ATE255899T1 - Isophosphoramide-senfgasanalogen und deren verwendung - Google Patents

Isophosphoramide-senfgasanalogen und deren verwendung

Info

Publication number
ATE255899T1
ATE255899T1 AT00939331T AT00939331T ATE255899T1 AT E255899 T1 ATE255899 T1 AT E255899T1 AT 00939331 T AT00939331 T AT 00939331T AT 00939331 T AT00939331 T AT 00939331T AT E255899 T1 ATE255899 T1 AT E255899T1
Authority
AT
Austria
Prior art keywords
analogues
isophosphoramide mustard
mustard gas
isophosphoramide
gas
Prior art date
Application number
AT00939331T
Other languages
English (en)
Inventor
Robert F Struck
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Application granted granted Critical
Publication of ATE255899T1 publication Critical patent/ATE255899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Artificial Filaments (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
AT00939331T 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung ATE255899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13583099P 1999-05-24 1999-05-24
PCT/US2000/014275 WO2000071134A1 (en) 1999-05-24 2000-05-24 Isophosphoramide mustard analogs and use thereof

Publications (1)

Publication Number Publication Date
ATE255899T1 true ATE255899T1 (de) 2003-12-15

Family

ID=22469903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00939331T ATE255899T1 (de) 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung

Country Status (9)

Country Link
US (1) US6197760B1 (de)
EP (1) EP1185276B1 (de)
JP (1) JP4629238B2 (de)
AT (1) ATE255899T1 (de)
AU (1) AU773061B2 (de)
CA (1) CA2373634C (de)
DE (1) DE60007120T2 (de)
HK (1) HK1043058A1 (de)
WO (1) WO2000071134A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2279873C2 (ru) * 2002-05-31 2006-07-20 Ар.Пи.ШЕРЕР ТЕКНОЛОДЖИЗ, ИНК. Пероральная фармацевтическая композиция для мягких капсул, содержащая винорелбин, и способ лечения
MXPA04006054A (es) * 2002-05-31 2004-09-27 Scherer Technologies Inc R P Composicion farmaceutica oral para capsulas blandas que contienen vinorelbine y metodo de tratamiento.
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
EP2336140B1 (de) 2004-10-25 2016-01-27 Dekk-Tec, Inc. Salze aus isophosphoramid-mustard und analoge davon als antitumormittel
AU2011221388B2 (en) * 2004-10-25 2014-08-21 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
US8003625B2 (en) 2005-06-29 2011-08-23 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
US8552048B2 (en) 2006-12-26 2013-10-08 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs for the treatment of cancer
CA2684747A1 (en) 2007-04-06 2008-10-16 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
AU2009276512B2 (en) * 2008-07-31 2014-12-18 Ziopharm Oncology, Inc. Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
US20130196000A1 (en) 2012-01-31 2013-08-01 Ziopharm Oncology, Inc. Combination therapy including isophosphoramide mustard, analogs, or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159886A (de) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5659061A (en) * 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities

Also Published As

Publication number Publication date
EP1185276A1 (de) 2002-03-13
JP4629238B2 (ja) 2011-02-09
CA2373634C (en) 2010-04-13
CA2373634A1 (en) 2000-11-30
WO2000071134A1 (en) 2000-11-30
US6197760B1 (en) 2001-03-06
AU773061B2 (en) 2004-05-13
DE60007120D1 (de) 2004-01-22
AU5443000A (en) 2000-12-12
DE60007120T2 (de) 2004-09-16
EP1185276A4 (de) 2002-12-04
JP2004515448A (ja) 2004-05-27
EP1185276B1 (de) 2003-12-10
HK1043058A1 (zh) 2002-09-06

Similar Documents

Publication Publication Date Title
IL147803A0 (en) 28-epirapalogs
CY1112743T1 (el) Στερεοϊσομερως εμπλουτισμενες ενωσεις 3-αμινοκαρβονυλ δικυκλοεπτενο πυριμιδινοδιαμινης και οι χρησεις τους
DE59903442D1 (de) Azidfreie, gaserzeugende Zusammensetzung
CY1105758T1 (el) Τροποποιημενη απιμιναση αργινινης
ID23731A (id) Metode dan aparatus untuk menambah perolehan karbon dioksida
DE69907954D1 (de) Gasverdichter
ID20234A (id) Pemrosesan gas hidrokarbon
ID20306A (id) Pemrosesan gas hidrokarbon
PT1143967E (pt) Utilizacao de derivados anticonvulsivos para o tratamento de cefaleias em salvas
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
ES2162681T3 (es) Conjugados de acido cis-docosahexaenoico y paclitaxel.
DE69730202D1 (de) Azidfreie, gaserzeugende zusammensetzungen
ATE396738T1 (de) Verwendung von glp-2-peptiden
HN1996000017A (es) Isotiazolonas
DE60007120D1 (de) Isophosphoramide-senfgasanalogen und deren verwendung
DK1104425T3 (da) Hidtil ukendte thiazolopyrimidinforbindelser
DE59807921D1 (de) Hochleistungs-Druckwellenquelle
DE19981911T1 (de) Gasbildende Zusammensetzung
DE59902827D1 (de) Azidfreie, gaserzeugende Zusammensetzung
ATE419268T1 (de) Haemasterlin analoge
DE19981910T1 (de) Gasbildende Zusammensetzung
DE60045330D1 (de) Wirbelsystem für einen ionisierbares Gas verwendenden Koagulator
EA200000519A1 (ru) 2-АРИЛБЕНЗО[b]ТИОФЕНЫ, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ СИНДРОМА ЭСТРОГЕННОЙ НЕДОСТАТОЧНОСТИ
DE50010265D1 (de) Azidfreie gaserzeugende Zusammensetzung
EA200000520A1 (ru) 2-АРИЛ-3-АРОИЛБЕНЗО[b]ТИОФЕНЫ, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ СИНДРОМА ЭСТРОГЕННОЙ НЕДОСТАТОЧНОСТИ

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties