ATE257842T1 - Verfahren zur gewinnung von 17beta-(n-tert- butylcarbamoyl)-3-on-4-aza-steroiden - Google Patents

Verfahren zur gewinnung von 17beta-(n-tert- butylcarbamoyl)-3-on-4-aza-steroiden

Info

Publication number: ATE257842T1
Authority: AT; Austria
Prior art keywords: tert; butylcarbamoyl; 17beta; obtaining; aza
Prior art date: 1999-07-05

Application number

AT00940431T

Other languages

English (en)

Inventor

Guisasola Luis Octavio Silva

Fernandez Cristina Blanco

Bonde-Larsen Antonio Lorente

Juarez Jorge Martin

Original Assignee

Ragactives Sl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-05

Filing date

2000-07-05

Publication date

2004-01-15

2000-07-05 Application filed by Ragactives Sl filed Critical Ragactives Sl

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE257842T1 publication Critical patent/ATE257842T1/de

Links

238000000034 method Methods 0.000 title abstract 2
201000004384 Alopecia Diseases 0.000 abstract 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
231100000360 alopecia Toxicity 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 abstract 1
229960004039 finasteride Drugs 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
ASSTXQFQQJYCIW-UHFFFAOYSA-N lithium;tert-butylazanide Chemical compound [Li+].CC(C)(C)[NH-] ASSTXQFQQJYCIW-UHFFFAOYSA-N 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)

AT00940431T 1999-07-05 2000-07-05 Verfahren zur gewinnung von 17beta-(n-tert- butylcarbamoyl)-3-on-4-aza-steroiden ATE257842T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009901487A ES2153789B1 (es)	1999-07-05	1999-07-05	Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
PCT/ES2000/000239 WO2001002422A1 (es)	1999-07-05	2000-07-05	PROCEDIMIENTO PARA LA OBTENCION DE 17β-(N-TERC-BUTILCARBAMOIL)-3-ONA-4-AZA-ESTEROIDES

Publications (1)

Publication Number	Publication Date
ATE257842T1 true ATE257842T1 (de)	2004-01-15

Family

ID=8309089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00940431T ATE257842T1 (de)	1999-07-05	2000-07-05	Verfahren zur gewinnung von 17beta-(n-tert- butylcarbamoyl)-3-on-4-aza-steroiden

Country Status (9)

Country	Link
US (1)	US6509466B2 (de)
EP (1)	EP1116725B1 (de)
JP (1)	JP2003503507A (de)
AT (1)	ATE257842T1 (de)
CA (1)	CA2342864A1 (de)
DE (1)	DE60007716T2 (de)
ES (1)	ES2153789B1 (de)
HU (1)	HUP0103002A3 (de)
WO (1)	WO2001002422A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100415858B1 (ko) *	2001-09-22	2004-01-24	한미약품 주식회사	17베타-(엔-3차-부틸카바모일)-3-온 스테로이드 화합물의제조방법
US10351615B2 (en)	2006-02-03	2019-07-16	Opko Biologics Ltd.	Methods of treatment with long-acting growth hormone
US9458444B2 (en)	2006-02-03	2016-10-04	Opko Biologics Ltd.	Long-acting coagulation factors and methods of producing same
EP3230309B1 (de)	2014-12-10	2023-03-29	OPKO Biologics Ltd.	Verfahren zur herstellung langwirkender ctp-modifizierter wachstumshormonpolypeptide
FR3106058B1 (fr) *	2020-01-09	2022-01-07	Oreal	Procédé de traitement cosmétique
CN114213502B (zh) *	2021-12-08	2024-02-13	湖南醇健制药科技有限公司	一种非那雄胺的精制方法及非那雄胺制剂和其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4760071A (en)	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US5237061A (en) *	1988-10-31	1993-08-17	Merck & Co., Inc.	Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
ES2173889T3 (es) *	1993-06-24	2002-11-01	Richter Gedeon Vegyeszet	Nuevo procedimiento para preparar derivados de 4-azaandrostano 17 beta-sustituidos.
US5670643A (en) *	1995-03-16	1997-09-23	Glaxo Wellcome Inc.	Method for preparing finasteride
GB2338234B (en) *	1998-06-10	2000-05-03	Torcan Chemical Ltd	Preparation of finasteride

1999
- 1999-07-05 ES ES009901487A patent/ES2153789B1/es not_active Expired - Fee Related
2000
- 2000-07-05 CA CA002342864A patent/CA2342864A1/en not_active Abandoned
- 2000-07-05 AT AT00940431T patent/ATE257842T1/de not_active IP Right Cessation
- 2000-07-05 HU HU0103002A patent/HUP0103002A3/hu unknown
- 2000-07-05 DE DE60007716T patent/DE60007716T2/de not_active Expired - Fee Related
- 2000-07-05 WO PCT/ES2000/000239 patent/WO2001002422A1/es not_active Ceased
- 2000-07-05 EP EP00940431A patent/EP1116725B1/de not_active Expired - Lifetime
- 2000-07-05 JP JP2001507858A patent/JP2003503507A/ja active Pending
2001
- 2001-03-05 US US09/800,019 patent/US6509466B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6509466B2 (en)	2003-01-21
WO2001002422A9 (es)	2001-04-05
HUP0103002A3 (en)	2002-09-30
EP1116725A1 (de)	2001-07-18
ES2153789A1 (es)	2001-03-01
CA2342864A1 (en)	2001-01-11
DE60007716D1 (de)	2004-02-19
US20010008895A1 (en)	2001-07-19
JP2003503507A (ja)	2003-01-28
HUP0103002A2 (hu)	2002-01-28
DE60007716T2 (de)	2004-12-09
EP1116725B1 (de)	2004-01-14
ES2153789B1 (es)	2001-10-16
WO2001002422A1 (es)	2001-01-11

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Legal Events

Date	Code	Title	Description
2004-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties