ATE254186T1 - Elektrochemilumineszente enzymbiosensoren - Google Patents
Elektrochemilumineszente enzymbiosensorenInfo
- Publication number
- ATE254186T1 ATE254186T1 AT96923261T AT96923261T ATE254186T1 AT E254186 T1 ATE254186 T1 AT E254186T1 AT 96923261 T AT96923261 T AT 96923261T AT 96923261 T AT96923261 T AT 96923261T AT E254186 T1 ATE254186 T1 AT E254186T1
- Authority
- AT
- Austria
- Prior art keywords
- ruthenium
- nadh
- glucose
- enzyme
- nad
- Prior art date
Links
- 108090000790 Enzymes Proteins 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 5
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 abstract 4
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 4
- 229950006238 nadide Drugs 0.000 abstract 4
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 4
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 4
- 229910052707 ruthenium Inorganic materials 0.000 abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
- 239000008103 glucose Substances 0.000 abstract 3
- 101710088194 Dehydrogenase Proteins 0.000 abstract 1
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 abstract 1
- 239000012327 Ruthenium complex Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- WZSDNEJJUSYNSG-UHFFFAOYSA-N azocan-1-yl-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)N2CCCCCCC2)=C1 WZSDNEJJUSYNSG-UHFFFAOYSA-N 0.000 abstract 1
- 150000002303 glucose derivatives Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/467,712 US6852502B1 (en) | 1995-06-06 | 1995-06-06 | Electrochemiluminescent enzyme biosensors |
| PCT/US1996/009869 WO1996039534A1 (en) | 1995-06-06 | 1996-06-06 | Electrochemiluminescent enzyme biosensors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE254186T1 true ATE254186T1 (de) | 2003-11-15 |
Family
ID=23856828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96923261T ATE254186T1 (de) | 1995-06-06 | 1996-06-06 | Elektrochemilumineszente enzymbiosensoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6852502B1 (2) |
| EP (1) | EP0837949B1 (2) |
| JP (1) | JP3618759B2 (2) |
| AT (1) | ATE254186T1 (2) |
| AU (1) | AU698465B2 (2) |
| CA (1) | CA2223017A1 (2) |
| DE (1) | DE69630688T2 (2) |
| WO (1) | WO1996039534A1 (2) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010003647A1 (en) * | 1995-06-07 | 2001-06-14 | Ji Sun | Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same |
| NZ306051A (en) * | 1995-03-10 | 1999-11-29 | Meso Scale Technologies Llc | Testing using electrochemiluminescence |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| US7400256B2 (en) | 2000-11-03 | 2008-07-15 | Cargill, Incorporated | Chill cooler storage and selection system |
| US6724309B2 (en) | 2000-11-03 | 2004-04-20 | Excel Corporation | Method and apparatus for tracking carcasses |
| US7766730B2 (en) | 2000-11-03 | 2010-08-03 | Cargill, Incorporated | Carcass tracking |
| KR100729307B1 (ko) * | 2002-06-17 | 2007-06-15 | 아크레이 인코퍼레이티드 | 글루코스 탈수소효소를 이용한 글루코스 농도 측정방법 및글루코스 센서 |
| KR101311815B1 (ko) * | 2005-06-03 | 2013-10-22 | 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 단일 패러데이 전극에서의 전기발생 화학발광 및 전기화학 |
| EP2359943B1 (en) | 2005-11-08 | 2014-01-22 | SurModics, Inc. | Ultra-thin photo-polymeric coatings and uses thereof |
| CA2682147C (en) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| US8008037B2 (en) * | 2008-03-27 | 2011-08-30 | Roche Diagnostics Operations, Inc. | Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline |
| PL2271938T3 (pl) | 2008-04-11 | 2014-07-31 | Univ Texas | Sposób i urządzenie do wzmacniania elektrogenerowanej chemiluminescencji nanocząsteczek |
| AU2009244904B2 (en) | 2008-05-08 | 2014-04-17 | Board Of Regents Of The University Of Texas System | Luminescent nanostructured materials for use in electrogenerated chemiluminescence |
| US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| MX2017004947A (es) | 2014-10-24 | 2017-06-29 | Bristol Myers Squibb Co | Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos. |
| KR102601323B1 (ko) | 2015-08-20 | 2023-11-10 | 에프. 호프만-라 로슈 아게 | 페길화 분석물-특이적 결합제를 사용하는 입자-기반 면역어세이 |
| BR112018017336A2 (pt) | 2016-03-07 | 2018-12-26 | Hoffmann La Roche | método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão |
| JP7068323B2 (ja) | 2017-02-02 | 2022-05-16 | エフ．ホフマン－ラ ロシュ アーゲー | 少なくとも２種のペグ化された分析物特異的結合剤を使用する免疫アッセイ |
| EP3781600A1 (en) | 2018-04-18 | 2021-02-24 | F. Hoffmann-La Roche AG | Novel anti-thymidine kinase antibodies |
| ES2983797T3 (es) | 2018-08-31 | 2024-10-24 | Hoffmann La Roche | Timidina cinasa (TK-1) en índices pronóstico para LDLBG |
| CN110938667A (zh) * | 2018-09-21 | 2020-03-31 | 中国科学院天津工业生物技术研究所 | 一种酶电极、生物传感器及其制备方法和用途 |
| KR20220016210A (ko) | 2019-07-22 | 2022-02-08 | 에프. 호프만-라 로슈 아게 | 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9 |
| JP2022542056A (ja) | 2019-07-22 | 2022-09-29 | エフ．ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ６ |
| JP7315781B2 (ja) | 2019-07-22 | 2023-07-26 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ１２ |
| JP7421631B2 (ja) | 2019-07-22 | 2024-01-24 | エフ． ホフマン－ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ８ |
| EP4004551A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
| BR112022009371A2 (pt) | 2019-11-15 | 2022-08-09 | Hoffmann La Roche | Métodos para determinar a quantidade ou concentração de um ou mais analitos antibióticos, tubos de amostragem, usos de um reagente de derivatização nucleofílica e analito antibiótico |
| WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN117099001A (zh) | 2021-04-01 | 2023-11-21 | 豪夫迈·罗氏有限公司 | Psp94作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| EP4341700A1 (en) | 2021-05-17 | 2024-03-27 | F. Hoffmann-La Roche AG | Sfrp4 as blood biomarker for the non-invasive diagnosis of adenomyosis |
| US20250042976A1 (en) | 2021-10-26 | 2025-02-06 | Roche Diagnostics Operations, Inc. | Monoclonal antibodies specific for sars-cov-2 rbd |
| KR20230060229A (ko) * | 2021-10-27 | 2023-05-04 | 한국전기연구원 | 광열 모듈레이션 레이저 스펙클 영상을 이용한 포도당 농도 측정 시스템, 방법, 및 상기 방법을 실행시키기 위한 컴퓨터 판독 가능한 프로그램을 기록한 기록 매체 |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| JP2025524025A (ja) | 2022-07-22 | 2025-07-25 | エフ． ホフマン－ラ ロシュ アーゲー | 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしてのロイコトリエンａ４ヒドロラーゼ（ｌｔａ４ｈ） |
| EP4558826A1 (en) | 2022-07-22 | 2025-05-28 | F. Hoffmann-La Roche AG | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| EP4558825A1 (en) | 2022-07-22 | 2025-05-28 | F. Hoffmann-La Roche AG | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| EP4630571A1 (en) | 2022-12-05 | 2025-10-15 | DirectSens GmbH | Enzymatic detection of non-lactate hydroxy acids |
| EP4747637A1 (en) | 2023-07-20 | 2026-05-27 | F. Hoffmann-La Roche AG | Screening methods for antibody compositions |
| JP2026526931A (ja) | 2023-07-28 | 2026-08-10 | エフ ホフマン－ラ ロッシュ アクチェン ゲゼルシャフト | 子宮内膜症のバイオマーカーとしての血清ＥｐｈＡ１ |
| WO2026120128A1 (en) | 2024-12-05 | 2026-06-11 | Roche Diagnostics Gmbh | Serum transcriptional regulator erg as biomarker for endometriosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5221605A (en) | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5310687A (en) | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5147806A (en) | 1988-04-29 | 1992-09-15 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescence measurements |
| US5250415A (en) | 1987-04-08 | 1993-10-05 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Process for the preparation of glucose dehydrogenase from Bacillus megaterium |
| US5061455A (en) | 1987-04-30 | 1991-10-29 | United Technologies Corporation | Apparatus for removing carbon dioxide from air |
| US5093268A (en) | 1988-04-28 | 1992-03-03 | Igen, Inc. | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
| US5340722A (en) | 1988-08-24 | 1994-08-23 | Avl Medical Instruments Ag | Method for the determination of the concentration of an enzyme substrate and a sensor for carrying out the method |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| US5235808A (en) | 1990-02-12 | 1993-08-17 | General Electric Company | Exhaust nozzle including idle thrust spoiling |
| US5324835A (en) | 1990-03-30 | 1994-06-28 | Biosensor Laboratories Co., Ltd. | Pyridazinoquinoxalinones for use as chemiluminescent agents |
| US5229202A (en) | 1990-05-22 | 1993-07-20 | Mitsubishi Kasei Corporation | Carbon fiber and carbon fiber-reinforced resin composition using it |
| US5264092A (en) | 1991-10-02 | 1993-11-23 | Moltech Corporation | Redox polymer modified electrode for the electrochemical regeneration of coenzyme |
| JP2541081B2 (ja) | 1992-08-28 | 1996-10-09 | 日本電気株式会社 | バイオセンサ及びバイオセンサの製造・使用方法 |
| US5527710A (en) * | 1994-12-02 | 1996-06-18 | Igen, Inc. | Rate measurements of biomolecular reactions using electrochemiluminescence |
| NZ306051A (en) * | 1995-03-10 | 1999-11-29 | Meso Scale Technologies Llc | Testing using electrochemiluminescence |
-
1995
- 1995-06-06 US US08/467,712 patent/US6852502B1/en not_active Expired - Fee Related
-
1996
- 1996-06-06 AU AU63822/96A patent/AU698465B2/en not_active Ceased
- 1996-06-06 CA CA002223017A patent/CA2223017A1/en not_active Abandoned
- 1996-06-06 JP JP50205997A patent/JP3618759B2/ja not_active Expired - Fee Related
- 1996-06-06 AT AT96923261T patent/ATE254186T1/de not_active IP Right Cessation
- 1996-06-06 EP EP96923261A patent/EP0837949B1/en not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009869 patent/WO1996039534A1/en not_active Ceased
- 1996-06-06 DE DE69630688T patent/DE69630688T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69630688D1 (de) | 2003-12-18 |
| EP0837949A4 (en) | 2000-05-17 |
| JPH11507536A (ja) | 1999-07-06 |
| AU6382296A (en) | 1996-12-24 |
| CA2223017A1 (en) | 1996-12-12 |
| AU698465B2 (en) | 1998-10-29 |
| US6852502B1 (en) | 2005-02-08 |
| WO1996039534A1 (en) | 1996-12-12 |
| DE69630688T2 (de) | 2004-09-23 |
| EP0837949A1 (en) | 1998-04-29 |
| JP3618759B2 (ja) | 2005-02-09 |
| EP0837949B1 (en) | 2003-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |