ATE254847T1 - Verfahren zur identifikation von verbindungen, welche die bindenden wechselwirkungen zwischen den vpr und rip-1 proteinen von hiv-1 aufheben können - Google Patents

Verfahren zur identifikation von verbindungen, welche die bindenden wechselwirkungen zwischen den vpr und rip-1 proteinen von hiv-1 aufheben können

Info

Publication number
ATE254847T1
ATE254847T1 AT95920426T AT95920426T ATE254847T1 AT E254847 T1 ATE254847 T1 AT E254847T1 AT 95920426 T AT95920426 T AT 95920426T AT 95920426 T AT95920426 T AT 95920426T AT E254847 T1 ATE254847 T1 AT E254847T1
Authority
AT
Austria
Prior art keywords
hiv
vpr
compounds
target
rip
Prior art date
Application number
AT95920426T
Other languages
English (en)
Inventor
David B Weiner
Yosef Refaeli
David M Levy
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/246,177 external-priority patent/US5639598A/en
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of ATE254847T1 publication Critical patent/ATE254847T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1147—Regulatory proteins, e.g. trans-activator of transcription [TAT], rev or vacuolar protein targeting [VPT]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT95920426T 1994-05-19 1995-05-17 Verfahren zur identifikation von verbindungen, welche die bindenden wechselwirkungen zwischen den vpr und rip-1 proteinen von hiv-1 aufheben können ATE254847T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/246,177 US5639598A (en) 1994-05-19 1994-05-19 Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US08/382,873 US5780220A (en) 1994-05-19 1995-02-03 Methods and compositions for inhibiting HIV replication
PCT/US1995/005981 WO1995031901A1 (en) 1994-05-19 1995-05-17 METHODS FOR THE IDENTIFICATION OF COMPOUNDS CAPABLE OF ABROGATING HIV-1 Vpr-rip-1 BINDING INTERACTIONS

Publications (1)

Publication Number Publication Date
ATE254847T1 true ATE254847T1 (de) 2003-12-15

Family

ID=26937772

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920426T ATE254847T1 (de) 1994-05-19 1995-05-17 Verfahren zur identifikation von verbindungen, welche die bindenden wechselwirkungen zwischen den vpr und rip-1 proteinen von hiv-1 aufheben können

Country Status (9)

Country Link
US (1) US5780220A (de)
EP (1) EP0759693B1 (de)
AT (1) ATE254847T1 (de)
AU (1) AU690694B2 (de)
CA (1) CA2190613A1 (de)
DE (1) DE69532197T2 (de)
ES (1) ES2210291T3 (de)
PT (1) PT759693E (de)
WO (1) WO1995031901A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1373395A (en) * 1993-12-15 1995-07-03 Trustees Of The University Of Pennsylvania, The Vpr receptor protein
US6060587A (en) * 1996-01-29 2000-05-09 The Trustees Of The University Of Pennsylvania Cellular receptor for HIV-1 VPR essential for G2/M phase transition of the cell cycle
US6087486A (en) * 1996-01-29 2000-07-11 The Trustees Of The University Of Pennsylvania Nucleotide sequences encoding vpr receptor protein
WO1998027986A1 (en) * 1996-12-24 1998-07-02 Zymogenetics, Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
WO1998035234A1 (en) * 1997-02-11 1998-08-13 The Regents Of The University Of California Identifying agents for treating lentiviral infection
US6818627B1 (en) 1997-08-14 2004-11-16 The Trustees Of The University Of Pennsylvania Functional fragments of HIV-1 Vpr protein and methods of using the same
US6020198A (en) * 1998-09-25 2000-02-01 Isis Pharmaceuticals Inc. Antisense modulation of RIP-1 expression
NZ334627A (en) * 1999-03-12 2002-07-26 Horticulture & Food Res Inst A therapeutic composition containing a therapeutic agent such as an anthelmintic and an antistress agent such as metyrapone or a nitric oxide promoter for increasing efficacy of therapeutic agents and animal growth
BR0108997A (pt) * 2000-03-09 2003-06-03 Schering Corp Terapia imune adjuvante para hiv
US7148244B2 (en) 2001-04-26 2006-12-12 Nippon Shinyaku Co. Ltd. Medicines in controlling Vpr function
US7598041B2 (en) * 2001-05-25 2009-10-06 The Trustees Of The University Of Pennsylvania HIV-1 VPR interactions with mitochondrial apoptosis inducing factor and methods of using the same
CA2487655A1 (en) * 2002-05-24 2003-12-04 The Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting hiv replication
WO2004112724A2 (en) * 2003-06-20 2004-12-29 Viral Genomix, Inc. Compositions for and methods for treating hiv
CN101014349A (zh) * 2003-06-20 2007-08-08 病毒基因混和公司 抗病毒组合物及其使用方法
WO2006007471A1 (en) * 2004-07-01 2006-01-19 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Monoclonal antibodies to hiv-1 vpr and methods of using same
WO2006133194A2 (en) * 2005-06-06 2006-12-14 Vgx Pharmaceuticals, Inc Methods for treating viral infection with oral or injectible drug solution
CN1899289A (zh) * 2005-07-22 2007-01-24 上海三合生物技术有限公司 赛米司酮类化合物用于治疗艾滋病的用途

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US4296206A (en) * 1980-04-30 1981-10-20 United States Of America Irreversible anti-glucocorticoids
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
US4978657A (en) * 1981-01-09 1990-12-18 Roussel Uclaf Novel 11β-substituted-19-nor-steroids
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
FR2639045B2 (fr) * 1982-03-01 1994-07-29 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments
DE3438994A1 (de) * 1984-10-22 1986-04-24 Schering AG, Berlin und Bergkamen, 1000 Berlin Antigestagene, glukokortikoide und prostaglandine zur geburtseinleitung oder fuer den schwangerschaftsabbruch
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3506785A1 (de) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2598421B1 (fr) * 1986-05-06 1988-08-19 Roussel Uclaf Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3625315A1 (de) * 1986-07-25 1988-01-28 Schering Ag 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
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DE3723788A1 (de) * 1987-07-16 1989-01-26 Schering Ag 11(beta)-phenyl-4,9,15-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2618783B1 (fr) * 1987-07-30 1991-02-01 Roussel Uclaf Nouveaux 17-aryle steroides, leurs procedes et des intermediaires de preparation comme medicaments et les compositions pharmaceutiques les renfermant
JP2785023B2 (ja) * 1987-12-30 1998-08-13 ルセル―ユクラフ １７α位置を置換された１７β―ＯＨ―１９―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物
DE3820948A1 (de) * 1988-06-16 1989-12-21 Schering Ag 10ss, 11ss-ueberbrueckte steroide
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5011829A (en) * 1989-06-02 1991-04-30 G. D. Searle & Co. Pharmaceutical composition and method of inhibiting virus
US5276023A (en) * 1989-08-08 1994-01-04 Roussel Uclaf 19-nor-steroid esters
FR2651233B1 (fr) * 1989-08-23 1991-12-13 Roussel Uclaf Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5241956A (en) * 1992-05-21 1993-09-07 Brain Archibald Ian Jeremy Laryngeal mask airway with concentric drainage of oesophagus discharge
WO1994017086A1 (en) * 1993-01-25 1994-08-04 Apollon, Inc. Gene regulation by targeting putative intramolecular triple helix
FR2711920B1 (fr) * 1993-03-15 1996-02-16 Andrieu Jean Marie Utilisation des glucocorticoïdes pour le traitement et la prévention du sida et compositions en contenant pour cet usage.
CA2186398A1 (en) * 1994-03-25 1995-10-05 Ahmed A. Azad Vpr and vpx proteins of hiv

Also Published As

Publication number Publication date
WO1995031901A1 (en) 1995-11-30
EP0759693B1 (de) 2003-11-26
DE69532197T2 (de) 2004-04-15
EP0759693A1 (de) 1997-03-05
AU690694B2 (en) 1998-04-30
PT759693E (pt) 2004-03-31
AU2588095A (en) 1995-12-18
US5780220A (en) 1998-07-14
CA2190613A1 (en) 1995-11-30
ES2210291T3 (es) 2004-07-01
EP0759693A4 (de) 1999-06-09
DE69532197D1 (de) 2004-01-08

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