PT949268E - Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos - Google Patents

Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos

Info

Publication number
PT949268E
PT949268E PT99400843T PT99400843T PT949268E PT 949268 E PT949268 E PT 949268E PT 99400843 T PT99400843 T PT 99400843T PT 99400843 T PT99400843 T PT 99400843T PT 949268 E PT949268 E PT 949268E
Authority
PT
Portugal
Prior art keywords
methyl
oxy
fluoro
alpha
oxoeritromycin
Prior art date
Application number
PT99400843T
Other languages
English (en)
Inventor
Alain Bonnet
Francoise Gambier
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PT949268E publication Critical patent/PT949268E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT99400843T 1998-04-08 1999-04-07 Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos PT949268E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804366A FR2777282B1 (fr) 1998-04-08 1998-04-08 Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments

Publications (1)

Publication Number Publication Date
PT949268E true PT949268E (pt) 2004-04-30

Family

ID=9524992

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99400843T PT949268E (pt) 1998-04-08 1999-04-07 Novos derivados da 2-fluoro-3-de¬(2,6-dedesoxi-3-c-metil-3-0-metil-alfa-l-ribo-hexopiranosil)oxi|-6-0-metil-3-oxoeritromicina seu procedimento de preparacao e sua aplicacao a sintese de principios activos de medicamentos

Country Status (12)

Country Link
US (1) US6121432A (pt)
EP (1) EP0949268B1 (pt)
JP (1) JP4707785B2 (pt)
KR (1) KR100633835B1 (pt)
CN (1) CN1130370C (pt)
AT (1) ATE256139T1 (pt)
DE (1) DE69913413T2 (pt)
DK (1) DK0949268T3 (pt)
ES (1) ES2210999T3 (pt)
FR (1) FR2777282B1 (pt)
HU (1) HU227562B1 (pt)
PT (1) PT949268E (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2001002222A0 (en) 1999-01-27 2001-09-30 Pfizer Prod Inc Ketolide antibiotics.
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6395710B1 (en) 1999-04-16 2002-05-28 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
JP2001261694A (ja) * 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
TR200401847T4 (tr) 2000-06-30 2004-09-21 Pfizer Products Inc. Makrolit antibiyotikler.
EP1638549A4 (en) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) * 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
EP3216798A3 (en) * 2010-12-09 2017-10-25 Wockhardt Limited Ketolide compounds
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
EP3190122A1 (en) 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
US5631355A (en) * 1992-04-22 1997-05-20 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide a derivatives
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose

Also Published As

Publication number Publication date
JP4707785B2 (ja) 2011-06-22
CN1130370C (zh) 2003-12-10
DE69913413D1 (de) 2004-01-22
HU227562B1 (en) 2011-08-29
ATE256139T1 (de) 2003-12-15
FR2777282B1 (fr) 2001-04-20
FR2777282A1 (fr) 1999-10-15
US6121432A (en) 2000-09-19
KR19990082977A (ko) 1999-11-25
JPH11310591A (ja) 1999-11-09
HU9900958D0 (en) 1999-06-28
HUP9900958A1 (hu) 1999-11-29
EP0949268A1 (fr) 1999-10-13
ES2210999T3 (es) 2004-07-01
KR100633835B1 (ko) 2006-10-13
EP0949268B1 (fr) 2003-12-10
CN1235162A (zh) 1999-11-17
DK0949268T3 (da) 2004-03-29
DE69913413T2 (de) 2004-12-02
HUP9900958A3 (en) 2000-04-28

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