0 (no)	2002-03-20
MXPA02003162A (es)	2003-08-20
JP2003510293A (ja)	2003-03-18
WO2001022998A1 (en)	2001-04-05
EP1216057A1 (de)	2002-06-26
ES2204692T3 (es)	2004-05-01
DE60006558D1 (de)	2003-12-18
US6211169B1 (en)	2001-04-03
DE60006558T2 (de)	2004-05-13
AU7616200A (en)	2001-04-30
NO20021402L (no)	2002-03-20
PT1216057E (pt)	2004-04-30
EP1216057B1 (de)	2003-11-12
CA2388438A1 (en)	2001-04-05

Legal Events

Date	Code	Title	Description
2004-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE253940T1 (de)	2003-11-15	Stabile lösung von calcitriol zum verpacken in phiolen
DE60018100D1 (en)	2005-03-17	Polymorphe form von atorvastatin-calcium
NO20031018D0 (no)	2003-03-05	Oksymorfonpreparater med kontrollert frigivelse
DE60126321D1 (de)	2007-03-15	Gelsystem zur ocularen verabreichung von arzneimitteln
SE9704545D0 (sv)	1997-12-05	Novel compounds
NO20030374D0 (no)	2003-01-24	Syklopentanoindoler, preparater som inneholder slike forbindelser og behandlingsfremgangsmåter
DE60115418D1 (de)	2006-01-05	Mikroinfusionsvorrichtung zur verabreichung von medikamenten
DE60333294D1 (de)	2010-08-19	Kontrollierte verabreichung von arzneien
SE9704546D0 (sv)	1997-12-05	Novel compounds
EE200200357A (et)	2003-10-15	Ravimaine suurenenud kontsentratsioone andvad farmatseutilised kompositsioonid
ES2098140T3 (es)	1997-04-16	Liosferas que contienen gonadotropina.
BR0208741A (pt)	2004-06-22	Derivados de piperidina
NO20025358L (no)	2002-11-08	Ortosubstituerte antranilsyreamider og deres anvendelse som legemidler
DK0458699T3 (da)	1995-06-12	Anvendelse af baclofen til fremstilling af lægemidler til behandling af angina pectoris
NO996208D0 (no)	1999-12-15	Nye 2-(iminometyl)amino- fenylderivater, fremstilling og blandinger derav, samt anvendelse som legemiddel
NO954768L (no)	1996-01-23	N-alkyltiopolyaminderivater som radiobeskyttende midler
EE200300537A (et)	2004-04-15	Meetod madalaannuselise farmatseutilise kompositsiooni tootmiseks
IT1265101B1 (it)	1996-10-30	Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
ATE282607T1 (de)	2004-12-15	Tryptase-inhibitoren
UY26371A1 (es)	2000-10-31	Imidazo-3-il-aminas biciclicas, procedimiento para su preparacion y medicamentos que las contienen
IL166483A0 (en)	2006-01-15	Pharmaceutical compositions containing ciclesonideand an antihistamine
DK0658585T3 (da)	2000-11-27	Amidinophenylalaninderivater, fremgangsmåde til deres fremstilling, deres anvendelse og midler indeholdende disse som antik
DE69808475D1 (de)	2002-11-07	Aminosäurederivate zur behandlung von schlaganfall
ES2173556T3 (es)	2002-10-16	Nuevos compuestos heterociclicos, su procedimiento de preparacion y los compuestos farmaceuticos que los contienen.
ITMI932189A0 (it)	1993-10-15	Composizioni farmaceutiche contenenti n-acetilcarnosina per il trattamento della cataratta