ATE256137T1 - Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament - Google Patents

Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament

Info

Publication number: ATE256137T1
Authority: AT; Austria
Prior art keywords: keratanesulfatoligosaccharide; fraction; sulfated; gal; containing same
Prior art date: 1994-12-01

Application number

AT95937170T

Other languages

English (en)

Inventor

Hiroshi Maruyama

Kiyoshi Morikawa

Akira Tawada

Satoshi Miyauchi

Keiichi Yoshida

Akira Asari

Original Assignee

Seikagaku Kogyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-01

Filing date

1995-11-22

Publication date

2003-12-15

1995-11-22 Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE256137T1 publication Critical patent/ATE256137T1/de

Links

229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 2
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 2
239000000411 inducer Substances 0.000 abstract 2
FZHXIRIBWMQPQF-UHFFFAOYSA-N Glc-NH2 Natural products O=CC(N)C(O)C(O)C(O)CO FZHXIRIBWMQPQF-UHFFFAOYSA-N 0.000 abstract 1
229920000288 Keratan sulfate Polymers 0.000 abstract 1
OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000000043 antiallergic agent Substances 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
150000002016 disaccharides Chemical class 0.000 abstract 1
229930182830 galactose Natural products 0.000 abstract 1
229960002442 glucosamine Drugs 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000002955 immunomodulating agent Substances 0.000 abstract 1
229940121354 immunomodulator Drugs 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
-1 keratan sulfate oligosaccharide Chemical class 0.000 abstract 1
229920001542 oligosaccharide Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Hematology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Rheumatology (AREA)
Materials Engineering (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Microbiology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Polymers & Plastics (AREA)

AT95937170T 1994-12-01 1995-11-22 Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament ATE256137T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP29829894		1994-12-01
PCT/JP1995/002386 WO1996016973A1 (en)	1994-12-01	1995-11-22	Keratan sulfate oligosaccharide fraction and drug containing the same

Publications (1)

Publication Number	Publication Date
ATE256137T1 true ATE256137T1 (de)	2003-12-15

Family

ID=17857841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937170T ATE256137T1 (de)	1994-12-01	1995-11-22	Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament

Country Status (10)

Country	Link
US (2)	US5939403A (de)
EP (1)	EP0795560B1 (de)
JP (3)	JP4429386B2 (de)
CN (1)	CN1174557A (de)
AT (1)	ATE256137T1 (de)
AU (1)	AU704429B2 (de)
CA (1)	CA2206611A1 (de)
DE (1)	DE69532293T2 (de)
HU (1)	HUT77134A (de)
WO (1)	WO1996016973A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5888984A (en) *	1994-05-12	1999-03-30	Dermal Research Laboratories, Inc.	Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
JP4023848B2 (ja) *	1996-03-29	2007-12-19	生化学工業株式会社	硫酸化ラクトサミンオリゴ糖の製造方法
AU3276697A (en) *	1996-07-10	1998-02-02	Takara Shuzo Co., Ltd.	Cell compositions
WO1998003524A1 (fr)	1996-07-23	1998-01-29	Seikagaku Corporation	Nouveaux oligosaccharides a base de lactosamine et procede de preparation
AU1214999A (en) *	1998-01-22	1999-08-12	Seikagaku Corporation	Antifibrotic agent
US20050159390A1 (en) *	1998-01-29	2005-07-21	Yash Sharma	Treatment and prevention of HIV and other viral infections
FR2774289B1 (fr) *	1998-02-03	2002-05-24	Goemar Lab Sa	Medicament pour le traitement des dereglements de l'apoptose
AU6557299A (en) *	1999-01-07	2000-07-13	Seikagaku Corporation	Method for producing oligosaccharide, and novel oligosaccharide and pharaceutical composition containing the same
JP4913272B2 (ja) *	1999-01-07	2012-04-11	生化学工業株式会社	オリゴ糖の製造方法ならびに新規オリゴ糖およびそれを含む医薬組成物
US6518302B1 (en)	1999-01-20	2003-02-11	Takara Shuzo Co., Ltd.	Remedies
EP1165097B1 (de)	1999-02-01	2007-05-02	Dermal Research Laboratories, Inc.	Pharmazeutische zusammensetzung aus komplexen kohlenhydraten deren anwendung
FR2789587B1 (fr) *	1999-02-11	2003-01-24	Inst Nat Sante Rech Med	Moyens pour la regulation de la differenciation hematopoietique
JP4676049B2 (ja) *	1999-07-21	2011-04-27	生化学工業株式会社	Ｉｌ−１２産生抑制剤
DE60008319T2 (de) *	1999-07-21	2004-12-09	Seikagaku Corp.	IL-12 Produktionsinhibitor
FR2808687B1 (fr) *	2000-04-27	2003-12-05	Goemar Lab Sa	Medicament contenant des substances polysaccharidiques pour l'activation de l'apoptose
JP4676048B2 (ja) *	2000-07-10	2011-04-27	生化学工業株式会社	脱髄性疾患処置剤
US7879824B2 (en)	2001-07-31	2011-02-01	Dermal Research Laboratories, Inc.	Methods of preventing or treating diseases and conditions using complex carbohydrates
WO2002103025A1 (fr) *	2001-06-14	2002-12-27	National Institute Of Advanced Industrial Science And Technology	Nouveau saccharide sulfate et procede de production associe
EP1438387A4 (de) *	2001-09-14	2004-10-13	Momenta Pharmaceuticals Inc	Verfahren zur herstellung von glycomolekülen mit verstärkten aktivitäten und verwendungen davon
DE10214507A1 (de) *	2002-04-02	2003-10-16	Beiersdorf Ag	Verwendung von Acarbose und deren Derivaten zur Behandlung und Prophylaxe degenerativer Hautzustände
JP4530633B2 (ja) *	2003-09-19	2010-08-25	生化学工業株式会社	シグナル伝達物質産生抑制剤
US20070099867A1 (en) *	2005-05-24	2007-05-03	Glycoscience Laboratories, Inc.	Pharmaceutical agent containing hyaluronan as an active ingredient
JP2009091248A (ja) *	2006-01-17	2009-04-30	Toshitsu Kagaku Kenkyusho:Kk	外傷性神経障害および／または運動機能障害の治療薬
EP1994934A4 (de)	2006-12-05	2010-03-10	Glycoscience Lab Inc	Therapeutisches mittel gegen degenerative arthritis
US20110059508A1 (en) *	2007-06-29	2011-03-10	National University Corporation Nagoya University	Improving agent for dysfunction due to neuropathy and rho kinase activation inhibitor
FR2920310B1 (fr) *	2007-09-03	2012-10-19	Natura Cosmeticos Sa	Procede pour la preparation d'un extrait vegetal de passiflora alata et utilisation dudit extrait dans des compositions cosmetiques et pharmaceutiques
WO2011105424A1 (ja) *	2010-02-23	2011-09-01	国立大学法人東京大学	樹状細胞免疫受容体刺激剤
WO2011127322A1 (en)	2010-04-07	2011-10-13	Momenta Pharmaceuticals, Inc.	High mannose glycans
EP2686671A4 (de)	2011-03-12	2015-06-24	Momenta Pharmaceuticals Inc	N-acetylhexosamin-haltige n-glykane in glycoproteinprodukten
WO2013181575A2 (en)	2012-06-01	2013-12-05	Momenta Pharmaceuticals, Inc.	Methods related to denosumab
EP2877589B1 (de)	2012-07-26	2024-03-06	Momenta Pharmaceuticals, Inc.	Glykoproteine mit entzündungshemmenden eigenschaften
CN103006560B (zh) *	2012-12-12	2014-10-15	上海市第六人民医院	透明质酸寡聚糖包裹的紫杉醇脂质体及其制备方法
US10450361B2 (en)	2013-03-15	2019-10-22	Momenta Pharmaceuticals, Inc.	Methods related to CTLA4-Fc fusion proteins
WO2014186310A1 (en)	2013-05-13	2014-11-20	Momenta Pharmaceuticals, Inc.	Methods for the treatment of neurodegeneration
EP3034085B1 (de)	2013-08-13	2019-10-23	Seikagaku Corporation	Arzneimittel mit kationisiertem chitosan
WO2015057622A1 (en)	2013-10-16	2015-04-23	Momenta Pharmaceuticals, Inc.	Sialylated glycoproteins
HUE053192T2 (hu)	2014-03-21	2021-06-28	Altergon Sa	Kondriotin-szulfát tisztítási módszer
WO2016006700A1 (ja)	2014-07-11	2016-01-14	学校法人東京理科大学	樹状細胞免疫受容体活性化剤、樹状細胞免疫受容体活性化方法、破骨細胞形成抑制剤、破骨細胞形成抑制方法、樹状細胞分化・増殖阻害剤、樹状細胞分化・増殖阻害方法、サイトカイン産生抑制剤、サイトカイン産生抑制方法、治療方法及びスクリーニング方法
JP7103581B2 (ja)	2017-05-12	2022-07-20	学校法人東京理科大学	糖鎖修飾酵素を含む医薬組成物及び医薬組成物を用いた樹状細胞免疫受容体関連疾患の治療方法
IT201900023142A1 (it) *	2019-12-05	2021-06-05	Sifi Spa	Composizione topica oculare contenente metaboliti della fermentazione di lactobacillus

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU561067B2 (en) *	1982-03-22	1987-04-30	Biocarb Ab	Anti-bacterial composition containing an oligosaccharide
EP0240098A3 (de) *	1986-04-04	1989-05-10	Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo	Oligo und Polysaccharide zur Behandlung von Krankheiten verursacht durch Retroviren
IT1213384B (it) *	1986-11-24	1989-12-20	Lab Derivati Organici Mediolan	Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
JP2726274B2 (ja) *	1988-08-24	1998-03-11	生化学工業株式会社	新規ケラタン硫酸分解酵素並びにそれを生産する微生物及び方法
JPH0296588A (ja) *	1988-09-29	1990-04-09	Rikagaku Kenkyusho	硫酸化オリゴ糖及びその関連物質
US5510418A (en) *	1988-11-21	1996-04-23	Collagen Corporation	Glycosaminoglycan-synthetic polymer conjugates
EP0493533A4 (en) *	1989-10-27	1992-10-28	Case Western Reserve University	Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
JP3037987B2 (ja) *	1990-09-28	2000-05-08	生化学工業株式会社	グリコサミノグリカンの分析方法
WO1993024506A1 (en) *	1992-05-26	1993-12-09	Alberta Research Council	IMMUNOSUPPRESSIVE AND TOLEROGENIC MODIFIED LEWISC AND LacNAc COMPOUNDS
MX9304638A (es) *	1992-07-31	1994-05-31	Neose Pharm Inc	Composicion para tratar e inhibir las ulceras gastricas y duodenales.
AU4859793A (en) *	1992-09-11	1994-04-12	Regents Of The University Of California, The	Sulfated ligands for l-selectins and use of chlorates and or sulfatases for the treatment of inflammation
AU7205894A (en) *	1993-06-08	1995-01-03	Neogenix, Inc.	Purified natural and synthetic compounds for the treatment of osteoarthritis
AU1255695A (en) *	1993-11-19	1995-06-06	Regents Of The University Of California, The	Sulfated ligands for l-selectin and methods of preventing sulfate addition
GB9422584D0 (en) *	1994-02-15	1995-01-04	Medical Res Council	Immunomodulation using oligosaccharides
DE69532591T2 (de) *	1994-11-22	2004-11-11	Seikagaku Corp.	Neuartige keratansulfat-hydrolase

1995
- 1995-11-22 CA CA002206611A patent/CA2206611A1/en not_active Abandoned
- 1995-11-22 AU AU39356/95A patent/AU704429B2/en not_active Ceased
- 1995-11-22 DE DE69532293T patent/DE69532293T2/de not_active Expired - Lifetime
- 1995-11-22 US US08/849,925 patent/US5939403A/en not_active Expired - Lifetime
- 1995-11-22 EP EP95937170A patent/EP0795560B1/de not_active Expired - Lifetime
- 1995-11-22 HU HU9701820A patent/HUT77134A/hu unknown
- 1995-11-22 CN CN95197492A patent/CN1174557A/zh active Pending
- 1995-11-22 JP JP51857396A patent/JP4429386B2/ja not_active Expired - Fee Related
- 1995-11-22 AT AT95937170T patent/ATE256137T1/de not_active IP Right Cessation
- 1995-11-22 WO PCT/JP1995/002386 patent/WO1996016973A1/ja not_active Ceased
1999
- 1999-05-24 US US09/317,380 patent/US6159954A/en not_active Expired - Lifetime
2008
- 2008-08-11 JP JP2008207058A patent/JP2009019044A/ja active Pending
2009
- 2009-09-29 JP JP2009224150A patent/JP5001989B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2206611A1 (en)	1996-06-06
AU704429B2 (en)	1999-04-22
JP4429386B2 (ja)	2010-03-10
HUT77134A (hu)	1998-03-02
CN1174557A (zh)	1998-02-25
DE69532293T2 (de)	2004-10-21
AU3935695A (en)	1996-06-19
JP5001989B2 (ja)	2012-08-15
JP2009019044A (ja)	2009-01-29
US5939403A (en)	1999-08-17
DE69532293D1 (de)	2004-01-22
EP0795560A4 (de)	1998-09-02
EP0795560A1 (de)	1997-09-17
EP0795560B1 (de)	2003-12-10
US6159954A (en)	2000-12-12
JP2010046070A (ja)	2010-03-04
WO1996016973A1 (en)	1996-06-06

Legal Events

Date	Code	Title	Description
2004-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE256137T1 (de)	2003-12-15	Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament
Chevolot et al.	2001	A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
ES2129037T3 (es)	1999-06-01	Heparosanos-n,o-sulfatados de alta masa molecular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DE69918523D1 (de)	2004-08-12	Neues glycosaminoglycan und dieses enthaltendes arzneimittel
WO1999057301A8 (en)	2000-01-06	Compounds having glucuronic acid derivatives and glucosamine derivatives in the structure, process for producing the same and utilization thereof
MY109669A (en)	1997-03-31	N,o-sulphated heparosans, process for, preparing them and pharmaceutical compositions containing them
ATE193023T1 (de)	2000-06-15	Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit
Toida et al.	1999	Preparation and anticoagulant activity of fully O-sulphonated glycosaminoglycans
KR930004324A (ko)	1993-03-22	황산화 글리코자미노글리카노이드 유도체
KR950008528A (ko)	1995-04-19	두개의 당류와 하나의 스페이서(spacer)를 함유하는 이결합체
AU737680C (en)	2002-05-02	Novel compounds having antiviral activity
WO1998040081A1 (en)	1998-09-17	Sulfated oligosaccharides having anticoagulant/antithrombotic activity
NO306305B1 (no)	1999-10-18	Halvsyntetiske glykosaminoglykaner som inneholder <alfa>-L-galakturonsyre med et nukleofilt radikal i 3-stillingen, samt fremgangsmÕte til fremstilling av samme
CA2063850A1 (en)	1992-09-27	Sulfated tocopheryl oligosaccharides and antiviral agents including the same as active ingredients
AU8748298A (en)	1999-03-16	Oligosaccharide derivatives and process for producing the same
DE69218438D1 (de)	1997-04-24	Dermatansulfatoligosaccharide, Verfahren zu ihrer Herstellung und diese enthaltende phamazeutische Zusammensetzungen
CA2258146A1 (fr)	1997-12-18	Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
NO914077L (no)	1992-04-21	Galaktomannanderivater for omhylling eller innleiring av aktive bestanddeler i legemidler
JPS643116A (en)	1989-01-06	Plaster for patch
AU5833694A (en)	1994-07-19	Oligosaccharides having biological activity and preparation of same from glycosaminoglycans
AU2676200A (en)	2000-08-29	Means for regulating hematopoietic differentiation
Casu	1990	Structure, shape and function of glycosaminoglycans
AU721179B2 (en)	2000-06-22	Sulfated oligosaccharides having anticoagulant/antithrombotic activity
DE3780080D1 (de)	1992-08-06	Coccidiozide mittel.
RU97111163A (ru)	1999-06-10	Фракция кератансульфатолигосахаридов и содержащий ее фармацевтический препарат