ATE255581T1 - Phenanthrolin-derivate - Google Patents

Phenanthrolin-derivate

Info

Publication number: ATE255581T1
Authority: AT; Austria
Prior art keywords: hydrogen; alkoxycarbonyl; alkyl; alkylcarbamoyl; carbamoyl
Prior art date: 1997-10-24

Application number

AT98967153T

Other languages

English (en)

Inventor

Philip Neil Edwards

Michael Stewart Large

Neil James Hales

George R Martin

Xinfan Huang

Original Assignee

Fibrogen Inc

Syngenta Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

1998-10-26

Publication date

2003-12-15

1997-10-24 Priority claimed from US08/957,450 external-priority patent/US5916898A/en

1998-10-26 Application filed by Fibrogen Inc, Syngenta Ltd filed Critical Fibrogen Inc

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE255581T1 publication Critical patent/ATE255581T1/de

Links

150000005041 phenanthrolines Chemical class 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
NSMJMUQZRGZMQC-UHFFFAOYSA-N 2-naphthalen-1-yl-1H-imidazo[4,5-f][1,10]phenanthroline Chemical compound C12=CC=CN=C2C2=NC=CC=C2C2=C1NC(C=1C3=CC=CC=C3C=CC=1)=N2 NSMJMUQZRGZMQC-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000003620 anti-fibroproliferative effect Effects 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT98967153T 1997-10-24 1998-10-26 Phenanthrolin-derivate ATE255581T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/957,450 US5916898A (en)	1997-10-24	1997-10-24	Phenanthroline derivatives
US17788898A	1998-10-23	1998-10-23
PCT/US1998/022704 WO1999021860A1 (en)	1997-10-24	1998-10-26	Phenanthroline derivatives

Publications (1)

Publication Number	Publication Date
ATE255581T1 true ATE255581T1 (de)	2003-12-15

Family

ID=26873748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98967153T ATE255581T1 (de)	1997-10-24	1998-10-26	Phenanthrolin-derivate

Country Status (7)

Country	Link
EP (1)	EP1027351B1 (de)
JP (1)	JP2003522093A (de)
AT (1)	ATE255581T1 (de)
AU (1)	AU754607B2 (de)
CA (1)	CA2308551C (de)
DE (1)	DE69820288T2 (de)
WO (1)	WO1999021860A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2295060B1 (de)	2001-12-06	2018-10-31	Fibrogen, Inc.	Behandlung ischämischer oder hypoxischer Zustände
US8318703B2 (en)	2001-12-06	2012-11-27	Fibrogen, Inc.	Methods for improving kidney function
DK2298301T3 (en)	2001-12-06	2018-10-01	Fibrogen Inc	MEDICINALS FOR TREATMENT OF ANEMIA ASSOCIATED WITH Kidney Disease
US8124582B2 (en) *	2002-12-06	2012-02-28	Fibrogen, Inc.	Treatment of diabetes
US7618940B2 (en)	2002-12-06	2009-11-17	Fibrogen, Inc.	Fat regulation
US20060251638A1 (en) *	2003-06-06	2006-11-09	Volkmar Guenzler-Pukall	Cytoprotection through the use of hif hydroxylase inhibitors
MX2007016160A (es)	2005-06-15	2008-03-07	Fibrogen Inc	Uso de moduladoers de hif-1 alfa para el tratamiento contra el cancer.
US7625927B2 (en)	2006-02-27	2009-12-01	Alcon Research, Ltd.	Method of treating glaucoma
GB201102659D0 (en)	2011-02-15	2011-03-30	Isis Innovation	Assay
GB201113101D0 (en)	2011-07-28	2011-09-14	Isis Innovation	Assay
CN104974187A (zh) *	2014-04-10	2015-10-14	吉林省博创药业有限公司	菲罗啉类衍生物及其制备方法和应用
EP3937941A4 (de) *	2019-03-11	2023-07-19	The Regents of the University of California	Hydrogels und verfahren zur verwendung davon

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5512031B2 (de) *	1972-10-31	1980-03-29
JPS5653678A (en) *	1980-06-25	1981-05-13	Taisho Pharmaceut Co Ltd	Preparation of 1,10-phenanthroilnes
DE3703959A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703963A1 (de) *	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3707429A1 (de) *	1987-03-07	1988-09-15	Hoechst Ag	Substituierte pyridin-2,4-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen

1998
- 1998-10-26 AU AU27027/99A patent/AU754607B2/en not_active Expired
- 1998-10-26 AT AT98967153T patent/ATE255581T1/de not_active IP Right Cessation
- 1998-10-26 WO PCT/US1998/022704 patent/WO1999021860A1/en not_active Ceased
- 1998-10-26 DE DE69820288T patent/DE69820288T2/de not_active Expired - Lifetime
- 1998-10-26 EP EP98967153A patent/EP1027351B1/de not_active Expired - Lifetime
- 1998-10-26 JP JP2000517970A patent/JP2003522093A/ja active Pending
- 1998-10-26 CA CA2308551A patent/CA2308551C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU754607B2 (en)	2002-11-21
DE69820288D1 (de)	2004-01-15
EP1027351A1 (de)	2000-08-16
EP1027351B1 (de)	2003-12-03
DE69820288T2 (de)	2004-10-21
WO1999021860A1 (en)	1999-05-06
CA2308551C (en)	2010-02-16
CA2308551A1 (en)	1999-05-06
HK1030214A1 (en)	2001-04-27
AU2702799A (en)	1999-05-17
WO1999021860B1 (en)	1999-08-05
JP2003522093A (ja)	2003-07-22

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Legal Events

Date	Code	Title	Description
2004-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties