ATE254611T1 - N-arylmethylthioanilid-derivate für die hemmung der hiv-replikation - Google Patents
N-arylmethylthioanilid-derivate für die hemmung der hiv-replikationInfo
- Publication number
- ATE254611T1 ATE254611T1 AT00963380T AT00963380T ATE254611T1 AT E254611 T1 ATE254611 T1 AT E254611T1 AT 00963380 T AT00963380 T AT 00963380T AT 00963380 T AT00963380 T AT 00963380T AT E254611 T1 ATE254611 T1 AT E254611T1
- Authority
- AT
- Austria
- Prior art keywords
- arylmethylthioanilide
- derivatives
- hiv replication
- inhibiting hiv
- replication
- Prior art date
Links
- 230000010076 replication Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/398,649 US6143780A (en) | 1999-09-17 | 1999-09-17 | N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV |
| PCT/US2000/024986 WO2001019811A2 (en) | 1999-09-17 | 2000-09-12 | N-arymethylthioanilide compounds useful for the inhibition of the replication of hiv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE254611T1 true ATE254611T1 (de) | 2003-12-15 |
Family
ID=23576222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00963380T ATE254611T1 (de) | 1999-09-17 | 2000-09-12 | N-arylmethylthioanilid-derivate für die hemmung der hiv-replikation |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6143780A (de) |
| EP (1) | EP1220848B1 (de) |
| AT (1) | ATE254611T1 (de) |
| CA (1) | CA2384134C (de) |
| DE (1) | DE60006706T2 (de) |
| DK (1) | DK1220848T3 (de) |
| ES (1) | ES2211608T3 (de) |
| WO (1) | WO2001019811A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050111306A (ko) | 2002-11-19 | 2005-11-24 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서의 치환된 아릴 티오우레아 및관련 화합물 |
| DE102006052504A1 (de) | 2006-11-06 | 2008-05-08 | Temper, Rupert | Verfahren zum Herstellen eines Mittels gegen eine Infektionskrankheit |
| US8461161B2 (en) * | 2006-11-15 | 2013-06-11 | Ym Biosciences Australia Pty Ltd | Substituted pyrazines as inhibitors of kinase activity |
| DE102008015033A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008015032A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| EP2414830A2 (de) * | 2009-03-31 | 2012-02-08 | Robert Zimmermann | Atgl(adipose triglyceride lipase )-modulation zur vorbeugung und behandlung von kachexie, gewichtsverlust und muskelatrophie sowie screening-verfahren dafür |
| EP3743063A4 (de) * | 2018-01-26 | 2021-10-20 | Nurix Therapeutics, Inc. | Inhibitoren von cbl-b und verfahren zu deren verwendung |
| CA3136348A1 (en) | 2019-04-09 | 2020-10-15 | Nurix Therapeutics, Inc. | 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus |
| US20250346567A1 (en) * | 2024-05-13 | 2025-11-13 | Pfizer Inc. | Substituted pyridine and phenyl compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696151A (en) * | 1995-11-30 | 1997-12-09 | Uniroyal Chemical Company, Inc. | Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants |
| US6017947A (en) * | 1999-09-17 | 2000-01-25 | Brouwer; Walter Gerhard | Heterocyclic carbodithioperoxyimidic compounds useful for the inhibition of the replication of HIV |
-
1999
- 1999-09-17 US US09/398,649 patent/US6143780A/en not_active Expired - Lifetime
-
2000
- 2000-09-12 WO PCT/US2000/024986 patent/WO2001019811A2/en not_active Ceased
- 2000-09-12 DE DE60006706T patent/DE60006706T2/de not_active Expired - Lifetime
- 2000-09-12 AT AT00963380T patent/ATE254611T1/de active
- 2000-09-12 EP EP00963380A patent/EP1220848B1/de not_active Expired - Lifetime
- 2000-09-12 ES ES00963380T patent/ES2211608T3/es not_active Expired - Lifetime
- 2000-09-12 DK DK00963380T patent/DK1220848T3/da active
- 2000-09-12 CA CA2384134A patent/CA2384134C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6143780A (en) | 2000-11-07 |
| WO2001019811A3 (en) | 2001-07-26 |
| DE60006706T2 (de) | 2004-08-19 |
| ES2211608T3 (es) | 2004-07-16 |
| DE60006706D1 (de) | 2003-12-24 |
| WO2001019811A2 (en) | 2001-03-22 |
| EP1220848A2 (de) | 2002-07-10 |
| CA2384134A1 (en) | 2001-03-22 |
| DK1220848T3 (da) | 2004-03-29 |
| EP1220848B1 (de) | 2003-11-19 |
| CA2384134C (en) | 2011-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO953305D0 (no) | Antranilsyrederivat | |
| DK1054874T3 (da) | Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler | |
| NO20023097L (no) | Heterocykliske forbindelser med sulfonamidgrupper | |
| EP1191931A4 (de) | 1-(4-sulfamylaryl)-3-substituierte 5-aryl-2-pyrazoline als gyclooxygenase-2 inhibitoren | |
| DK0769010T3 (da) | 2-[1',2',4'-triazol-3'-yloxymethylen]-anilider og deres anvendelse som pesticider | |
| DE60006706D1 (de) | N-arylmethylthioanilid-derivate für die hemmung der hiv-replikation | |
| DE69319614D1 (de) | 1,4-benzodiazepinderivate und ihre verwendung als cck-modulatoren | |
| UY24802A1 (es) | Nuevos compuestos | |
| ATE269851T1 (de) | Benzimidazole derivate | |
| EP1144393A3 (de) | Heterocyclische derivate und ihre verwendung als integrininhibitore | |
| DE59908317D1 (de) | 2-arylalkylthio -imidazole, 2-arylalkenyl -thio -imidazole und 2-arylalkinyl -thio -imidazole als entzündungs -hemmstoffe und hemmstoffe der cytokin -freisetzung | |
| DK372285A (da) | Pesticidt virksomme urinstofderivater | |
| BR0215911A (pt) | Compostos 1,2,4-tiadiazol e utilização dos mesmos | |
| IL84300A0 (en) | 1-carbamoyl-2-pyrazoline derivatives,their preparation and their use as herbicides | |
| EP1431293A4 (de) | Wasserlösliche phenylpyridazinderivate und diese enthaltende arzneimittel | |
| TR199600181A2 (tr) | 4-alkiltio-pirimidin-5-ilasetik asit türevleri. | |
| MXPA02012072A (es) | Derivados de 4,5-dihidro-tiazol-2-ilamina y su uso como inhibidores de no-sintasa. | |
| ES2112774A1 (es) | Nuevos derivados azolicos con actividad antifungica. | |
| TH52198A (th) | สารประกอบไตรไซคลิกที่ถูกแทนที่ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1220848 Country of ref document: EP |