ATE254174T1 - Herstellung von d-pantoinsäure und d- pantothensäure - Google Patents

Herstellung von d-pantoinsäure und d- pantothensäure

Info

Publication number: ATE254174T1
Authority: AT; Austria
Prior art keywords: acid; alpha; pantoic; salt; producing
Prior art date: 1992-09-25

Application number

AT93307487T

Other languages

English (en)

Inventor

Yuichi Hikichi

Takeo Moriya

Ikuo Nogami

Hiroshi Miki

Takamasa Yamaguchi

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-25

Filing date

1993-09-22

Publication date

2003-11-15

1993-09-22 Application filed by Basf Ag filed Critical Basf Ag

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE254174T1 publication Critical patent/ATE254174T1/de

Links

GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title abstract 11
OTOIIPJYVQJATP-BYPYZUCNSA-N (R)-pantoic acid Chemical compound OCC(C)(C)[C@@H](O)C(O)=O OTOIIPJYVQJATP-BYPYZUCNSA-N 0.000 title abstract 5
150000003839 salts Chemical class 0.000 abstract 6
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 4
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 4
238000000034 method Methods 0.000 abstract 3
YYLQUHNPNCGKJQ-NHYDCYSISA-N (3R)-3-hydroxy-L-aspartic acid Chemical compound OC(=O)[C@@H](N)[C@@H](O)C(O)=O YYLQUHNPNCGKJQ-NHYDCYSISA-N 0.000 abstract 2
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 abstract 2
QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 abstract 2
TYEYBOSBBBHJIV-UHFFFAOYSA-N 2-oxobutanoic acid Chemical compound CCC(=O)C(O)=O TYEYBOSBBBHJIV-UHFFFAOYSA-N 0.000 abstract 2
QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 abstract 2
QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 abstract 2
FYCWLJLGIAUCCL-DMTCNVIQSA-N O-methyl-L-threonine Chemical compound CO[C@H](C)[C@H](N)C(O)=O FYCWLJLGIAUCCL-DMTCNVIQSA-N 0.000 abstract 2
229940000635 beta-alanine Drugs 0.000 abstract 2
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 2
229960004889 salicylic acid Drugs 0.000 abstract 2
241000588921 Enterobacteriaceae Species 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
OTOIIPJYVQJATP-UHFFFAOYSA-N pantoic acid Chemical compound OCC(C)(C)C(O)C(O)=O OTOIIPJYVQJATP-UHFFFAOYSA-N 0.000 abstract 1
SERHXTVXHNVDKA-UHFFFAOYSA-N pantolactone Chemical compound CC1(C)COC(=O)C1O SERHXTVXHNVDKA-UHFFFAOYSA-N 0.000 abstract 1
229940055726 pantothenic acid Drugs 0.000 abstract 1
235000019161 pantothenic acid Nutrition 0.000 abstract 1
239000011713 pantothenic acid Substances 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT93307487T 1992-09-25 1993-09-22 Herstellung von d-pantoinsäure und d- pantothensäure ATE254174T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP25652492		1992-09-25

Publications (1)

Publication Number	Publication Date
ATE254174T1 true ATE254174T1 (de)	2003-11-15

Family

ID=17293824

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93307487T ATE254174T1 (de)	1992-09-25	1993-09-22	Herstellung von d-pantoinsäure und d- pantothensäure

Country Status (8)

Country	Link
US (1)	US5518906A (de)
EP (1)	EP0590857B1 (de)
JP (1)	JP3710497B2 (de)
KR (1)	KR100282278B1 (de)
CN (5)	CN1056192C (de)
AT (1)	ATE254174T1 (de)
DE (1)	DE69333295T2 (de)
DK (1)	DK0590857T3 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0822989T3 (da) *	1995-04-21	2001-04-17	Takeda Chemical Industries Ltd	Fremgangsmåde til fremstilling af D-pantothenat
KR100421088B1 (ko) *	1995-09-13	2004-06-04	바스프 악티엔게젤샤프트	디-판토산및디-판토텐산또는그의염의생성방법
DE19855312A1 (de) *	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien
DE19855314A1 (de) *	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae
DE19855313A1 (de) *	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
PT1050219E (pt) *	1999-05-05	2003-04-30	Degussa	Aditivos alimentares para animais contendo acido d-pantotenico e/ou seus sais e processo para a sua preparacao
US6319528B1 (en) *	1999-05-05	2001-11-20	Degussa Aktiengesellschaft	Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof
US6238714B1 (en) *	1999-05-05	2001-05-29	Degussa-Huls Ag	Feedstuff additive which contains D-pantothenic acid and/or its salts and a process for the preparation thereof
EP2163629B1 (de) *	1999-09-21	2017-03-08	Basf Se	Verfahren und Mikroorganismen zur Produktion von Panto-Verbindungen
US8232081B2 (en)	1999-09-21	2012-07-31	Basf Se	Methods and microorganisms for production of panto-compounds
DE10021515A1 (de) *	2000-05-03	2001-11-08	Degussa	Verfahren zur Herstellung von Erdalkalisalzen der D-Pantothensäure
DE10032349A1 (de)	2000-07-04	2002-01-17	Degussa	Rieselfähige D-Pantothensäure und/oder deren Salze enthaltende Futtermittel-Additive und Verfahren zu deren Herstellung
BR0113399A (pt) *	2000-09-20	2003-07-15	Basf Ag	Processo para a preparação de um suplemento de ração animal, suplemento de ração animal, e, uso do mesmo
US6911329B2 (en)	2000-09-23	2005-06-28	Degussa Ag	Process for the fermentative preparation of D-pantothenic acid using coryneform bacteria
EP1320586B1 (de) *	2000-09-30	2004-08-25	Degussa AG	Prozess zur fermentativen herstellung von d-pantothensäure mit coryneformen bakterien
KR20040004496A (ko) *	2001-01-19	2004-01-13	바스프 악티엔게젤샤프트	판토테네이트 생산의 증가 방법
DE10106461A1 (de) *	2001-02-13	2002-08-14	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106459A1 (de) *	2001-02-13	2002-08-14	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106460A1 (de) *	2001-02-13	2002-08-14	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10108225A1 (de) *	2001-02-21	2002-10-10	Basf Ag	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
WO2002066664A2 (de) *	2001-02-21	2002-08-29	Basf Aktiengesellschaft	Verfahren zur herstellung von d-pantothensäure und/oder salze als zusatz zu tierfuttermitteln
BR0207473A (pt) *	2001-02-21	2004-04-06	Basf Ag	Processo para preparar ácido d-pantotênico e/ou seus sais, e, composição para uso como aditivo de alimento para animal e/ou suplemento de alimento para animal
DE10108223A1 (de) *	2001-02-21	2002-10-10	Basf Ag	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
US6623944B2 (en)	2001-03-14	2003-09-23	Degussa Ag	Process for preparation of D-pantothenic acid and/or salts thereof
DE10112102A1 (de) *	2001-03-14	2002-09-19	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10128780A1 (de) *	2001-06-13	2002-12-19	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10132178A1 (de)	2001-07-03	2003-01-23	Degussa	Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen
WO2003004673A1 (en) *	2001-07-03	2003-01-16	Degussa Ag	Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
AU2002316940A1 (en)	2001-07-07	2003-01-29	Degussa Ag	Process for the preparation of d-pantothenic acid and/or salts thereof
DE10147960A1 (de) *	2001-09-28	2003-04-10	Degussa	Verfahren zur fermentativen Herstellung von D-Panthothensäure und/oder deren Salzen
CA2491145A1 (en)	2002-07-03	2004-01-15	Basf Aktiengesellschaft	Microorganisms and processes for enhanced production of pantothenate
KR100975978B1 (ko)	2010-02-10	2010-08-16	주식회사 장원엔지니어링	턴디쉬 노즐용 통기량 자동 측정장치
WO2012175574A1 (en)	2011-06-21	2012-12-27	Dsm Ip Assets B.V.	Increased pantothenate (vitamin b5) production
WO2012175575A2 (en)	2011-06-21	2012-12-27	Dsm Ip Assets B.V.	Increased vitamin b5 production
EP3294072A4 (de) *	2015-05-15	2019-03-13	The Johns Hopkins University	Neuartige pränatale nahrungsergänzung mit fluorid
CN111621541B (zh) *	2019-02-27	2025-10-31	广安摩珈生物科技有限公司	使用电渗析技术拆分光学异构体的方法
EP4174185A4 (de) *	2020-06-28	2024-05-22	Mint Biotechnologies Co., Ltd.	Verfahren zur herstellung von pantothensäure, panthensäure und panthenol sowie salzen davon
KR102838362B1 (ko) *	2022-03-18	2025-07-23	씨제이제일제당 (주)	거짓쌀도둑거저리 유래 아스파테이트 1-디카복실라아제의 활성이 강화된 미생물, 및 이의 용도
KR102922207B1 (ko) *	2023-01-19	2026-02-02	씨제이제일제당 (주)	고순도의 d-판토텐산 염을 높은 수율로 얻는 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61293384A (ja) *	1985-06-22	1986-12-24	Seitetsu Kagaku Co Ltd	Ｄ−パント酸または／およびｄ−パント酸塩の製造方法
JP2510682B2 (ja) *	1988-07-19	1996-06-26	株式会社日立ビルシステムサービス	ホ―ムエレベ―タを備えた住宅設備
EP0493060A3 (en) *	1990-12-25	1993-04-14	Takeda Chemical Industries, Ltd.	Production method of d-pantothenic acid and plasmids and microorganisms thereof
CN1060309A (zh) *	1991-10-10	1992-04-15	四川省射洪沱牌曲酒厂	生物激素在酿酒业上的应用

1993
- 1993-09-16 JP JP23020293A patent/JP3710497B2/ja not_active Expired - Fee Related
- 1993-09-22 AT AT93307487T patent/ATE254174T1/de not_active IP Right Cessation
- 1993-09-22 DE DE69333295T patent/DE69333295T2/de not_active Expired - Lifetime
- 1993-09-22 EP EP93307487A patent/EP0590857B1/de not_active Expired - Lifetime
- 1993-09-22 DK DK93307487T patent/DK0590857T3/da active
- 1993-09-24 KR KR1019930019662A patent/KR100282278B1/ko not_active Expired - Fee Related
- 1993-09-25 CN CN93114174A patent/CN1056192C/zh not_active Expired - Fee Related
- 1993-09-25 CN CNB98121553XA patent/CN100392069C/zh not_active Expired - Fee Related
1995
- 1995-06-07 US US08/480,325 patent/US5518906A/en not_active Expired - Lifetime
1998
- 1998-10-26 CN CN98121552A patent/CN1114697C/zh not_active Expired - Fee Related
- 1998-10-26 CN CN98121554A patent/CN1124344C/zh not_active Expired - Fee Related
- 1998-10-26 CN CN98121555A patent/CN1097039C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR940007186A (ko)	1994-04-26
US5518906A (en)	1996-05-21
CN1225388A (zh)	1999-08-11
CN1114697C (zh)	2003-07-16
DE69333295T2 (de)	2004-08-26
JPH06261772A (ja)	1994-09-20
CN1124344C (zh)	2003-10-15
CN1225392A (zh)	1999-08-11
CN1056192C (zh)	2000-09-06
KR100282278B1 (ko)	2001-02-15
EP0590857A2 (de)	1994-04-06
DK0590857T3 (da)	2004-03-29
EP0590857B1 (de)	2003-11-12
DE69333295D1 (de)	2003-12-18
CN1225394A (zh)	1999-08-11
JP3710497B2 (ja)	2005-10-26
CN100392069C (zh)	2008-06-04
CN1097039C (zh)	2002-12-25
EP0590857A3 (en)	1995-09-27
CN1225358A (zh)	1999-08-11
CN1095105A (zh)	1994-11-16

Legal Events

Date

Code

Title

Description

2004-07-15

UEP

Publication of translation of european patent specification

Ref document number: 0590857

Country of ref document: EP

2006-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69333295D1 (de)	2003-12-18	Herstellung von D-Pantoinsäure und D-Pantothensäure
DE60301031D1 (de)	2005-08-25	Verfahren zur Herstellung von L-Aminosäuren
DE60004803D1 (de)	2003-10-02	Pulmonare abgabe von protonierter/angesäuerter nukleinsäure
DE69942140D1 (de)	2010-04-29	Verfahren zur Herstellung von L-Aminosäuren
DK0413528T3 (da)	1996-03-11	Amphotere præparater og polymere former af alphahydroxysyrer og deres terapeutiske anvendelse
ATE329894T1 (de)	2006-07-15	Verwendung von cyclopropancyclus enthaltenden carbonsäureverbindungen als medikament
ATE417094T1 (de)	2008-12-15	Verfahren zur herstellung von l-aminosäure
ATE312603T1 (de)	2005-12-15	Theanin enthaltende zusammensetzung zur unterdrückung von verhaltensstörungen der haustieren
RU2005138514A (ru)	2006-06-10	Способ получения l-глутаминовой кислоты
BR0002297A (pt)	2001-05-22	Aditivo de gênero alimentìcio que contém ácido d-pantotênico e/ou seus sais e um processo para a sua preparação
BR0207818A (pt)	2004-03-02	Processo para a produção de vitamina e, construção de ácido nucléico, combinação de construções de ácido nucléico, organismo geneticamente modificado, uso do mesmo, processo para a produção de organismos geneticamente modificados, e, uso dos ácidos nucléicos, ou das construções de ácido nucléico, ou das combinações de construções de ácido nucléico
MX9200977A (es)	1992-09-01	Proceso para producir l-lisina por fermentacion.
MX9200910A (es)	1994-03-31	Procedimiento microbiologico para la preparacion de s-(+)-2,2- dimetilciclopropancarboxamida y acido r-(-)-2,2-dimetilciclopropancarboxilico.
UA27817C2 (uk)	2000-10-16	Спосіб біокаталітичного одержання одного з енантіомерів хіральної 2-арилалканової кислоти
DK0846768T3 (da)	2006-11-13	Esterasegen og anvendelsen deraf
ATE312181T1 (de)	2005-12-15	Verfahren zur fermentativen herstellung von d- pantothensäure und/oder deren salzen
JPS57115190A (en)	1982-07-17	Preparation of l-glutamic acid by fermentation
BR9811579A (pt)	2000-08-22	Processo para preparação de ácidos 3-ciano-2,4-dialógeno-5-fluorobenzóicos
ATE305046T1 (de)	2005-10-15	Verfahren zur verbesserten herstellung und isolierung von trans-dihydroxy-cyclohexadien- carbonsäuren und/oder deren folgeprodukte sowie ein dazu geeigneter genetisch veränderter organismus
JPS54144332A (en)	1979-11-10	Racemization of optically active 2-(4-chlorophenyl)-3- methylbutyric acid
BR0003561A (pt)	2001-06-05	Processo para a preparação fermentativa de produtos metabólicos e para as sequências de nucleotìdeos codificando para o gene sod
ATE123625T1 (de)	1995-06-15	Herstellung von erhöhten biokontrollwirkstoffen.
FR2665897B1 (fr)	1994-03-18	Procede de transformation de l'acide (benzoyl-3 phenyl)-2 propionique-r(-) en isomere s(+).
ATE46152T1 (de)	1989-09-15	Piperazinylmethyl-1,2,4-triazolylmethylcarbinole.
ITMI913375A1 (it)	1993-06-17	Procedimento per la produzione di neuraminidasi