ES2118846T3 - Formas cristalinas de monohidrato de hidrocloruro de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamida y de monohidrato de hidrocloruro de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamid - Google Patents

Formas cristalinas de monohidrato de hidrocloruro de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamida y de monohidrato de hidrocloruro de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamid

Info

Publication number
ES2118846T3
ES2118846T3 ES93104564T ES93104564T ES2118846T3 ES 2118846 T3 ES2118846 T3 ES 2118846T3 ES 93104564 T ES93104564 T ES 93104564T ES 93104564 T ES93104564 T ES 93104564T ES 2118846 T3 ES2118846 T3 ES 2118846T3
Authority
ES
Spain
Prior art keywords
azabiciclo
endo
dihydro
oct
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93104564T
Other languages
English (en)
Inventor
Enzo Cereda
Enrica Dubini
Antoine Ezhaya
Grazia Maffione
Marco Turconi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Italia SpA
Original Assignee
Boehringer Ingelheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI920720A external-priority patent/IT1254562B/it
Priority claimed from ITMI920723A external-priority patent/IT1254565B/it
Application filed by Boehringer Ingelheim Italia SpA filed Critical Boehringer Ingelheim Italia SpA
Application granted granted Critical
Publication of ES2118846T3 publication Critical patent/ES2118846T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN MONOHIDRATOS CRISTALINOS DE HIDROCLORURO DE ENDO-2,3-DIHIDRO-N-(8-METIL-8-AZABICICLO[3-2,1]OCT-3-IL)-2-OXO-1H-BENZIMIDAZOLA-1-CARBOXAMIDO Y DE HIDROCLORURO DE ENDO-3-ETIL-2,3-DIHIDRO-N-(8-METIL.-8-AZABICICLO[3.2.1]OCT-3-IL)2-OXO1H-BENZIMIDAZOLA-1-CARBOXAMIDO DE LA FORMULA I (COMPUESTO 2A: R = H) (COMPUESTO 2B: R = C2H5), ASIMISMO SE PRESENTA EL PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
ES93104564T 1992-03-26 1993-03-19 Formas cristalinas de monohidrato de hidrocloruro de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamida y de monohidrato de hidrocloruro de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamid Expired - Lifetime ES2118846T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI920720A IT1254562B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato
ITMI920723A IT1254565B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-2,3-diidro-n-(8 metil-8-azabiciclo-(3.2.1) ott-3-il)-2-oxo-1h-benzimidazolo-1-carbossamide cloridrato

Publications (1)

Publication Number Publication Date
ES2118846T3 true ES2118846T3 (es) 1998-10-01

Family

ID=26330860

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93104564T Expired - Lifetime ES2118846T3 (es) 1992-03-26 1993-03-19 Formas cristalinas de monohidrato de hidrocloruro de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamida y de monohidrato de hidrocloruro de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamid

Country Status (27)

Country Link
US (1) US5468758A (es)
EP (1) EP0567767B1 (es)
JP (1) JP3279707B2 (es)
AT (1) ATE169016T1 (es)
AU (1) AU654082B2 (es)
BR (1) BR1100564A (es)
CA (1) CA2092510C (es)
CZ (1) CZ286590B6 (es)
DE (1) DE69319955T2 (es)
DK (1) DK0567767T3 (es)
ES (1) ES2118846T3 (es)
FI (1) FI113472B (es)
HR (1) HRP930479B1 (es)
HU (2) HU211075B (es)
IL (1) IL105143A (es)
MX (1) MX9301668A (es)
NO (1) NO300975B1 (es)
NZ (1) NZ247234A (es)
PH (1) PH30413A (es)
PL (1) PL172890B1 (es)
RU (1) RU2125054C1 (es)
SG (1) SG43225A1 (es)
SI (1) SI9300150B (es)
SK (1) SK280555B6 (es)
TW (1) TW385310B (es)
UA (1) UA37179C2 (es)
UY (2) UY25939A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2240637T3 (es) 1996-01-17 2005-10-16 Ricoh Company, Ltd. Aparato de fijacion para un aparato de formacion de imagenes.
JPH1039679A (ja) * 1996-05-24 1998-02-13 Ricoh Co Ltd 定着装置
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
CA2787063C (en) 2010-01-11 2018-11-27 Astraea Therapeutics, Llc Nicotinic acetylcholine receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136189A (en) * 1975-09-16 1979-01-23 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 2-(5-nitro-furfurylidene)-amino-benzimidoles and fungicidal compositions containing the same
IT1231413B (it) * 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
US5223511A (en) * 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
GB9121835D0 (en) * 1991-10-15 1991-11-27 Smithkline Beecham Plc Pharmaceuticals
DK0554794T3 (da) * 1992-02-04 1999-04-26 Eisai Co Ltd Aminobenzoesyrederivater

Also Published As

Publication number Publication date
NO931112D0 (no) 1993-03-25
UA37179C2 (uk) 2001-05-15
HRP930479B1 (en) 1999-10-31
SK22693A3 (en) 1993-11-10
IL105143A (en) 1996-10-16
RU2125054C1 (ru) 1999-01-20
TW385310B (en) 2000-03-21
HU211131A9 (en) 1995-10-30
EP0567767B1 (en) 1998-07-29
PL298263A1 (en) 1994-01-10
HK1010719A1 (en) 1999-06-25
ATE169016T1 (de) 1998-08-15
JP3279707B2 (ja) 2002-04-30
SG43225A1 (en) 1997-10-17
UY25938A1 (es) 2000-09-29
AU3541393A (en) 1993-09-30
SK280555B6 (sk) 2000-03-13
CA2092510C (en) 2004-02-03
US5468758A (en) 1995-11-21
CZ286590B6 (cs) 2000-05-17
MX9301668A (es) 1993-09-01
HRP930479A2 (en) 1995-02-28
HU211075B (en) 1995-10-30
PL172890B1 (pl) 1997-12-31
DK0567767T3 (da) 1999-02-01
FI931329L (fi) 1993-09-27
CA2092510A1 (en) 1993-09-27
PH30413A (en) 1997-05-09
SI9300150A (en) 1993-09-30
BR1100564A (pt) 2000-06-27
HUT63846A (en) 1993-10-28
UY25939A1 (es) 2001-08-27
CZ44393A3 (en) 1994-01-19
SI9300150B (sl) 1998-06-30
DE69319955D1 (de) 1998-09-03
NZ247234A (en) 1995-12-21
AU654082B2 (en) 1994-10-20
FI931329A0 (fi) 1993-03-25
FI113472B (fi) 2004-04-30
HU9300868D0 (en) 1993-06-28
NO931112L (no) 1993-09-27
DE69319955T2 (de) 1999-04-15
EP0567767A1 (en) 1993-11-03
NO300975B1 (no) 1997-08-25
JPH0673053A (ja) 1994-03-15

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