ATE256101T1 - Gelbe polymorphe form von 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypro yl)-isophthalamid - Google Patents

Gelbe polymorphe form von 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypro yl)-isophthalamid

Info

Publication number
ATE256101T1
ATE256101T1 AT98922947T AT98922947T ATE256101T1 AT E256101 T1 ATE256101 T1 AT E256101T1 AT 98922947 T AT98922947 T AT 98922947T AT 98922947 T AT98922947 T AT 98922947T AT E256101 T1 ATE256101 T1 AT E256101T1
Authority
AT
Austria
Prior art keywords
triiodo
isophthalamide
bis
amino
yellow
Prior art date
Application number
AT98922947T
Other languages
English (en)
Inventor
Dick Malthe-Sorenssen
Audun Aukrust
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health As filed Critical Amersham Health As
Application granted granted Critical
Publication of ATE256101T1 publication Critical patent/ATE256101T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Polyamides (AREA)
  • Indole Compounds (AREA)
AT98922947T 1997-05-23 1998-05-22 Gelbe polymorphe form von 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypro yl)-isophthalamid ATE256101T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710726.2A GB9710726D0 (en) 1997-05-23 1997-05-23 Compound
PCT/GB1998/001492 WO1998052911A1 (en) 1997-05-23 1998-05-22 Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide

Publications (1)

Publication Number Publication Date
ATE256101T1 true ATE256101T1 (de) 2003-12-15

Family

ID=10812988

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98922947T ATE256101T1 (de) 1997-05-23 1998-05-22 Gelbe polymorphe form von 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypro yl)-isophthalamid

Country Status (18)

Country Link
US (1) US6337422B1 (de)
EP (1) EP0983230B1 (de)
JP (1) JP4476366B2 (de)
KR (1) KR100543856B1 (de)
CN (1) CN1161324C (de)
AT (1) ATE256101T1 (de)
AU (1) AU725565B2 (de)
BR (1) BRPI9809153B8 (de)
CA (1) CA2290544A1 (de)
CZ (1) CZ297243B6 (de)
DE (1) DE69820435T2 (de)
GB (1) GB9710726D0 (de)
HU (1) HU224128B1 (de)
IL (1) IL133100A (de)
NO (1) NO327490B1 (de)
PL (1) PL190905B1 (de)
PT (1) PT983230E (de)
WO (1) WO1998052911A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524515B2 (en) * 2003-01-10 2009-04-28 Mutual Pharmaceuticals, Inc. Pharmaceutical safety dosage forms
EP1989179B1 (de) 2006-02-15 2011-01-26 Ge Healthcare As Kontrastmittel
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
CN102271715A (zh) 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
EP2281807A1 (de) * 2009-07-21 2011-02-09 GE Healthcare AS Entfärben von 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamid, ein Kontrastmittelzwischenprodukt
US20110021834A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous process of preparing intermediate for non-ionic x-ray contrast agents
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
JP6210988B2 (ja) 2011-09-19 2017-10-11 オレクソ・アクチエボラゲット オピオイド依存を治療するための新規乱用耐性医薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
JPH0625094B2 (ja) * 1988-03-01 1994-04-06 マリンクロット，インコーポレイテッド 非イオン性ｘ線コントラスト剤、組成物及び方法
US5013865A (en) * 1988-04-06 1991-05-07 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
US5256393A (en) * 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
DE69524088T2 (de) * 1994-06-21 2002-08-29 Mallinckrodt, Inc. Verbesserte synthese von ioversol unter verwendung einer mit phosphorsäure modifizierten koaddition
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
AU5773396A (en) * 1995-05-24 1996-12-11 Nycomed Imaging As Iodination process

Also Published As

Publication number Publication date
PT983230E (pt) 2004-04-30
JP2001526678A (ja) 2001-12-18
PL336848A1 (en) 2000-07-17
KR100543856B1 (ko) 2006-01-23
NO995676D0 (no) 1999-11-19
US6337422B1 (en) 2002-01-08
CN1257479A (zh) 2000-06-21
BRPI9809153A (pt) 2000-08-01
KR20010012794A (ko) 2001-02-26
CZ417199A3 (cs) 2000-05-17
GB9710726D0 (en) 1997-07-16
IL133100A0 (en) 2001-03-19
PL190905B1 (pl) 2006-02-28
HU224128B1 (hu) 2005-05-30
NO995676L (no) 1999-11-19
AU725565B2 (en) 2000-10-12
EP0983230A1 (de) 2000-03-08
CZ297243B6 (cs) 2006-10-11
JP4476366B2 (ja) 2010-06-09
HUP0003637A3 (en) 2001-06-28
CA2290544A1 (en) 1998-11-26
HUP0003637A1 (hu) 2001-02-28
IL133100A (en) 2004-07-25
AU7540798A (en) 1998-12-11
DE69820435D1 (en) 2004-01-22
WO1998052911A1 (en) 1998-11-26
NO327490B1 (no) 2009-07-13
EP0983230B1 (de) 2003-12-10
BRPI9809153B8 (pt) 2021-07-06
BRPI9809153B1 (pt) 2017-11-14
CN1161324C (zh) 2004-08-11
DE69820435T2 (de) 2004-10-07

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