ATE419268T1 - Haemasterlin analoge - Google Patents
Haemasterlin analogeInfo
- Publication number
- ATE419268T1 ATE419268T1 AT98962157T AT98962157T ATE419268T1 AT E419268 T1 ATE419268 T1 AT E419268T1 AT 98962157 T AT98962157 T AT 98962157T AT 98962157 T AT98962157 T AT 98962157T AT E419268 T1 ATE419268 T1 AT E419268T1
- Authority
- AT
- Austria
- Prior art keywords
- haemasterlin
- analogue
- analogs
- hemiasterlin
- synthesis
- Prior art date
Links
- KQODQNJLJQHFQV-UHFFFAOYSA-N (-)-hemiasterlin Natural products C1=CC=C2C(C(C)(C)C(C(=O)NC(C(=O)N(C)C(C=C(C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-UHFFFAOYSA-N 0.000 abstract 1
- KQODQNJLJQHFQV-MKWZWQCGSA-N (e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid Chemical compound C1=CC=C2C(C(C)(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-MKWZWQCGSA-N 0.000 abstract 1
- 239000003080 antimitotic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 229930187626 hemiasterlin Natural products 0.000 abstract 1
- 108010057806 hemiasterlin Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Junction Field-Effect Transistors (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Amplifiers (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002225325A CA2225325A1 (en) | 1997-12-19 | 1997-12-19 | Hemiasterlin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419268T1 true ATE419268T1 (de) | 2009-01-15 |
Family
ID=4161925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98962157T ATE419268T1 (de) | 1997-12-19 | 1998-12-18 | Haemasterlin analoge |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7579323B1 (de) |
| EP (1) | EP1040119B1 (de) |
| JP (1) | JP4417551B2 (de) |
| KR (1) | KR100937756B1 (de) |
| CN (1) | CN100422208C (de) |
| AT (1) | ATE419268T1 (de) |
| AU (1) | AU762691C (de) |
| BR (1) | BR9813817A (de) |
| CA (2) | CA2225325A1 (de) |
| DE (1) | DE69840415D1 (de) |
| DK (1) | DK1040119T3 (de) |
| ES (1) | ES2320499T3 (de) |
| HU (1) | HUP0105460A3 (de) |
| IL (1) | IL136654A0 (de) |
| NZ (1) | NZ505086A (de) |
| WO (1) | WO1999032509A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003072754A2 (en) * | 2002-02-27 | 2003-09-04 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use |
| WO2003082268A2 (en) * | 2002-03-22 | 2003-10-09 | Eisai Co. Ltd | Hemiasterlin derivatives and uses thereof in the treatment of cancer |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| US20040121965A1 (en) * | 2002-09-20 | 2004-06-24 | Wyeth Holdings Corporation | Method of treating resistant tumors |
| EP1539682A2 (de) | 2002-09-20 | 2005-06-15 | Wyeth Holdings Corporation | Verfahren zur herstellung von zwischenprodukten für die synthese von tubulinhemmern |
| US20070026478A1 (en) * | 2002-11-21 | 2007-02-01 | Wyeth | Hemiasterlin affinity probes and their uses |
| US7390910B2 (en) | 2003-08-08 | 2008-06-24 | Wyeth | Compounds for treating tumors |
| GB201001070D0 (en) | 2010-01-22 | 2010-03-10 | St George's Hospital Medical School | Theraputic compounds and their use |
| HK1220626A1 (zh) * | 2013-03-15 | 2017-05-12 | The Centre For Drug Research And Development | 具细胞毒性和抗有丝分裂的化合物以及其使用方法 |
| KR102384740B1 (ko) * | 2013-12-27 | 2022-04-07 | 자임워크스 인코포레이티드 | 약물 접합체를 위한 설폰아마이드-함유 연결 시스템 |
| MX2016008448A (es) * | 2013-12-27 | 2017-01-09 | Zymeworks Inc | Conjugados de var2csa-farmaco. |
| ES2905569T3 (es) | 2014-09-17 | 2022-04-11 | Zymeworks Inc | Compuestos citotóxicos y antimitóticos y métodos para utilizarlos |
| CN114716506A (zh) * | 2015-01-30 | 2022-07-08 | 苏特罗生物制药公司 | 用于偶联和治疗的哈米特林（hemiasterlin）衍生物 |
| SI3464336T1 (sl) | 2016-06-01 | 2022-06-30 | Athira Pharma, Inc. | Spojine |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| WO2018128745A1 (en) | 2017-01-06 | 2018-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligands and methods of using the same |
| CN111051329B (zh) | 2017-08-10 | 2024-07-30 | 住友制药株式会社 | 哈米特林衍生物及它们的抗体药物复合物 |
| CA3072153A1 (en) | 2017-08-10 | 2019-02-14 | Sumitomo Dainippon Pharma Co., Ltd. | Antibody-drug conjugates including hemiasterlin derivative |
| CN113412271B (zh) | 2019-02-13 | 2024-10-22 | 住友制药株式会社 | 具有半胱氨酸残基的哈米特林衍生物 |
| US12178879B2 (en) | 2019-02-13 | 2024-12-31 | Sumitomo Pharma Co., Ltd. | Hemiasterlin derivative and antibody-drug conjugate thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1049404B (it) | 1975-04-09 | 1981-01-20 | Zambeletti Spa L | Tripeptidi loro esteri ed amidi ad attivita antiulcera |
| EP0150227A1 (de) | 1983-12-23 | 1985-08-07 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Dipeptidderivate und ihre Verwendung für die Bestimmung der Aktivität von Carboxypeptidasen |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| US4820691A (en) | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
| WO1991004040A1 (en) | 1989-09-15 | 1991-04-04 | Biomeasure, Inc. | Treatment of colon cancer |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5811515A (en) * | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| US5661175A (en) | 1995-06-20 | 1997-08-26 | Kashman; Yoel | Hemiasterlin and geodiamolide TA |
| DE69633623T2 (de) * | 1995-07-17 | 2005-12-01 | Medivir Uk Ltd. | Cystein-Protease-Inhibitoren für die Behandlung von allergischen Krankheiten verursacht duch IgE |
| US6214799B1 (en) * | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| US6331554B1 (en) * | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
| US6194578B1 (en) | 1998-11-20 | 2001-02-27 | Pfizer Inc. | Dipeptide derivatives |
-
1997
- 1997-12-19 CA CA002225325A patent/CA2225325A1/en not_active Abandoned
-
1998
- 1998-12-13 US US09/581,511 patent/US7579323B1/en not_active Expired - Fee Related
- 1998-12-18 HU HU0105460A patent/HUP0105460A3/hu unknown
- 1998-12-18 AU AU17459/99A patent/AU762691C/en not_active Ceased
- 1998-12-18 CN CNB988124343A patent/CN100422208C/zh not_active Expired - Fee Related
- 1998-12-18 EP EP98962157A patent/EP1040119B1/de not_active Expired - Lifetime
- 1998-12-18 IL IL13665498A patent/IL136654A0/xx unknown
- 1998-12-18 KR KR1020007006814A patent/KR100937756B1/ko not_active Expired - Fee Related
- 1998-12-18 CA CA2312826A patent/CA2312826C/en not_active Expired - Fee Related
- 1998-12-18 DK DK98962157T patent/DK1040119T3/da active
- 1998-12-18 BR BR9813817-0A patent/BR9813817A/pt not_active Application Discontinuation
- 1998-12-18 NZ NZ505086A patent/NZ505086A/en unknown
- 1998-12-18 WO PCT/CA1998/001184 patent/WO1999032509A2/en not_active Ceased
- 1998-12-18 DE DE69840415T patent/DE69840415D1/de not_active Expired - Lifetime
- 1998-12-18 JP JP2000525446A patent/JP4417551B2/ja not_active Expired - Fee Related
- 1998-12-18 ES ES98962157T patent/ES2320499T3/es not_active Expired - Lifetime
- 1998-12-18 AT AT98962157T patent/ATE419268T1/de not_active IP Right Cessation
-
2009
- 2009-06-25 US US12/491,839 patent/US20090264487A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1040119B1 (de) | 2008-12-31 |
| AU1745999A (en) | 1999-07-12 |
| AU762691B2 (en) | 2003-07-03 |
| CA2225325A1 (en) | 1999-06-19 |
| WO1999032509A2 (en) | 1999-07-01 |
| WO1999032509A3 (en) | 1999-10-07 |
| CN1282336A (zh) | 2001-01-31 |
| DK1040119T3 (da) | 2009-04-14 |
| ES2320499T3 (es) | 2009-05-22 |
| JP2001526294A (ja) | 2001-12-18 |
| CN100422208C (zh) | 2008-10-01 |
| DE69840415D1 (de) | 2009-02-12 |
| NZ505086A (en) | 2003-05-30 |
| AU762691C (en) | 2004-07-08 |
| EP1040119A2 (de) | 2000-10-04 |
| HK1034523A1 (zh) | 2001-10-26 |
| KR100937756B1 (ko) | 2010-01-20 |
| US7579323B1 (en) | 2009-08-25 |
| HUP0105460A2 (en) | 2002-06-29 |
| JP4417551B2 (ja) | 2010-02-17 |
| KR20010024783A (ko) | 2001-03-26 |
| CA2312826C (en) | 2013-06-11 |
| HUP0105460A3 (en) | 2002-08-28 |
| IL136654A0 (en) | 2001-06-14 |
| BR9813817A (pt) | 2000-10-10 |
| CA2312826A1 (en) | 1999-07-01 |
| US20090264487A1 (en) | 2009-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |