ATE258066T1 - Ein hydrophobes rezeptormolekül für antigene stoffen enthaltender immunstimulierender komplex (iscom) oder matrix gebundener immunstimulierender komplex (iscom-matrix) - Google Patents
Ein hydrophobes rezeptormolekül für antigene stoffen enthaltender immunstimulierender komplex (iscom) oder matrix gebundener immunstimulierender komplex (iscom-matrix)Info
- Publication number
- ATE258066T1 ATE258066T1 AT97905539T AT97905539T ATE258066T1 AT E258066 T1 ATE258066 T1 AT E258066T1 AT 97905539 T AT97905539 T AT 97905539T AT 97905539 T AT97905539 T AT 97905539T AT E258066 T1 ATE258066 T1 AT E258066T1
- Authority
- AT
- Austria
- Prior art keywords
- iscom
- matrix
- immunstimulative
- complex
- bonded
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Nanotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600648A SE9600648D0 (sv) | 1996-02-21 | 1996-02-21 | Receptorbimdande enhet |
| PCT/SE1997/000287 WO1997030726A1 (en) | 1996-02-21 | 1997-02-20 | Iscom or iscom-matrix comprising hydrophobic receptor molecules for antigenic substances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258066T1 true ATE258066T1 (de) | 2004-02-15 |
Family
ID=20401482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97905539T ATE258066T1 (de) | 1996-02-21 | 1997-02-20 | Ein hydrophobes rezeptormolekül für antigene stoffen enthaltender immunstimulierender komplex (iscom) oder matrix gebundener immunstimulierender komplex (iscom-matrix) |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6027732A (de) |
| EP (1) | EP0944397B1 (de) |
| AT (1) | ATE258066T1 (de) |
| AU (1) | AU718443B2 (de) |
| BR (1) | BR9707638A (de) |
| CA (1) | CA2247103C (de) |
| DE (1) | DE69727314T2 (de) |
| DK (1) | DK0944397T3 (de) |
| ES (1) | ES2214608T3 (de) |
| NZ (1) | NZ331418A (de) |
| SE (1) | SE9600648D0 (de) |
| WO (1) | WO1997030726A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| US6693086B1 (en) * | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| DE60044236D1 (de) * | 1999-02-17 | 2010-06-02 | Csl Ltd | Immunogene komplexe und methoden in bezug auf diese |
| DE60039715D1 (de) * | 1999-11-19 | 2008-09-11 | Csl Ltd | Hcv-impfstoff zusammensetzungen |
| SE0003538D0 (sv) * | 2000-09-29 | 2000-09-29 | Isconova Ab | New immunogenic complex |
| US7713942B2 (en) * | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| US20030138434A1 (en) * | 2001-08-13 | 2003-07-24 | Campbell Robert L. | Agents for enhancing the immune response |
| ATE361097T1 (de) * | 2002-01-15 | 2007-05-15 | Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh | Orale vakzinierung mit dem tumor-antigen-mimotop gln-met-trp-ala-pro-gln-trp-gly-pro-asp |
| EP1608403A2 (de) * | 2003-04-02 | 2005-12-28 | Coley Pharmaceutical Group, Ltd. | Immunostimulatorische nukleinsäure öl-in-wasser emulsionen zur topischen anwendung |
| US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
| TWI235440B (en) * | 2004-03-31 | 2005-07-01 | Advanced Semiconductor Eng | Method for making leadless semiconductor package |
| JP2008506789A (ja) * | 2004-07-18 | 2008-03-06 | シーエスエル、リミテッド | インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物 |
| EP2468300B1 (de) | 2006-09-26 | 2017-12-20 | Infectious Disease Research Institute | Impfstoffzusammensetzung mit einem synthetischen Adjuvans |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| ES2325243B1 (es) * | 2008-02-27 | 2011-05-04 | Universidad De Granada | Antigeno recombinante. |
| CA2764374C (en) | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
| NZ616304A (en) | 2011-04-08 | 2016-01-29 | Immune Design Corp | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| PL2811981T3 (pl) | 2012-02-07 | 2019-09-30 | Infectious Disease Research Institute | Ulepszone formulacje adiuwantowe zawierające agonistę TLR4 oraz sposoby ich zastosowania |
| SMT201800368T1 (it) | 2012-05-16 | 2018-09-13 | Immune Design Corp | Vaccini per l'infezione da virus-2 herpes simplex |
| CA2909221A1 (en) | 2013-04-18 | 2014-10-23 | Immune Design Corp. | Gla monotherapy for use in cancer treatment |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| IL310015B2 (en) | 2013-12-31 | 2026-02-01 | Access To Advanced Health Inst | Single vial formulation |
| BR112021023726A2 (pt) | 2019-05-25 | 2022-02-15 | Infectious Disease Res Inst | Composição e método para secagem por pulverização de uma emulsão de vacina adjuvante |
| EP4058581A1 (de) | 2019-11-15 | 2022-09-21 | Infectious Disease Research Institute | Rig-i-agonist und adjuvans-formulierung zur tumorbehandlung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2403081A1 (fr) * | 1977-09-19 | 1979-04-13 | Merieux Inst | Nouveau materiau particulaire, sa preparation et son application, notamment comme medicament |
| US5178860A (en) * | 1989-09-01 | 1993-01-12 | Coopers Animal Health Limited | Adjuvant complexes and vaccine made therefrom |
| NL9002314A (nl) * | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
-
1996
- 1996-02-21 SE SE9600648A patent/SE9600648D0/xx unknown
-
1997
- 1997-02-20 EP EP97905539A patent/EP0944397B1/de not_active Expired - Lifetime
- 1997-02-20 DE DE1997627314 patent/DE69727314T2/de not_active Expired - Lifetime
- 1997-02-20 AU AU22383/97A patent/AU718443B2/en not_active Expired
- 1997-02-20 ES ES97905539T patent/ES2214608T3/es not_active Expired - Lifetime
- 1997-02-20 WO PCT/SE1997/000287 patent/WO1997030726A1/en not_active Ceased
- 1997-02-20 NZ NZ331418A patent/NZ331418A/xx not_active IP Right Cessation
- 1997-02-20 BR BR9707638-4A patent/BR9707638A/pt not_active IP Right Cessation
- 1997-02-20 DK DK97905539T patent/DK0944397T3/da active
- 1997-02-20 CA CA002247103A patent/CA2247103C/en not_active Expired - Fee Related
- 1997-02-20 US US09/125,588 patent/US6027732A/en not_active Expired - Lifetime
- 1997-02-20 AT AT97905539T patent/ATE258066T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0944397B1 (de) | 2004-01-21 |
| CA2247103A1 (en) | 1997-08-28 |
| NZ331418A (en) | 2000-03-27 |
| US6027732A (en) | 2000-02-22 |
| CA2247103C (en) | 2009-01-20 |
| AU2238397A (en) | 1997-09-10 |
| BR9707638A (pt) | 2000-01-04 |
| EP0944397A1 (de) | 1999-09-29 |
| SE9600648D0 (sv) | 1996-02-21 |
| DK0944397T3 (da) | 2004-06-01 |
| WO1997030726A1 (en) | 1997-08-28 |
| AU718443B2 (en) | 2000-04-13 |
| DE69727314D1 (de) | 2004-02-26 |
| ES2214608T3 (es) | 2004-09-16 |
| DE69727314T2 (de) | 2004-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0944397 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |