ATE257156T1 - (1,2,4)triazolo(1,5-c)pyrimidin-derivate - Google Patents

(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Info

Publication number: ATE257156T1
Authority: AT; Austria
Prior art keywords: substituted; lower alkyl; unsubstituted aryl; represents hydrogen; unsubstituted
Prior art date: 1997-03-24

Application number

AT98909835T

Other languages

English (en)

Inventor

Hiroshi Tsumuki

Junichi Shimada

Hironori Imma

Akiko Nakamura

Hiromi Nonaka

Shizuo Shiozaki

Shunji Ichikawa

Tomoyuki Kanda

Yoshihisa Kuwana

Michio Ichimura

Fumio Suzuki

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-24

Filing date

1998-03-24

Publication date

2004-01-15

1998-03-24 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE257156T1 publication Critical patent/ATE257156T1/de

Links

QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
102000007471 Adenosine A2A receptor Human genes 0.000 abstract 2
108010085277 Adenosine A2A receptor Proteins 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002774 3,4-dimethoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
230000008485 antagonism Effects 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
208000013403 hyperactivity Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98909835T 1997-03-24 1998-03-24 (1,2,4)triazolo(1,5-c)pyrimidin-derivate ATE257156T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP6956697		1997-03-24
PCT/JP1998/001266 WO1998042711A1 (en)	1997-03-24	1998-03-24	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
ATE257156T1 true ATE257156T1 (de)	2004-01-15

Family

ID=13406463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98909835T ATE257156T1 (de)	1997-03-24	1998-03-24	(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Country Status (8)

Country	Link
US (1)	US6222035B1 (de)
EP (1)	EP0976753B1 (de)
JP (1)	JP4195729B2 (de)
AT (1)	ATE257156T1 (de)
AU (1)	AU743910B2 (de)
CA (1)	CA2284737C (de)
DE (1)	DE69820866T2 (de)
WO (1)	WO1998042711A1 (de)

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JPWO2002079204A1 (ja) *	2001-03-28	2004-07-22	協和醗酵工業株式会社	８−チアゾリル［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
JP5280597B2 (ja)	2001-03-30	2013-09-04	サンスター技研株式会社	一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材
US20040110826A1 (en) *	2001-09-28	2004-06-10	Noriaki Uesaka	Receptor Antagonists
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AR038366A1 (es) *	2001-11-30	2005-01-12	Schering Corp	Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
KR101098209B1 (ko)	2002-01-28	2011-12-23	교와 핫꼬 기린 가부시키가이샤	운동성 질환에 걸린 환자의 치료 방법
JPWO2003068776A1 (ja) *	2002-02-15	2005-06-02	協和醗酵工業株式会社	［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
WO2004029056A1 (ja) *	2002-09-24	2004-04-08	Kyowa Hakko Kogyo Co., Ltd.	[１，２，４]トリアゾロ[１，５−ｃ]ピリミジン誘導体
WO2004092170A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
WO2004092172A2 (en) *	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosin e receptor antagonists
WO2004092173A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
WO2004092177A1 (en) *	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
WO2005056524A2 (en) *	2003-12-09	2005-06-23	Euro-Celtique S.A.	Therapeutic agents useful for treating pain
CA2591125A1 (en) *	2004-12-21	2006-06-29	Schering Corporation	Pyrazolo[1,5-a]pyrimidine adenosine a2a receptor antagonists
WO2006129626A1 (ja) *	2005-05-30	2006-12-07	Kyowa Hakko Kogyo Co., Ltd.	[1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法
EP2258372B8 (de)	2005-06-07	2012-12-19	Kyowa Hakko Kirin Co., Ltd.	A2A Antagonisten zur Behandlung von motorischen Störungen
ES2273599B1 (es)	2005-10-14	2008-06-01	Universidad De Barcelona	Compuestos para el tratamiento de la fibrilacion auricular.
WO2009146358A1 (en) *	2008-05-29	2009-12-03	Sirtris Pharmaceuticals, Inc.	Imidazopyridine and related analogs as sirtuin modulators
KR20110040856A (ko)	2008-07-23	2011-04-20	교와 핫꼬 기린 가부시키가이샤	편두통 치료제
AU2011306358B2 (en) *	2010-09-24	2014-08-14	Impetis Biosciences Ltd.	Fused tricyclic compounds as adenosine receptor antagonist
AU2018233367B2 (en) *	2017-03-16	2021-08-12	Jiangsu Hengrui Medicine Co., Ltd.	Heteroaryl[4,3-c]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
PL3611174T3 (pl) *	2017-04-07	2022-08-08	Medshine Discovery Inc.	Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a
WO2019002606A1 (en) *	2017-06-30	2019-01-03	Selvita S.A.	ADENOSINE A2A RECEPTOR 5,6-BICYCLO-IMIDAZO [1,2-A] PYRAZINE MODULATORS
CN109535161B (zh) *	2017-09-22	2021-09-03	江苏恒瑞医药股份有限公司	三唑并嘧啶类衍生物、其制备方法及其在医药上的应用
JP6836693B2 (ja) *	2017-09-28	2021-03-03	シーストーン・ファーマスーティカルズ・（スージョウ）・カンパニー・リミテッドＣｓｔｏｎｅＰｈａｒｍａｃｅｕｔｉｃａｌｓ（Ｓｕｚｈｏｕ）Ｃｏ．，Ｌｔｄ．	Ａ２ａ受容体アンタゴニストとしての縮合環誘導体
TWI877770B (zh) *	2018-02-27	2025-03-21	美商英塞特公司	作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶
PL3766884T3 (pl) *	2018-04-28	2022-07-18	Medshine Discovery Inc.	Postać krystaliczna i rodzaj soli związku triazolopirymidynowego oraz sposób jej wytwarzania
EP3810610A1 (de)	2018-05-18	2021-04-28	Incyte Corporation	Kondensierte pyrimidinderivate als a2a/a2b-inhibitoren
WO2020010197A1 (en) *	2018-07-05	2020-01-09	Incyte Corporation	Fused pyrazine derivatives as a2a / a2b inhibitors
AR116315A1 (es) *	2018-09-12	2021-04-21	Dizal Jiangsu Pharmaceutical Co Ltd	Compuestos de triazolo-pirimidina y usos de los mismos
AU2019383948A1 (en)	2018-11-20	2021-05-20	Merck Sharp & Dohme Llc	Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
PE20230372A1 (es) *	2019-08-26	2023-03-06	Incyte Corp	Triazolopirimidinas como inhibidores de a2a/a2b

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ES2051772T3 (es) *	1986-09-30	1994-07-01	Ciba Geigy Ag	2-sustituido-e-fusionado-(1,2,4)-triazol(1,5-c)pirimidinas, composiciones farmaceuticas y sus usos.
EP0459702A1 (de) *	1990-05-29	1991-12-04	Zeneca Limited	Azolderivate
US5358950A (en)	1991-07-05	1994-10-25	Laboratoires Upsa	Triazolopyrimidine derivatives which are angiotensin II receptor antagonists
FR2678618B1 (fr)	1991-07-05	1993-11-05	Upsa Laboratoires	Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
WO1995003806A1 (en) *	1993-07-27	1995-02-09	Kyowa Hakko Kogyo Co., Ltd.	Remedy for parkinson's disease

1998
- 1998-03-24 DE DE69820866T patent/DE69820866T2/de not_active Expired - Fee Related
- 1998-03-24 JP JP54543398A patent/JP4195729B2/ja not_active Expired - Fee Related
- 1998-03-24 WO PCT/JP1998/001266 patent/WO1998042711A1/ja not_active Ceased
- 1998-03-24 AU AU64221/98A patent/AU743910B2/en not_active Ceased
- 1998-03-24 AT AT98909835T patent/ATE257156T1/de not_active IP Right Cessation
- 1998-03-24 CA CA002284737A patent/CA2284737C/en not_active Expired - Fee Related
- 1998-03-24 EP EP98909835A patent/EP0976753B1/de not_active Expired - Lifetime
1999
- 1999-09-23 US US09/401,984 patent/US6222035B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1998042711A1 (en)	1998-10-01
CA2284737A1 (en)	1998-10-01
EP0976753B1 (de)	2004-01-02
AU743910B2 (en)	2002-02-07
EP0976753A4 (de)	2000-07-05
US6222035B1 (en)	2001-04-24
AU6422198A (en)	1998-10-20
JP4195729B2 (ja)	2008-12-10
DE69820866T2 (de)	2004-12-30
DE69820866D1 (de)	2004-02-05
CA2284737C (en)	2007-03-13
EP0976753A1 (de)	2000-02-02

Legal Events

Date	Code	Title	Description
2004-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE257156T1 (de)	2004-01-15	(1,2,4)triazolo(1,5-c)pyrimidin-derivate
PT1159279E (pt)	2003-02-28	4-oxo-4,7-di-hidrotieno¬2,3-b\|piridino-5-carboxamidas como agentes antivirais
EP0666079A4 (de)	1998-02-04	Behandlung der parkinsonschen Krankheit.
DK0550113T3 (da)	1998-02-09	Triazolpyrimidinderivater med fungicid virkning
PL349036A1 (en)	2002-07-01	Quinoline derivatives and quinazoline derivatives
BR0306208A (pt)	2004-10-13	Compostos de dibenzilamina e seu uso farmacêutico
CY1117132T1 (el)	2017-04-05	Παραγωγο θειαζολιου
JO2503B1 (en)	2009-10-05	Benzathiazole derivatives
DK0658548T3 (da)	1998-03-16	Benzensylfonamidderivat og fremgangsmåde til fremstilling deraf
FI953968A0 (fi)	1995-08-23	Antraniiliset happojohdannaiset
AR053301A1 (es)	2007-05-02	Derivados de pirazina y su uso farmaceutico
NO20055510L (no)	2006-01-20	2-alkynyl- og 2-alkenylpyrazolo [4,3-E]-1,2,4-triazolo-[1,5-C]-pyrimidin-adenosin A2A-reseptorantagonister
EP1116722A4 (de)	2002-05-29	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
WO2003068776A1 (en)	2003-08-21	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
ATE480527T1 (de)	2010-09-15	Thiadiazolinderivate zur krebsbehandlung
HU9202449D0 (en)	1992-12-28	Method for producing substituted 2-amino-1,2,3,4-tetrahydro-naphtaline derivatives and 3-chromane ones thereof
KR940019705A (ko)	1994-09-14	2- [4 -(4 - 아졸릴 부틸)-1- 피페라지닐]-5- 히드록시- 피라미딘 유도체, 이들의 제조 및 의약제품으로서 이들의 이용
FI952420A0 (fi)	1995-05-18	Glukopyranosidibentsotiofeenit
NO20062202L (no)	2006-07-03	Amidometylsubstituerte 2-(4-sulfonylamino)-3-hydroksy-3,4-dihydro-2H-kromen-6-yl-derivater, fremgangsmate og mellomprodukter for deres fremstilling, og legemidler som inneholder disse forbindelsene
DK0855398T3 (da)	2003-08-04	Sesquiterpenderivater med antiviral aktivitet
DE69910574D1 (de)	2003-09-25	Pyrazolo[1,5-a]triazine als crf antagonisten
FI893570A0 (fi)	1989-07-26	Menetelmä lääkeaineina käyttökelpoisten 1H-imidatso/1,2-b/-pyratsolin johdannaisten valmistamiseksi
AU7962000A (en)	2001-05-14	Us0027324for eating disorders
DK0686641T3 (da)	1998-11-23	2'-Deoxy-5-fluoruridinderivat, farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf, og antitumorlægem
TH60395A (th)	2004-01-16	อนุพันธ์ของเบนโซไธอะซอลที่มีการออกฤทธิ์เป็นลิแกนด์ของอะดีโนซีนรีเซพเตอร์