ATE256117T1 - Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen - Google Patents
Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogenInfo
- Publication number
- ATE256117T1 ATE256117T1 AT00932151T AT00932151T ATE256117T1 AT E256117 T1 ATE256117 T1 AT E256117T1 AT 00932151 T AT00932151 T AT 00932151T AT 00932151 T AT00932151 T AT 00932151T AT E256117 T1 ATE256117 T1 AT E256117T1
- Authority
- AT
- Austria
- Prior art keywords
- paclitaxel
- cleavage
- analogues
- taxane
- silyl ethers
- Prior art date
Links
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 9
- 229930012538 Paclitaxel Natural products 0.000 title abstract 6
- 229960001592 paclitaxel Drugs 0.000 title abstract 6
- 238000003776 cleavage reaction Methods 0.000 title abstract 2
- 230000007017 scission Effects 0.000 title abstract 2
- -1 SILYL ETHERS Chemical class 0.000 title 1
- 229940123237 Taxane Drugs 0.000 abstract 4
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 3
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 238000007086 side reaction Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13446999P | 1999-05-17 | 1999-05-17 | |
| PCT/US2000/012469 WO2000069840A1 (en) | 1999-05-17 | 2000-05-08 | Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol®) and paclitaxel analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE256117T1 true ATE256117T1 (de) | 2003-12-15 |
Family
ID=22463532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00932151T ATE256117T1 (de) | 1999-05-17 | 2000-05-08 | Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6184395B1 (de) |
| EP (1) | EP1178979B1 (de) |
| JP (1) | JP2002544269A (de) |
| KR (1) | KR100648125B1 (de) |
| AT (1) | ATE256117T1 (de) |
| AU (1) | AU761389B2 (de) |
| CA (1) | CA2373819A1 (de) |
| DE (1) | DE60007115T2 (de) |
| DK (1) | DK1178979T3 (de) |
| ES (1) | ES2211550T3 (de) |
| HK (1) | HK1042302B (de) |
| HU (1) | HUP0201176A3 (de) |
| IL (1) | IL144976A0 (de) |
| MX (1) | MXPA01011046A (de) |
| PT (1) | PT1178979E (de) |
| TW (1) | TWI257387B (de) |
| WO (1) | WO2000069840A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6750246B1 (en) | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
| US6916942B2 (en) * | 2000-02-03 | 2005-07-12 | Bristol-Myers Squibb Company | Process for the preparation of C-4 carbonate taxanes |
| US7410980B2 (en) * | 2001-11-29 | 2008-08-12 | Daiichi Pharmaceutical Co., Ltd. | Crystals of taxane derivative and process for their production |
| EP1465618A2 (de) * | 2001-12-20 | 2004-10-13 | Bristol-Myers Squibb Company | Pharmazeutische zusammensetzungen oral aktiver taxanderivate mit verbesserter bioverfügbarkeit |
| CA2741496C (en) | 2002-08-04 | 2013-01-08 | Natural Pharmaceuticals, Inc. | Methods and compositions for converting taxane amides to paclitaxel or other taxanes |
| US8703982B2 (en) | 2003-03-17 | 2014-04-22 | Phyton Holdings Llc | Purification of taxanes |
| JP4499383B2 (ja) * | 2003-07-11 | 2010-07-07 | 良明 木曽 | 水溶性プロドラッグ |
| FR2859996B1 (fr) * | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| FR2882362B1 (fr) * | 2005-02-23 | 2007-05-11 | Seripharm | Procede de preparation du paclitaxel |
| US20090292131A1 (en) * | 2008-05-07 | 2009-11-26 | Ladislav Cvak | Processes for preparation of taxanes and intermediates thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| USRE34277E (en) | 1988-04-06 | 1993-06-08 | Centre National De La Recherche Scientifique | Process for preparing taxol |
| FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
| FR2687150B1 (fr) * | 1992-02-07 | 1995-04-28 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
| FR2702212B1 (fr) | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| TW467896B (en) | 1993-03-19 | 2001-12-11 | Bristol Myers Squibb Co | Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes |
| FR2718135B1 (fr) * | 1994-04-05 | 1996-04-26 | Rhone Poulenc Rorer Sa | Procédé de préparation d'hydroxy-7 taxanes. |
| EP1087955A1 (de) * | 1998-04-20 | 2001-04-04 | Lolita Zamir | Die halbsynthese von baccatin iii |
-
2000
- 2000-05-08 IL IL14497600A patent/IL144976A0/xx active IP Right Grant
- 2000-05-08 DE DE60007115T patent/DE60007115T2/de not_active Expired - Fee Related
- 2000-05-08 HK HK02104143.6A patent/HK1042302B/en not_active IP Right Cessation
- 2000-05-08 PT PT00932151T patent/PT1178979E/pt unknown
- 2000-05-08 EP EP00932151A patent/EP1178979B1/de not_active Expired - Lifetime
- 2000-05-08 HU HU0201176A patent/HUP0201176A3/hu unknown
- 2000-05-08 JP JP2000618257A patent/JP2002544269A/ja active Pending
- 2000-05-08 MX MXPA01011046A patent/MXPA01011046A/es active IP Right Grant
- 2000-05-08 ES ES00932151T patent/ES2211550T3/es not_active Expired - Lifetime
- 2000-05-08 AT AT00932151T patent/ATE256117T1/de not_active IP Right Cessation
- 2000-05-08 CA CA002373819A patent/CA2373819A1/en not_active Abandoned
- 2000-05-08 AU AU49920/00A patent/AU761389B2/en not_active Ceased
- 2000-05-08 KR KR1020017014635A patent/KR100648125B1/ko not_active Expired - Fee Related
- 2000-05-08 WO PCT/US2000/012469 patent/WO2000069840A1/en not_active Ceased
- 2000-05-08 DK DK00932151T patent/DK1178979T3/da active
- 2000-05-11 TW TW089109043A patent/TWI257387B/zh not_active IP Right Cessation
- 2000-05-16 US US09/571,234 patent/US6184395B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60007115T2 (de) | 2004-09-02 |
| JP2002544269A (ja) | 2002-12-24 |
| CA2373819A1 (en) | 2000-11-23 |
| KR20010112493A (ko) | 2001-12-20 |
| HUP0201176A2 (en) | 2002-08-28 |
| HK1042302B (en) | 2004-10-08 |
| AU761389B2 (en) | 2003-06-05 |
| MXPA01011046A (es) | 2002-07-22 |
| US6184395B1 (en) | 2001-02-06 |
| KR100648125B1 (ko) | 2006-11-24 |
| DE60007115D1 (de) | 2004-01-22 |
| ES2211550T3 (es) | 2004-07-16 |
| TWI257387B (en) | 2006-07-01 |
| HUP0201176A3 (en) | 2005-02-28 |
| EP1178979B1 (de) | 2003-12-10 |
| WO2000069840A1 (en) | 2000-11-23 |
| AU4992000A (en) | 2000-12-05 |
| IL144976A0 (en) | 2002-06-30 |
| DK1178979T3 (da) | 2004-03-22 |
| EP1178979A1 (de) | 2002-02-13 |
| PT1178979E (pt) | 2004-04-30 |
| HK1042302A1 (en) | 2003-12-19 |
| EP1178979A4 (de) | 2002-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1178979 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |