ATE256139T1 - 2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln - Google Patents

2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln

Info

Publication number
ATE256139T1
ATE256139T1 AT99400843T AT99400843T ATE256139T1 AT E256139 T1 ATE256139 T1 AT E256139T1 AT 99400843 T AT99400843 T AT 99400843T AT 99400843 T AT99400843 T AT 99400843T AT E256139 T1 ATE256139 T1 AT E256139T1
Authority
AT
Austria
Prior art keywords
methyl
dideoxy
oxy
alpha
ribohexopyranosyl
Prior art date
Application number
AT99400843T
Other languages
English (en)
Inventor
Alain Bonnet
Francoise Gambier
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE256139T1 publication Critical patent/ATE256139T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99400843T 1998-04-08 1999-04-07 2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln ATE256139T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804366A FR2777282B1 (fr) 1998-04-08 1998-04-08 Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments

Publications (1)

Publication Number Publication Date
ATE256139T1 true ATE256139T1 (de) 2003-12-15

Family

ID=9524992

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99400843T ATE256139T1 (de) 1998-04-08 1999-04-07 2-fluor 3-de (2,6-dideoxy 3-c-methyl-3-0-methyl- alpha-l-ribohexopyranosyl oxy) 6-1-methyl 3-oxo erythromycin, ihrer verfahren zur herstellung und ihrer verwendung zur synthese von arzneimitteln

Country Status (12)

Country Link
US (1) US6121432A (de)
EP (1) EP0949268B1 (de)
JP (1) JP4707785B2 (de)
KR (1) KR100633835B1 (de)
CN (1) CN1130370C (de)
AT (1) ATE256139T1 (de)
DE (1) DE69913413T2 (de)
DK (1) DK0949268T3 (de)
ES (1) ES2210999T3 (de)
FR (1) FR2777282B1 (de)
HU (1) HU227562B1 (de)
PT (1) PT949268E (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2359708C (en) 1999-01-27 2005-10-25 Pfizer Products Inc. Ketolide antibiotics
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
CA2370743A1 (en) 1999-04-16 2000-10-26 Dennis Hlasta Ketolide antibacterials
HUP0201516A3 (en) * 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
JP2001261694A (ja) * 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
EP1167376B1 (de) 2000-06-30 2004-07-14 Pfizer Products Inc. Makrolid-Antibiotika
EP1638549A4 (de) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc Neue antibakterielle mittel
EP2214484A4 (de) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc Verfahren zur herstellung von antibakteriellen makrolid-wirkstoffen
JP5711135B2 (ja) 2008-10-24 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド 胃腸疾患を治療するための方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es) 2010-03-22 2018-12-05 Cempra Pharmaceuticals Inc Star Formas cristalinas de un macrólido y usos para las mismas.
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (de) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc Wasserstoffbindung zur formung von fluorketoliden zur behandlung von krankheiten
PT2673285T (pt) 2010-12-09 2017-10-19 Wockhardt Ltd Resumo
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
EP3190122A1 (de) 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. Neuartiger syntheseweg zu solithromycin und reinigung davon
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
ATE135707T1 (de) * 1992-04-22 1996-04-15 Taisho Pharmaceutical Co Ltd 5-0-desosaminylerythronolid a derivate
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose

Also Published As

Publication number Publication date
DK0949268T3 (da) 2004-03-29
KR100633835B1 (ko) 2006-10-13
PT949268E (pt) 2004-04-30
HUP9900958A1 (hu) 1999-11-29
JPH11310591A (ja) 1999-11-09
HU227562B1 (en) 2011-08-29
FR2777282A1 (fr) 1999-10-15
KR19990082977A (ko) 1999-11-25
DE69913413D1 (de) 2004-01-22
CN1235162A (zh) 1999-11-17
EP0949268B1 (de) 2003-12-10
DE69913413T2 (de) 2004-12-02
FR2777282B1 (fr) 2001-04-20
US6121432A (en) 2000-09-19
EP0949268A1 (de) 1999-10-13
JP4707785B2 (ja) 2011-06-22
HUP9900958A3 (en) 2000-04-28
CN1130370C (zh) 2003-12-10
HU9900958D0 (en) 1999-06-28
ES2210999T3 (es) 2004-07-01

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