ATE254648T1 - Rot-emittierende (8,9)benzophenoxazin- nukleinsäurefarbstoffe und verfahren zu deren verwendung - Google Patents
Rot-emittierende (8,9)benzophenoxazin- nukleinsäurefarbstoffe und verfahren zu deren verwendungInfo
- Publication number
- ATE254648T1 ATE254648T1 AT00959749T AT00959749T ATE254648T1 AT E254648 T1 ATE254648 T1 AT E254648T1 AT 00959749 T AT00959749 T AT 00959749T AT 00959749 T AT00959749 T AT 00959749T AT E254648 T1 ATE254648 T1 AT E254648T1
- Authority
- AT
- Austria
- Prior art keywords
- emitting
- red
- nucleic acid
- benzophenoxazine
- acid dyes
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- -1 (8,9)BENZOPHENOXAZINE NUCLEIC ACID Chemical class 0.000 title 1
- 239000000980 acid dye Substances 0.000 title 1
- 239000000975 dye Substances 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- VKQAFQHYTKYTON-UHFFFAOYSA-N 12h-naphtho[1,2-g][1,2]benzoxazine Chemical compound C1=CC=CC2=C3CC4=CC=NOC4=CC3=CC=C21 VKQAFQHYTKYTON-UHFFFAOYSA-N 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B19/00—Oxazine dyes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Coloring (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/389,918 US6140500A (en) | 1999-09-03 | 1999-09-03 | Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use |
| PCT/US2000/024057 WO2001018124A1 (en) | 1999-09-03 | 2000-09-01 | Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE254648T1 true ATE254648T1 (de) | 2003-12-15 |
Family
ID=23540303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00959749T ATE254648T1 (de) | 1999-09-03 | 2000-09-01 | Rot-emittierende (8,9)benzophenoxazin- nukleinsäurefarbstoffe und verfahren zu deren verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6140500A (de) |
| EP (1) | EP1208160B1 (de) |
| JP (1) | JP2003509528A (de) |
| AT (1) | ATE254648T1 (de) |
| AU (1) | AU753608B2 (de) |
| CA (1) | CA2382593C (de) |
| DE (1) | DE60006685T2 (de) |
| WO (1) | WO2001018124A1 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465644B1 (en) | 2000-05-02 | 2002-10-15 | Applera Corporation | Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates |
| CA2417816A1 (en) | 2000-08-04 | 2002-02-14 | Molecular Probes, Inc. | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
| US7169922B2 (en) | 2000-08-04 | 2007-01-30 | Invitrogen Corporation | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
| EP1317511B1 (de) * | 2000-09-06 | 2005-01-19 | Evotec OAI AG | Oxazinderivate |
| EP1213328A1 (de) * | 2000-12-08 | 2002-06-12 | Evotec OAI AG | Oxazinderivate |
| DE60216468T2 (de) | 2001-03-09 | 2007-09-27 | Boston Probes, Inc., Bedford | Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen |
| EP1448800A4 (de) | 2001-11-21 | 2007-05-16 | Applera Corp | Digitaler assay |
| WO2004022578A2 (en) * | 2002-09-08 | 2004-03-18 | Applera Corporation | Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis |
| US7570443B2 (en) | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
| US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
| US20060029948A1 (en) * | 2003-09-19 | 2006-02-09 | Gary Lim | Sealing cover and dye compatibility selection |
| ATE419263T1 (de) * | 2003-11-20 | 2009-01-15 | Exiqon As | Löscher-zusammensetzung mit anthraquinon |
| WO2005077125A2 (en) * | 2004-02-11 | 2005-08-25 | Applera Corporation | Methods and compositions for detecting nucleic acids |
| US7473529B1 (en) * | 2004-03-31 | 2009-01-06 | Iowa State University Research Foundation, Inc. | System and method for detecting cells or components thereof |
| US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
| EP2290072B1 (de) | 2004-05-28 | 2014-12-17 | Asuragen, Inc. | Verfahren und Zusammensetzungen mit MicroRNA |
| WO2006016978A1 (en) * | 2004-06-30 | 2006-02-16 | Applera Corporation | Analog probe complexes |
| ES2534304T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US20060292586A1 (en) * | 2004-12-17 | 2006-12-28 | Schroth Gary P | ID-tag complexes, arrays, and methods of use thereof |
| US20060166238A1 (en) * | 2004-12-22 | 2006-07-27 | Ramsing Niels B | Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same |
| EP2208796B1 (de) | 2005-01-06 | 2014-06-18 | Applied Biosystems, LLC | Polypeptide mit Nukleinsäurebindungsaktivität und Zusammensetzungen und Verfahren zur Nukleinsäurenamplifikation |
| EP2312317A3 (de) | 2005-05-03 | 2011-06-08 | Life Technologies Corporation | Fluoreszentes Erkennungssystem und Farbstoffsatz zur Verwendung damit |
| US8362250B2 (en) | 2005-05-24 | 2013-01-29 | Enzo Biochem, Inc. | Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest |
| US20070087360A1 (en) * | 2005-06-20 | 2007-04-19 | Boyd Victoria L | Methods and compositions for detecting nucleotides |
| US20070059713A1 (en) | 2005-09-09 | 2007-03-15 | Lee Jun E | SSB-DNA polymerase fusion proteins |
| EP1994182B1 (de) | 2006-03-15 | 2019-05-29 | Siemens Healthcare Diagnostics Inc. | Abgleit-nucleobase-analoga |
| US20080124726A1 (en) | 2006-05-26 | 2008-05-29 | Althea Technologies, Inc. | Biochemical analysis of partitioned cells |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| CA2671194A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| US20080274458A1 (en) * | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
| EP2198050A1 (de) | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon |
| US8071562B2 (en) | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| US8715944B2 (en) * | 2008-09-08 | 2014-05-06 | Enzo Life Sciences, Inc. | Fluorochromes for organelle tracing and multi-color imaging |
| US9250249B2 (en) | 2008-09-08 | 2016-02-02 | Enzo Biochem, Inc. | Autophagy and phospholipidosis pathway assays |
| US9334281B2 (en) * | 2008-09-08 | 2016-05-10 | Enzo Life Sciences, Inc. | Fluorochromes for organelle tracing and multi-color imaging |
| EP3597657B1 (de) | 2009-05-21 | 2021-09-01 | Siemens Healthcare Diagnostics Inc. | Universaletiketten mit nichtnatürlichen nukleobasen |
| AU2010249421A1 (en) | 2009-05-22 | 2011-12-08 | Asuragen, Inc. | miRNA biomarkers of prostate disease |
| EP2470897A4 (de) | 2009-08-28 | 2013-05-29 | Asuragen Inc | Mirna-biomarker für lungenerkrankungen |
| EP2633073B1 (de) | 2010-10-29 | 2017-04-26 | Asuragen, Inc. | Mpcr verfahren zur analyse von wiederholungssequenzen |
| WO2012092403A1 (en) | 2010-12-29 | 2012-07-05 | Life Technologies Corporation | Ddao compounds as fluorescent reference standards |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| WO2014093291A1 (en) | 2012-12-10 | 2014-06-19 | Advandx, Inc. | Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest |
| EP3425066A1 (de) | 2014-01-05 | 2019-01-09 | Biomirna Holdings Ltd. | Lungenkrebsbestimmung mit mirna |
| WO2015120382A1 (en) | 2014-02-07 | 2015-08-13 | The Johns Hopkins University | Predicting response to epigenetic drug therapy |
| EP3183054B1 (de) | 2014-08-19 | 2020-09-23 | Roche Diagnostics GmbH | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren |
| WO2016094330A2 (en) | 2014-12-08 | 2016-06-16 | 20/20 Genesystems, Inc | Methods and machine learning systems for predicting the liklihood or risk of having cancer |
| EP3292214A1 (de) | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Verfahren zur quantifizierung von mirnas mittels normalisierung |
| US11214829B2 (en) | 2015-07-23 | 2022-01-04 | Asuragen, Inc. | Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments |
| WO2018045162A1 (en) | 2016-09-01 | 2018-03-08 | Biogen Ma Inc. | Biomarkers predictive of primary progressive multiple sclerosis and uses thereof |
| CN107602498B (zh) * | 2017-07-26 | 2020-07-28 | 华南理工大学 | 一种荧光探针及其制备方法与在酪氨酸酶检测中的应用 |
| WO2019193544A1 (en) * | 2018-04-04 | 2019-10-10 | Universidade Do Minho | Benzophenoxazine derivatives for diagnosis of neoplasia or infection |
| WO2020090294A1 (ja) * | 2018-10-31 | 2020-05-07 | 日立化成株式会社 | イオン性化合物、有機エレクトロニクス材料、インク組成物、及び有機エレクトロニクス素子 |
| EP3719144A1 (de) | 2019-04-05 | 2020-10-07 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung |
| EP3999664A1 (de) | 2019-07-19 | 2022-05-25 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Verfahren zur bestimmung des ansprechens auf die behandlung eines patienten mit nicht-kleinzelligem lungenkarzinom (nsclc) |
| EP4367104A4 (de) * | 2021-07-02 | 2025-11-19 | Univ Oregon Health & Science | Wasserlösliche nervenfarbstoffe zur nervenspezifischen in-vivo-bildgebung |
| KR102783485B1 (ko) | 2021-10-15 | 2025-03-20 | 아주대학교산학협력단 | miR-625-3p의 건선 중증도 진단용 바이오마커로서의 용도 |
| KR20240177780A (ko) | 2023-06-19 | 2024-12-30 | 재단법인 아산사회복지재단 | 맥락막 비후 질환의 진단 또는 예후 예측용 조성물, 키트 및 진단 또는 예후 예측을 위한 정보를 제공하는 방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE488945C (de) * | 1924-09-12 | 1930-01-25 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Aminoalkylaminosubstitutionsprodukten der Azin-, Oxazin- und Thiazinreihe |
| US4386149A (en) * | 1978-02-28 | 1983-05-31 | Ciba-Geigy Ag | Process for the production of photographic images by dye diffusion transfer and photographic material suitable in this process |
| US4237281A (en) * | 1978-10-13 | 1980-12-02 | Ciba-Geigy Aktiengesellschaft | Dyestuffs containing amino or imino groups |
| US4789742A (en) * | 1984-08-27 | 1988-12-06 | Spyros Theodoropulos | Isomaleimide and isophthalimide derivatives of chromophors |
| US4622395A (en) * | 1984-10-01 | 1986-11-11 | Minnesota Mining And Manufacturing Company | Phenoxazine and phenothiazine dyes and leuco forms thereof |
| US4714763A (en) * | 1985-07-11 | 1987-12-22 | Viomedics Inc. | Novel oxazine-ureas and thiazine urea chromophors as fluorescent labels |
| US4962197A (en) * | 1988-02-12 | 1990-10-09 | Rowland Institute For Science | Photo-inactivation of cancer cells |
| US5783687A (en) * | 1990-03-14 | 1998-07-21 | The Regents Of The University Of California | Dyes designed for high sensitivity detection of double-stranded DNA |
| DE59309805D1 (de) * | 1992-12-15 | 1999-11-04 | Ciba Sc Holding Ag | Oxazinfarbstoffe, Verfahren zu deren Herstellung und deren Verwendung |
| US5410030A (en) * | 1993-04-05 | 1995-04-25 | Molecular Probes, Inc. | Dimers of unsymmetrical cyanine dyes containing pyridinium moieties |
| US5436134A (en) * | 1993-04-13 | 1995-07-25 | Molecular Probes, Inc. | Cyclic-substituted unsymmetrical cyanine dyes |
| US5565554A (en) * | 1994-07-29 | 1996-10-15 | The Regents Of The University Of California | Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores |
| GB9602265D0 (en) * | 1996-02-05 | 1996-04-03 | Amersham Int Plc | Benzophenoxazine dyes |
| ID17684A (id) * | 1996-02-08 | 1998-01-22 | Bpb Plc | Papan bersemen |
| US5876946A (en) * | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
-
1999
- 1999-09-03 US US09/389,918 patent/US6140500A/en not_active Expired - Lifetime
-
2000
- 2000-09-01 JP JP2001522339A patent/JP2003509528A/ja not_active Ceased
- 2000-09-01 CA CA002382593A patent/CA2382593C/en not_active Expired - Fee Related
- 2000-09-01 DE DE60006685T patent/DE60006685T2/de not_active Expired - Lifetime
- 2000-09-01 WO PCT/US2000/024057 patent/WO2001018124A1/en not_active Ceased
- 2000-09-01 EP EP00959749A patent/EP1208160B1/de not_active Expired - Lifetime
- 2000-09-01 AU AU71015/00A patent/AU753608B2/en not_active Ceased
- 2000-09-01 AT AT00959749T patent/ATE254648T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU753608B2 (en) | 2002-10-24 |
| DE60006685T2 (de) | 2004-10-14 |
| CA2382593C (en) | 2008-04-08 |
| JP2003509528A (ja) | 2003-03-11 |
| AU7101500A (en) | 2001-04-10 |
| WO2001018124A1 (en) | 2001-03-15 |
| EP1208160A1 (de) | 2002-05-29 |
| US6140500A (en) | 2000-10-31 |
| CA2382593A1 (en) | 2001-03-15 |
| DE60006685D1 (de) | 2003-12-24 |
| EP1208160B1 (de) | 2003-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |