ATE256188T1 - Verbesserte riboflavin-herstellung - Google Patents

Verbesserte riboflavin-herstellung

Info

Publication number: ATE256188T1
Authority: AT; Austria
Prior art keywords: dna sequence; riboflavin; vectors; bacillus subtilis; substantially homologous
Prior art date: 1996-07-24

Application number

AT97111984T

Other languages

English (en)

Inventor

Hans-Peter Hohmann

Markus Huembelin

Loon Adolphus Van

Walter Schurter

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-24

Filing date

1997-07-15

Publication date

2003-12-15

1997-07-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE256188T1 publication Critical patent/ATE256188T1/de

Links

AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 6
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title abstract 3
229960002477 riboflavin Drugs 0.000 title abstract 3
235000019192 riboflavin Nutrition 0.000 title abstract 3
239000002151 riboflavin Substances 0.000 title abstract 3
108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
241000894006 Bacteria Species 0.000 abstract 3
239000013598 vector Substances 0.000 abstract 3
244000063299 Bacillus subtilis Species 0.000 abstract 2
235000014469 Bacillus subtilis Nutrition 0.000 abstract 2
238000013518 transcription Methods 0.000 abstract 2
230000035897 transcription Effects 0.000 abstract 2
210000000349 chromosome Anatomy 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
101150084911 ribA gene Proteins 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fodder In General (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

AT97111984T 1996-07-24 1997-07-15 Verbesserte riboflavin-herstellung ATE256188T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96111905		1996-07-24

Publications (1)

Publication Number	Publication Date
ATE256188T1 true ATE256188T1 (de)	2003-12-15

Family

ID=8223032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97111984T ATE256188T1 (de)	1996-07-24	1997-07-15	Verbesserte riboflavin-herstellung

Country Status (9)

Country	Link
US (1)	US6322995B1 (de)
EP (1)	EP0821063B1 (de)
JP (1)	JPH1084978A (de)
CN (1)	CN1189556C (de)
AT (1)	ATE256188T1 (de)
BR (1)	BR9704067A (de)
DE (1)	DE69726652T2 (de)
DK (1)	DK0821063T3 (de)
ES (1)	ES2210424T3 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0926243T3 (da)	1997-12-04	2004-12-20	Dsm Ip Assets Bv	Riboflavinglucosid
DE19823834A1 (de) *	1998-05-28	1999-12-02	Basf Ag	Genetisches Verfahren zur Herstellung von Riboflavin
US8232081B2 (en) *	1999-09-21	2012-07-31	Basf Se	Methods and microorganisms for production of panto-compounds
DE10209363A1 (de) *	2002-03-02	2003-09-11	Basf Ag	Verfahren zur Herstellung von Riboflavin
KR100422305B1 (ko)	2002-12-05	2004-03-10	씨제이 주식회사	리보플라빈을 생산하는 미생물 및 이를 이용한리보플라빈의 생산방법
KR100422307B1 (ko)	2002-12-05	2004-03-10	씨제이 주식회사	리보플라빈을 생산하는 미생물 및 이를 이용한리보플라빈의 생산방법
KR100542563B1 (ko) *	2003-12-05	2006-01-11	씨제이 주식회사	리보플라빈을 생산하는 미생물 및 이를 이용한 리보플라빈의 생산방법
WO2006003015A2 (en) *	2004-07-07	2006-01-12	Dsm Ip Assets B.V.	Improved enzymes
US7182739B2 (en) *	2005-05-12	2007-02-27	S.C. Johnson & Son, Inc.	Therapy patch
EP1731617A1 (de) *	2005-06-06	2006-12-13	DSM IP Assets B.V.	Rückführung lysierter Biomasse als Nährmedium bei der fermentativen Herstellung von Riboflavin
DE102008063234B4 (de)	2008-12-15	2011-06-22	Insilico Biotechnology AG, 70569	Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute
KR101335853B1 (ko)	2011-12-01	2013-12-02	씨제이제일제당 (주)	Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법
KR102561864B1 (ko) *	2014-11-19	2023-08-01	바스프 에스이	Rib７ 프로모터를 사용하여 유전자 발현을 하향조절하기 위한 에레모테시움의 유전적 변형
CN108277189A (zh) *	2017-01-05	2018-07-13	上海创诺医药集团有限公司	一种生产核黄素的工程菌株及其应用
CN110699413B (zh) *	2019-09-20	2021-07-27	河北圣雪大成制药有限责任公司	一种利用氧载体提高核黄素产量的方法及其发酵装置
JP2023530890A (ja) *	2020-06-23	2023-07-20	ディーエスエムアイピーアセッツビー．ブイ．	発酵プロセス
CN113025550B (zh) *	2021-05-24	2021-09-10	中国科学院天津工业生物技术研究所	高产维生素b2枯草芽孢杆菌工程菌株、其构建及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5310155B2 (de)	1972-10-26	1978-04-11
CN1066486C (zh) *	1989-06-22	2001-05-30	霍夫曼-拉罗奇有限公司	高产核黄素的细菌菌株
JPH06225776A (ja) *	1992-12-07	1994-08-16	Kyowa Hakko Kogyo Co Ltd	リボフラビンの製造法

1997
- 1997-07-10 JP JP9184843A patent/JPH1084978A/ja active Pending
- 1997-07-15 ES ES97111984T patent/ES2210424T3/es not_active Expired - Lifetime
- 1997-07-15 DK DK97111984T patent/DK0821063T3/da active
- 1997-07-15 AT AT97111984T patent/ATE256188T1/de not_active IP Right Cessation
- 1997-07-15 EP EP97111984A patent/EP0821063B1/de not_active Expired - Lifetime
- 1997-07-15 DE DE69726652T patent/DE69726652T2/de not_active Expired - Fee Related
- 1997-07-23 CN CNB971171637A patent/CN1189556C/zh not_active Expired - Lifetime
- 1997-07-23 US US08/899,241 patent/US6322995B1/en not_active Expired - Lifetime
- 1997-07-24 BR BR9704067A patent/BR9704067A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2210424T3 (es)	2004-07-01
EP0821063A2 (de)	1998-01-28
JPH1084978A (ja)	1998-04-07
DK0821063T3 (da)	2004-04-13
EP0821063B1 (de)	2003-12-10
CN1189556C (zh)	2005-02-16
BR9704067A (pt)	1999-01-05
DE69726652D1 (de)	2004-01-22
CN1177004A (zh)	1998-03-25
DE69726652T2 (de)	2004-10-07
EP0821063A3 (de)	1999-05-06
US6322995B1 (en)	2001-11-27

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Legal Events

Date	Code	Title	Description
2004-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties