ATE256117T1 - Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen - Google Patents

Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen

Info

Publication number: ATE256117T1
Authority: AT; Austria
Prior art keywords: paclitaxel; cleavage; analogues; taxane; silyl ethers
Prior art date: 1999-05-17

Application number

AT00932151T

Other languages

English (en)

Inventor

Ambarish Singh

Raymond E Weaver Jr

Gerald L Powers

Victor W Rosso

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-17

Filing date

2000-05-08

Publication date

2003-12-15

2000-05-08 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE256117T1 publication Critical patent/ATE256117T1/de

Links

RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 9
229930012538 Paclitaxel Natural products 0.000 title abstract 6
229960001592 paclitaxel Drugs 0.000 title abstract 6
238000003776 cleavage reaction Methods 0.000 title abstract 2
230000007017 scission Effects 0.000 title abstract 2
-1 SILYL ETHERS Chemical class 0.000 title 1
229940123237 Taxane Drugs 0.000 abstract 4
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
239000002243 precursor Substances 0.000 abstract 3
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
238000007086 side reaction Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)

AT00932151T 1999-05-17 2000-05-08 Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen ATE256117T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13446999P	1999-05-17	1999-05-17
PCT/US2000/012469 WO2000069840A1 (en)	1999-05-17	2000-05-08	Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol®) and paclitaxel analogues

Publications (1)

Publication Number	Publication Date
ATE256117T1 true ATE256117T1 (de)	2003-12-15

Family

ID=22463532

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00932151T ATE256117T1 (de)	1999-05-17	2000-05-08	Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen

Country Status (17)

Country	Link
US (1)	US6184395B1 (de)
EP (1)	EP1178979B1 (de)
JP (1)	JP2002544269A (de)
KR (1)	KR100648125B1 (de)
AT (1)	ATE256117T1 (de)
AU (1)	AU761389B2 (de)
CA (1)	CA2373819A1 (de)
DE (1)	DE60007115T2 (de)
DK (1)	DK1178979T3 (de)
ES (1)	ES2211550T3 (de)
HK (1)	HK1042302B (de)
HU (1)	HUP0201176A3 (de)
IL (1)	IL144976A0 (de)
MX (1)	MXPA01011046A (de)
PT (1)	PT1178979E (de)
TW (1)	TWI257387B (de)
WO (1)	WO2000069840A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6750246B1 (en)	2000-02-03	2004-06-15	Bristol-Myers Squibb Company	C-4 carbonate taxanes
US6916942B2 (en) *	2000-02-03	2005-07-12	Bristol-Myers Squibb Company	Process for the preparation of C-4 carbonate taxanes
CA2468953C (en) *	2001-11-29	2010-05-11	Daiichi Pharmaceutical Co., Ltd.	Taxane derivative crystal and method for preparing the same
EP1465618A2 (de) *	2001-12-20	2004-10-13	Bristol-Myers Squibb Company	Pharmazeutische zusammensetzungen oral aktiver taxanderivate mit verbesserter bioverfügbarkeit
ES2503265T3 (es)	2002-08-04	2014-10-06	Phyton Holdings, Llc	Métodos para convertir amidas de taxano en paclitaxel u otros taxanos
US8703982B2 (en)	2003-03-17	2014-04-22	Phyton Holdings Llc	Purification of taxanes
JP4499383B2 (ja) *	2003-07-11	2010-07-07	良明木曽	水溶性プロドラッグ
FR2859996B1 (fr) *	2003-09-19	2006-02-03	Aventis Pharma Sa	Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2882362B1 (fr) *	2005-02-23	2007-05-11	Seripharm	Procede de preparation du paclitaxel
WO2009137084A2 (en) *	2008-05-07	2009-11-12	Ivax Research, Llc	Processes for preparation of taxanes and intermediates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601676B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
USRE34277E (en)	1988-04-06	1993-06-08	Centre National De La Recherche Scientifique	Process for preparing taxol
FR2687150B1 (fr) *	1992-02-07	1995-04-28	Rhone Poulenc Rorer Sa	Procede de preparation de derives du taxane.
FR2702212B1 (fr)	1993-03-02	1995-04-07	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW467896B (en)	1993-03-19	2001-12-11	Bristol Myers Squibb Co	Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
FR2718135B1 (fr) *	1994-04-05	1996-04-26	Rhone Poulenc Rorer Sa	Procédé de préparation d'hydroxy-7 taxanes.
AU3402699A (en) *	1998-04-20	1999-11-08	Gaetan Caron	The semi-synthesis of baccatin iii

2000
- 2000-05-08 AT AT00932151T patent/ATE256117T1/de not_active IP Right Cessation
- 2000-05-08 IL IL14497600A patent/IL144976A0/xx active IP Right Grant
- 2000-05-08 MX MXPA01011046A patent/MXPA01011046A/es active IP Right Grant
- 2000-05-08 EP EP00932151A patent/EP1178979B1/de not_active Expired - Lifetime
- 2000-05-08 KR KR1020017014635A patent/KR100648125B1/ko not_active Expired - Fee Related
- 2000-05-08 HU HU0201176A patent/HUP0201176A3/hu unknown
- 2000-05-08 CA CA002373819A patent/CA2373819A1/en not_active Abandoned
- 2000-05-08 AU AU49920/00A patent/AU761389B2/en not_active Ceased
- 2000-05-08 ES ES00932151T patent/ES2211550T3/es not_active Expired - Lifetime
- 2000-05-08 PT PT00932151T patent/PT1178979E/pt unknown
- 2000-05-08 WO PCT/US2000/012469 patent/WO2000069840A1/en not_active Ceased
- 2000-05-08 DE DE60007115T patent/DE60007115T2/de not_active Expired - Fee Related
- 2000-05-08 DK DK00932151T patent/DK1178979T3/da active
- 2000-05-08 JP JP2000618257A patent/JP2002544269A/ja active Pending
- 2000-05-08 HK HK02104143.6A patent/HK1042302B/en not_active IP Right Cessation
- 2000-05-11 TW TW089109043A patent/TWI257387B/zh not_active IP Right Cessation
- 2000-05-16 US US09/571,234 patent/US6184395B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60007115D1 (de)	2004-01-22
AU761389B2 (en)	2003-06-05
JP2002544269A (ja)	2002-12-24
EP1178979A4 (de)	2002-06-12
KR100648125B1 (ko)	2006-11-24
HK1042302A1 (en)	2003-12-19
EP1178979B1 (de)	2003-12-10
HUP0201176A2 (en)	2002-08-28
WO2000069840A1 (en)	2000-11-23
AU4992000A (en)	2000-12-05
KR20010112493A (ko)	2001-12-20
HK1042302B (en)	2004-10-08
TWI257387B (en)	2006-07-01
CA2373819A1 (en)	2000-11-23
EP1178979A1 (de)	2002-02-13
IL144976A0 (en)	2002-06-30
HUP0201176A3 (en)	2005-02-28
US6184395B1 (en)	2001-02-06
ES2211550T3 (es)	2004-07-16
DE60007115T2 (de)	2004-09-02
MXPA01011046A (es)	2002-07-22
DK1178979T3 (da)	2004-03-22
PT1178979E (pt)	2004-04-30

Legal Events

Date

Code

Title

Description

2004-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1178979

Country of ref document: EP

2009-02-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE256117T1 (de)	2003-12-15	Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen
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EP1785416A3 (de)	2007-05-30	9, 10-Alpha, Alpha-OH-Taxan-Analogen und Herstellungsverfahren dafür
IL166985A (en)	2010-04-15	Method for the purification of lansoprazole
DE60102000T2 (de)	2004-07-29	Verfahren zur herstellung von flavonoiden
EP0918764B1 (de)	2004-05-12	Methoden zur selektiven acylierung von 10-deacetylbaccatin iii in der c-10 position
NO20011634L (no)	2001-05-30	Krystall av diuridintetrafosfat eller salter derav, og fremgangsmåte for fremstilling av samme og fremgangsmåte forfremstilling av nevnte forbindelse
TW200633977A (en)	2006-10-01	Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
MX2007004157A (es)	2007-06-20	Procedimiento de semisintesis para la preparacion de 10-desacetil-n-debenzoil-paclitaxel.
DE69502772T2 (de)	1998-11-05	Baccatinderivate und Verfahren zu ihrer Herstellung
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US8299279B2 (en)	2012-10-30	Semi-synthetic process for the preparation of taxane derivatives
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