ATE254479T1 - Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung - Google Patents

Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung

Info

Publication number
ATE254479T1
ATE254479T1 AT98950704T AT98950704T ATE254479T1 AT E254479 T1 ATE254479 T1 AT E254479T1 AT 98950704 T AT98950704 T AT 98950704T AT 98950704 T AT98950704 T AT 98950704T AT E254479 T1 ATE254479 T1 AT E254479T1
Authority
AT
Austria
Prior art keywords
tissue
contrast
state
binding
targeted tissue
Prior art date
Application number
AT98950704T
Other languages
English (en)
Inventor
Randall B Lauffer
Stephen O Dunham
Original Assignee
Epix Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Medical Inc filed Critical Epix Medical Inc
Application granted granted Critical
Publication of ATE254479T1 publication Critical patent/ATE254479T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT98950704T 1997-10-02 1998-09-24 Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung ATE254479T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94298997A 1997-10-02 1997-10-02
PCT/US1998/020182 WO1999017809A2 (en) 1997-10-02 1998-09-24 Contrast-enhanced diagnostic imaging method for monitoring interventional therapies

Publications (1)

Publication Number Publication Date
ATE254479T1 true ATE254479T1 (de) 2003-12-15

Family

ID=25478927

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98950704T ATE254479T1 (de) 1997-10-02 1998-09-24 Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung

Country Status (19)

Country Link
US (2) US6861045B1 (de)
EP (1) EP1019094B1 (de)
JP (2) JP2001518523A (de)
KR (1) KR20010030854A (de)
AT (1) ATE254479T1 (de)
AU (1) AU742438C (de)
BR (1) BR9812716A (de)
CA (1) CA2303426C (de)
DE (1) DE69819925T2 (de)
DK (1) DK1019094T3 (de)
ES (1) ES2206996T3 (de)
HU (1) HUP0101245A3 (de)
IL (1) IL134985A0 (de)
IS (1) IS2041B (de)
NO (1) NO321966B1 (de)
NZ (1) NZ503402A (de)
PT (1) PT1019094E (de)
SK (1) SK4842000A3 (de)
WO (1) WO1999017809A2 (de)

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US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
CA2666005C (en) 2002-03-01 2016-01-19 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
PT2949658T (pt) 2003-03-03 2018-10-18 Bracco Suisse Sa Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos
US20050064045A1 (en) * 2003-09-18 2005-03-24 Sheng-Ping Zhong Injectable therapeutic formulations
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WO2007073792A1 (de) * 2005-12-19 2007-07-05 Bayer Schering Pharma Aktiengesellschaft Verfahren zur herstellung von 4,4-diphenylcyclohexanol
KR101336505B1 (ko) 2006-08-17 2013-12-05 에픽스 파마슈티칼스, 인코포레이티드 림프계의 영상화 방법
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
US20100092389A1 (en) * 2008-10-10 2010-04-15 The General Hospital Corporation Detection of atherosclerosis using indocyanine green
US9423480B2 (en) * 2008-10-27 2016-08-23 The University Of Western Ontario System and method for magnetic resonance imaging
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
EP2408790A1 (de) 2009-03-19 2012-01-25 Wyeth LLC Verfahren zur herstellung von [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)- en-2-yl)ethyl]phosphonsäure und vorstufen davon
WO2011095898A1 (en) 2010-02-02 2011-08-11 Koninklijke Philips Electronics N.V. Functional imaging
AU2012282678B2 (en) 2011-07-11 2016-03-03 California Institute Of Technology Akt-specific capture agents, compositions, and methods of using and making
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Also Published As

Publication number Publication date
IS5399A (is) 2000-03-10
IL134985A0 (en) 2001-05-20
DE69819925T2 (de) 2004-09-02
US7175829B2 (en) 2007-02-13
US6861045B1 (en) 2005-03-01
BR9812716A (pt) 2000-08-22
KR20010030854A (ko) 2001-04-16
HK1030744A1 (en) 2001-05-18
AU742438C (en) 2003-05-22
NZ503402A (en) 2002-03-01
NO20001707L (no) 2000-05-31
SK4842000A3 (en) 2000-11-07
EP1019094B1 (de) 2003-11-19
NO321966B1 (no) 2006-07-31
ES2206996T3 (es) 2004-05-16
JP2006077020A (ja) 2006-03-23
DK1019094T3 (da) 2004-02-16
IS2041B (is) 2005-09-15
AU742438B2 (en) 2002-01-03
CA2303426C (en) 2008-09-23
AU9668698A (en) 1999-04-27
NO20001707D0 (no) 2000-04-03
EP1019094A2 (de) 2000-07-19
HUP0101245A2 (hu) 2001-08-28
CA2303426A1 (en) 1999-04-15
HUP0101245A3 (en) 2003-10-28
US20050118103A1 (en) 2005-06-02
WO1999017809A2 (en) 1999-04-15
JP2001518523A (ja) 2001-10-16
DE69819925D1 (de) 2003-12-24
PT1019094E (pt) 2004-03-31
WO1999017809A3 (en) 1999-05-20

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