ATE256139T1 - 2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln - Google Patents

2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln

Info

Publication number
ATE256139T1
ATE256139T1 AT99400843T AT99400843T ATE256139T1 AT E256139 T1 ATE256139 T1 AT E256139T1 AT 99400843 T AT99400843 T AT 99400843T AT 99400843 T AT99400843 T AT 99400843T AT E256139 T1 ATE256139 T1 AT E256139T1
Authority
AT
Austria
Prior art keywords
methyl
dideoxy
oxy
alpha
ribohexopyranosyl
Prior art date
Application number
AT99400843T
Other languages
English (en)
Inventor
Alain Bonnet
Francoise Gambier
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE256139T1 publication Critical patent/ATE256139T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99400843T 1998-04-08 1999-04-07 2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln ATE256139T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804366A FR2777282B1 (fr) 1998-04-08 1998-04-08 Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments

Publications (1)

Publication Number Publication Date
ATE256139T1 true ATE256139T1 (de) 2003-12-15

Family

ID=9524992

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99400843T ATE256139T1 (de) 1998-04-08 1999-04-07 2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln

Country Status (12)

Country Link
US (1) US6121432A (de)
EP (1) EP0949268B1 (de)
JP (1) JP4707785B2 (de)
KR (1) KR100633835B1 (de)
CN (1) CN1130370C (de)
AT (1) ATE256139T1 (de)
DE (1) DE69913413T2 (de)
DK (1) DK0949268T3 (de)
ES (1) ES2210999T3 (de)
FR (1) FR2777282B1 (de)
HU (1) HU227562B1 (de)
PT (1) PT949268E (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1147121T3 (da) * 1999-01-27 2004-04-13 Pfizer Prod Inc Ketolidantibiotika
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6399582B1 (en) 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
AU775637B2 (en) 1999-04-16 2004-08-12 Kosan Biosciences, Inc. Macrolide antiinfective agents
EE200100613A (et) * 1999-05-24 2003-02-17 Pfizer Products Inc. 13-metüülerütromütsiini derivaadid
JP2001261694A (ja) * 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
EP1167376B1 (de) 2000-06-30 2004-07-14 Pfizer Products Inc. Makrolid-Antibiotika
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
RU2601550C2 (ru) * 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
EP3190122A1 (de) 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. Neuartiger syntheseweg zu solithromycin und reinigung davon
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
ES2087737T3 (es) * 1992-04-22 1996-07-16 Taisho Pharmaceutical Co Ltd Un derivado 5-o-desosaminil-eritronoluro a.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose

Also Published As

Publication number Publication date
DK0949268T3 (da) 2004-03-29
FR2777282B1 (fr) 2001-04-20
EP0949268B1 (de) 2003-12-10
ES2210999T3 (es) 2004-07-01
DE69913413T2 (de) 2004-12-02
HU9900958D0 (en) 1999-06-28
EP0949268A1 (de) 1999-10-13
CN1130370C (zh) 2003-12-10
HUP9900958A3 (en) 2000-04-28
CN1235162A (zh) 1999-11-17
US6121432A (en) 2000-09-19
KR19990082977A (ko) 1999-11-25
HU227562B1 (en) 2011-08-29
PT949268E (pt) 2004-04-30
JP4707785B2 (ja) 2011-06-22
JPH11310591A (ja) 1999-11-09
FR2777282A1 (fr) 1999-10-15
DE69913413D1 (de) 2004-01-22
HUP9900958A1 (hu) 1999-11-29
KR100633835B1 (ko) 2006-10-13

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