ATE256137T1 - Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament - Google Patents

Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament

Info

Publication number: ATE256137T1
Authority: AT; Austria
Prior art keywords: keratanesulfatoligosaccharide; fraction; sulfated; gal; containing same
Prior art date: 1994-12-01

Application number

AT95937170T

Other languages

English (en)

Inventor

Hiroshi Maruyama

Kiyoshi Morikawa

Akira Tawada

Satoshi Miyauchi

Keiichi Yoshida

Akira Asari

Original Assignee

Seikagaku Kogyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-01

Filing date

1995-11-22

Publication date

2003-12-15

1995-11-22 Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE256137T1 publication Critical patent/ATE256137T1/de

Links

229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 2
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 2
239000000411 inducer Substances 0.000 abstract 2
FZHXIRIBWMQPQF-UHFFFAOYSA-N Glc-NH2 Natural products O=CC(N)C(O)C(O)C(O)CO FZHXIRIBWMQPQF-UHFFFAOYSA-N 0.000 abstract 1
229920000288 Keratan sulfate Polymers 0.000 abstract 1
OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000000043 antiallergic agent Substances 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
150000002016 disaccharides Chemical class 0.000 abstract 1
229930182830 galactose Natural products 0.000 abstract 1
229960002442 glucosamine Drugs 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000002955 immunomodulating agent Substances 0.000 abstract 1
229940121354 immunomodulator Drugs 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
-1 keratan sulfate oligosaccharide Chemical class 0.000 abstract 1
229920001542 oligosaccharide Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- C—CHEMISTRY; METALLURGY
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- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Reproductive Health (AREA)
General Engineering & Computer Science (AREA)
Polymers & Plastics (AREA)
Rheumatology (AREA)
Materials Engineering (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Microbiology (AREA)
Oncology (AREA)

AT95937170T 1994-12-01 1995-11-22 Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament ATE256137T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP29829894		1994-12-01
PCT/JP1995/002386 WO1996016973A1 (en)	1994-12-01	1995-11-22	Keratan sulfate oligosaccharide fraction and drug containing the same

Publications (1)

Publication Number	Publication Date
ATE256137T1 true ATE256137T1 (de)	2003-12-15

Family

ID=17857841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937170T ATE256137T1 (de)	1994-12-01	1995-11-22	Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament

Country Status (10)

Country	Link
US (2)	US5939403A (de)
EP (1)	EP0795560B1 (de)
JP (3)	JP4429386B2 (de)
CN (1)	CN1174557A (de)
AT (1)	ATE256137T1 (de)
AU (1)	AU704429B2 (de)
CA (1)	CA2206611A1 (de)
DE (1)	DE69532293T2 (de)
HU (1)	HUT77134A (de)
WO (1)	WO1996016973A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5888984A (en) *	1994-05-12	1999-03-30	Dermal Research Laboratories, Inc.	Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
JP4023848B2 (ja) *	1996-03-29	2007-12-19	生化学工業株式会社	硫酸化ラクトサミンオリゴ糖の製造方法
JP3683912B2 (ja) *	1996-07-10	2005-08-17	タカラバイオ株式会社	細胞組成物
EP0926154B1 (de)	1996-07-23	2010-01-27	Seikagaku Corporation	Neue laktosamin-oligosaccharide und verfahren zu ihrer herstellung
AU1214999A (en) *	1998-01-22	1999-08-12	Seikagaku Corporation	Antifibrotic agent
US20050148541A1 (en) *	1998-01-29	2005-07-07	Yash Sharma	Treatment and prevention of HIV and other viral infections
FR2774289B1 (fr) *	1998-02-03	2002-05-24	Goemar Lab Sa	Medicament pour le traitement des dereglements de l'apoptose
AU6557299A (en) *	1999-01-07	2000-07-13	Seikagaku Corporation	Method for producing oligosaccharide, and novel oligosaccharide and pharaceutical composition containing the same
JP4913272B2 (ja) *	1999-01-07	2012-04-11	生化学工業株式会社	オリゴ糖の製造方法ならびに新規オリゴ糖およびそれを含む医薬組成物
KR100593393B1 (ko) *	1999-01-20	2006-06-28	다카라 바이오 가부시키가이샤	치료제
AU2745700A (en)	1999-02-01	2000-08-18	Dermal Research Laboratories, Inc.	A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
FR2789587B1 (fr) *	1999-02-11	2003-01-24	Inst Nat Sante Rech Med	Moyens pour la regulation de la differenciation hematopoietique
EP1074260B1 (de)	1999-07-21	2004-02-18	Seikagaku Corporation	IL-12 Produktionsinhibitor
JP4676049B2 (ja) *	1999-07-21	2011-04-27	生化学工業株式会社	Ｉｌ−１２産生抑制剤
FR2808687B1 (fr) *	2000-04-27	2003-12-05	Goemar Lab Sa	Medicament contenant des substances polysaccharidiques pour l'activation de l'apoptose
JP4676048B2 (ja) *	2000-07-10	2011-04-27	生化学工業株式会社	脱髄性疾患処置剤
US7879824B2 (en)	2001-07-31	2011-02-01	Dermal Research Laboratories, Inc.	Methods of preventing or treating diseases and conditions using complex carbohydrates
US20050004069A1 (en) *	2001-06-14	2005-01-06	Hirotaka Uzawa	Novel sulfated saccharide and process for producing the same
WO2003025133A2 (en) *	2001-09-14	2003-03-27	Mimeon, Inc.	Methods of making glycolmolecules with enhanced activities and uses thereof
DE10214507A1 (de) *	2002-04-02	2003-10-16	Beiersdorf Ag	Verwendung von Acarbose und deren Derivaten zur Behandlung und Prophylaxe degenerativer Hautzustände
JP4530633B2 (ja) *	2003-09-19	2010-08-25	生化学工業株式会社	シグナル伝達物質産生抑制剤
US20070099867A1 (en) *	2005-05-24	2007-05-03	Glycoscience Laboratories, Inc.	Pharmaceutical agent containing hyaluronan as an active ingredient
JP2009091248A (ja) *	2006-01-17	2009-04-30	Toshitsu Kagaku Kenkyusho:Kk	外傷性神経障害および／または運動機能障害の治療薬
CN101389342B (zh)	2006-12-05	2012-08-08	株式会社糖质科学研究所	用于变性关节炎的治疗剂
JP5341756B2 (ja) *	2007-06-29	2013-11-13	国立大学法人名古屋大学	神経障害に基づく機能不全の改善剤およびＲｈｏキナーゼ活性化抑制剤
FR2920310B1 (fr) *	2007-09-03	2012-10-19	Natura Cosmeticos Sa	Procede pour la preparation d'un extrait vegetal de passiflora alata et utilisation dudit extrait dans des compositions cosmetiques et pharmaceutiques
JP5641508B2 (ja) *	2010-02-23	2014-12-17	国立大学法人東京大学	樹状細胞免疫受容体刺激剤
CA2794697A1 (en)	2010-04-07	2011-10-13	Momenta Pharmaceuticals, Inc.	High mannose glycans
US9170249B2 (en)	2011-03-12	2015-10-27	Momenta Pharmaceuticals, Inc.	N-acetylhexosamine-containing N-glycans in glycoprotein products
EP2856159A4 (de)	2012-06-01	2016-04-13	Momenta Pharmaceuticals Inc	Verfahren im zusammenhang mit denosumab
EP2877589B1 (de)	2012-07-26	2024-03-06	Momenta Pharmaceuticals, Inc.	Glykoproteine mit entzündungshemmenden eigenschaften
CN103006560B (zh) *	2012-12-12	2014-10-15	上海市第六人民医院	透明质酸寡聚糖包裹的紫杉醇脂质体及其制备方法
EP2855533A4 (de)	2013-03-15	2015-11-25	Momenta Pharmaceuticals Inc	Verfahren in zusammenhang mit ctla4-fc-fusionsproteinen
US10464996B2 (en)	2013-05-13	2019-11-05	Momenta Pharmaceuticals, Inc.	Methods for the treatment of neurodegeneration
WO2015022907A1 (ja)	2013-08-13	2015-02-19	生化学工業株式会社	カチオン化キトサンを含有する医薬
WO2015057622A1 (en)	2013-10-16	2015-04-23	Momenta Pharmaceuticals, Inc.	Sialylated glycoproteins
CN106103493B (zh)	2014-03-21	2019-04-19	阿尔特刚股份有限公司	硫酸软骨素纯化方法
JP6674685B2 (ja)	2014-07-11	2020-04-01	学校法人東京理科大学	樹状細胞免疫受容体活性化剤、樹状細胞免疫受容体活性化方法、破骨細胞形成抑制剤、破骨細胞形成抑制方法、樹状細胞分化・増殖阻害剤、樹状細胞分化・増殖阻害方法、サイトカイン産生抑制剤、サイトカイン産生抑制方法、治療方法及びスクリーニング方法
WO2018207949A1 (ja)	2017-05-12	2018-11-15	学校法人東京理科大学	糖鎖修飾酵素を含む医薬組成物及び医薬組成物を用いた樹状細胞免疫受容体関連疾患の治療方法
IT201900023142A1 (it) *	2019-12-05	2021-06-05	Sifi Spa	Composizione topica oculare contenente metaboliti della fermentazione di lactobacillus

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU561067B2 (en) *	1982-03-22	1987-04-30	Biocarb Ab	Anti-bacterial composition containing an oligosaccharide
EP0240098A3 (de) *	1986-04-04	1989-05-10	Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo	Oligo und Polysaccharide zur Behandlung von Krankheiten verursacht durch Retroviren
IT1213384B (it) *	1986-11-24	1989-12-20	Lab Derivati Organici Mediolan	Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
JP2726274B2 (ja) *	1988-08-24	1998-03-11	生化学工業株式会社	新規ケラタン硫酸分解酵素並びにそれを生産する微生物及び方法
JPH0296588A (ja) *	1988-09-29	1990-04-09	Rikagaku Kenkyusho	硫酸化オリゴ糖及びその関連物質
US5510418A (en) *	1988-11-21	1996-04-23	Collagen Corporation	Glycosaminoglycan-synthetic polymer conjugates
AU6872691A (en) *	1989-10-27	1991-05-31	Case Western Reserve University	Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
JP3037987B2 (ja) *	1990-09-28	2000-05-08	生化学工業株式会社	グリコサミノグリカンの分析方法
WO1993024506A1 (en) *	1992-05-26	1993-12-09	Alberta Research Council	IMMUNOSUPPRESSIVE AND TOLEROGENIC MODIFIED LEWISC AND LacNAc COMPOUNDS
MX9304638A (es) *	1992-07-31	1994-05-31	Neose Pharm Inc	Composicion para tratar e inhibir las ulceras gastricas y duodenales.
AU4859793A (en) *	1992-09-11	1994-04-12	Regents Of The University Of California, The	Sulfated ligands for l-selectins and use of chlorates and or sulfatases for the treatment of inflammation
AU7205894A (en) *	1993-06-08	1995-01-03	Neogenix, Inc.	Purified natural and synthetic compounds for the treatment of osteoarthritis
AU1255695A (en) *	1993-11-19	1995-06-06	Regents Of The University Of California, The	Sulfated ligands for l-selectin and methods of preventing sulfate addition
GB9422584D0 (en) *	1994-02-15	1995-01-04	Medical Res Council	Immunomodulation using oligosaccharides
EP0798376B1 (de) *	1994-11-22	2004-02-18	Seikagaku Corporation	Neuartige keratansulfat-hydrolase

1995
- 1995-11-22 EP EP95937170A patent/EP0795560B1/de not_active Expired - Lifetime
- 1995-11-22 DE DE69532293T patent/DE69532293T2/de not_active Expired - Lifetime
- 1995-11-22 JP JP51857396A patent/JP4429386B2/ja not_active Expired - Fee Related
- 1995-11-22 AT AT95937170T patent/ATE256137T1/de not_active IP Right Cessation
- 1995-11-22 WO PCT/JP1995/002386 patent/WO1996016973A1/ja not_active Ceased
- 1995-11-22 HU HU9701820A patent/HUT77134A/hu unknown
- 1995-11-22 CN CN95197492A patent/CN1174557A/zh active Pending
- 1995-11-22 AU AU39356/95A patent/AU704429B2/en not_active Ceased
- 1995-11-22 US US08/849,925 patent/US5939403A/en not_active Expired - Lifetime
- 1995-11-22 CA CA002206611A patent/CA2206611A1/en not_active Abandoned
1999
- 1999-05-24 US US09/317,380 patent/US6159954A/en not_active Expired - Lifetime
2008
- 2008-08-11 JP JP2008207058A patent/JP2009019044A/ja active Pending
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WO1996016973A1 (en)	1996-06-06
EP0795560A4 (de)	1998-09-02
US5939403A (en)	1999-08-17
EP0795560A1 (de)	1997-09-17
EP0795560B1 (de)	2003-12-10
CN1174557A (zh)	1998-02-25
HUT77134A (hu)	1998-03-02
AU3935695A (en)	1996-06-19
JP2009019044A (ja)	2009-01-29
JP5001989B2 (ja)	2012-08-15
CA2206611A1 (en)	1996-06-06
JP2010046070A (ja)	2010-03-04
AU704429B2 (en)	1999-04-22
JP4429386B2 (ja)	2010-03-10
DE69532293T2 (de)	2004-10-21
DE69532293D1 (de)	2004-01-22
US6159954A (en)	2000-12-12

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2004-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69532293T2 (de)	2004-10-21	Keratansulfatoligosaccharid-fraktion und sie enthaltendes medikament
Chevolot et al.	2001	A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
EP0544592A3 (en)	1993-11-18	High molecular weight n,o-sulfated heparosans, process for producing the same and pharmaceutical compositions containing them
DE69918523D1 (de)	2004-08-12	Neues glycosaminoglycan und dieses enthaltendes arzneimittel
CA2218872A1 (en)	1996-10-31	Preparation and use of sulfated oligosaccharides
DE69842021D1 (de)	2011-01-05	Aminozucker, Chondroitin und S-Adenosylmethionin enthaltende Zusammensetzungen
MY109669A (en)	1997-03-31	N,o-sulphated heparosans, process for, preparing them and pharmaceutical compositions containing them
DE69516960D1 (de)	2000-06-21	Sulfatierte hyaluronsäure mit 0.5 bis weniger als 2 sulfate gruppen pro einheit
ATE94554T1 (de)	1993-10-15	Oligosaccharide, verwendbar als haarwuchsmittel.
AU758575C (en)	2003-11-20	Compounds having glucuronic acid derivative and glucosamine derivative in structure thereof, method for producing the compounds, and uses of the compounds
KR930004324A (ko)	1993-03-22	황산화 글리코자미노글리카노이드 유도체
AU737680C (en)	2002-05-02	Novel compounds having antiviral activity
CA2238521A1 (en)	1997-06-12	Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
CA2063850A1 (en)	1992-09-27	Sulfated tocopheryl oligosaccharides and antiviral agents including the same as active ingredients
AU3689693A (en)	1993-10-21	Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3
AU8748298A (en)	1999-03-16	Oligosaccharide derivatives and process for producing the same
DE69218438D1 (de)	1997-04-24	Dermatansulfatoligosaccharide, Verfahren zu ihrer Herstellung und diese enthaltende phamazeutische Zusammensetzungen
CA3122066A1 (en)	2020-06-11	Monomethyl fumarate-carrier conjugates and methods of their use
CA2049548A1 (en)	1992-02-21	Lps-producing bacteria, lpss, and lps-containing medicines and veterinary medicines
HRP940646A2 (en)	1997-04-30	Water-soluble retinoids
DK0904299T3 (da)	2001-12-17	Syntetiske polysaccharider, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne polysaccharider
NO914077L (no)	1992-04-21	Galaktomannanderivater for omhylling eller innleiring av aktive bestanddeler i legemidler
WO2002008239A1 (es)	2002-01-31	Nuevos disacaridos con accion antiartrosica
HU9401977D0 (en)	1994-09-28	Process for producing pharmaceutical compositions containing beta-naphtoquinone derivatives and salts thereof with epithalial proliferation fastening and no-synthetase inhibiting activity
AU5833694A (en)	1994-07-19	Oligosaccharides having biological activity and preparation of same from glycosaminoglycans