ATE253941T1 - Zusammensetzung mit erhöhter lagerstabilität enthaltend cyclodextrin und wirkstoffe oder wirkstoff-vorstufen, die in wasserunlösliche komponenten zersetzt werden - Google Patents
Zusammensetzung mit erhöhter lagerstabilität enthaltend cyclodextrin und wirkstoffe oder wirkstoff-vorstufen, die in wasserunlösliche komponenten zersetzt werdenInfo
- Publication number
- ATE253941T1 ATE253941T1 AT98928901T AT98928901T ATE253941T1 AT E253941 T1 ATE253941 T1 AT E253941T1 AT 98928901 T AT98928901 T AT 98928901T AT 98928901 T AT98928901 T AT 98928901T AT E253941 T1 ATE253941 T1 AT E253941T1
- Authority
- AT
- Austria
- Prior art keywords
- active ingredients
- decomposed
- composition
- water
- storage stability
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title 2
- 239000000651 prodrug Substances 0.000 abstract 4
- 229940002612 prodrug Drugs 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5090997P | 1997-06-13 | 1997-06-13 | |
| PCT/US1998/011596 WO1998056422A1 (en) | 1997-06-13 | 1998-06-12 | Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253941T1 true ATE253941T1 (de) | 2003-11-15 |
Family
ID=21968241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98928901T ATE253941T1 (de) | 1997-06-13 | 1998-06-12 | Zusammensetzung mit erhöhter lagerstabilität enthaltend cyclodextrin und wirkstoffe oder wirkstoff-vorstufen, die in wasserunlösliche komponenten zersetzt werden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6133248A (de) |
| EP (1) | EP0986403B1 (de) |
| JP (1) | JP4439596B2 (de) |
| AT (1) | ATE253941T1 (de) |
| AU (1) | AU750207B2 (de) |
| DE (1) | DE69819721T2 (de) |
| ES (1) | ES2210769T3 (de) |
| PT (1) | PT986403E (de) |
| WO (1) | WO1998056422A1 (de) |
Families Citing this family (76)
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| AR030312A1 (es) * | 2000-08-03 | 2003-08-20 | Antares Pharma Ipl Ag | Composicion novedosa para la administracion transdermica y/o transmucosica de compuestos activos, que asegura adecuados niveles terapeuticos |
| US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| PE20020300A1 (es) * | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
| AR031135A1 (es) | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
| US6566556B2 (en) * | 2000-12-19 | 2003-05-20 | Nippon Shokubai Co., Ltd. | Method for production of alkanolamine and apparatus therefor |
| EP1414498A2 (de) * | 2001-06-29 | 2004-05-06 | Maxygen Aps | Stabilisierte formulierungen für interferon mit sulfoalkyl ether cyclodextrinen |
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| BR0307898A (pt) * | 2002-02-22 | 2004-12-07 | Pharmacia Corp | Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio |
| AU2003213210A1 (en) * | 2002-02-22 | 2003-09-09 | Pharmacia Corporation | Ophthalmic formulation with gum system |
| NZ546106A (en) | 2003-10-10 | 2008-10-31 | Antares Pharma Ipl Ag | Transdermal pharmaceutical formulation for minimizing skin residues |
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| PT2061458E (pt) * | 2006-09-15 | 2015-03-11 | Univ Minnesota | Composições de topiramato e métodos para a sua utilização |
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| JP5675629B2 (ja) | 2008-10-21 | 2015-02-25 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンを用いた併用療法 |
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| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
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| WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
| CA2791651C (en) | 2010-03-01 | 2019-08-20 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| AU2011245630B2 (en) | 2010-04-07 | 2014-07-03 | Onyx Therapeutics, Inc. | Crystalline peptide epoxyketone immunoproteasome inhibitor |
| ES2691671T3 (es) | 2010-06-24 | 2018-11-28 | Alkermes Pharma Ireland Limited | Profármacos de compuestos NH-acídicos: derivados de éster, carbonato, carbamato y fosfonato |
| DE102011011028A1 (de) * | 2011-02-11 | 2012-08-16 | Ditter Plastic Gmbh + Co. Kg | Frontplatte mit darin eingespritztem Lichtleiter |
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| TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| EP4083075A1 (de) | 2012-02-15 | 2022-11-02 | CyDex Pharmaceuticals, Inc. | Verfahren zur herstellung von cyclodextrinderivaten |
| WO2013130666A1 (en) | 2012-02-28 | 2013-09-06 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| JP6471089B2 (ja) | 2012-03-19 | 2019-02-13 | アルカームス ファーマ アイルランド リミテッド | 脂肪酸エステルを含む医薬組成物 |
| EP2827867B1 (de) | 2012-03-19 | 2019-11-06 | Alkermes Pharma Ireland Limited | Pharmazeutische zusammensetzungen mit glycerinestern |
| JP6333802B2 (ja) | 2012-03-19 | 2018-05-30 | アルカームス ファーマ アイルランド リミテッド | ベンジルアルコールを含む医薬組成物 |
| US9309283B2 (en) | 2012-07-09 | 2016-04-12 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
| EP2897592B1 (de) | 2012-09-19 | 2020-02-19 | Alkermes Pharma Ireland Limited | Pharmazeutische zusammensetzungen mit verbesserter lagerstabilität |
| MX360192B (es) | 2012-10-22 | 2018-10-24 | Cydex Pharmaceuticals Inc | Composiciones de ciclodextrinas alquiladas y procesos para preparar y usar las mismas. |
| CN110368360A (zh) | 2014-03-20 | 2019-10-25 | 奥克梅斯制药爱尔兰有限公司 | 具有增加的注射速度的阿立哌唑制剂 |
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| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
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| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
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| US12377076B2 (en) | 2018-12-18 | 2025-08-05 | Purdue Pharma L.P. | Compounds for treating lymphoma or a T-cell malignant disease |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| CN110279664B (zh) * | 2019-07-30 | 2021-09-03 | 四川农业大学 | 一种氟苯尼考包合物冻干粉针剂及其制备方法 |
| WO2021026310A1 (en) | 2019-08-06 | 2021-02-11 | L.E.A.F. Holdings Group Llc | Processes of preparing polyglutamated antifolates and uses of their compositions |
| JP2023551145A (ja) | 2020-11-18 | 2023-12-07 | ベクソン バイオメディカル,インク. | 医薬化合物の錯化剤塩製剤 |
| CN114588116B (zh) * | 2020-12-04 | 2024-03-15 | 四川科瑞德制药股份有限公司 | 磷苯妥英钠固体组合物、冻干方法、及其用途 |
| KR20230096074A (ko) * | 2020-12-04 | 2023-06-29 | 시추안 크레딧 파마슈티컬스 컴퍼니 리미티드 | 포스페니토인 나트륨 고체 조성물, 동결건조 방법 및 포스페니토인 나트륨 고체 조성물의 사용 |
| EP4525916A1 (de) * | 2022-05-18 | 2025-03-26 | Bexson Biomedical, Inc. | Komplexbildnersalzformulierungen von pharmazeutischen verbindungen bei niedrigen stöchiometrischen verhältnissen |
| WO2024231293A1 (en) | 2023-05-05 | 2024-11-14 | Euro-Celtique S.A. | Combinations for treating cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191101B (en) * | 1983-02-14 | 1987-01-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups |
| US4616008A (en) * | 1984-05-02 | 1986-10-07 | Takeda Chemical Industries, Ltd. | Antibacterial solid composition for oral administration |
| JPS61165322A (ja) * | 1985-01-14 | 1986-07-26 | Microbial Chem Res Found | スパガリン類の注射用凍結乾燥製剤 |
| US4728509A (en) * | 1985-08-19 | 1988-03-01 | Takeda Chemical Industries, Ltd. | Aqueous liquid preparation |
| US4925860A (en) * | 1987-08-05 | 1990-05-15 | E. I. Du Pont De Nemours And Company | Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester |
| DE3938227C1 (en) * | 1989-11-17 | 1991-05-02 | Dolorgiet Gmbh & Co Kg, 5205 St Augustin, De | Oral antiinflammatory and analgetic pharmaceutical compsn. - comprises magnesium ibuprofen dissolved in mixt. of water, propane-1,2-diol and glycerol |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
| DE839528T1 (de) * | 1996-10-29 | 1998-10-22 | Staroil Ltd | Mundlösliche Zusammensetzungen die N-Acetylcystein und Cyclodextrin enthalten |
-
1998
- 1998-06-12 JP JP50289599A patent/JP4439596B2/ja not_active Expired - Lifetime
- 1998-06-12 ES ES98928901T patent/ES2210769T3/es not_active Expired - Lifetime
- 1998-06-12 WO PCT/US1998/011596 patent/WO1998056422A1/en not_active Ceased
- 1998-06-12 EP EP98928901A patent/EP0986403B1/de not_active Expired - Lifetime
- 1998-06-12 AT AT98928901T patent/ATE253941T1/de active
- 1998-06-12 US US09/096,747 patent/US6133248A/en not_active Expired - Lifetime
- 1998-06-12 AU AU80591/98A patent/AU750207B2/en not_active Expired
- 1998-06-12 DE DE69819721T patent/DE69819721T2/de not_active Expired - Lifetime
- 1998-06-12 PT PT98928901T patent/PT986403E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6133248A (en) | 2000-10-17 |
| PT986403E (pt) | 2004-04-30 |
| JP2002511861A (ja) | 2002-04-16 |
| EP0986403A1 (de) | 2000-03-22 |
| AU750207B2 (en) | 2002-07-11 |
| DE69819721T2 (de) | 2004-09-23 |
| EP0986403B1 (de) | 2003-11-12 |
| DE69819721D1 (de) | 2003-12-18 |
| AU8059198A (en) | 1998-12-30 |
| ES2210769T3 (es) | 2004-07-01 |
| JP4439596B2 (ja) | 2010-03-24 |
| WO1998056422A1 (en) | 1998-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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| EEFA | Change of the company name |