ATE419268T1 - Haemasterlin analoge - Google Patents
Haemasterlin analogeInfo
- Publication number
- ATE419268T1 ATE419268T1 AT98962157T AT98962157T ATE419268T1 AT E419268 T1 ATE419268 T1 AT E419268T1 AT 98962157 T AT98962157 T AT 98962157T AT 98962157 T AT98962157 T AT 98962157T AT E419268 T1 ATE419268 T1 AT E419268T1
- Authority
- AT
- Austria
- Prior art keywords
- haemasterlin
- analogue
- analogs
- hemiasterlin
- synthesis
- Prior art date
Links
- KQODQNJLJQHFQV-UHFFFAOYSA-N (-)-hemiasterlin Natural products C1=CC=C2C(C(C)(C)C(C(=O)NC(C(=O)N(C)C(C=C(C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-UHFFFAOYSA-N 0.000 abstract 1
- KQODQNJLJQHFQV-MKWZWQCGSA-N (e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid Chemical compound C1=CC=C2C(C(C)(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-MKWZWQCGSA-N 0.000 abstract 1
- 239000003080 antimitotic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 229930187626 hemiasterlin Natural products 0.000 abstract 1
- 108010057806 hemiasterlin Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Junction Field-Effect Transistors (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Amplifiers (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002225325A CA2225325A1 (en) | 1997-12-19 | 1997-12-19 | Hemiasterlin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419268T1 true ATE419268T1 (de) | 2009-01-15 |
Family
ID=4161925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98962157T ATE419268T1 (de) | 1997-12-19 | 1998-12-18 | Haemasterlin analoge |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7579323B1 (de) |
| EP (1) | EP1040119B1 (de) |
| JP (1) | JP4417551B2 (de) |
| KR (1) | KR100937756B1 (de) |
| CN (1) | CN100422208C (de) |
| AT (1) | ATE419268T1 (de) |
| AU (1) | AU762691C (de) |
| BR (1) | BR9813817A (de) |
| CA (2) | CA2225325A1 (de) |
| DE (1) | DE69840415D1 (de) |
| DK (1) | DK1040119T3 (de) |
| ES (1) | ES2320499T3 (de) |
| HU (1) | HUP0105460A3 (de) |
| IL (1) | IL136654A0 (de) |
| NZ (1) | NZ505086A (de) |
| WO (1) | WO1999032509A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1531846A4 (de) * | 2002-02-27 | 2006-04-19 | Us Gov Health & Human Serv | Konjugate aus ligand, linker und zytotoxischem agens sowie verwandte zusammensetzungen und verwendungsverfahren |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| KR101208266B1 (ko) * | 2002-03-22 | 2012-12-05 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 헤미아스텔린 유도체 및 이의 용도 |
| MXPA05002874A (es) | 2002-09-20 | 2005-05-27 | Wyeth Corp | Procedimiento para la sintesis de intermediarios utiles para la sintesis de inhibidores de tubulina. |
| WO2004026293A2 (en) * | 2002-09-20 | 2004-04-01 | Wyeth Holdings Corporation | Hemiasterlin derivatives for treating resistant tumors |
| AU2003295808A1 (en) * | 2002-11-21 | 2004-06-18 | Wyeth | Hemiasterlin affinity probes and their uses |
| US7390910B2 (en) * | 2003-08-08 | 2008-06-24 | Wyeth | Compounds for treating tumors |
| GB201001070D0 (en) | 2010-01-22 | 2010-03-10 | St George's Hospital Medical School | Theraputic compounds and their use |
| HK1220626A1 (zh) | 2013-03-15 | 2017-05-12 | The Centre For Drug Research And Development | 具细胞毒性和抗有丝分裂的化合物以及其使用方法 |
| WO2015095953A1 (en) | 2013-12-27 | 2015-07-02 | The Centre For Drug Research And Development | Sulfonamide-containing linkage systems for drug conjugates |
| BR112016015105A8 (pt) * | 2013-12-27 | 2018-04-24 | Var2 Pharmaceuticals Aps | conjugados var2csa-droga |
| ES2905569T3 (es) | 2014-09-17 | 2022-04-11 | Zymeworks Inc | Compuestos citotóxicos y antimitóticos y métodos para utilizarlos |
| PT3250237T (pt) | 2015-01-30 | 2021-06-30 | Sutro Biopharma Inc | Derivados de hemiasterlina para conjugação e terapêutica |
| US11021514B2 (en) | 2016-06-01 | 2021-06-01 | Athira Pharma, Inc. | Compounds |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| WO2018128745A1 (en) | 2017-01-06 | 2018-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligands and methods of using the same |
| EP4321523A3 (de) | 2017-08-10 | 2024-04-24 | Sumitomo Pharma Co., Ltd. | Hemiasterlinderivate und antikörper-wirkstoff-konjugate damit |
| PL3666787T3 (pl) | 2017-08-10 | 2024-04-29 | Sumitomo Pharma Co., Ltd. | Koniugaty przeciwciało-lek zawierające pochodną hemiasterliny |
| JP7432531B2 (ja) | 2019-02-13 | 2024-02-16 | 住友ファーマ株式会社 | システイン残基を有するヘミアスタリン誘導体 |
| WO2020166592A1 (ja) | 2019-02-13 | 2020-08-20 | 大日本住友製薬株式会社 | ヘミアスタリン誘導体とその抗体薬物複合体 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1049404B (it) | 1975-04-09 | 1981-01-20 | Zambeletti Spa L | Tripeptidi loro esteri ed amidi ad attivita antiulcera |
| EP0150227A1 (de) | 1983-12-23 | 1985-08-07 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Dipeptidderivate und ihre Verwendung für die Bestimmung der Aktivität von Carboxypeptidasen |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| US4820691A (en) * | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
| CA2042027A1 (en) | 1989-09-15 | 1991-03-16 | Arthur E. Bogden | Treatment of colon cancer |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5811515A (en) * | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| US5661175A (en) | 1995-06-20 | 1997-08-26 | Kashman; Yoel | Hemiasterlin and geodiamolide TA |
| US6034066A (en) * | 1995-07-17 | 2000-03-07 | Peptide Therapeutics Limited | Cysteine protease inhibitors for use in treatment of IGE mediated allergic diseases |
| US6214799B1 (en) * | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| US6331554B1 (en) * | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
| US6194578B1 (en) | 1998-11-20 | 2001-02-27 | Pfizer Inc. | Dipeptide derivatives |
-
1997
- 1997-12-19 CA CA002225325A patent/CA2225325A1/en not_active Abandoned
-
1998
- 1998-12-13 US US09/581,511 patent/US7579323B1/en not_active Expired - Fee Related
- 1998-12-18 ES ES98962157T patent/ES2320499T3/es not_active Expired - Lifetime
- 1998-12-18 DK DK98962157T patent/DK1040119T3/da active
- 1998-12-18 CA CA2312826A patent/CA2312826C/en not_active Expired - Fee Related
- 1998-12-18 BR BR9813817-0A patent/BR9813817A/pt not_active Application Discontinuation
- 1998-12-18 JP JP2000525446A patent/JP4417551B2/ja not_active Expired - Fee Related
- 1998-12-18 NZ NZ505086A patent/NZ505086A/en unknown
- 1998-12-18 CN CNB988124343A patent/CN100422208C/zh not_active Expired - Fee Related
- 1998-12-18 HU HU0105460A patent/HUP0105460A3/hu unknown
- 1998-12-18 AU AU17459/99A patent/AU762691C/en not_active Ceased
- 1998-12-18 AT AT98962157T patent/ATE419268T1/de not_active IP Right Cessation
- 1998-12-18 IL IL13665498A patent/IL136654A0/xx unknown
- 1998-12-18 WO PCT/CA1998/001184 patent/WO1999032509A2/en not_active Ceased
- 1998-12-18 KR KR1020007006814A patent/KR100937756B1/ko not_active Expired - Fee Related
- 1998-12-18 DE DE69840415T patent/DE69840415D1/de not_active Expired - Lifetime
- 1998-12-18 EP EP98962157A patent/EP1040119B1/de not_active Expired - Lifetime
-
2009
- 2009-06-25 US US12/491,839 patent/US20090264487A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2312826C (en) | 2013-06-11 |
| US20090264487A1 (en) | 2009-10-22 |
| AU1745999A (en) | 1999-07-12 |
| US7579323B1 (en) | 2009-08-25 |
| JP4417551B2 (ja) | 2010-02-17 |
| CA2225325A1 (en) | 1999-06-19 |
| CN100422208C (zh) | 2008-10-01 |
| CN1282336A (zh) | 2001-01-31 |
| WO1999032509A3 (en) | 1999-10-07 |
| HUP0105460A2 (en) | 2002-06-29 |
| HK1034523A1 (zh) | 2001-10-26 |
| JP2001526294A (ja) | 2001-12-18 |
| DE69840415D1 (de) | 2009-02-12 |
| EP1040119B1 (de) | 2008-12-31 |
| KR20010024783A (ko) | 2001-03-26 |
| DK1040119T3 (da) | 2009-04-14 |
| AU762691C (en) | 2004-07-08 |
| BR9813817A (pt) | 2000-10-10 |
| KR100937756B1 (ko) | 2010-01-20 |
| ES2320499T3 (es) | 2009-05-22 |
| IL136654A0 (en) | 2001-06-14 |
| CA2312826A1 (en) | 1999-07-01 |
| EP1040119A2 (de) | 2000-10-04 |
| NZ505086A (en) | 2003-05-30 |
| HUP0105460A3 (en) | 2002-08-28 |
| AU762691B2 (en) | 2003-07-03 |
| WO1999032509A2 (en) | 1999-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |