ATE254131T1 - Benzimidazolderivate - Google Patents

Benzimidazolderivate

Info

Publication number
ATE254131T1
ATE254131T1 AT98904273T AT98904273T ATE254131T1 AT E254131 T1 ATE254131 T1 AT E254131T1 AT 98904273 T AT98904273 T AT 98904273T AT 98904273 T AT98904273 T AT 98904273T AT E254131 T1 ATE254131 T1 AT E254131T1
Authority
AT
Austria
Prior art keywords
8alkyl
14aryl
6alkynyl
6alkenyl
hydrogen
Prior art date
Application number
AT98904273T
Other languages
English (en)
Inventor
Jeffrey H Tidwell
Stanley Dawes Chamberlain
George Andrew Freeman
Joseph Howing Chan
George Walter Koszalka
Leroy Townsend
John Drach
Original Assignee
Glaxo Group Ltd
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9703134.8A external-priority patent/GB9703134D0/en
Application filed by Glaxo Group Ltd, Univ Michigan filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE254131T1 publication Critical patent/ATE254131T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Insulated Conductors (AREA)
  • Saccharide Compounds (AREA)
AT98904273T 1997-02-13 1998-02-13 Benzimidazolderivate ATE254131T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3799297P 1997-02-13 1997-02-13
GBGB9703134.8A GB9703134D0 (en) 1997-02-14 1997-02-14 Benzimidazole derivates
PCT/GB1998/000448 WO1998035977A1 (en) 1997-02-13 1998-02-13 Benzimidazole derivatives

Publications (1)

Publication Number Publication Date
ATE254131T1 true ATE254131T1 (de) 2003-11-15

Family

ID=26311002

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98904273T ATE254131T1 (de) 1997-02-13 1998-02-13 Benzimidazolderivate

Country Status (8)

Country Link
US (1) US6413938B1 (de)
EP (1) EP0970100B1 (de)
JP (1) JP2001512453A (de)
AT (1) ATE254131T1 (de)
AU (1) AU6221998A (de)
CA (1) CA2280761A1 (de)
DE (1) DE69819695D1 (de)
WO (1) WO1998035977A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840743A (en) 1996-01-23 1998-11-24 The Regents Of The University Of Michigan Modified benzimidazole nucleosides as antiviral agents
AU744176B2 (en) 1997-07-30 2002-02-14 Glaxo Group Limited Lyxofuranosyl benzimidazoles as antiviral agents
JP3256513B2 (ja) 1998-02-11 2002-02-12 ファイザー製薬株式会社 ベンゾイミダゾールシクロオキシゲナーゼ−２阻害剤
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
WO2012070069A2 (en) * 2010-11-24 2012-05-31 Sequent Scientific Limited A process for preparation of albendazole
IL319923A (en) 2022-10-12 2025-05-01 Takeda Pharmaceuticals Co Maribavir preparation method
CN119119151A (zh) * 2024-09-04 2024-12-13 斯坦德药典标准物质研发(湖北)有限公司 一种马立巴韦的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
DE2130030A1 (de) 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
US4002623A (en) 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
FR2551442B1 (fr) 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
DK405988A (da) 1987-07-29 1989-01-30 Hoffmann La Roche Benzimidazolderivater
IT1226100B (it) 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1992018517A1 (en) 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9205071D0 (en) 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
WO1994008456A1 (en) 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5399580A (en) 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
JPH10505092A (ja) 1994-09-09 1998-05-19 ザ・ウエルカム・ファンデーション・リミテッド 環状炭素に連結される置換されたベンズイミダゾール塩基を含む抗ウイルス性ヌクレオシドアナログ
WO1997007125A1 (en) 1995-08-18 1997-02-27 The Regents Of The University Of Michigan 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9600142D0 (en) 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
US5840743A (en) 1996-01-23 1998-11-24 The Regents Of The University Of Michigan Modified benzimidazole nucleosides as antiviral agents

Also Published As

Publication number Publication date
EP0970100A1 (de) 2000-01-12
WO1998035977A1 (en) 1998-08-20
US6413938B1 (en) 2002-07-02
EP0970100B1 (de) 2003-11-12
AU6221998A (en) 1998-09-08
DE69819695D1 (en) 2003-12-18
CA2280761A1 (en) 1998-08-20
JP2001512453A (ja) 2001-08-21

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties