ATE255899T1 - Isophosphoramide-senfgasanalogen und deren verwendung - Google Patents

Isophosphoramide-senfgasanalogen und deren verwendung

Info

Publication number
ATE255899T1
ATE255899T1 AT00939331T AT00939331T ATE255899T1 AT E255899 T1 ATE255899 T1 AT E255899T1 AT 00939331 T AT00939331 T AT 00939331T AT 00939331 T AT00939331 T AT 00939331T AT E255899 T1 ATE255899 T1 AT E255899T1
Authority
AT
Austria
Prior art keywords
analogues
isophosphoramide mustard
mustard gas
isophosphoramide
gas
Prior art date
Application number
AT00939331T
Other languages
English (en)
Inventor
Robert F Struck
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Application granted granted Critical
Publication of ATE255899T1 publication Critical patent/ATE255899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Artificial Filaments (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
AT00939331T 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung ATE255899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13583099P 1999-05-24 1999-05-24
PCT/US2000/014275 WO2000071134A1 (en) 1999-05-24 2000-05-24 Isophosphoramide mustard analogs and use thereof

Publications (1)

Publication Number Publication Date
ATE255899T1 true ATE255899T1 (de) 2003-12-15

Family

ID=22469903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00939331T ATE255899T1 (de) 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung

Country Status (9)

Country Link
US (1) US6197760B1 (de)
EP (1) EP1185276B1 (de)
JP (1) JP4629238B2 (de)
AT (1) ATE255899T1 (de)
AU (1) AU773061B2 (de)
CA (1) CA2373634C (de)
DE (1) DE60007120T2 (de)
HK (1) HK1043058A1 (de)
WO (1) WO2000071134A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE462419T1 (de) * 2002-05-31 2010-04-15 Rp Scherer Technologies Llc Orale pharmazeutische zusammensetzung für weichkapseln mit vinorelbin und behandlungsverfahren
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
RU2279873C2 (ru) * 2002-05-31 2006-07-20 Ар.Пи.ШЕРЕР ТЕКНОЛОДЖИЗ, ИНК. Пероральная фармацевтическая композиция для мягких капсул, содержащая винорелбин, и способ лечения
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
AU2011221388B2 (en) * 2004-10-25 2014-08-21 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
EP2336140B1 (de) 2004-10-25 2016-01-27 Dekk-Tec, Inc. Salze aus isophosphoramid-mustard und analoge davon als antitumormittel
EP1896040B1 (de) 2005-06-29 2012-08-01 Threshold Pharmaceuticals, Inc. Phosphoramidat-alkylator-prodrugs
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
ES2884044T3 (es) 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
MX2009010820A (es) 2007-04-06 2010-03-18 Ziopharm Oncology Inc Sales de mostaza isofosforamida y analogos de la misma.
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
NZ601139A (en) 2008-07-31 2014-02-28 Ziopharm Oncology Inc Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
US20130196000A1 (en) 2012-01-31 2013-08-01 Ziopharm Oncology, Inc. Combination therapy including isophosphoramide mustard, analogs, or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159886A (de) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5659061A (en) * 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities

Also Published As

Publication number Publication date
US6197760B1 (en) 2001-03-06
JP2004515448A (ja) 2004-05-27
EP1185276B1 (de) 2003-12-10
EP1185276A1 (de) 2002-03-13
EP1185276A4 (de) 2002-12-04
AU5443000A (en) 2000-12-12
HK1043058A1 (zh) 2002-09-06
DE60007120T2 (de) 2004-09-16
CA2373634C (en) 2010-04-13
JP4629238B2 (ja) 2011-02-09
DE60007120D1 (de) 2004-01-22
CA2373634A1 (en) 2000-11-30
WO2000071134A1 (en) 2000-11-30
AU773061B2 (en) 2004-05-13

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Legal Events

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