JP3618759B2 - 電気化学発光性酵素バイオセンサー - Google Patents

電気化学発光性酵素バイオセンサー Download PDF

Info

Publication number
JP3618759B2
JP3618759B2 JP50205997A JP50205997A JP3618759B2 JP 3618759 B2 JP3618759 B2 JP 3618759B2 JP 50205997 A JP50205997 A JP 50205997A JP 50205997 A JP50205997 A JP 50205997A JP 3618759 B2 JP3618759 B2 JP 3618759B2
Authority
JP
Japan
Prior art keywords
enzyme
nad
oxidoreductase
dehydrogenase
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50205997A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11507536A (ja
JPH11507536A5 (2
Inventor
ティー. マーチン,マーク
Original Assignee
イゲン,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イゲン,インコーポレイテッド filed Critical イゲン,インコーポレイテッド
Publication of JPH11507536A publication Critical patent/JPH11507536A/ja
Publication of JPH11507536A5 publication Critical patent/JPH11507536A5/ja
Application granted granted Critical
Publication of JP3618759B2 publication Critical patent/JP3618759B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/535Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
JP50205997A 1995-06-06 1996-06-06 電気化学発光性酵素バイオセンサー Expired - Fee Related JP3618759B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/467,712 US6852502B1 (en) 1995-06-06 1995-06-06 Electrochemiluminescent enzyme biosensors
US08/467,712 1995-06-06
PCT/US1996/009869 WO1996039534A1 (en) 1995-06-06 1996-06-06 Electrochemiluminescent enzyme biosensors

Publications (3)

Publication Number Publication Date
JPH11507536A JPH11507536A (ja) 1999-07-06
JPH11507536A5 JPH11507536A5 (2) 2004-07-29
JP3618759B2 true JP3618759B2 (ja) 2005-02-09

Family

ID=23856828

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50205997A Expired - Fee Related JP3618759B2 (ja) 1995-06-06 1996-06-06 電気化学発光性酵素バイオセンサー

Country Status (8)

Country Link
US (1) US6852502B1 (2)
EP (1) EP0837949B1 (2)
JP (1) JP3618759B2 (2)
AT (1) ATE254186T1 (2)
AU (1) AU698465B2 (2)
CA (1) CA2223017A1 (2)
DE (1) DE69630688T2 (2)
WO (1) WO1996039534A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023075465A1 (ko) * 2021-10-27 2023-05-04 한국전기연구원 광열 모듈레이션 레이저 스펙클 영상을 이용한 포도당 농도 측정 시스템, 방법, 및 상기 방법을 실행시키기 위한 컴퓨터 판독 가능한 프로그램을 기록한 기록 매체

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010003647A1 (en) * 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
KR100449615B1 (ko) * 1995-03-10 2004-12-08 메소 스케일 테크놀러지즈, 엘엘시 다-배열,다-특이적전기화학발광시험법
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US6724309B2 (en) 2000-11-03 2004-04-20 Excel Corporation Method and apparatus for tracking carcasses
US7400256B2 (en) 2000-11-03 2008-07-15 Cargill, Incorporated Chill cooler storage and selection system
US7766730B2 (en) 2000-11-03 2010-08-03 Cargill, Incorporated Carcass tracking
ATE403742T1 (de) 2002-06-17 2008-08-15 Arkray Inc Glucosesensor unter verwendung von glucosedehydrogenase
JP5590796B2 (ja) * 2005-06-03 2014-09-17 ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム 電気化学および単一ファラデー電極による電気化学発光
ATE498460T1 (de) 2005-11-08 2011-03-15 Surmodics Inc Ultradünne photopolymer-beschichtungen und verwendungen davon
KR101476472B1 (ko) 2007-03-30 2015-01-05 암브룩스, 인코포레이티드 변형된 fgf-21 폴리펩티드 및 그 용도
US8008037B2 (en) * 2008-03-27 2011-08-30 Roche Diagnostics Operations, Inc. Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
JP5490095B2 (ja) 2008-04-11 2014-05-14 ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム ナノ粒子による電気化学発光の増幅方法および増幅装置
WO2009137002A2 (en) 2008-05-08 2009-11-12 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
BR112017008157A2 (pt) 2014-10-24 2017-12-19 Bristol Myers Squibb Co polipeptídeos de fgf-21 modificados e usos dos mesmos
BR112018001956A2 (pt) 2015-08-20 2018-09-11 Hoffmann La Roche ?método de medição de analitos e kit?
CN108780092A (zh) 2016-03-07 2018-11-09 豪夫迈·罗氏有限公司 抗p53抗体的检测
WO2018141768A1 (en) 2017-02-02 2018-08-09 Roche Diagnostics Gmbh Immunoassay using at least two pegylated analyte-specific binding agents
WO2019201901A1 (en) 2018-04-18 2019-10-24 F. Hoffmann-La Roche Ag Novel anti-thymidine kinase antibodies
CN112639475A (zh) 2018-08-31 2021-04-09 豪夫迈·罗氏有限公司 Dlbcl的预后指数中的胸苷激酶(tk-1)
CN110938667A (zh) * 2018-09-21 2020-03-31 中国科学院天津工业生物技术研究所 一种酶电极、生物传感器及其制备方法和用途
EP4004552A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis
EP4004553A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013781A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag Substance p as blood biomarker for the non-invasive diagnosis of endometriosis
EP4004554A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis
JP2022542056A (ja) 2019-07-22 2022-09-29 エフ.ホフマン-ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのs100a6
JP7783809B2 (ja) 2019-11-15 2025-12-10 エフ. ホフマン-ラ ロシュ アーゲー 患者試料における質量分析測定のためのβ-ラクタム抗生物質の誘導体化
WO2022090455A1 (en) 2020-11-02 2022-05-05 F. Hoffmann-La Roche Ag Sars-cov-2 nucleocapsid antibodies
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022207685A1 (en) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis
CN117337394A (zh) 2021-05-17 2024-01-02 豪夫迈·罗氏有限公司 sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断
WO2023072904A1 (en) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Monoclonal antibodies specific for sars-cov-2 rbd
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
US20260036596A1 (en) 2022-07-22 2026-02-05 Roche Diagnostics Operations, Inc. Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
EP4558825A1 (en) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
CN119585618A (zh) 2022-07-22 2025-03-07 豪夫迈·罗氏有限公司 成纤维细胞生长因子结合蛋白1(fgfbp1)作为(血液)生物标志物用于诊断多囊卵巢综合征
EP4630571A1 (en) 2022-12-05 2025-10-15 DirectSens GmbH Enzymatic detection of non-lactate hydroxy acids
CN121532654A (zh) 2023-07-20 2026-02-13 豪夫迈·罗氏有限公司 针对抗体组合物的筛选方法
WO2025026908A1 (en) 2023-07-28 2025-02-06 Roche Diagnostics Gmbh Serum epha1 as biomarker for endometriosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5221605A (en) 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5250415A (en) 1987-04-08 1993-10-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Process for the preparation of glucose dehydrogenase from Bacillus megaterium
US5061455A (en) 1987-04-30 1991-10-29 United Technologies Corporation Apparatus for removing carbon dioxide from air
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5340722A (en) 1988-08-24 1994-08-23 Avl Medical Instruments Ag Method for the determination of the concentration of an enzyme substrate and a sensor for carrying out the method
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5235808A (en) 1990-02-12 1993-08-17 General Electric Company Exhaust nozzle including idle thrust spoiling
US5324835A (en) 1990-03-30 1994-06-28 Biosensor Laboratories Co., Ltd. Pyridazinoquinoxalinones for use as chemiluminescent agents
US5229202A (en) 1990-05-22 1993-07-20 Mitsubishi Kasei Corporation Carbon fiber and carbon fiber-reinforced resin composition using it
US5264092A (en) 1991-10-02 1993-11-23 Moltech Corporation Redox polymer modified electrode for the electrochemical regeneration of coenzyme
JP2541081B2 (ja) 1992-08-28 1996-10-09 日本電気株式会社 バイオセンサ及びバイオセンサの製造・使用方法
US5527710A (en) * 1994-12-02 1996-06-18 Igen, Inc. Rate measurements of biomolecular reactions using electrochemiluminescence
KR100449615B1 (ko) * 1995-03-10 2004-12-08 메소 스케일 테크놀러지즈, 엘엘시 다-배열,다-특이적전기화학발광시험법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023075465A1 (ko) * 2021-10-27 2023-05-04 한국전기연구원 광열 모듈레이션 레이저 스펙클 영상을 이용한 포도당 농도 측정 시스템, 방법, 및 상기 방법을 실행시키기 위한 컴퓨터 판독 가능한 프로그램을 기록한 기록 매체

Also Published As

Publication number Publication date
CA2223017A1 (en) 1996-12-12
DE69630688T2 (de) 2004-09-23
EP0837949A1 (en) 1998-04-29
JPH11507536A (ja) 1999-07-06
AU698465B2 (en) 1998-10-29
WO1996039534A1 (en) 1996-12-12
US6852502B1 (en) 2005-02-08
AU6382296A (en) 1996-12-24
EP0837949B1 (en) 2003-11-12
ATE254186T1 (de) 2003-11-15
EP0837949A4 (en) 2000-05-17
DE69630688D1 (de) 2003-12-18

Similar Documents

Publication Publication Date Title
EP0837949B1 (en) Electrochemiluminescent enzyme biosensors
US4882013A (en) Application of tetrathiafulvalenes in bioelectrochemical processes
Chaubey et al. Mediated biosensors
Blum Bio-and chemi-luminescent sensors
Rubinstein et al. Electrogenerated chemiluminescent determination of oxalate
JP3784072B2 (ja) 電気化学発光酵素イムノアッセイ
Wollenberger et al. Enhancing biosensor performance using multienzyme systems
US4234681A (en) Immobolized light emitting systems
JPS62501171A (ja) 生化学的アッセイのための方法と装置
Zhang et al. Heterogeneous reconstitution of the PQQ-dependent glucose dehydrogenase immobilized on an electrode: A sensitive strategy for PQQ detection down to picomolar levels
Dzyadevich et al. Glucose conductometric biosensor with potassium hexacyanoferrate (III) as an oxidizing agent
Chang et al. Electrochemical immunosensors based on the solubility difference of electroactive probe and the dual signal amplification of nanocarrier plus redox cycling
Wright et al. Specific binding assay for biotin based on enzyme channelling with direct electron transfer electrochemical detection using horseradish peroxidase
Winartasaputra et al. Amperometric enzymic determination of triglycerides in serum
JP2005118014A (ja) 分析方法およびそれに用いる試薬
Hasebe et al. Highly sensitive flow detection of uric acid based on an intermediate regeneration of uricase
Benkert et al. Size Exclusion Redox‐Labeled Immunoassay (SERI): a new format for homogeneous amperometric creatinine determination
JP4702341B2 (ja) フェニルアラニンセンサ及びフェニルアラニン測定方法
Yao et al. Amperometric enzyme-immunosensor based on ferrocene-mediated amplification
Monroe Amperometric immunoassay
JP3867081B2 (ja) 酸化還元指示薬としてのアミン−n−オキサイドによるアナライトの蛍光測定
JPWO2005056824A1 (ja) 硫酸抱合型胆汁酸の検出方法、それに用いられる試験紙およびバイオセンサ
JPS6017347A (ja) 一種以上の酵素を利用する検定方法
Kochana et al. Introduction to Biosensors
JP4756284B2 (ja) グルコース及びアスコルビン酸の測定装置

Legal Events

Date Code Title Description
TRDD Decision of grant or rejection written
A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20041018

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20041102

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20041111

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071119

Year of fee payment: 3

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

Free format text: JAPANESE INTERMEDIATE CODE: R313111

R360 Written notification for declining of transfer of rights

Free format text: JAPANESE INTERMEDIATE CODE: R360

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071119

Year of fee payment: 3

R360 Written notification for declining of transfer of rights

Free format text: JAPANESE INTERMEDIATE CODE: R360

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071119

Year of fee payment: 3

R360 Written notification for declining of transfer of rights

Free format text: JAPANESE INTERMEDIATE CODE: R360

R371 Transfer withdrawn

Free format text: JAPANESE INTERMEDIATE CODE: R371

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

Free format text: JAPANESE INTERMEDIATE CODE: R313111

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071119

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20081119

Year of fee payment: 4

LAPS Cancellation because of no payment of annual fees