ATE254104T1 - 1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidin derivate als für den menschlichen nk3-rezeptor selektive antagonisten - Google Patents

1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidin derivate als für den menschlichen nk3-rezeptor selektive antagonisten

Info

Publication number: ATE254104T1
Authority: AT; Austria
Prior art keywords: phenyl; alkyl; piperidinopropyl; acyl; receptor
Prior art date: 1995-09-14

Application number

AT96931126T

Other languages

English (en)

Inventor

Daniel Bichon

Xavier Edmonds-Alt

Patrick Gueule

Vincenzo Proietto

Broeck Didier Van

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-14

Filing date

1996-09-13

Publication date

2003-11-15

1996-09-13 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE254104T1 publication Critical patent/ATE254104T1/de

Links

101001125071 Homo sapiens Neuromedin-K receptor Proteins 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
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Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Anesthesiology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96931126T 1995-09-14 1996-09-13 1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidin derivate als für den menschlichen nk3-rezeptor selektive antagonisten ATE254104T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9510776A FR2738819B1 (fr)	1995-09-14	1995-09-14	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
PCT/FR1996/001416 WO1997010211A1 (fr)	1995-09-14	1996-09-13	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant

Publications (1)

Publication Number	Publication Date
ATE254104T1 true ATE254104T1 (de)	2003-11-15

Family

ID=9482536

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96931126T ATE254104T1 (de)	1995-09-14	1996-09-13	1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidin derivate als für den menschlichen nk3-rezeptor selektive antagonisten

Country Status (11)

Country	Link
US (4)	US6028082A (de)
EP (2)	EP1241168A1 (de)
JP (2)	JPH11514983A (de)
AT (1)	ATE254104T1 (de)
AU (1)	AU6992596A (de)
BR (1)	BR9610081A (de)
CA (1)	CA2232007A1 (de)
DE (1)	DE69630717T2 (de)
FR (1)	FR2738819B1 (de)
MX (1)	MX9801890A (de)
WO (1)	WO1997010211A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2738819B1 (fr) *	1995-09-14	1997-12-05	Sanofi Sa	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
US6040316A (en) *	1996-09-16	2000-03-21	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines
WO1998011090A2 (en) *	1996-09-16	1998-03-19	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines
AU6133098A (en) *	1997-01-21	1998-08-07	Merck & Co., Inc.	3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6124319A (en) *	1997-01-21	2000-09-26	Merck & Co., Inc.	3,3-disubstituted piperidines as modulators of chemokine receptor activity
EP1052992A1 (de) *	1998-02-02	2000-11-22	Merck & Co., Inc.	Cyclische amine modulatoren der chemokinrezeptoren
US6140349A (en) *	1998-02-02	2000-10-31	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
GB9821898D0 (en) *	1998-10-08	1998-12-02	Pfizer Ltd	Heterocycles
FR2784377B3 (fr) *	1998-10-09	2000-11-17	Sanofi Sa	Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2787449B3 (fr)	1998-12-15	2001-01-12	Sanofi Sa	Derives de 3-phenyl-2,6-dioxopiperidin-3-yl propionamide et leur procede de preparation
FR2787790A1 (fr)	1998-12-23	2000-06-30	Sanofi Sa	Procede de preparation du (r)-(+)-3-{1[2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates
FR2792199B3 (fr)	1999-04-13	2001-05-18	Sanofi Sa	Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur
US20020099076A1 (en) *	2000-05-25	2002-07-25	Richard Scheyer D.	Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis
FR2824828B1 (fr) *	2001-05-21	2005-05-20	Sanofi Synthelabo	Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
AR045368A1 (es) *	2003-08-15	2005-10-26	Lundbeck & Co As H	Derivados de ciclopropilo como antagonistas del receptor nk3
EP1656349B1 (de)	2003-08-15	2011-10-12	H. Lundbeck A/S	Cyclopropylderivate als nk3 rezeptor-antagonisten
FR2873373B1 (fr) *	2004-07-23	2006-09-08	Sanofi Synthelabo	Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
RU2008137583A (ru) *	2006-02-22	2010-03-27	Вертекс Фармасьютикалз Инкорпорейшн (Us)	Спиропиперидины в качестве модуляторов мускариновых рецепторов
US20090320896A1 (en) *	2008-06-25	2009-12-31	Gerhardinger Peter F	Moisture resistant solar panel and method of making same
EP2391615B1 (de) *	2009-01-30	2013-01-16	F. Hoffmann-La Roche AG	Piperidinderivate als nk3-rezeptorantagonisten
WO2021030335A1 (en) *	2019-08-12	2021-02-18	Millendo Therapeutics, Inc.	A stereoisomerically pure nk-3 receptor antagonist and crystalline forms thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676054B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) *	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
WO1994026735A1 (en) *	1993-05-06	1994-11-24	Merrell Dow Pharmaceuticals Inc.	Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
GB9310066D0 (en) *	1993-05-17	1993-06-30	Zeneca Ltd	Alkyl substituted heterocycles
FR2719311B1 (fr) *	1994-03-18	1998-06-26	Sanofi Sa	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
US5563133A (en) *	1995-02-21	1996-10-08	Eli Lilly And Company	Hexamethyleneiminyl tachykinin receptor antagonists
FR2738819B1 (fr) *	1995-09-14	1997-12-05	Sanofi Sa	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant

1995
- 1995-09-14 FR FR9510776A patent/FR2738819B1/fr not_active Expired - Fee Related
1996
- 1996-09-13 DE DE69630717T patent/DE69630717T2/de not_active Expired - Fee Related
- 1996-09-13 EP EP02010824A patent/EP1241168A1/de not_active Withdrawn
- 1996-09-13 WO PCT/FR1996/001416 patent/WO1997010211A1/fr not_active Ceased
- 1996-09-13 US US09/043,247 patent/US6028082A/en not_active Expired - Fee Related
- 1996-09-13 JP JP9511718A patent/JPH11514983A/ja active Pending
- 1996-09-13 CA CA002232007A patent/CA2232007A1/en not_active Abandoned
- 1996-09-13 AT AT96931126T patent/ATE254104T1/de not_active IP Right Cessation
- 1996-09-13 BR BR9610081A patent/BR9610081A/pt not_active Application Discontinuation
- 1996-09-13 MX MX9801890A patent/MX9801890A/es not_active IP Right Cessation
- 1996-09-13 EP EP96931126A patent/EP1019373B1/de not_active Expired - Lifetime
- 1996-09-13 AU AU69925/96A patent/AU6992596A/en not_active Abandoned
1999
- 1999-11-09 US US09/437,203 patent/US6291672B1/en not_active Expired - Fee Related
2001
- 2001-09-18 US US09/954,862 patent/US6710042B2/en not_active Expired - Fee Related
2004
- 2004-03-22 US US10/805,733 patent/US20040220223A1/en not_active Abandoned
2007
- 2007-11-15 JP JP2007296689A patent/JP2008115182A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
FR2738819A1 (fr)	1997-03-21
EP1241168A1 (de)	2002-09-18
JP2008115182A (ja)	2008-05-22
DE69630717D1 (de)	2003-12-18
US20040220223A1 (en)	2004-11-04
FR2738819B1 (fr)	1997-12-05
EP1019373A1 (de)	2000-07-19
US6710042B2 (en)	2004-03-23
US20020049329A1 (en)	2002-04-25
AU6992596A (en)	1997-04-01
EP1019373B1 (de)	2003-11-12
WO1997010211A1 (fr)	1997-03-20
JPH11514983A (ja)	1999-12-21
US6028082A (en)	2000-02-22
BR9610081A (pt)	1999-01-05
MX9801890A (es)	1998-05-31
US6291672B1 (en)	2001-09-18
CA2232007A1 (en)	1997-03-20
DE69630717T2 (de)	2004-09-23

Legal Events

Date	Code	Title	Description
2004-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69630717D1 (de)	2003-12-18	1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidin-derivate als für den menschlichen nk3-rezeptor selektive antagonisten
DK1022277T3 (da)	2003-01-06	Nye taxanderivater
NO20024531L (no)	2002-11-19	4,5-dihydro-1H-pyrazolderivater med CB1-antagonist aktivitet
BG103964A (en)	2000-08-31	SUBSTITUTED PYRAZOLS AS p38 KINASE INHIBITORS
WO2001023354A3 (de)	2002-02-28	Trifluormethylsubstituierte spirocyclische ketoenole und ihre verwendung alsschädlingsbekämpfungsmittel und herbizide
IL90102A0 (en)	1989-12-15	Fused polycyclic compounds,method of manufacture,and their use as paf antagonists,antihistamines and/or antiinflammatory agents
RU93046497A (ru)	1996-06-20	Фенильные гетероциклические производные, способ их получения, фармацевтическая композиция и промежуточный продукт
ATE176470T1 (de)	1999-02-15	Xanthinderivate
DE69627281D1 (de)	2003-05-15	Neue 1-Aryl Pyrazol Derivate und ihre Verwendung als Schädlingsbekämpfungsmittel
ATE260897T1 (de)	2004-03-15	3-(4-subst.-piperidinyl-1)-1-(3,4- dichlorophenyl)propylcarbamate und -harnstoffe und andere derivative als neue neurokinin- antagonisten
ATE157362T1 (de)	1997-09-15	N-pyridyl carboxamidderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutischen zusammensetzungen
ATE214053T1 (de)	2002-03-15	3-(het)aryl-carbonsäurederivate, verfahren und zwischenprodukte zu ihrer herstellung
DE69013511D1 (de)	1994-11-24	Aminosäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EP0300882A3 (de)	1989-04-19	5-Aminomethylen-2,4-imidazolidindione und 5-Aminomethylen-2-thionoimidazolidin-4-one
BG104232A (bg)	2000-10-31	Заместени 1,2,3,4,5,6-хексахидро-2,6-метано-3-бензазоцин- 10-оли, метод за тяхното получаване и приложението им като лекарствени средства
YU75394A (sh)	1997-09-30	Anelirani dihidropiridini i njihova primena za pripremanje farmaceutskih preparata
EP0822194A4 (de)	1998-04-29	ANNELLIIERTE IMIDAZO[1,2-a]PYRIDINE
AR240828A2 (es)	1991-02-28	Procedimiento para obtener nuevos derivados de 1h,3h-pirrolo[1,2-c!tiazol y sus sales
DE3878074D1 (de)	1993-03-18	Substituierte pyridylethanolamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren.
BR9807312A (pt)	2000-05-02	Derivados de (4-piperidinil)-1h-2-benzopirano úteis como agentes antipsicóticos
ATE73123T1 (de)	1992-03-15	Neue 3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte.
BG105247A (en)	2001-11-30	N-substituted azabicycloheptane derivatives, production and use thereof
IE33218B1 (en)	1974-04-17	Benzodiazepine derivatives
NO974313D0 (no)	1997-09-18	Hydrokinon-derivat og farmasöytisk bruk derav
IT8023120A0 (it)	1980-06-30	[2,3-c] piridine,procedimento per 4-fenil-4,5,6,7-tetraidropirrolo la loro fabbricazione,nonche'composizioni farmaceutiche relative