ATE25684T1 - Verfahren zur herstellung von biopterin und dessen derivaten. - Google Patents

Verfahren zur herstellung von biopterin und dessen derivaten.

Info

Publication number: ATE25684T1
Authority: AT; Austria
Prior art keywords: biopterin; diacyl; tetrahydro; prepared; derivatives
Prior art date: 1981-11-13

Application number

AT82110366T

Other languages

English (en)

Inventor

Max Viscontini

Original Assignee

Kanegafuchi Chemical Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-11-13

Filing date

1982-11-10

Publication date

1987-03-15

1982-11-10 Application filed by Kanegafuchi Chemical Ind filed Critical Kanegafuchi Chemical Ind

1987-03-15 Application granted granted Critical

1987-03-15 Publication of ATE25684T1 publication Critical patent/ATE25684T1/de

Links

LHQIJBMDNUYRAM-UHFFFAOYSA-N L-erythro-Biopterin Natural products N1=C(N)NC(=O)C2=NC(C(O)C(O)C)=CN=C21 LHQIJBMDNUYRAM-UHFFFAOYSA-N 0.000 title 1
LHQIJBMDNUYRAM-DZSWIPIPSA-N L-erythro-biopterin Chemical compound N1=C(N)NC(=O)C2=NC([C@@H](O)[C@@H](O)C)=CN=C21 LHQIJBMDNUYRAM-DZSWIPIPSA-N 0.000 title 1
201000011252 Phenylketonuria Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
230000008499 blood brain barrier function Effects 0.000 abstract 1
210000001218 blood-brain barrier Anatomy 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000007812 deficiency Effects 0.000 abstract 1
150000002429 hydrazines Chemical class 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
108010064332 quinonoid dihydropterin reductase Proteins 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT82110366T 1981-11-13 1982-11-10 Verfahren zur herstellung von biopterin und dessen derivaten. ATE25684T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP56182948A JPS5883691A (ja)	1981-11-13	1981-11-13	１′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
EP82110366A EP0079574B1 (de)	1981-11-13	1982-11-10	Verfahren zur Herstellung von Biopterin und dessen Derivaten

Publications (1)

Publication Number	Publication Date
ATE25684T1 true ATE25684T1 (de)	1987-03-15

Family

ID=16127151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT82110366T ATE25684T1 (de)	1981-11-13	1982-11-10	Verfahren zur herstellung von biopterin und dessen derivaten.

Country Status (6)

Country	Link
US (1)	US4540783A (de)
EP (1)	EP0079574B1 (de)
JP (1)	JPS5883691A (de)
AT (1)	ATE25684T1 (de)
CA (1)	CA1208218A (de)
DE (1)	DE3275546D1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3378634D1 (en) *	1982-09-20	1989-01-12	Wellcome Found	Pharmaceutically active pteridine derivatives
GB8318833D0 (en) *	1983-07-12	1983-08-10	Wellcome Found	Chemical compounds
JPS5976086A (ja) *	1982-09-20	1984-04-28	ザ　ウエルカム　フアウンデ−シヨン　リミテツド	プテリジン化合物
JPS59112987A (ja) *	1982-12-20	1984-06-29	Kanegafuchi Chem Ind Co Ltd	１′，２′―ジアシル―（６ｒ，ｓ）―５，６，７，８―テトラヒドロ―ｌ―ビオプテリンおよびその製法
JPS60178887A (ja) *	1984-02-23	1985-09-12	Kanegafuchi Chem Ind Co Ltd	５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60199889A (ja) *	1984-03-24	1985-10-09	Kanegafuchi Chem Ind Co Ltd	５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法
US4550109A (en) *	1984-05-31	1985-10-29	The Board Of Regents, The University Of Texas System	Lipoidal biopterin compounds
US4665176A (en) *	1984-10-23	1987-05-12	Mitsui Toatsu Chemicals, Incorporated	Process for the preparation of 5,6,7,8-tetrahydrofolic acid
US4937342A (en) *	1987-11-30	1990-06-26	Kabushiki Kaisha Vitamin Kenkyusyo	Intermediates for synthesizing BH4 and its derivatives
JP2843592B2 (ja) *	1989-02-28	1999-01-06	日清製粉株式会社	Ｌ−リボース誘導体
US6162914A (en) *	1998-04-24	2000-12-19	Cerbios-Pharma S.A.	Process for the reduction of pterins
US7442372B2 (en)	2003-08-29	2008-10-28	Biomarin Pharmaceutical Inc.	Delivery of therapeutic compounds to the brain and other tissues
PL3138566T3 (pl)	2003-11-17	2022-03-07	Biomarin Pharmaceutical Inc.	Leczenie fenyloketonurii z użyciem bh4
RU2434870C2 (ru) *	2003-11-17	2011-11-27	Мерк Эпрова Аг	Кристаллические формы дигидрохлорида (6r)-l-эритро-тетрагидробиоптерина
AU2012200512C1 (en) *	2003-11-17	2020-04-30	Merck & Cie	Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
EP2436379A1 (de)	2004-11-17	2012-04-04	BioMarin Pharmaceutical Inc.	Stabile Tablettenformulierung
EP1819340A2 (de) *	2004-12-08	2007-08-22	Biomarin Pharmaceutical Inc.	Verfahren und zusammensetzungen zur behandlung von lungenhypertonie bei neugeborenen
US7361759B2 (en)	2004-12-27	2008-04-22	Shiratori Pharmaceutical Co., Ltd	Method for producing L-biopterin
AU2006321942A1 (en) *	2005-12-05	2007-06-14	Biomarin Pharmaceutical Inc.	Methods and compositions for the treatment of disease
JP4946391B2 (ja) *	2006-11-28	2012-06-06	ダイキン工業株式会社	熱交換器およびこれを備える空調ユニット
WO2008089148A1 (en) *	2007-01-12	2008-07-24	Biomarin Pharmaceutical Inc.	Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
CA2675134A1 (en) *	2007-01-12	2008-07-24	Biomarin Pharmaceutical Inc.	Pterin analogs
PL2139485T3 (pl)	2007-04-11	2013-03-29	Biomarin Pharm Inc	Metoda podawania tetrahydrobiopteryny, powiązane kompozycje i sposoby pomiaru
AU2008347005B2 (en)	2008-01-03	2013-10-03	Biomarin Pharmaceutical Inc.	Pterin analog for treating BH4 responsive condition
MX2010007452A (es)	2008-01-07	2010-08-18	Biomarin Pharm Inc	Metodo para sintetizar tetrahidrobiopterin.
US9216178B2 (en)	2011-11-02	2015-12-22	Biomarin Pharmaceutical Inc.	Dry blend formulation of tetrahydrobiopterin
WO2019175332A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4pathwayactivationandusethereoffortreatingcancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH500999A (de) *	1967-04-07	1970-12-31	Ciba Geigy Ag	Verfahren zur Herstellung von Pterinderivaten
US3505329A (en) *	1968-02-06	1970-04-07	Smithkline Corp	Process for the synthesis of biopterin

1981
- 1981-11-13 JP JP56182948A patent/JPS5883691A/ja active Pending
1982
- 1982-11-10 CA CA000415245A patent/CA1208218A/en not_active Expired
- 1982-11-10 EP EP82110366A patent/EP0079574B1/de not_active Expired
- 1982-11-10 AT AT82110366T patent/ATE25684T1/de not_active IP Right Cessation
- 1982-11-10 DE DE8282110366T patent/DE3275546D1/de not_active Expired
- 1982-11-15 US US06/441,736 patent/US4540783A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS5883691A (ja)	1983-05-19
CA1208218A (en)	1986-07-22
EP0079574A1 (de)	1983-05-25
DE3275546D1 (en)	1987-04-09
US4540783A (en)	1985-09-10
EP0079574B1 (de)	1987-03-04

Similar Documents

Publication	Publication Date	Title
ATE25684T1 (de)	1987-03-15	Verfahren zur herstellung von biopterin und dessen derivaten.
ATE120961T1 (de)	1995-04-15	Konzentrate von aktiven verbindungen und kombinationen von aktiven verbindungen, ihre verfahren zur herstellung und arzneimittel, die die konzentrate oder die kombinationen enthalten.
ATE15798T1 (de)	1985-10-15	Heterozyklische carboxamide, zubereitungen, die solche verbindungen enthalten, verfahren zu ihrer herstellung und methoden zur behandlung damit.
DE3483629D1 (de)	1991-01-03	2-pyrimidinyl-l-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE3684409D1 (de)	1992-04-23	Verwendung von gamma-linolensaeure und verwandten verbindungen zur herstellung eubnes arzneimittels zur behandlung von endometriose.
DE3877751D1 (de)	1993-03-04	Kunstlunge vom membrantyp und verfahren zur herstellung.
DE3769174D1 (de)	1991-05-16	Indolizin-derivate, verfahren zur herstellung und diese enthaltende zusammensetzungen.
ZA934550B (en)	1994-01-27	Derivatives in the vitamin D series with modifications in 20-position, process for their production,intermediate products for this process,pharmaceutical prepartions containing these derivatives as well as their use for the production of pharmaceutical agents
DE3581566D1 (de)	1991-03-07	Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte.
ATE48417T1 (de)	1989-12-15	Pyridazin-derivate, wirksam auf das zentralnervensystem, verfahren zur herstellung, und diese enthaltende arzneimittel.
ATE66678T1 (de)	1991-09-15	Verfahren zur herstellung von makrolidderivaten.
AT338525B (de)	1977-08-25	Verfahren zur herstellung von copolyamiden enthaltend caprolactam, laurinlactam und 11-aminoundecansaure
DE3382299D1 (de)	1991-07-04	Pyrazolo(3,4-b)pyridinderivate und verfahren zu ihrer herstellung.
HU911140D0 (en)	1991-10-28	Process for producing cyclo-alkano-(b)-dihydro-indole derivatives and their sulfonamides as well as pharmaceutical preparatives containing said compounds
HU902098D0 (en)	1990-07-28	Process for producing substituted 1,8-naphthyridine derivatives and pharmaceutical preparatives containing such compounds
DE3787437D1 (de)	1993-10-21	Sialosylcholesterol, verfahren zu dessen herstellung und arzneimittel zur behandlung von krankheiten des nervensystems.
DE3782207D1 (de)	1992-11-19	2-acyloxypropylamin-derivate, verfahren zur herstellung und diese enthaltende arzneimittel.
ATE86619T1 (de)	1993-03-15	Verfahren zur herstellung von nitroethenderivaten.
ATE173735T1 (de)	1998-12-15	Thiomarinol-derivate und verfahren zu ihrer herstellung
ATE166642T1 (de)	1998-06-15	9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln
AT345830B (de)	1978-10-10	Verfahren zur herstellung von neuen 5:6-benzo- gamma-pyron-derivaten bzw. von pharmazeutisch annehmbaren salzen und von optischen isomeren hievon
DE68918471D1 (de)	1994-11-03	Milchsäure-Bakterien-Starter für die Futterherstellung und ein diese lebensfähigen Bakterien enthaltendes Mittel.
DE59309380D1 (de)	1999-03-25	Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsäure
ATE65778T1 (de)	1991-08-15	4-oxo-thiazolidin-2-yliden-acetamid-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel zur bekaempfung von erkrankungen des zentralnervensystems.
DE3887212D1 (de)	1994-03-03	Verfahren zur Herstellung von Derivaten von 6,7-Diazyl-7-desacetylforskolin.

Legal Events

Date	Code	Title	Description
1987-08-15	UEP	Publication of translation of european patent specification
1999-08-15	REN	Ceased due to non-payment of the annual fee