ATE254112T1 - Verfahren zur herstellung von substituierten pyrimidinonen - Google Patents
Verfahren zur herstellung von substituierten pyrimidinonenInfo
- Publication number
- ATE254112T1 ATE254112T1 AT98963791T AT98963791T ATE254112T1 AT E254112 T1 ATE254112 T1 AT E254112T1 AT 98963791 T AT98963791 T AT 98963791T AT 98963791 T AT98963791 T AT 98963791T AT E254112 T1 ATE254112 T1 AT E254112T1
- Authority
- AT
- Austria
- Prior art keywords
- producing substituted
- present
- substituted pyrimidinones
- mixing
- base
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 abstract 1
- 102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
- 108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
- 108090001005 Interleukin-6 Proteins 0.000 abstract 1
- 102000004890 Interleukin-8 Human genes 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6751397P | 1997-12-04 | 1997-12-04 | |
| US20456998A | 1998-12-03 | 1998-12-03 | |
| PCT/US1998/025790 WO1999028303A1 (en) | 1997-12-04 | 1998-12-04 | Process of preparing substituted pyrimidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE254112T1 true ATE254112T1 (de) | 2003-11-15 |
Family
ID=26747950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98963791T ATE254112T1 (de) | 1997-12-04 | 1998-12-04 | Verfahren zur herstellung von substituierten pyrimidinonen |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1037881B1 (de) |
| JP (1) | JP2001524544A (de) |
| AT (1) | ATE254112T1 (de) |
| AU (1) | AU1903899A (de) |
| CA (1) | CA2312338A1 (de) |
| DE (1) | DE69819774T2 (de) |
| DK (1) | DK1037881T3 (de) |
| ES (1) | ES2207024T3 (de) |
| PT (1) | PT1037881E (de) |
| WO (1) | WO1999028303A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024119067A1 (en) | 2022-12-02 | 2024-06-06 | Neumora Therapeutics, Inc. | Methods of treating neurological disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5100897A (en) * | 1989-08-28 | 1992-03-31 | Merck & Co., Inc. | Substituted pyrimidinones as angiotensin ii antagonists |
| TW229142B (de) * | 1992-04-15 | 1994-09-01 | Nissan Detrochem Corp |
-
1998
- 1998-12-04 AT AT98963791T patent/ATE254112T1/de not_active IP Right Cessation
- 1998-12-04 CA CA002312338A patent/CA2312338A1/en not_active Abandoned
- 1998-12-04 WO PCT/US1998/025790 patent/WO1999028303A1/en not_active Ceased
- 1998-12-04 EP EP98963791A patent/EP1037881B1/de not_active Expired - Lifetime
- 1998-12-04 JP JP2000523197A patent/JP2001524544A/ja not_active Withdrawn
- 1998-12-04 DE DE69819774T patent/DE69819774T2/de not_active Expired - Fee Related
- 1998-12-04 DK DK98963791T patent/DK1037881T3/da active
- 1998-12-04 AU AU19038/99A patent/AU1903899A/en not_active Abandoned
- 1998-12-04 ES ES98963791T patent/ES2207024T3/es not_active Expired - Lifetime
- 1998-12-04 PT PT98963791T patent/PT1037881E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1037881B1 (de) | 2003-11-12 |
| PT1037881E (pt) | 2004-04-30 |
| CA2312338A1 (en) | 1999-06-10 |
| ES2207024T3 (es) | 2004-05-16 |
| AU1903899A (en) | 1999-06-16 |
| EP1037881A1 (de) | 2000-09-27 |
| DK1037881T3 (da) | 2004-02-02 |
| DE69819774D1 (de) | 2003-12-18 |
| WO1999028303A1 (en) | 1999-06-10 |
| JP2001524544A (ja) | 2001-12-04 |
| DE69819774T2 (de) | 2004-09-23 |
| HK1028243A1 (en) | 2001-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1037881 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |