ATE257156T1 - (1,2,4)triazolo(1,5-c)pyrimidin-derivate - Google Patents

(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Info

Publication number: ATE257156T1
Authority: AT; Austria
Prior art keywords: substituted; lower alkyl; unsubstituted aryl; represents hydrogen; unsubstituted
Prior art date: 1997-03-24

Application number

AT98909835T

Other languages

English (en)

Inventor

Hiroshi Tsumuki

Junichi Shimada

Hironori Imma

Akiko Nakamura

Hiromi Nonaka

Shizuo Shiozaki

Shunji Ichikawa

Tomoyuki Kanda

Yoshihisa Kuwana

Michio Ichimura

Fumio Suzuki

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-24

Filing date

1998-03-24

Publication date

2004-01-15

1998-03-24 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE257156T1 publication Critical patent/ATE257156T1/de

Links

QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
102000007471 Adenosine A2A receptor Human genes 0.000 abstract 2
108010085277 Adenosine A2A receptor Proteins 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002774 3,4-dimethoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
230000008485 antagonism Effects 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
208000013403 hyperactivity Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT98909835T 1997-03-24 1998-03-24 (1,2,4)triazolo(1,5-c)pyrimidin-derivate ATE257156T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP6956697		1997-03-24
PCT/JP1998/001266 WO1998042711A1 (en)	1997-03-24	1998-03-24	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
ATE257156T1 true ATE257156T1 (de)	2004-01-15

Family

ID=13406463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98909835T ATE257156T1 (de)	1997-03-24	1998-03-24	(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Country Status (8)

Country	Link
US (1)	US6222035B1 (de)
EP (1)	EP0976753B1 (de)
JP (1)	JP4195729B2 (de)
AT (1)	ATE257156T1 (de)
AU (1)	AU743910B2 (de)
CA (1)	CA2284737C (de)
DE (1)	DE69820866T2 (de)
WO (1)	WO1998042711A1 (de)

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WO2002079204A1 (en) *	2001-03-28	2002-10-10	Kyowa Hakko Kogyo Co., Ltd.	8-thiazolyl[1,2,4]triazolo[1,5-c]pyrimidine derivative
JP5280597B2 (ja)	2001-03-30	2013-09-04	サンスター技研株式会社	一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材
EP1430898A4 (de) *	2001-09-28	2005-11-02	Kyowa Hakko Kogyo Kk	Rezeptorantagonist
BR0213172A (pt) *	2001-10-08	2004-09-14	Hoffmann La Roche	Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico
TW200300686A (en) *	2001-11-30	2003-06-16	Schering Corp	Adenosine A2a receptor antagonists
CA2468658C (en) *	2001-11-30	2009-04-14	Schering Corporation	[1,2,4]-triazole bicyclic adenosine a2a receptor antagonists
ES2716404T3 (es)	2002-01-28	2019-06-12	Kyowa Hakko Kogyo Kk	Antagonistas de receptores A2A para su uso en el tratamiento de trastornos del movimiento
JPWO2003068776A1 (ja) *	2002-02-15	2005-06-02	協和醗酵工業株式会社	［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
AU2003272886A1 (en) *	2002-09-24	2004-04-19	Kyowa Hakko Kogyo Co., Ltd.	(1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
EP1633756B1 (de)	2003-04-09	2008-12-24	Biogen Idec MA Inc.	A2a-adenosinrezeptorantagonisten
EP1618109A2 (de) *	2003-04-09	2006-01-25	Biogen Idec MA Inc.	Als a2a-adenosinrezeptorantagonisten geeignete triazolo[1,5-c]pyrimidine und pyrazolo[1,5-c]pyrimidine
WO2004092170A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
EP1615931A1 (de) *	2003-04-09	2006-01-18	Biogen Idec MA Inc.	Triazolopyrazine und verfahren zu deren herstellung und anwendung
WO2005056524A2 (en) *	2003-12-09	2005-06-23	Euro-Celtique S.A.	Therapeutic agents useful for treating pain
CN101119998A (zh)	2004-12-21	2008-02-06	先灵公司	吡唑并[1,5－A]嘧啶腺苷A2a受体拮抗剂
WO2006129626A1 (ja) *	2005-05-30	2006-12-07	Kyowa Hakko Kogyo Co., Ltd.	[1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法
JPWO2006132275A1 (ja)	2005-06-07	2009-01-08	協和醗酵工業株式会社	運動障害の予防および／または治療剤
ES2273599B1 (es)	2005-10-14	2008-06-01	Universidad De Barcelona	Compuestos para el tratamiento de la fibrilacion auricular.
CN102112475A (zh) *	2008-05-29	2011-06-29	西特里斯药业公司	作为沉默调节蛋白调节剂的咪唑并吡啶和相关的类似物
NZ590793A (en) *	2008-07-23	2012-07-27	Kyowa Hakko Kirin Co Ltd	Therapeutic agent for migraine
CN103261202B (zh) *	2010-09-24	2016-01-20	阿迪维纳斯疗法有限公司	作为腺苷受体拮抗剂的稠合三环化合物
KR20190129851A (ko) *	2017-03-16	2019-11-20	지앙수 헨그루이 메디슨 컴퍼니 리미티드	헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도
EP3611174B1 (de) *	2017-04-07	2022-06-08	Medshine Discovery Inc.	[1,2,4] triazolo [1,5-c] pyrimidin-derivate als a2a-rezeptor-inhibitor
AU2018294557A1 (en) *	2017-06-30	2020-01-02	Ryvu Therapeutics S.A.	Imidazo(1,2-a)pyrazine modulators of the adenosine A2A receptor
CN109535161B (zh) *	2017-09-22	2021-09-03	江苏恒瑞医药股份有限公司	三唑并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2019062803A1 (zh)	2017-09-28	2019-04-04	基石药业	作为a2a受体抑制剂的并环类衍生物
AU2019227607C1 (en) *	2018-02-27	2023-07-20	Incyte Corporation	Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
CN112105617B (zh) *	2018-04-28	2022-04-05	南京明德新药研发有限公司	一种三唑并嘧啶类化合物的晶型、盐型及其制备方法
EP3810610A1 (de)	2018-05-18	2021-04-28	Incyte Corporation	Kondensierte pyrimidinderivate als a2a/a2b-inhibitoren
CN117304191A (zh)	2018-07-05	2023-12-29	因赛特公司	作为a2a/a2b抑制剂的稠合吡嗪衍生物
AR116315A1 (es)	2018-09-12	2021-04-21	Dizal Jiangsu Pharmaceutical Co Ltd	Compuestos de triazolo-pirimidina y usos de los mismos
JP2022507734A (ja)	2018-11-20	2022-01-18	メルク・シャープ・アンド・ドーム・コーポレーション	置換アミノトリアゾロピリミジン及びアミノトリアゾロピラジンアデノシン受容体アンタゴニスト、医薬組成物及びそれらの使用
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
PH12022550470A1 (en) *	2019-08-26	2023-02-27	Incyte Corp	Triazolopyrimidines as a2a / a2b inhibitors

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DE3781080T2 (de) *	1986-09-30	1992-12-24	Ciba Geigy Ag	2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
EP0459702A1 (de) *	1990-05-29	1991-12-04	Zeneca Limited	Azolderivate
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FR2678618B1 (fr) *	1991-07-05	1993-11-05	Upsa Laboratoires	Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
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1998
- 1998-03-24 WO PCT/JP1998/001266 patent/WO1998042711A1/ja not_active Ceased
- 1998-03-24 JP JP54543398A patent/JP4195729B2/ja not_active Expired - Fee Related
- 1998-03-24 EP EP98909835A patent/EP0976753B1/de not_active Expired - Lifetime
- 1998-03-24 CA CA002284737A patent/CA2284737C/en not_active Expired - Fee Related
- 1998-03-24 DE DE69820866T patent/DE69820866T2/de not_active Expired - Fee Related
- 1998-03-24 AT AT98909835T patent/ATE257156T1/de not_active IP Right Cessation
- 1998-03-24 AU AU64221/98A patent/AU743910B2/en not_active Ceased
1999
- 1999-09-23 US US09/401,984 patent/US6222035B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6222035B1 (en)	2001-04-24
EP0976753A1 (de)	2000-02-02
EP0976753B1 (de)	2004-01-02
DE69820866D1 (de)	2004-02-05
AU743910B2 (en)	2002-02-07
DE69820866T2 (de)	2004-12-30
CA2284737C (en)	2007-03-13
CA2284737A1 (en)	1998-10-01
JP4195729B2 (ja)	2008-12-10
WO1998042711A1 (en)	1998-10-01
EP0976753A4 (de)	2000-07-05
AU6422198A (en)	1998-10-20

Legal Events

Date	Code	Title	Description
2004-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69820866D1 (de)	2004-02-05	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
PT1159279E (pt)	2003-02-28	4-oxo-4,7-di-hidrotieno¬2,3-b\|piridino-5-carboxamidas como agentes antivirais
DK0550113T3 (da)	1998-02-09	Triazolpyrimidinderivater med fungicid virkning
PL349036A1 (en)	2002-07-01	Quinoline derivatives and quinazoline derivatives
ATE160341T1 (de)	1997-12-15	Benzolsulfonamid-derivate und verfahren zur herstellung
BR0306208A (pt)	2004-10-13	Compostos de dibenzilamina e seu uso farmacêutico
CY1117132T1 (el)	2017-04-05	Παραγωγο θειαζολιου
CY1107401T1 (el)	2012-12-19	Παραγωγα βενζοθειαζολιου πα την θεραπευτικη αντιμετωπιση της νοσου alzheimer και της νοσου parkinson
FI953968A0 (fi)	1995-08-23	Antraniiliset happojohdannaiset
DE69428977D1 (de)	2001-12-13	Arzneimittel gegen Parkinsonsche Krankheit
AR053301A1 (es)	2007-05-02	Derivados de pirazina y su uso farmaceutico
NO20055510L (no)	2006-01-20	2-alkynyl- og 2-alkenylpyrazolo [4,3-E]-1,2,4-triazolo-[1,5-C]-pyrimidin-adenosin A2A-reseptorantagonister
EP1116722A4 (de)	2002-05-29	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
GR3003378T3 (en)	1993-02-17	Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments
WO2003068776A1 (en)	2003-08-21	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
ATE480527T1 (de)	2010-09-15	Thiadiazolinderivate zur krebsbehandlung
GR3015136T3 (en)	1995-05-31	Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes.
EP1034783A4 (de)	2001-03-28	Amidederivaten
FI952420A0 (fi)	1995-05-18	Glukopyranosidibentsotiofeenit
NO20062202L (no)	2006-07-03	Amidometylsubstituerte 2-(4-sulfonylamino)-3-hydroksy-3,4-dihydro-2H-kromen-6-yl-derivater, fremgangsmate og mellomprodukter for deres fremstilling, og legemidler som inneholder disse forbindelsene
DK0855398T3 (da)	2003-08-04	Sesquiterpenderivater med antiviral aktivitet
DE69910574D1 (de)	2003-09-25	Pyrazolo[1,5-a]triazine als crf antagonisten
FI893570A0 (fi)	1989-07-26	Menetelmä lääkeaineina käyttökelpoisten 1H-imidatso/1,2-b/-pyratsolin johdannaisten valmistamiseksi
DK0686641T3 (da)	1998-11-23	2'-Deoxy-5-fluoruridinderivat, farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf, og antitumorlægem