ATE256186T1 - Verwendungen von angiogenischer factor vegf145 in der behandlung von kardiovaskulaeren krankheiten - Google Patents

Verwendungen von angiogenischer factor vegf145 in der behandlung von kardiovaskulaeren krankheiten

Info

Publication number
ATE256186T1
ATE256186T1 AT97940771T AT97940771T ATE256186T1 AT E256186 T1 ATE256186 T1 AT E256186T1 AT 97940771 T AT97940771 T AT 97940771T AT 97940771 T AT97940771 T AT 97940771T AT E256186 T1 ATE256186 T1 AT E256186T1
Authority
AT
Austria
Prior art keywords
vegf145
derivatives
novel
protein products
vegf
Prior art date
Application number
AT97940771T
Other languages
English (en)
Inventor
Gera Neufeld
Eli Keshet
Israel Vlodavsky
Zoya Poltorak
Original Assignee
Technion Res & Dev Co Ltd
Collateral Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technion Res & Dev Co Ltd, Collateral Therapeutics filed Critical Technion Res & Dev Co Ltd
Application granted granted Critical
Publication of ATE256186T1 publication Critical patent/ATE256186T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT97940771T 1996-09-06 1997-09-04 Verwendungen von angiogenischer factor vegf145 in der behandlung von kardiovaskulaeren krankheiten ATE256186T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2553796P 1996-09-06 1996-09-06
US08/784,551 US6013780A (en) 1996-09-06 1997-01-21 VEGF145 expression vectors
PCT/US1997/015471 WO1998010071A1 (en) 1996-09-06 1997-09-04 Angiogenic factor and use thereof in treating cardiovascular disease

Publications (1)

Publication Number Publication Date
ATE256186T1 true ATE256186T1 (de) 2003-12-15

Family

ID=26699889

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97940771T ATE256186T1 (de) 1996-09-06 1997-09-04 Verwendungen von angiogenischer factor vegf145 in der behandlung von kardiovaskulaeren krankheiten

Country Status (14)

Country Link
US (3) US6013780A (de)
EP (1) EP0925360B1 (de)
JP (1) JP2001500728A (de)
KR (1) KR20000068506A (de)
CN (1) CN1236390A (de)
AT (1) ATE256186T1 (de)
AU (1) AU737898B2 (de)
CA (1) CA2265252C (de)
DE (1) DE69726741T2 (de)
EA (1) EA004646B1 (de)
ES (1) ES2212127T3 (de)
IL (1) IL128727A (de)
NZ (1) NZ334508A (de)
WO (1) WO1998010071A1 (de)

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US20020172678A1 (en) 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
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US6783953B1 (en) 1998-12-22 2004-08-31 Janssen Pharmaceutica N.V. Vascular endothelial growth factor-X
US7097832B1 (en) 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
US20040131601A1 (en) * 2000-03-30 2004-07-08 Foundry Networks, Inc., A Delaward Corporation Injection of bone marrow-derived cells and medium for angiogenesis
US7125856B1 (en) 1999-04-15 2006-10-24 St. Elizabeth's Medical Center Of Boston, Inc. Angiogenic growth factors for treatment of peripheral neuropathy
CA2374050A1 (en) * 1999-05-20 2000-11-30 Scios Inc. Vascular endothelial growth factor dimers
JP2003507006A (ja) * 1999-05-20 2003-02-25 サイオス，インコーポレーテッド 血管内皮増殖因子改変体
AU2623201A (en) * 1999-12-30 2001-07-16 Kam W Leong Controlled delivery of therapeutic agents by insertable medical devices
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8460367B2 (en) 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
JP5859179B2 (ja) * 2000-03-15 2016-02-10 オーバスネイチ メディカル、インコーポレイテッド 内皮細胞接着を促進するコーティング
ATE526981T1 (de) 2000-04-12 2011-10-15 Vib Vzw Verwendung von vegf 165 und homologen zur behandlung von neurologischen störungen
CA2412847A1 (en) * 2000-06-30 2002-01-10 Collateral Therapeutics, Inc. Dual recombinant gene therapy compositions and methods of use
CA2419245A1 (en) * 2000-08-17 2002-02-21 Keiya Ozawa Adeno-associated virus-mediated delivery of angiogenic factors
US6953560B1 (en) 2000-09-28 2005-10-11 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
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AU2884102A (en) 2000-12-07 2002-06-18 Sangamo Biosciences Inc Regulation of angiogenesis with zinc finger proteins
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US6663662B2 (en) 2000-12-28 2003-12-16 Advanced Cardiovascular Systems, Inc. Diffusion barrier layer for implantable devices
US20050142130A1 (en) * 2001-01-04 2005-06-30 Roks Antonius J.M. Use of angiotensin-(1-7) for preventing and/or reducing the formation of neointima
AU2002319402B2 (en) * 2001-06-28 2008-09-11 Domantis Limited Dual-specific ligand and its use
US20050271663A1 (en) * 2001-06-28 2005-12-08 Domantis Limited Compositions and methods for treating inflammatory disorders
BR0212070A (pt) 2001-08-29 2004-09-28 Genentech Inc ácidos nucléicos e polipeptìdeos bv8 com atividade mitogênica
WO2003020215A2 (en) 2001-08-29 2003-03-13 Regenerx Biopharmaceuticals, Inc. Methods of treating mycocardial event related coditions with thymosin beta 4
US6753071B1 (en) * 2001-09-27 2004-06-22 Advanced Cardiovascular Systems, Inc. Rate-reducing membrane for release of an agent
US20040043003A1 (en) * 2002-01-31 2004-03-04 Wei Chen Clinical grade vectors based on natural microflora for use in delivering therapeutic compositions
US20040009937A1 (en) * 2002-01-31 2004-01-15 Wei Chen Methods and composition for delivering nucleic acids and/or proteins to the respiratory system
US20050075298A1 (en) * 2002-01-31 2005-04-07 Wei Chen Methods and composition for delivering nucleic acids and/or proteins to the intestinal mucosa
EP1513404A4 (de) * 2002-05-30 2006-01-04 Myocardial Therapeutics Inc Intramyokardiale injektionen von autologem knochenmark
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
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US20060251643A1 (en) * 2002-12-09 2006-11-09 Toolgen, Inc. Regulatory zinc finger proteins
US20060252919A1 (en) * 2002-12-17 2006-11-09 Technion Research & Development Foundation Ltd. Vegf variant that lacks vegfr-1 binding activity and its use in promotion of re-endothelization and prevention of in-stent restenosis
JP2006523090A (ja) * 2002-12-27 2006-10-12 ドマンティス リミテッド リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体
AU2004219592C1 (en) 2003-03-12 2011-02-24 Genentech, Inc. Use of Bv8 and/or EG-VEGF to promote hematopoiesis
MX2007012766A (es) * 2005-04-12 2008-10-01 Intradigm Corp Composición y métodos de terapéuticos de arni para el tratamiento de cáncer y otras enfermedades de neovascularización.
US7893244B2 (en) * 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
KR100772424B1 (ko) * 2005-08-05 2007-11-01 박기랑 ⅤＥＧＦ－Ａ，ⅤＥＧＦ－Ｂ，및 ⅤＥＧＦ－Ｃ의 안티센스 ｃＤＮＡ를 함유하는 재조합 아데노-연관 바이러스 및 ⅤＥＧＦＲ 트렁케이티드 솔루블 ｃＤＮＡ를 함유하는 재조합 아데노-연관 바이러스를 포함하는 암의 유전자 치료제
CN101454344A (zh) * 2005-12-01 2009-06-10 杜门蒂斯有限公司 与白细胞介素-1受体1型结合的非竞争性域抗体形式
NZ580530A (en) * 2007-06-06 2012-04-27 Domantis Ltd Anti vegf polypeptides, antibody variable domains and antagonists
WO2010042471A2 (en) * 2008-10-07 2010-04-15 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents to body lumens
CN110760542B (zh) * 2019-11-18 2022-07-26 天津大学 一种共表达znf580和vegf165双基因的质粒及应用

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Also Published As

Publication number Publication date
ES2212127T3 (es) 2004-07-16
AU4247197A (en) 1998-03-26
DE69726741T2 (de) 2004-09-30
US6589782B1 (en) 2003-07-08
AU737898B2 (en) 2001-09-06
EA199900262A1 (ru) 1999-10-28
EA004646B1 (ru) 2004-06-24
JP2001500728A (ja) 2001-01-23
CA2265252C (en) 2005-04-19
HK1020756A1 (en) 2000-05-19
EP0925360B1 (de) 2003-12-10
NZ334508A (en) 2001-03-30
EP0925360A1 (de) 1999-06-30
KR20000068506A (ko) 2000-11-25
CN1236390A (zh) 1999-11-24
CA2265252A1 (en) 1998-03-12
DE69726741D1 (de) 2004-01-22
IL128727A (en) 2007-06-17
US6583276B1 (en) 2003-06-24
WO1998010071A1 (en) 1998-03-12
IL128727A0 (en) 2005-11-20
US6013780A (en) 2000-01-11

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