ATE256116T1 - Isolierung und reinigung von paclitaxel und cephalomannine - Google Patents

Isolierung und reinigung von paclitaxel und cephalomannine

Info

Publication number: ATE256116T1
Authority: AT; Austria
Prior art keywords: paclitaxel; taxanes; unsaturated; mixture; taxane derivatives
Prior art date: 1995-12-13

Application number

AT96937101T

Other languages

English (en)

Inventor

Ramesh C Pandey

Luben K Yankov

Original Assignee

Xechem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-13

Filing date

1996-11-01

Publication date

2003-12-15

1995-12-13 Priority claimed from US08/572,240 external-priority patent/US5654448A/en

1996-11-01 Application filed by Xechem Inc filed Critical Xechem Inc

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE256116T1 publication Critical patent/ATE256116T1/de

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 5
229960001592 paclitaxel Drugs 0.000 title abstract 5
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 5
238000002955 isolation Methods 0.000 title abstract 2
238000000746 purification Methods 0.000 title 1
229940123237 Taxane Drugs 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 3
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 3
230000026030 halogenation Effects 0.000 abstract 2
238000005658 halogenation reaction Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000012454 non-polar solvent Substances 0.000 abstract 2
239000002798 polar solvent Substances 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
DBXFAPJCZABTDR-KUEXGRMWSA-N Cephalomannine Natural products O=C(O[C@@H]1C(C)=C2[C@@H](OC(=O)C)C(=O)[C@]3(C)[C@@H](O)C[C@@H]4[C@](OC(=O)C)([C@H]3[C@H](OC(=O)c3ccccc3)[C@@](O)(C2(C)C)C1)CO4)[C@@H](O)[C@H](NC(=O)/C(=C\C)/C)c1ccccc1 DBXFAPJCZABTDR-KUEXGRMWSA-N 0.000 abstract 1
241000233866 Fungi Species 0.000 abstract 1
241001116500 Taxus Species 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
DBXFAPJCZABTDR-WBYYIXQISA-N cephalomannine Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]31)OC(C)=O)C2(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C(/C)=C/C)C=1C=CC=CC=1)C(=O)C1=CC=CC=C1 DBXFAPJCZABTDR-WBYYIXQISA-N 0.000 abstract 1
239000000287 crude extract Substances 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
238000000638 solvent extraction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96937101T 1995-12-13 1996-11-01 Isolierung und reinigung von paclitaxel und cephalomannine ATE256116T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/572,240 US5654448A (en)	1995-10-02	1995-12-13	Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
PCT/US1996/017545 WO1997021696A1 (en)	1995-12-13	1996-11-01	Isolation and purification of paclitaxel and cephalomannine

Publications (1)

Publication Number	Publication Date
ATE256116T1 true ATE256116T1 (de)	2003-12-15

Family

ID=29712450

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96937101T ATE256116T1 (de)	1995-12-13	1996-11-01	Isolierung und reinigung von paclitaxel und cephalomannine

Country Status (4)

Country	Link
KR (1)	KR100467531B1 (de)
AT (1)	ATE256116T1 (de)
DE (1)	DE69631036T2 (de)
MX (1)	MX9706180A (de)

1996
- 1996-11-01 KR KR1019970705563A patent/KR100467531B1/ko not_active Expired - Fee Related
- 1996-11-01 DE DE69631036T patent/DE69631036T2/de not_active Expired - Fee Related
- 1996-11-01 MX MX9706180A patent/MX9706180A/es not_active IP Right Cessation
- 1996-11-01 AT AT96937101T patent/ATE256116T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
MX9706180A (es)	1997-11-29
DE69631036D1 (de)	2004-01-22
DE69631036T2 (de)	2004-09-09
KR100467531B1 (ko)	2005-12-16
KR19980702168A (ko)	1998-07-15
HK1005375A1 (en)	1999-01-08

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