ATE257156T1 - (1,2,4)triazolo(1,5-c)pyrimidin-derivate - Google Patents

(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Info

Publication number: ATE257156T1
Authority: AT; Austria
Prior art keywords: substituted; lower alkyl; unsubstituted aryl; represents hydrogen; unsubstituted
Prior art date: 1997-03-24

Application number

AT98909835T

Other languages

English (en)

Inventor

Hiroshi Tsumuki

Junichi Shimada

Hironori Imma

Akiko Nakamura

Hiromi Nonaka

Shizuo Shiozaki

Shunji Ichikawa

Tomoyuki Kanda

Yoshihisa Kuwana

Michio Ichimura

Fumio Suzuki

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-24

Filing date

1998-03-24

Publication date

2004-01-15

1998-03-24 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE257156T1 publication Critical patent/ATE257156T1/de

Links

QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
102000007471 Adenosine A2A receptor Human genes 0.000 abstract 2
108010085277 Adenosine A2A receptor Proteins 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002774 3,4-dimethoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
230000008485 antagonism Effects 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
208000013403 hyperactivity Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98909835T 1997-03-24 1998-03-24 (1,2,4)triazolo(1,5-c)pyrimidin-derivate ATE257156T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP6956697		1997-03-24
PCT/JP1998/001266 WO1998042711A1 (en)	1997-03-24	1998-03-24	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
ATE257156T1 true ATE257156T1 (de)	2004-01-15

Family

ID=13406463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98909835T ATE257156T1 (de)	1997-03-24	1998-03-24	(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Country Status (8)

Country	Link
US (1)	US6222035B1 (de)
EP (1)	EP0976753B1 (de)
JP (1)	JP4195729B2 (de)
AT (1)	ATE257156T1 (de)
AU (1)	AU743910B2 (de)
CA (1)	CA2284737C (de)
DE (1)	DE69820866T2 (de)
WO (1)	WO1998042711A1 (de)

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PE20030739A1 (es)	2001-11-30	2003-08-28	Schering Corp	Antagonistas del receptor de adenosina a2a
BR0306919A (pt)	2002-01-28	2004-11-09	Kyowa Hakko Kogyo Kk	Métodos para reduzir ou suprimir a efetividade adversa da terapia de l-dopa e/ou do agonista da dopamina, e para tratamento moderado de l-dopa, composição para tratamento moderado de l-dopa, método para tratar doença de parkinson e/ou complicações motoras de l-dopa, composição para o tratamento da doença de parkinson, e, métodos para prolongar o tratamento eficaz da doença de parkinson, e para tratar os distúrbios de movimento
AU2003211993A1 (en) *	2002-02-15	2003-09-04	Kyowa Hakko Kogyo Co., Ltd.	(1,2,4)TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVES
AU2003272886A1 (en) *	2002-09-24	2004-04-19	Kyowa Hakko Kogyo Co., Ltd.	(1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
US7674791B2 (en)	2003-04-09	2010-03-09	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
US20070010522A1 (en) *	2003-04-09	2007-01-11	Chi Vu	Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists
DE602004018637D1 (de)	2003-04-09	2009-02-05	Biogen Idec Inc	A2a-adenosinrezeptorantagonisten
WO2004092170A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
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JPWO2006129626A1 (ja) *	2005-05-30	2009-01-08	協和醗酵工業株式会社	［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法
EP2258372B8 (de)	2005-06-07	2012-12-19	Kyowa Hakko Kirin Co., Ltd.	A2A Antagonisten zur Behandlung von motorischen Störungen
ES2273599B1 (es)	2005-10-14	2008-06-01	Universidad De Barcelona	Compuestos para el tratamiento de la fibrilacion auricular.
MX2010012961A (es) *	2008-05-29	2011-03-03	Sirtris Pharmaceuticals Inc Star	Imidazopiridina y analogos relacionados como moduladores de sirtuina.
AU2009274876C1 (en)	2008-07-23	2016-08-18	Kyowa Kirin Co., Ltd.	Therapeutic agent for migraine
JP5843869B2 (ja) *	2010-09-24	2016-01-13	アドヴィナス・セラピューティックス・リミテッド	アデノシン受容体拮抗薬としての縮合三環化合物
RU2764655C2 (ru) *	2017-03-16	2022-01-19	Цзянсу Хэнжуй Медицин Ко., Лтд.	ПРОИЗВОДНОЕ ГЕТЕРОАРИЛ[4,3-с]ПИРИМИДИН-5-АМИНА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО МЕДИЦИНСКИЕ ПРИМЕНЕНИЯ
ES2919474T3 (es) *	2017-04-07	2022-07-26	Medshine Discovery Inc	Derivado de [1,2,4]triazolo[1,5-c]pirimidina como inhibidor del receptor A2A
KR20200022027A (ko) *	2017-06-30	2020-03-02	리부 세라퓨틱스 에스.에이.	아데노신 A2A 수용체의 이미다조[1,2,a]피라진 조절물질
CN109535161B (zh) *	2017-09-22	2021-09-03	江苏恒瑞医药股份有限公司	三唑并嘧啶类衍生物、其制备方法及其在医药上的应用
ES2927086T3 (es) *	2017-09-28	2022-11-02	Cstone Pharmaceuticals Suzhou Co Ltd	Derivado de anillo condensado como inhibidor del receptor A2A
US20190292188A1 (en) *	2018-02-27	2019-09-26	Incyte Corporation	Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
DK3766884T3 (da) *	2018-04-28	2022-03-28	Medshine Discovery Inc	Krystalform og salttype af triazolopyrimidinforbindelse og fremstillingsfremgangsmåde dertil
MA52940A (fr)	2018-05-18	2021-04-28	Incyte Corp	Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
CN113166153B (zh)	2018-07-05	2024-11-01	因赛特公司	作为a2a/a2b抑制剂的稠合吡嗪衍生物
TWI820209B (zh)	2018-09-12	2023-11-01	大陸商迪哲（江蘇）醫藥股份有限公司	三唑并－嘧啶化合物及其用途
KR20210093964A (ko) *	2018-11-20	2021-07-28	머크 샤프 앤드 돔 코포레이션	치환된 아미노 트리아졸로피리미딘 및 아미노 트리아졸로피라진 아데노신 수용체 길항제, 제약 조성물 및 그의 용도
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CA3150766A1 (en) *	2019-08-26	2021-03-04	Incyte Corporation	Triazolopyrimidines as a2a / a2b inhibitors

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1998
- 1998-03-24 CA CA002284737A patent/CA2284737C/en not_active Expired - Fee Related
- 1998-03-24 AU AU64221/98A patent/AU743910B2/en not_active Ceased
- 1998-03-24 WO PCT/JP1998/001266 patent/WO1998042711A1/ja not_active Ceased
- 1998-03-24 EP EP98909835A patent/EP0976753B1/de not_active Expired - Lifetime
- 1998-03-24 DE DE69820866T patent/DE69820866T2/de not_active Expired - Fee Related
- 1998-03-24 JP JP54543398A patent/JP4195729B2/ja not_active Expired - Fee Related
- 1998-03-24 AT AT98909835T patent/ATE257156T1/de not_active IP Right Cessation
1999
- 1999-09-23 US US09/401,984 patent/US6222035B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2284737C (en)	2007-03-13
CA2284737A1 (en)	1998-10-01
WO1998042711A1 (en)	1998-10-01
AU6422198A (en)	1998-10-20
EP0976753B1 (de)	2004-01-02
EP0976753A4 (de)	2000-07-05
EP0976753A1 (de)	2000-02-02
US6222035B1 (en)	2001-04-24
JP4195729B2 (ja)	2008-12-10
DE69820866T2 (de)	2004-12-30
AU743910B2 (en)	2002-02-07
DE69820866D1 (de)	2004-02-05

Legal Events

Date	Code	Title	Description
2004-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE257156T1 (de)	2004-01-15	(1,2,4)triazolo(1,5-c)pyrimidin-derivate
PT1159279E (pt)	2003-02-28	4-oxo-4,7-di-hidrotieno¬2,3-b\|piridino-5-carboxamidas como agentes antivirais
EP0666079A4 (de)	1998-02-04	Behandlung der parkinsonschen Krankheit.
DK0550113T3 (da)	1998-02-09	Triazolpyrimidinderivater med fungicid virkning
EP1153920A4 (de)	2002-04-17	Chinolinderivate und chinazolinderivate
ATE160341T1 (de)	1997-12-15	Benzolsulfonamid-derivate und verfahren zur herstellung
CY1117132T1 (el)	2017-04-05	Παραγωγο θειαζολιου
JO2503B1 (en)	2009-10-05	Benzathiazole derivatives
FI953968A0 (fi)	1995-08-23	Antraniiliset happojohdannaiset
AR053301A1 (es)	2007-05-02	Derivados de pirazina y su uso farmaceutico
NO20055510L (no)	2006-01-20	2-alkynyl- og 2-alkenylpyrazolo [4,3-E]-1,2,4-triazolo-[1,5-C]-pyrimidin-adenosin A2A-reseptorantagonister
EP1116722A4 (de)	2002-05-29	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
ZA888241B (en)	1989-10-25	Process for the synthesis of 3-thio-4-quinolene derivatives and intermediate compounds for use therein,and their use as medicaments
WO2003068776A1 (en)	2003-08-21	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
DE60237637D1 (de)	2010-10-21	Thiadiazolinderivate zur Krebsbehandlung
GR3015136T3 (en)	1995-05-31	Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes.
ES2060303T3 (es)	1994-11-16	Derivados de piperidiloxiisoxazol y quinuclidiniloxiisoxazol, su preparacion y su uso terapeutico.
KR940019705A (ko)	1994-09-14	2- [4 -(4 - 아졸릴 부틸)-1- 피페라지닐]-5- 히드록시- 피라미딘 유도체, 이들의 제조 및 의약제품으로서 이들의 이용
FI952420A0 (fi)	1995-05-18	Glukopyranosidibentsotiofeenit
DK0855398T3 (da)	2003-08-04	Sesquiterpenderivater med antiviral aktivitet
DE69910574D1 (de)	2003-09-25	Pyrazolo[1,5-a]triazine als crf antagonisten
FI893570A0 (fi)	1989-07-26	Menetelmä lääkeaineina käyttökelpoisten 1H-imidatso/1,2-b/-pyratsolin johdannaisten valmistamiseksi
AU7962000A (en)	2001-05-14	Us0027324for eating disorders
DK0686641T3 (da)	1998-11-23	2'-Deoxy-5-fluoruridinderivat, farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf, og antitumorlægem
TH60395A (th)	2004-01-16	อนุพันธ์ของเบนโซไธอะซอลที่มีการออกฤทธิ์เป็นลิแกนด์ของอะดีโนซีนรีเซพเตอร์