ATE256664T1 - Herstellung von (s)-decahydroisochinolin-3- carbonsäure-t-butylamid - Google Patents

Herstellung von (s)-decahydroisochinolin-3- carbonsäure-t-butylamid

Info

Publication number: ATE256664T1
Authority: AT; Austria
Prior art keywords: tic; butylamide; carboxylic acid; decahydroisocinoline; production
Prior art date: 1996-02-20

Application number

AT96936615T

Other languages

English (en)

Inventor

David R Allen

Scott Jenkins

Loraine Klein

Robert Erickson

Diana Froen

Original Assignee

Pcbu Services Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-20

Filing date

1996-10-18

Publication date

2004-01-15

1996-10-18 Application filed by Pcbu Services Inc filed Critical Pcbu Services Inc

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE256664T1 publication Critical patent/ATE256664T1/de

Links

230000015572 biosynthetic process Effects 0.000 abstract 2
NSENYWQRQUNUGD-HACHORDNSA-N (3s)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid Chemical compound C1CCCC2CN[C@H](C(=O)O)CC21 NSENYWQRQUNUGD-HACHORDNSA-N 0.000 abstract 1
DMJXRYSGXCLCFP-LBPRGKRZSA-N (3s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide Chemical compound C1=CC=C2CN[C@H](C(=O)NC(C)(C)C)CC2=C1 DMJXRYSGXCLCFP-LBPRGKRZSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
UWYZHKAOTLEWKK-UHFFFAOYSA-N tetrahydro-isoquinoline Natural products C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 abstract 1
150000003526 tetrahydroisoquinolines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT96936615T 1996-02-20 1996-10-18 Herstellung von (s)-decahydroisochinolin-3- carbonsäure-t-butylamid ATE256664T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/603,744 US5587481A (en)	1996-02-20	1996-02-20	Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide
PCT/US1996/016628 WO1997030976A1 (en)	1996-02-20	1996-10-18	Preparation of (s)-decahydroisoquinoline-3-carboxylic acid t-butylamide

Publications (1)

Publication Number	Publication Date
ATE256664T1 true ATE256664T1 (de)	2004-01-15

Family

ID=24416734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96936615T ATE256664T1 (de)	1996-02-20	1996-10-18	Herstellung von (s)-decahydroisochinolin-3- carbonsäure-t-butylamid

Country Status (10)

Country	Link
US (1)	US5587481A (de)
EP (1)	EP0902781B1 (de)
JP (1)	JP2001506575A (de)
KR (1)	KR19990076981A (de)
AT (1)	ATE256664T1 (de)
AU (1)	AU713924B2 (de)
CA (1)	CA2238478A1 (de)
DE (1)	DE69631169T2 (de)
NO (1)	NO312293B1 (de)
WO (1)	WO1997030976A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69603419T3 (de) *	1995-06-30	2006-06-29	Ajinomoto Co., Inc.	Verfahren zur Herstellung von optisch aktiven Amiden
IT1301825B1 (it) *	1998-06-26	2000-07-07	Archimica Spa	Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
CZ299699B6 (cs) *	1998-12-14	2008-10-22	Sk Corporation	Zpusob výroby [3S-(3alfa, 4alfabeta, 8alfabeta)]-N-terc-butyl-dekahydro-3-izochinolinkarboxamidu s vysokým optickým výtežkem
KR100277723B1 (ko) *	1998-12-14	2001-01-15	남창우	광학적으로 순수한 데카하이드로이소퀴놀린카르복사미드의 연속제조공정
IT1313682B1 (it) *	1999-11-25	2002-09-09	Archimica Spa	Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
IT1318986B1 (it) *	2000-10-09	2003-09-19	Archimica S P A Ora Clariant L	Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
US8627573B2 (en) *	2002-10-05	2014-01-14	Braun Gmbh	Hair-removing device
NZ543236A (en) *	2003-05-08	2008-06-30	Pfizer	Intermediates useful in the synthesis of nelfinavir and methods for preparing the same
CN1300115C (zh) *	2004-03-26	2007-02-14	厦门大学	一种合成1，2，3，4－四氢异喹啉衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
GB8927913D0 (en) *	1989-12-11	1990-02-14	Hoffmann La Roche	Amino acid derivatives
AU2228992A (en) *	1991-07-08	1993-02-11	Glaxo Group Limited	Thiazolidine derivatives and their use as anti-viral compounds
US5256783A (en) *	1991-09-18	1993-10-26	Hoffmann-La Roche Inc.	Method for producing 2-isoquinoline compounds
US5380849A (en) *	1992-11-09	1995-01-10	Merck & Co., Inc.	Process for optically pure decahydroisoqiunolines
DE69603419T3 (de) *	1995-06-30	2006-06-29	Ajinomoto Co., Inc.	Verfahren zur Herstellung von optisch aktiven Amiden

1996
- 1996-02-20 US US08/603,744 patent/US5587481A/en not_active Expired - Lifetime
- 1996-10-18 AU AU74494/96A patent/AU713924B2/en not_active Ceased
- 1996-10-18 CA CA002238478A patent/CA2238478A1/en not_active Abandoned
- 1996-10-18 KR KR1019980705110A patent/KR19990076981A/ko not_active Abandoned
- 1996-10-18 DE DE69631169T patent/DE69631169T2/de not_active Expired - Fee Related
- 1996-10-18 WO PCT/US1996/016628 patent/WO1997030976A1/en not_active Ceased
- 1996-10-18 JP JP53011497A patent/JP2001506575A/ja active Pending
- 1996-10-18 EP EP96936615A patent/EP0902781B1/de not_active Expired - Lifetime
- 1996-10-18 AT AT96936615T patent/ATE256664T1/de not_active IP Right Cessation
1998
- 1998-08-19 NO NO19983803A patent/NO312293B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU713924B2 (en)	1999-12-16
CA2238478A1 (en)	1997-08-28
NO983803L (no)	1998-10-19
EP0902781A4 (de)	2000-07-19
DE69631169T2 (de)	2004-11-11
US5587481A (en)	1996-12-24
KR19990076981A (ko)	1999-10-25
EP0902781A1 (de)	1999-03-24
EP0902781B1 (de)	2003-12-17
DE69631169D1 (de)	2004-01-29
JP2001506575A (ja)	2001-05-22
AU7449496A (en)	1997-09-10
WO1997030976A1 (en)	1997-08-28
NO983803D0 (no)	1998-08-19
NO312293B1 (no)	2002-04-22

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Legal Events

Date	Code	Title	Description
2004-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties