ATE254174T1 - Herstellung von d-pantoinsäure und d- pantothensäure - Google Patents

Herstellung von d-pantoinsäure und d- pantothensäure

Info

Publication number: ATE254174T1
Authority: AT; Austria
Prior art keywords: acid; alpha; pantoic; salt; producing
Prior art date: 1992-09-25

Application number

AT93307487T

Other languages

English (en)

Inventor

Yuichi Hikichi

Takeo Moriya

Ikuo Nogami

Hiroshi Miki

Takamasa Yamaguchi

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-25

Filing date

1993-09-22

Publication date

2003-11-15

1993-09-22 Application filed by Basf Ag filed Critical Basf Ag

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE254174T1 publication Critical patent/ATE254174T1/de

Links

GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title abstract 11
OTOIIPJYVQJATP-BYPYZUCNSA-N (R)-pantoic acid Chemical compound OCC(C)(C)[C@@H](O)C(O)=O OTOIIPJYVQJATP-BYPYZUCNSA-N 0.000 title abstract 5
150000003839 salts Chemical class 0.000 abstract 6
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 4
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 4
238000000034 method Methods 0.000 abstract 3
YYLQUHNPNCGKJQ-NHYDCYSISA-N (3R)-3-hydroxy-L-aspartic acid Chemical compound OC(=O)[C@@H](N)[C@@H](O)C(O)=O YYLQUHNPNCGKJQ-NHYDCYSISA-N 0.000 abstract 2
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract 2
QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 abstract 2
TYEYBOSBBBHJIV-UHFFFAOYSA-N 2-oxobutanoic acid Chemical compound CCC(=O)C(O)=O TYEYBOSBBBHJIV-UHFFFAOYSA-N 0.000 abstract 2
QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 abstract 2
QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 abstract 2
FYCWLJLGIAUCCL-DMTCNVIQSA-N O-methyl-L-threonine Chemical compound CO[C@H](C)[C@H](N)C(O)=O FYCWLJLGIAUCCL-DMTCNVIQSA-N 0.000 abstract 2
229940000635 beta-alanine Drugs 0.000 abstract 2
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 2
229960004889 salicylic acid Drugs 0.000 abstract 2
241000588921 Enterobacteriaceae Species 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
OTOIIPJYVQJATP-UHFFFAOYSA-N pantoic acid Chemical compound OCC(C)(C)C(O)C(O)=O OTOIIPJYVQJATP-UHFFFAOYSA-N 0.000 abstract 1
SERHXTVXHNVDKA-UHFFFAOYSA-N pantolactone Chemical compound CC1(C)COC(=O)C1O SERHXTVXHNVDKA-UHFFFAOYSA-N 0.000 abstract 1
229940055726 pantothenic acid Drugs 0.000 abstract 1
235000019161 pantothenic acid Nutrition 0.000 abstract 1
239000011713 pantothenic acid Substances 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT93307487T 1992-09-25 1993-09-22 Herstellung von d-pantoinsäure und d- pantothensäure ATE254174T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP25652492		1992-09-25

Publications (1)

Publication Number	Publication Date
ATE254174T1 true ATE254174T1 (de)	2003-11-15

Family

ID=17293824

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93307487T ATE254174T1 (de)	1992-09-25	1993-09-22	Herstellung von d-pantoinsäure und d- pantothensäure

Country Status (8)

Country	Link
US (1)	US5518906A (de)
EP (1)	EP0590857B1 (de)
JP (1)	JP3710497B2 (de)
KR (1)	KR100282278B1 (de)
CN (5)	CN100392069C (de)
AT (1)	ATE254174T1 (de)
DE (1)	DE69333295T2 (de)
DK (1)	DK0590857T3 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5287396A (en) *	1995-04-21	1996-11-07	Takeda Chemical Industries Ltd.	Process for producing calcium d-pantothenate
AU6943696A (en) *	1995-09-13	1997-04-01	Takeda Chemical Industries Ltd.	Process for producing d-pantoic acid and d-pantothenic acid or salts thereof
DE19855314A1 (de) *	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae
DE19855313A1 (de) *	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
DE19855312A1 (de) *	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
US6319528B1 (en) *	1999-05-05	2001-11-20	Degussa Aktiengesellschaft	Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof
ATE227938T1 (de) *	1999-05-05	2002-12-15	Degussa	D-pantothensäure und/oder eines ihrer salze enthaltende futtermittel-additive und verfahren zu deren herstellung
US6238714B1 (en) *	1999-05-05	2001-05-29	Degussa-Huls Ag	Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof
MXPA02003017A (es) *	1999-09-21	2004-09-06	Basf Ag	Metodos y microorganismos para la produccion de panto-compuestos.
US8232081B2 (en)	1999-09-21	2012-07-31	Basf Se	Methods and microorganisms for production of panto-compounds
DE10021515A1 (de) *	2000-05-03	2001-11-08	Degussa	Verfahren zur Herstellung von Erdalkalisalzen der D-Pantothensäure
DE10032349A1 (de)	2000-07-04	2002-01-17	Degussa	Rieselfähige D-Pantothensäure und/oder deren Salze enthaltende Futtermittel-Additive und Verfahren zu deren Herstellung
KR20030038751A (ko) *	2000-09-20	2003-05-16	바스프 악티엔게젤샤프트	Ｄ-판토텐산 또는 그의 염을 포함하는 동물 사료 보충물,그의 개선된 제조 방법 및 그의 용도
US6911329B2 (en)	2000-09-23	2005-06-28	Degussa Ag	Process for the fermentative preparation of D-pantothenic acid using coryneform bacteria
AU2001291825A1 (en) *	2000-09-30	2002-04-15	Degussa A.G.	Process for the fermentative preparation of d-pantothenic acid using coryneform bacteria
BR0206587A (pt) *	2001-01-19	2005-12-13	Basf Ag	Processo para a produção de uma composição de pantotenato livre de hmbpa, produto, composição de pantotenato livre de hmbpa, composição sintetizada por um microorganismo possuindo uma rota biossintética de pantotenato desregulada, microorganismo recombinante para a produção de composições de pantotenato livres de hmbpa, e, processo para a produção de uma composição de pantotenato: hmbpa seletivamente misturada
DE10106460A1 (de) *	2001-02-13	2002-08-14	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106459A1 (de) *	2001-02-13	2002-08-14	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106461A1 (de) *	2001-02-13	2002-08-14	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
CN1294271C (zh) *	2001-02-21	2007-01-10	巴斯福股份公司	制备作为动物饲料添加剂的d－泛酸和/或其盐的方法
DE10108223A1 (de) *	2001-02-21	2002-10-10	Basf Ag	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
DE10108225A1 (de)	2001-02-21	2002-10-10	Basf Ag	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
RU2003128532A (ru)	2001-02-21	2005-03-27	Басф Акциенгезелльшафт (De)	Способ получения d-пантотеновой кислоты и/или ее солей, используемых в качестве добавок при производстве кормов для животных
DE10112102A1 (de) *	2001-03-14	2002-09-19	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
US6623944B2 (en)	2001-03-14	2003-09-23	Degussa Ag	Process for preparation of D-pantothenic acid and/or salts thereof
DE10128780A1 (de) *	2001-06-13	2002-12-19	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
EP1402047A1 (de) *	2001-07-03	2004-03-31	Degussa AG	Verfahren zur fermentativen herstellung von pantothensäure und/oder ihren salzen
DE10132178A1 (de)	2001-07-03	2003-01-23	Degussa	Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen
EP1404840A2 (de)	2001-07-07	2004-04-07	Degussa AG	Verfahren zur herstellung von d-pantothensäure und/oder salzen davon
DE10147960A1 (de) *	2001-09-28	2003-04-10	Degussa	Verfahren zur fermentativen Herstellung von D-Panthothensäure und/oder deren Salzen
MXPA04012812A (es)	2002-07-03	2005-02-24	Basf Ag	Microorganismos y proceso para la produccion aumentada de pantotenato.
KR100975978B1 (ko)	2010-02-10	2010-08-16	주식회사 장원엔지니어링	턴디쉬 노즐용 통기량 자동 측정장치
EP2723878B1 (de)	2011-06-21	2020-05-20	DSM IP Assets B.V.	Herstellung von vitamin b5
WO2012175574A1 (en)	2011-06-21	2012-12-27	Dsm Ip Assets B.V.	Increased pantothenate (vitamin b5) production
US20180146703A1 (en) *	2015-05-15	2018-05-31	The Johns Hopkins University	Novel fluoride prenatal dietary supplement
CN111621541B (zh) *	2019-02-27	2025-10-31	广安摩珈生物科技有限公司	使用电渗析技术拆分光学异构体的方法
EP4174185A4 (de) *	2020-06-28	2024-05-22	Mint Biotechnologies Co., Ltd.	Verfahren zur herstellung von pantothensäure, panthensäure und panthenol sowie salzen davon
KR102389327B1 (ko)	2020-07-01	2022-04-20	씨제이제일제당 (주)	3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도
KR102838362B1 (ko) *	2022-03-18	2025-07-23	씨제이제일제당 (주)	거짓쌀도둑거저리 유래 아스파테이트 1-디카복실라아제의 활성이 강화된 미생물, 및 이의 용도
KR102922207B1 (ko) *	2023-01-19	2026-02-02	씨제이제일제당 (주)	고순도의 d-판토텐산 염을 높은 수율로 얻는 방법

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Publication number	Priority date	Publication date	Assignee	Title
JPS61293384A (ja) *	1985-06-22	1986-12-24	Seitetsu Kagaku Co Ltd	Ｄ−パント酸または／およびｄ−パント酸塩の製造方法
JP2510682B2 (ja) *	1988-07-19	1996-06-26	株式会社日立ビルシステムサービス	ホ―ムエレベ―タを備えた住宅設備
EP0493060A3 (en) *	1990-12-25	1993-04-14	Takeda Chemical Industries, Ltd.	Production method of d-pantothenic acid and plasmids and microorganisms thereof
CN1060309A (zh) *	1991-10-10	1992-04-15	四川省射洪沱牌曲酒厂	生物激素在酿酒业上的应用

1993
- 1993-09-16 JP JP23020293A patent/JP3710497B2/ja not_active Expired - Fee Related
- 1993-09-22 DK DK93307487T patent/DK0590857T3/da active
- 1993-09-22 AT AT93307487T patent/ATE254174T1/de not_active IP Right Cessation
- 1993-09-22 EP EP93307487A patent/EP0590857B1/de not_active Expired - Lifetime
- 1993-09-22 DE DE69333295T patent/DE69333295T2/de not_active Expired - Lifetime
- 1993-09-24 KR KR1019930019662A patent/KR100282278B1/ko not_active Expired - Fee Related
- 1993-09-25 CN CNB98121553XA patent/CN100392069C/zh not_active Expired - Fee Related
- 1993-09-25 CN CN93114174A patent/CN1056192C/zh not_active Expired - Fee Related
1995
- 1995-06-07 US US08/480,325 patent/US5518906A/en not_active Expired - Lifetime
1998
- 1998-10-26 CN CN98121552A patent/CN1114697C/zh not_active Expired - Fee Related
- 1998-10-26 CN CN98121555A patent/CN1097039C/zh not_active Expired - Fee Related
- 1998-10-26 CN CN98121554A patent/CN1124344C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69333295T2 (de)	2004-08-26
CN1095105A (zh)	1994-11-16
EP0590857A2 (de)	1994-04-06
US5518906A (en)	1996-05-21
CN1225394A (zh)	1999-08-11
DK0590857T3 (da)	2004-03-29
CN1225388A (zh)	1999-08-11
CN1056192C (zh)	2000-09-06
JP3710497B2 (ja)	2005-10-26
EP0590857A3 (en)	1995-09-27
KR100282278B1 (ko)	2001-02-15
DE69333295D1 (de)	2003-12-18
EP0590857B1 (de)	2003-11-12
CN1225358A (zh)	1999-08-11
CN1124344C (zh)	2003-10-15
KR940007186A (ko)	1994-04-26
JPH06261772A (ja)	1994-09-20
CN100392069C (zh)	2008-06-04
CN1225392A (zh)	1999-08-11
CN1114697C (zh)	2003-07-16
CN1097039C (zh)	2002-12-25

Legal Events

Date

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2004-07-15

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2006-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69333295D1 (de)	2003-12-18	Herstellung von D-Pantoinsäure und D-Pantothensäure
BG48934A3 (bg)	1991-06-14	Метод за биологично получаване на амиди
DE60301031D1 (de)	2005-08-25	Verfahren zur Herstellung von L-Aminosäuren
ATE247972T1 (de)	2003-09-15	Pulmonare abgabe von protonierter/angesäuerter nukleinsäure
ATE461270T1 (de)	2010-04-15	Verfahren zur herstellung von l-aminosäuren
EP0671162A3 (de)	1995-12-27	Amphotere Zusammensetzungen und Polymerformen von alpha-Hydroxy-Säuren, und ihre therapeutische Anwendung.
DK0400958T3 (da)	1996-01-15	Levende vacciner
DE60120752D1 (de)	2006-07-27	Verwendung von cyclopropancyclus enthaltenden carbonsäureverbindungen als medikament
RU2005138514A (ru)	2006-06-10	Способ получения l-глутаминовой кислоты
ATE312603T1 (de)	2005-12-15	Theanin enthaltende zusammensetzung zur unterdrückung von verhaltensstörungen der haustieren
BR0002297A (pt)	2001-05-22	Aditivo de gênero alimentìcio que contém ácido d-pantotênico e/ou seus sais e um processo para a sua preparação
BR9905785A (pt)	2001-04-24	Processo de fermantação para a preparação de ácido d-panto-tênico utilizando cepas da famìlia enterobacteriaceae
MX9200977A (es)	1992-09-01	Proceso para producir l-lisina por fermentacion.
DE69505389D1 (de)	1998-11-19	Rückgewinnung einer carbonsäure aus einer ein amin und ein extraktionsanreicherungsmittel enthaltenden lösung
MX9200910A (es)	1994-03-31	Procedimiento microbiologico para la preparacion de s-(+)-2,2- dimetilciclopropancarboxamida y acido r-(-)-2,2-dimetilciclopropancarboxilico.
UA27817C2 (uk)	2000-10-16	Спосіб біокаталітичного одержання одного з енантіомерів хіральної 2-арилалканової кислоти
DK0846768T3 (da)	2006-11-13	Esterasegen og anvendelsen deraf
RU93004665A (ru)	1997-01-20	Микробиологический способ гидроксилирования азот-гетероциклических-карбоновых кислот
ATE312181T1 (de)	2005-12-15	Verfahren zur fermentativen herstellung von d- pantothensäure und/oder deren salzen
JPS57115190A (en)	1982-07-17	Preparation of l-glutamic acid by fermentation
JPS54144332A (en)	1979-11-10	Racemization of optically active 2-(4-chlorophenyl)-3- methylbutyric acid
BR0003561A (pt)	2001-06-05	Processo para a preparação fermentativa de produtos metabólicos e para as sequências de nucleotìdeos codificando para o gene sod
DE69228761D1 (de)	1999-04-29	Verfahren zur herstellung von neuraminidase
RU2003135681A (ru)	2005-05-20	Способ получения препарата для повышения резистентности организма животных
DE60105182D1 (de)	2004-09-30	Prozess zur fermentativen herstellung von d-pantothensäure mit coryneformen bakterien