ATE257018T1 - Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauch - Google Patents

Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauch

Info

Publication number
ATE257018T1
ATE257018T1 AT94930647T AT94930647T ATE257018T1 AT E257018 T1 ATE257018 T1 AT E257018T1 AT 94930647 T AT94930647 T AT 94930647T AT 94930647 T AT94930647 T AT 94930647T AT E257018 T1 ATE257018 T1 AT E257018T1
Authority
AT
Austria
Prior art keywords
vivo
cell
bioreactor
artificial kidney
coated artificial
Prior art date
Application number
AT94930647T
Other languages
English (en)
Inventor
David H Humes
Deborah A Cieslinski
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Application granted granted Critical
Publication of ATE257018T1 publication Critical patent/ATE257018T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0687—Renal stem cells; Renal progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/25—Urinary tract cells, renal cells
    • C12N2502/256—Renal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT94930647T 1993-10-08 1994-10-11 Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauch ATE257018T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/133,436 US5549674A (en) 1992-03-02 1993-10-08 Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
PCT/US1994/011384 WO1995011048A2 (en) 1993-10-08 1994-10-11 METHODS AND COMPOSITIONS OF A BIOARTIFICIAL KIDNEY SUITABLE FOR USE IN VIVO OR $i(EX VIVO)

Publications (1)

Publication Number Publication Date
ATE257018T1 true ATE257018T1 (de) 2004-01-15

Family

ID=22458619

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94930647T ATE257018T1 (de) 1993-10-08 1994-10-11 Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauch

Country Status (8)

Country Link
US (2) US5549674A (de)
EP (1) EP0746343B1 (de)
JP (2) JP3614853B2 (de)
AT (1) ATE257018T1 (de)
AU (1) AU692191B2 (de)
CA (2) CA2710965C (de)
DE (1) DE69433464T2 (de)
WO (1) WO1995011048A2 (de)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410320B1 (en) 1992-03-02 2002-06-25 The University Of Michigan Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
SE9900043D0 (sv) * 1999-01-11 1999-01-11 Astra Ab New use
JPH09512184A (ja) * 1994-04-29 1997-12-09 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド 内皮下細胞外基質上の内皮を利用する改善された血液接触表面
US6152141A (en) * 1994-07-28 2000-11-28 Heartport, Inc. Method for delivery of therapeutic agents to the heart
DE69633189T2 (de) * 1995-10-06 2005-08-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Fester Träger zur Verwendung in der Zellkultivierung, insbesondere für die Kultivierung von Leberzellen, Bioreaktor, welcher den festen Träger enthält, und die Verwendung davon in einem biologisch-künstlichen Lebersystem
US6673339B1 (en) 1996-09-05 2004-01-06 Children's Medical Center Corporation Prosthetic kidney and its use for treating kidney disease
WO1998009582A1 (en) * 1996-09-05 1998-03-12 Children's Medical Center Corporation Prosthetic kidney and its use for treating kidney disease
US6150164A (en) * 1996-09-30 2000-11-21 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5902336A (en) * 1996-10-15 1999-05-11 Mirimedical, Inc. Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure
DE69834836T2 (de) * 1997-10-31 2007-05-16 Children's Medical Center Corp., Boston Penis-rekonstruktion
CA2307567C (en) 1997-10-31 2009-01-20 Children's Medical Center Corporation Polymer matrix/cell construct for bladder reconstruction
WO2000061630A1 (en) * 1999-04-08 2000-10-19 President And Fellows Of Harvard College Induction of kidney tubule formation
JP4347528B2 (ja) * 1999-04-23 2009-10-21 ネフリオン， インコーポレイテッド 体外回路および関連方法
WO2000066036A2 (en) * 1999-04-30 2000-11-09 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds
AU2004201641B2 (en) * 1999-04-30 2007-04-19 The Charles Stark Draper Laboratory, Inc. Fabrication of Vascularized Tissue Using Microfabricated Two-Dimensional Molds
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US20040167634A1 (en) * 1999-05-26 2004-08-26 Anthony Atala Prosthetic kidney and its use for treating kidney disease
JP3229599B2 (ja) * 1999-06-01 2001-11-19 ホスパル株式会社 血液浄化装置とそれを使用した人工腎臓
AU779579B2 (en) * 1999-08-10 2005-01-27 Innovata Plc Method for delivery of therapeutic agents using a solution of dextrin
DE19943205C1 (de) * 1999-09-10 2000-11-16 Geesthacht Gkss Forschung Verfahren zur Erzeugung, zum Transport und zur Eliminierung von biochemischen Stoffen mittels aktiver biologischer Zellen
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
AU2001253012B2 (en) * 2000-03-31 2006-02-23 The General Hospital Corporation Methods of modulating hair growth
US7776021B2 (en) * 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
CN100363066C (zh) * 2000-10-12 2008-01-23 肾脏治疗公司 在体液体外处理中用于体液流动控制的装置和方法
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US7033498B2 (en) * 2000-11-28 2006-04-25 Renal Solutions, Inc. Cartridges useful in cleaning dialysis solutions
US6627164B1 (en) 2000-11-28 2003-09-30 Renal Solutions, Inc. Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
EP1341476A2 (de) * 2000-12-01 2003-09-10 Nephros Therapeutics, Inc. Gerät für intravaskuläre arzneiverabreichung und seine verwendung
US6659973B2 (en) * 2001-01-04 2003-12-09 Transvivo, Inc. Apparatus and method for in-vivo plasmapheresis using periodic backflush
US7476210B2 (en) * 2001-01-04 2009-01-13 Transvivo Inc. Apparatus and method for in-vivo plasmapheresis using periodic backflush containing anticoagulant
US6582955B2 (en) * 2001-05-11 2003-06-24 Spectrum Laboratories, Inc. Bioreactor with application as blood therapy device
TWI221421B (en) * 2001-05-17 2004-10-01 Gejyo Fumitake Artificial kidney having function of metabolizing protein and method of constructing the same
US6653131B2 (en) 2001-08-30 2003-11-25 The Regents Of The University Of Michigan Method of treating systemic inflammatory response syndrome
US7332330B2 (en) * 2001-09-11 2008-02-19 Renamed Biologics, Inc. Device for maintaining vascularization near an implant
MXPA04004534A (es) * 2001-11-16 2004-08-11 Childrens Medical Center Aumento de la funcion de un organo.
US6878283B2 (en) * 2001-11-28 2005-04-12 Renal Solutions, Inc. Filter cartridge assemblies and methods for filtering fluids
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US20050008626A1 (en) * 2001-12-07 2005-01-13 Fraser John K. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7595043B2 (en) * 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US8404229B2 (en) * 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
KR100811995B1 (ko) 2001-12-07 2008-03-10 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US20050048036A1 (en) * 2001-12-07 2005-03-03 Hedrick Marc H. Methods of using regenerative cells in the treatment of inherited and acquired disorders of the bone, bone marrow, liver, and other tissues
US7514075B2 (en) * 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US7442546B2 (en) * 2002-03-15 2008-10-28 The Regents Of The University Of Michigan Method of modulating inflammatory response
CA2501965C (en) * 2002-09-11 2012-04-10 The Regents Of The University Of Michigan Ultrafiltration membrane, device, bioartificial organ, and methods
EP1589814B1 (de) 2003-01-16 2009-08-12 The General Hospital Corporation Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
WO2005034624A2 (en) 2003-05-21 2005-04-21 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US7998101B2 (en) * 2003-07-28 2011-08-16 Renal Solutions, Inc. Devices and methods for body fluid flow control in extracorporeal fluid treatment
EP1660644A1 (de) * 2003-08-29 2006-05-31 Regents Of The University Of Minnesota Aus der niere stammende stammzellen und methoden zu deren isolierung, differenzierung und verwendung
WO2005084223A2 (en) * 2004-02-27 2005-09-15 The General Hospital Corporation Methods and compositions for hair growth
DE102004017476B4 (de) 2004-04-08 2009-03-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung
ATE478942T1 (de) * 2004-07-01 2010-09-15 Cytori Therapeutics Inc Verfahren zur verwendung regenerativer zellen bei der behandlung von nierenkrankheiten und störungen
US7083653B2 (en) * 2004-08-12 2006-08-01 Charles Edward Jennings Implantable human kidney replacement unit
US20080140451A1 (en) * 2005-01-10 2008-06-12 Cytori Therapeutics, Inc. Devices and Methods for Monitoring, Managing, and Servicing Medical Devices
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US7874998B2 (en) * 2005-11-04 2011-01-25 The Regents Of The University Of Michigan Filtration devices and related methods thereof
US8764697B2 (en) * 2006-02-01 2014-07-01 Agathos Holdings Llc Systems and methods for an advanced medical device
US8096967B2 (en) * 2006-02-02 2012-01-17 Milan Radojicic Tissue engineered cerebrospinal fluid shunt
EP1989144A4 (de) 2006-02-02 2014-01-29 Innovative Bio Therapies Extrakorporale zellbasierte therapeutische vorrichtung und freisetzungssystem
US8012118B2 (en) * 2006-03-08 2011-09-06 Fresenius Medical Care Holdings, Inc. Artificial kidney dialysis system
US8715221B2 (en) * 2006-03-08 2014-05-06 Fresenius Medical Care Holdings, Inc. Wearable kidney
US20080090765A1 (en) * 2006-05-25 2008-04-17 The Trustees Of Columbia University In The City Of New York Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage
US10478555B2 (en) 2006-08-17 2019-11-19 Milan Radojicic Systems and methods for lumbar cerebrospinal fluid access and treatment
US9770180B2 (en) * 2006-08-17 2017-09-26 Milan Radojicic System and method for monitoring and delivering therapeutics to the spinal cord
US20080045611A1 (en) * 2006-08-17 2008-02-21 Milan Radojicic Methods for the therapeutic use of a carbonic anhydrase inhibitor for reducing spinal cord edema
DE102006042732B3 (de) * 2006-09-12 2008-04-10 Gerlach, Jörg, Dr.med. Künstliches arterio-venöses permeables Hohlfaserkapillarsystem
ES2583371T3 (es) 2006-10-11 2016-09-20 The General Hospital Corporation Composiciones, métodos, y dispositivos para tratar enfermedades hepáticas
US20090209019A1 (en) * 2006-10-17 2009-08-20 Tokai University Educational System Bioartificial Renal Tubule
JP4672632B2 (ja) * 2006-10-17 2011-04-20 学校法人東海大学 バイオ人工糸球体
US9403126B2 (en) 2007-01-10 2016-08-02 The Regents Of The University Of Michigan Ultrafiltration membrane, device, bioartificial organ, and related methods
EP2115116B1 (de) * 2007-03-05 2018-01-24 Terumo BCT, Inc. Verfahren zur kontrolle der zellbewegung in hohlfaserbioreaktoren
CA2688265C (en) * 2007-06-08 2021-02-16 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US10590391B2 (en) * 2007-06-08 2020-03-17 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US9580688B2 (en) * 2007-06-08 2017-02-28 Wake Forest University Health Sciences Kidney structures and methods of forming the same
CN102171332A (zh) 2008-06-18 2011-08-31 创新生物制剂疗法公司 促进肾前体细胞增殖的方法
US9463276B2 (en) 2008-08-16 2016-10-11 Milan Radojicic Systems and methods for a computational medical device in dynamic body systems
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
EP2177603A1 (de) * 2008-09-25 2010-04-21 Gambro Lundia AB Vorrichtung für Nierenzellexpansion
EP2168666A1 (de) 2008-09-25 2010-03-31 Gambro Lundia AB Bestrahlte Membran für Zellexpansion
EP2168668A1 (de) 2008-09-25 2010-03-31 Gambro Lundia AB Membran für Zellexpansion
ATE545440T1 (de) 2008-09-25 2012-03-15 Gambro Lundia Ab Hybride biologische künstliche niere
MX2011004631A (es) * 2008-11-03 2011-06-17 Fresenius Med Care Hldg Inc Sistema de dialisis peritoneal portatil.
CA2959048A1 (en) * 2008-11-06 2010-05-14 Xerem Medical Ltd. Blood filtering device and method
EP2358375B1 (de) * 2008-11-12 2013-07-24 Tengion, Inc. Isolierte nierenzellen und verwendungen dafür
EP2370564A4 (de) * 2008-12-02 2013-11-06 Agency Science Tech & Res Verfahren zur herstellung von nierentubuli
WO2010127310A1 (en) 2009-05-01 2010-11-04 Cytori Therapeutics, Inc. Systems, methods and compositions for optimizing tissue and cell enriched grafts
EP2566951B1 (de) 2010-05-05 2020-03-04 Terumo BCT, Inc. Verfahren zur neuaussaat von in einem hohlfaser-bioreaktorsystem gezüchteten adhärenten zellen
TWI690320B (zh) 2010-05-12 2020-04-11 開曼群島商英瑞金公司 生物活性腎細胞
EP2412798A1 (de) * 2010-07-27 2012-02-01 Gambro Lundia AB Biomimetische Membran zur Kultivierung von Zellen
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
SG190002A1 (en) * 2010-10-25 2013-06-28 Agency Science Tech & Res Tubular fiber membrane with nanoporous skin
KR102302069B1 (ko) 2010-11-10 2021-09-14 인리젠 장기 확대를 위한 주사가능 제제
CN103764190B (zh) * 2011-06-15 2019-03-08 查尔斯斯塔克布料实验室公司 与仿生细胞化肾单位有关的系统、方法和装置
EP2797645B1 (de) 2011-12-28 2017-10-18 Xerem Medical Ltd. System und verfahren zur blutfilterung und/oder behandlung
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN105457118B (zh) * 2015-12-17 2018-01-02 珠海健帆生物科技股份有限公司 血液净化装置及系统
CN105733944A (zh) * 2016-05-04 2016-07-06 浙江大学 六孔板肝细胞中空纤维反应器的构建方法
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
EP3509653A4 (de) * 2016-09-06 2020-04-29 President and Fellows of Harvard College Lebende vorrichtung zum ersetzen von organen oder spezifischen organfunktionen, verfahren und verwendungen davon
US11052230B2 (en) 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3778872A4 (de) * 2018-04-13 2022-01-05 Nikkiso Co., Ltd. Zellkulturverfahren, verfahren zur herstellung eines zellträgerkomplexes, kultivierte zelle und zellträgerkomplex
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
WO2023210765A1 (ja) * 2022-04-28 2023-11-02 株式会社クラレ 免疫隔離デバイス
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734851A (en) * 1969-12-29 1973-05-22 K Matsumura Method and device for purifying blood
GB1479002A (en) * 1973-06-06 1977-07-06 Spielberg T Artificial gland structure
US4242460A (en) * 1978-12-26 1980-12-30 Chick William L Cell culture device
EP0058275A1 (de) * 1981-02-17 1982-08-25 SENKO MEDICAL INSTRUMENT Mfg Co., LTD Künstliche Niere aus Hohlfasern
US4354933A (en) * 1981-02-23 1982-10-19 Lester James P Implantable artificial kidney
JPS61115569A (ja) * 1984-11-09 1986-06-03 テルモ株式会社 一過性白血球減少症軽減用人工腎臓およびその製造方法
US5035708A (en) * 1985-06-06 1991-07-30 Thomas Jefferson University Endothelial cell procurement and deposition kit
IL78950A (en) * 1985-06-06 1991-12-15 Univ Jefferson Coating for prosthetic devices
JP2739758B2 (ja) * 1987-02-24 1998-04-15 ヴィレス，ジョセフ・エム 形質転換細胞株を用いる肝臓補助装置
WO1989001967A1 (en) * 1987-09-03 1989-03-09 Brown University Research Foundation Blood purification with cultured renal cells
JP2835629B2 (ja) * 1989-05-18 1998-12-14 ザ リージェンツ オブ ザ ユニヴァーシティ オブ ミネソタ バイオリアクター装置
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
WO1992007615A1 (en) * 1990-10-29 1992-05-14 Regents Of The University Of Minnesota A bioartificial liver
US5429938A (en) * 1992-03-02 1995-07-04 University Of Michigan Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules

Also Published As

Publication number Publication date
AU692191B2 (en) 1998-06-04
WO1995011048A2 (en) 1995-04-27
US5549674A (en) 1996-08-27
JPH09503941A (ja) 1997-04-22
EP0746343A4 (de) 1997-12-03
DE69433464D1 (de) 2004-02-05
DE69433464T2 (de) 2004-11-11
JP3795900B2 (ja) 2006-07-12
CA2710965C (en) 2012-10-09
EP0746343A1 (de) 1996-12-11
JP2004267795A (ja) 2004-09-30
AU7970194A (en) 1995-05-08
WO1995011048A3 (en) 1995-06-22
CA2173594A1 (en) 1995-04-27
CA2173594C (en) 2004-09-07
CA2710965A1 (en) 1995-04-27
EP0746343B1 (de) 2004-01-02
JP3614853B2 (ja) 2005-01-26
US5686289A (en) 1997-11-11

Similar Documents

Publication Publication Date Title
DE69433464D1 (de) Mit zellen beschichtete künstliche nieren betreffende vorrichtungen zum in vivo oder ex vivo gebrauch
ATE31549T1 (de) Verfahren zur zuechtung von zellkulturen.
FR2640638B1 (fr) Bioreacteur et dispositif pour la culture de cellules animales
DE69832402D1 (de) Erzeugung von hämatopoietischen zellen aus multipotenten neuronalen stammzellen
FR2323759A1 (fr) Boite de culture de micro-organismes, cellules et tissus
DK494688D0 (da) Fremgangsmaade til opbevaring eller dyrkning af celler og poroes, uorganisk baere-membran og apparat dertil
DE69028524D1 (de) In vivo-neomorphogenese von knorpel aus zellkulturen
ATE384782T1 (de) Rekonstruktion von organen aus einem dezellularisierten biologischem gerüst
ATE232748T1 (de) Hemmung von gefässverengungen nach eingriffen an den gefässen
ATE314102T1 (de) Verwendung einer kollagenmembrane zur herstellung eines implantates für gesteuerte geweberegeneration
ATE71298T1 (de) Immunoregulation.
CA2244659A1 (en) Biological reactor for the cultivation of cells
ATE260076T1 (de) Nierenprothese
ATE277648T1 (de) Kollagenmembran mit makromolekularer anordnung
DK0532628T3 (da) Beholder til opbevaring og distribution af forbindinger til hudsår
ATE237373T1 (de) Epithelzellen enthaltendes biomaterial und ihre verwendung als transplantat
ATE15693T1 (de) Zellkultur-verfahren.
Doillon et al. Fibroblast and epidermal cell-type I collagen interactions: cell culture and human studies
FI963373L (fi) Ruumiin ulkopuolinen soluviljelmä ja transplantaatiopakkauksia
NO960050D0 (no) Nye stromacellelinjer fra human benmarg og anvendelse av disse
DE69110906D1 (de) Verwendung von Wirtszellphospholipiden zur Hemmung bakterieller Besiedlung.
DE3666458D1 (en) Method and device for the _i(in vitro) culture of plant cells and organs, as well as for the micropropagation and regeneration of complete plants
DE3871530D1 (de) Vorrichtung zum kultivieren von ruhenden zellen in einem bioreaktor.
DE69634363D1 (de) Vorläufer von normalen neuralen epithelzellen
WANG CULTIVATION OF HUMAN EPIDERMAL CELLS ON FIBRONECTIN COATED SUBSTRATE AND I'TS CLINICAL APPLICATION

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0746343

Country of ref document: EP