ATE257479T1 - 5-ring heteroarylsubstituierte 1,4- dihydropyridine als bradykinin antagonisten - Google Patents

5-ring heteroarylsubstituierte 1,4- dihydropyridine als bradykinin antagonisten

Info

Publication number: ATE257479T1
Authority: AT; Austria
Prior art keywords: alkyl; substituted; optionally substituted; dihydropyridines; ring heteroaryl
Prior art date: 1999-12-10

Application number

AT00310793T

Other languages

English (en)

Inventor

Makoto Kawai

Noriaki Murase

Takafumi Ikeda

Yuji Shishido

Seiji Nukui

Yoshiyuki Okumura

Mitsuhiro Kawamura

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-10

Filing date

2000-12-05

Publication date

2004-01-15

2000-12-05 Application filed by Pfizer filed Critical Pfizer

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE257479T1 publication Critical patent/ATE257479T1/de

Links

239000003152 bradykinin antagonist Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
-1 substituted Chemical class 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 2
101800004538 Bradykinin Proteins 0.000 abstract 1
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
102100035792 Kininogen-1 Human genes 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
150000001602 bicycloalkyls Chemical group 0.000 abstract 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Virology (AREA)
Oncology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Immunology (AREA)
Cardiology (AREA)
Dermatology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)

AT00310793T 1999-12-10 2000-12-05 5-ring heteroarylsubstituierte 1,4- dihydropyridine als bradykinin antagonisten ATE257479T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17014299P	1999-12-10	1999-12-10

Publications (1)

Publication Number	Publication Date
ATE257479T1 true ATE257479T1 (de)	2004-01-15

Family

ID=22618718

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00310793T ATE257479T1 (de)	1999-12-10	2000-12-05	5-ring heteroarylsubstituierte 1,4- dihydropyridine als bradykinin antagonisten

Country Status (12)

Country	Link
US (1)	US6444677B2 (de)
EP (1)	EP1106614B1 (de)
JP (2)	JP3651885B2 (de)
AT (1)	ATE257479T1 (de)
BR (1)	BR0006371A (de)
CA (1)	CA2327925A1 (de)
DE (1)	DE60007603T2 (de)
DK (1)	DK1106614T3 (de)
ES (1)	ES2211460T3 (de)
MX (1)	MXPA00012398A (de)
PT (1)	PT1106614E (de)
TR (1)	TR200400220T4 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6653313B2 (en)	2000-08-10	2003-11-25	Warner-Lambert Company Llc	1,4-dihydropyridine compounds as bradykinin antagonists
GB2383326A (en) *	2001-12-20	2003-06-25	Bayer Ag	Antiinflammatory dihydropyridines
US6861422B2 (en) *	2003-02-26	2005-03-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
US7759485B2 (en) *	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
US20060217362A1 (en) *	2004-12-29	2006-09-28	Tung Jay S	Novel compounds useful for bradykinin B1 receptor antagonism
WO2007029078A2 (en) *	2005-09-05	2007-03-15	Ranbaxy Laboratories Limited	Succinimide and glutarimide derivatives as adrenergic receptor antagonists
CA2690327A1 (en)	2007-06-15	2008-12-18	Thomas P. Cleary	A novel process for the preparation of 3-amino-pentan-1,5-diol
WO2013169939A2 (en)	2012-05-08	2013-11-14	Aeromics, Llc	New methods
CA2929821A1 (en)	2013-11-06	2015-05-14	Aeromics, Inc.	2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate formulations and kits
CN110988215B (zh) *	2019-12-31	2022-05-17	湖南九典制药股份有限公司	一种依巴斯汀中有关物质的检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996006083A1 (en) *	1994-08-24	1996-02-29	Pfizer Pharmaceuticals Inc.	2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists
MX9701245A (es) *	1996-02-19	1998-04-30	Pfizer	Compuestos de 1,4 dihidropiridina.
DE19610784A1 (de) *	1996-03-19	1997-09-25	Hoechst Ag	Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH11106375A (ja) *	1997-08-18	1999-04-20	Pfizer Pharmaceut Inc	ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物

2000
- 2000-12-05 ES ES00310793T patent/ES2211460T3/es not_active Expired - Lifetime
- 2000-12-05 DE DE60007603T patent/DE60007603T2/de not_active Expired - Fee Related
- 2000-12-05 EP EP00310793A patent/EP1106614B1/de not_active Expired - Lifetime
- 2000-12-05 TR TR2004/00220T patent/TR200400220T4/xx unknown
- 2000-12-05 PT PT00310793T patent/PT1106614E/pt unknown
- 2000-12-05 DK DK00310793T patent/DK1106614T3/da active
- 2000-12-05 AT AT00310793T patent/ATE257479T1/de not_active IP Right Cessation
- 2000-12-07 US US09/731,995 patent/US6444677B2/en not_active Expired - Fee Related
- 2000-12-07 JP JP2000373447A patent/JP3651885B2/ja not_active Expired - Fee Related
- 2000-12-08 CA CA002327925A patent/CA2327925A1/en not_active Abandoned
- 2000-12-11 MX MXPA00012398A patent/MXPA00012398A/es active IP Right Grant
- 2000-12-11 BR BR0006371-1A patent/BR0006371A/pt not_active IP Right Cessation
2004
- 2004-12-16 JP JP2004364980A patent/JP2005120107A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DK1106614T3 (da)	2004-04-13
PT1106614E (pt)	2004-04-30
JP2001187793A (ja)	2001-07-10
JP3651885B2 (ja)	2005-05-25
DE60007603T2 (de)	2004-06-24
DE60007603D1 (de)	2004-02-12
BR0006371A (pt)	2001-07-24
US20010046993A1 (en)	2001-11-29
CA2327925A1 (en)	2001-06-10
MXPA00012398A (es)	2003-12-11
EP1106614B1 (de)	2004-01-07
TR200400220T4 (tr)	2004-02-23
US6444677B2 (en)	2002-09-03
JP2005120107A (ja)	2005-05-12
ES2211460T3 (es)	2004-07-16
EP1106614A1 (de)	2001-06-13

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Publication	Publication Date	Title
NO882036D0 (no)	1988-05-10	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske ketoner.
DE60000120D1 (de)	2002-05-16	Bicyclische Carbonyl-Indolverbindungen als entzündungshemmende/ analgetische Wirkstoffe und als COX-2 Inhibitoren
DE60007603D1 (de)	2004-02-12	5-Ring Heteroarylsubstituierte 1,4-Dihydropyridine als Bradykinin Antagonisten
DK1157998T3 (da)	2004-06-14	Heterocykliske forbindelser, mellemprodukter derfor og elastaseinhibitorer
NO982873L (no)	1998-08-21	1-metylkarbapenemderivater
DE60101137D1 (de)	2003-12-11	N-Benzensulfonyl-L-Prolin Derivate und deren Verwendung als Bradykinin Antagonisten
DE60045821D1 (de)	2011-05-19	Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
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