ATE234818T1 - Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents
Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittelInfo
- Publication number
- ATE234818T1 ATE234818T1 AT97919665T AT97919665T ATE234818T1 AT E234818 T1 ATE234818 T1 AT E234818T1 AT 97919665 T AT97919665 T AT 97919665T AT 97919665 T AT97919665 T AT 97919665T AT E234818 T1 ATE234818 T1 AT E234818T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- pct
- production
- medicinal products
- quinoline derivatives
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPN9526A AUPN952696A0 (en) | 1996-04-29 | 1996-04-29 | New heterocyclic compounds |
| PCT/JP1997/001415 WO1997041104A1 (en) | 1996-04-29 | 1997-04-24 | Quinoline derivatives, processes for their preparation, and their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE234818T1 true ATE234818T1 (de) | 2003-04-15 |
Family
ID=3793840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97919665T ATE234818T1 (de) | 1996-04-29 | 1997-04-24 | Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6083959A (de) |
| EP (1) | EP0900203B1 (de) |
| JP (1) | JP2000509066A (de) |
| AT (1) | ATE234818T1 (de) |
| AU (1) | AUPN952696A0 (de) |
| DE (1) | DE69719974T2 (de) |
| ES (1) | ES2189956T3 (de) |
| WO (1) | WO1997041104A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2790260B1 (fr) * | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
| EP1914236A1 (de) | 2002-04-10 | 2008-04-23 | Ortho-McNeil Pharmaceutical, Inc. | Neue Heteroaryl-Alkylamid-Derivate als Bradykininrezeptormodulatoren |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| TWI407960B (zh) * | 2007-03-23 | 2013-09-11 | Jerini Ag | 小分子緩激肽b2受體調節劑 |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| AR113839A1 (es) * | 2017-11-24 | 2020-06-17 | Pharvaris B V | Antagonistas del receptor b2 de bradiquinina |
| AR118983A1 (es) | 2019-05-23 | 2021-11-17 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| UY38706A (es) | 2019-05-23 | 2020-12-31 | Pharvaris Gmbh | Antagonistas cíclicos del receptor b2 de bradiquinina |
| MA61123B1 (fr) | 2021-08-05 | 2024-06-28 | Pharvaris Gmbh | Composition à base de lipides pour l'administration par voie orale d'antagonistes des récepteurs b2 de la bradykinine |
| ES3062067T3 (en) | 2022-03-25 | 2026-04-08 | Pharvaris Gmbh | Solid composition comprising solubilised bradykinin b2-receptor antagonists |
| US20250268887A1 (en) | 2022-03-25 | 2025-08-28 | Pharvaris Gmbh | Therapeutic uses of bradykinin b2-receptor antagonists |
| TW202345810A (zh) | 2022-03-25 | 2023-12-01 | 瑞士商帕法瑞斯有限責任公司 | 包含緩激肽b2受體拮抗劑之固態延長釋放組成物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3617183A1 (de) * | 1985-11-16 | 1987-05-27 | Bayer Ag | Substituierte benzylether |
| DE3632329A1 (de) * | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| US5212182A (en) * | 1990-10-03 | 1993-05-18 | American Home Products Corpooration | Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics |
| AU686115B2 (en) * | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
| US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
| AU680870B2 (en) * | 1993-04-28 | 1997-08-14 | Astellas Pharma Inc. | New heterocyclic compounds |
| ES2218554T3 (es) * | 1994-10-27 | 2004-11-16 | Fujisawa Pharmaceutical Co., Ltd. | Piridopirimidonas, quinolinas y n-heterociclos condensados que son antagonistas de bradiquinina. |
| GB9519077D0 (en) * | 1995-09-18 | 1995-11-15 | Fujisawa Pharmaceutical Co | New heterocyclic compounds |
-
1996
- 1996-04-29 AU AUPN9526A patent/AUPN952696A0/en not_active Abandoned
-
1997
- 1997-04-24 ES ES97919665T patent/ES2189956T3/es not_active Expired - Lifetime
- 1997-04-24 JP JP9538734A patent/JP2000509066A/ja not_active Ceased
- 1997-04-24 AT AT97919665T patent/ATE234818T1/de not_active IP Right Cessation
- 1997-04-24 US US09/147,193 patent/US6083959A/en not_active Expired - Fee Related
- 1997-04-24 DE DE69719974T patent/DE69719974T2/de not_active Expired - Lifetime
- 1997-04-24 WO PCT/JP1997/001415 patent/WO1997041104A1/en not_active Ceased
- 1997-04-24 EP EP97919665A patent/EP0900203B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000509066A (ja) | 2000-07-18 |
| EP0900203B1 (de) | 2003-03-19 |
| US6083959A (en) | 2000-07-04 |
| EP0900203A1 (de) | 1999-03-10 |
| DE69719974T2 (de) | 2003-08-28 |
| DE69719974D1 (de) | 2003-04-24 |
| ES2189956T3 (es) | 2003-07-16 |
| AUPN952696A0 (en) | 1996-05-23 |
| WO1997041104A1 (en) | 1997-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9401408A (es) | Nuevos derivados heterociclicos. | |
| IL142649A0 (en) | Azole derivatives | |
| BR9610960A (pt) | Derivados de 8-azabiciclo [3.2.1] oct -2- eno sua preparação e uso | |
| ES2132415T3 (es) | Nuevos derivados de 5-pirrolil-2-piridilmetilsulfinilbencimidazol. | |
| DE50011034D1 (de) | N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| DE69607650D1 (de) | 2,3,5-trimethyl-hydroxyanilid-derivative, ihre herstellung und ihre theraoeutische verwendung | |
| ATE234818T1 (de) | Chinolinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| UY24802A1 (es) | Nuevos compuestos | |
| AU1556997A (en) | Chinoline and benzimidazole derivatives as bradykinin agonists | |
| ATE86602T1 (de) | Alpha,alpha disubstituierte n-cycloalkylalkylbenzylamine, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und ihre zwischenprodukte bei der herstellung. | |
| MX9400253A (es) | Derivados de piperazina, proceso para su preparacion y composiciones farmaceuticas que los contienen. | |
| DE69318563D1 (de) | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATE, IHRE HERSTELLUNG UND DIE SIE ENTHALTENDEN ARZNEIMITTEL | |
| ATE233741T1 (de) | Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung | |
| NO955328L (no) | Pyridazinon-derivater | |
| ATE225335T1 (de) | Amide derivate als 5-ht1a liganden | |
| ATE191465T1 (de) | Carbamoylcarbonsäureamide | |
| ATE238284T1 (de) | Phenanthridinderivate, verfahren zu ihrer herstellung und arzneimittel, enthaltend phenanthridinderivate | |
| TR199801683A2 (xx) | Yeni �re t�revleri. | |
| DE69943259D1 (de) | Neue 2-Halogen-Derivate von 5-O-Desosaminylerythronolid A, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel | |
| ZA941334B (en) | Amide derivative . | |
| DE3481059D1 (de) | Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel. | |
| DE3762341D1 (de) | Chinolinderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen. | |
| ATE136029T1 (de) | Carbostyrylderivate | |
| KR950011417A (ko) | 아미드기를 가지는 n-치환된 벤즈아미다졸 유도체 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |