PT949268E - Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos - Google Patents

Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos

Info

Publication number: PT949268E
Authority: PT; Portugal
Prior art keywords: methyl; oxy; fluoro; alpha; oxoeritromycin
Prior art date: 1998-04-08

Application number

PT99400843T

Other languages

English (en)

Inventor

Alain Bonnet

Francoise Gambier

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-08

Filing date

1999-04-07

Publication date

2004-04-30

1999-04-07 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2004-04-30 Publication of PT949268E publication Critical patent/PT949268E/pt

Links

238000002360 preparation method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000005587 carbonate group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT99400843T 1998-04-08 1999-04-07 Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos PT949268E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9804366A FR2777282B1 (fr)	1998-04-08	1998-04-08	Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments

Publications (1)

Publication Number	Publication Date
PT949268E true PT949268E (pt)	2004-04-30

Family

ID=9524992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99400843T PT949268E (pt)	1998-04-08	1999-04-07	Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi\|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos

Country Status (12)

Country	Link
US (1)	US6121432A (pt)
EP (1)	EP0949268B1 (pt)
JP (1)	JP4707785B2 (pt)
KR (1)	KR100633835B1 (pt)
CN (1)	CN1130370C (pt)
AT (1)	ATE256139T1 (pt)
DE (1)	DE69913413T2 (pt)
DK (1)	DK0949268T3 (pt)
ES (1)	ES2210999T3 (pt)
FR (1)	FR2777282B1 (pt)
HU (1)	HU227562B1 (pt)
PT (1)	PT949268E (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2359708C (en) *	1999-01-27	2005-10-25	Pfizer Products Inc.	Ketolide antibiotics
US6939861B2 (en)	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
US6514944B2 (en)	1999-04-16	2003-02-04	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6590083B1 (en)	1999-04-16	2003-07-08	Ortho-Mcneil Pharmaceutical, Inc.	Ketolide antibacterials
US6451768B1 (en)	1999-04-16	2002-09-17	Kosan Biosciences, Inc.	Macrolide antiinfective agents
IL145976A0 (en)	1999-04-16	2002-07-25	Ortho Mcneil Pharm Inc	Ketolide antibacterials
ID30547A (id) *	1999-04-16	2001-12-20	Kosan Biosciences Inc	Zat anti-infeksi makrolida
EA200100983A1 (ru) *	1999-05-24	2002-10-31	Пфайзер Продактс Инк.	Производные 13-метилэритромицина
JP2001261694A (ja)	2000-03-06	2001-09-26	Pfizer Prod Inc	ケトライド抗生物質
DE60104240T2 (de)	2000-06-30	2005-08-04	Pfizer Products Inc., Groton	Makrolid-Antibiotika
ES2552682T3 (es)	2003-03-10	2015-12-01	Merck Sharp & Dohme Corp.	Agentes antibacterianos novedosos
CN105732745A (zh)	2007-10-25	2016-07-06	森普拉制药公司	大环内酯类抗菌剂的制备方法
AU2009308182B2 (en) *	2008-10-24	2016-05-19	Cempra Pharmaceuticals, Inc.	Biodefenses using triazole-containing macrolides
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
US9480679B2 (en)	2009-09-10	2016-11-01	Cempra Pharmaceuticals, Inc.	Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en)	2010-03-22	2016-02-29	Cempra Pharmaceuticals Inc	CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
CN105198944B (zh)	2010-05-20	2018-06-01	森普拉制药公司	制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en)	2010-09-10	2014-01-15	Cempra Pharmaceuticals Inc	HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
WO2012076989A1 (en)	2010-12-09	2012-06-14	Wockhardt Limited	Ketolide compounds
MX2014011537A (es)	2012-03-27	2015-02-10	Cempra Pharmaceuticals Inc	Formulaciones parenterales para la administracion de antibioticos macrolidos.
HK1217665A1 (zh)	2013-03-14	2017-01-20	森普拉制药公司	用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru)	2013-03-15	2017-04-24	Семпра Фармасьютикалс, Инк.	Конвергентные способы получения макролидных антибактериальных агентов
CN106518939B (zh) *	2015-09-14	2019-12-31	江苏奥赛康药业有限公司	一种制备Solithromycin化合物的方法
CN106554381A (zh) *	2015-09-25	2017-04-05	苏州鹏旭医药科技有限公司	酮内酯类抗生素中间体及其制备方法和应用
EP3190122A1 (en)	2016-01-08	2017-07-12	LEK Pharmaceuticals d.d.	A novel synthetic pathway towards solithromycin and purification thereof
CN106432383A (zh) *	2016-09-14	2017-02-22	重庆两江药物研发中心有限公司	索利霉素及其中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4742049A (en) *	1986-06-04	1988-05-03	Abbott Laboratories	Semisynthetic erythromycin antibiotics
US4740502A (en) *	1986-06-20	1988-04-26	Abbott Laboratories	Semisynthetic erythromycin antibiotics
IL114589A (en) *	1990-11-21	1999-12-22	Roussel Uclaf	Intermediates for the preparation of erythromycin derivatives
US5523399A (en) *	1991-12-27	1996-06-04	Taisho Pharmaceutical Co., Ltd.	5-O-desosaminylerythronolide derivatives
ATE135707T1 (de) *	1992-04-22	1996-04-15	Taisho Pharmaceutical Co Ltd	5-0-desosaminylerythronolid a derivate
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
FR2739620B1 (fr) *	1995-10-09	1997-12-19	Roussel Uclaf	Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
FR2742757B1 (fr) *	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2771008B1 (fr) *	1997-11-17	2000-04-28	Hoechst Marion Roussel Inc	Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose

1998
- 1998-04-08 FR FR9804366A patent/FR2777282B1/fr not_active Expired - Lifetime
1999
- 1999-03-22 US US09/273,846 patent/US6121432A/en not_active Expired - Lifetime
- 1999-03-30 JP JP08858099A patent/JP4707785B2/ja not_active Expired - Lifetime
- 1999-04-07 DE DE69913413T patent/DE69913413T2/de not_active Expired - Lifetime
- 1999-04-07 DK DK99400843T patent/DK0949268T3/da active
- 1999-04-07 AT AT99400843T patent/ATE256139T1/de active
- 1999-04-07 KR KR1019990011936A patent/KR100633835B1/ko not_active Expired - Lifetime
- 1999-04-07 PT PT99400843T patent/PT949268E/pt unknown
- 1999-04-07 HU HU9900958A patent/HU227562B1/hu unknown
- 1999-04-07 CN CN99104863A patent/CN1130370C/zh not_active Expired - Lifetime
- 1999-04-07 EP EP99400843A patent/EP0949268B1/fr not_active Expired - Lifetime
- 1999-04-07 ES ES99400843T patent/ES2210999T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0949268A1 (fr)	1999-10-13
JPH11310591A (ja)	1999-11-09
JP4707785B2 (ja)	2011-06-22
DK0949268T3 (da)	2004-03-29
FR2777282B1 (fr)	2001-04-20
DE69913413T2 (de)	2004-12-02
HUP9900958A1 (hu)	1999-11-29
ATE256139T1 (de)	2003-12-15
HU227562B1 (en)	2011-08-29
US6121432A (en)	2000-09-19
CN1235162A (zh)	1999-11-17
KR19990082977A (ko)	1999-11-25
KR100633835B1 (ko)	2006-10-13
DE69913413D1 (de)	2004-01-22
ES2210999T3 (es)	2004-07-01
CN1130370C (zh)	2003-12-10
HUP9900958A3 (en)	2000-04-28
HU9900958D0 (en)	1999-06-28
FR2777282A1 (fr)	1999-10-15
EP0949268B1 (fr)	2003-12-10

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