ATE258163T1 - Verbesserte arylamin-synthese - Google Patents
Verbesserte arylamin-syntheseInfo
- Publication number
- ATE258163T1 ATE258163T1 AT99937293T AT99937293T ATE258163T1 AT E258163 T1 ATE258163 T1 AT E258163T1 AT 99937293 T AT99937293 T AT 99937293T AT 99937293 T AT99937293 T AT 99937293T AT E258163 T1 ATE258163 T1 AT E258163T1
- Authority
- AT
- Austria
- Prior art keywords
- imine
- arylamin
- synthesis
- improved
- preparation
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229910052723 transition metal Inorganic materials 0.000 abstract 2
- 150000003624 transition metals Chemical class 0.000 abstract 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical class NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000879 imine group Chemical group 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 238000000844 transformation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/10—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
- C07C209/18—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/122,324 US6323366B1 (en) | 1997-07-29 | 1998-07-24 | Arylamine synthesis |
| PCT/US1999/016257 WO2000005199A1 (en) | 1998-07-24 | 1999-07-23 | Improved arylamine synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258163T1 true ATE258163T1 (de) | 2004-02-15 |
Family
ID=22402053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99937293T ATE258163T1 (de) | 1998-07-24 | 1999-07-23 | Verbesserte arylamin-synthese |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6323366B1 (de) |
| EP (1) | EP1100774B1 (de) |
| JP (1) | JP2002521359A (de) |
| AT (1) | ATE258163T1 (de) |
| CA (1) | CA2336976A1 (de) |
| DE (1) | DE69914337T2 (de) |
| PT (1) | PT1100774E (de) |
| WO (1) | WO2000005199A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003256970A1 (en) * | 2002-08-02 | 2004-02-23 | Rhodia Pharma Solutions Inc. | Copper catalyzed arylation |
| US7138555B2 (en) | 2004-04-20 | 2006-11-21 | Xerox Corporation | Process for preparing iodoaromatic compounds and using the same |
| US7629470B2 (en) * | 2004-07-08 | 2009-12-08 | Merck & Co., Inc. | Formation of tetra-substituted enamides and stereoselective reduction thereof |
| US8022053B2 (en) * | 2004-11-02 | 2011-09-20 | Bayer Schering Pharma Aktiengesellschaft | Oral solid dosage forms containing a low dose of estradiol |
| ITMI20050062A1 (it) | 2005-01-20 | 2006-07-21 | Polimeri Europa Spa | Processo per la preparazione di fenolo |
| GT200600207A (es) * | 2005-06-09 | 2007-01-15 | Novartis Ag | Proceso para la síntesis de compuestos orgánicos |
| SA06270147B1 (ar) * | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
| KR102107954B1 (ko) * | 2007-03-12 | 2020-05-07 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| DE102007039155A1 (de) | 2007-08-16 | 2009-02-19 | Leibnitz-Institut für Katalyse e.V. an der Universität Rostock | Verfahren zur katalytischen Herstellung von N-monoalkylierten Aryl- und Heteroarylaminen |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| CA2805748A1 (en) | 2010-07-16 | 2012-01-19 | Shashank Shekhar | Process for preparing n-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide |
| SG187103A1 (en) | 2010-07-16 | 2013-02-28 | Abbvie Inc | Phosphine ligands for catalytic reactions |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| JP5929298B2 (ja) * | 2011-03-02 | 2016-06-01 | Jnc株式会社 | ジアミン、これを用いた液晶配向剤、液晶表示素子および液晶配向膜の形成方法 |
| KR20140146192A (ko) | 2012-04-14 | 2014-12-24 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
| KR102373288B1 (ko) | 2013-12-03 | 2022-03-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CA2944755A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| DK3407889T3 (da) | 2016-03-25 | 2021-08-09 | Intra Cellular Therapies Inc | Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet |
| EP3436455A4 (de) | 2016-03-28 | 2019-09-04 | Intra-Cellular Therapies, Inc. | Neuartige salze und kristalle |
| US11014925B2 (en) | 2016-03-28 | 2021-05-25 | Intra-Cellular Therapies, Inc. | Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| EP3525763B1 (de) | 2016-10-12 | 2025-03-05 | Intra-Cellular Therapies, Inc. | Amorphe feste dispersionen |
| EP3562484B1 (de) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalinderivate zur behandlung von erkrankungen des zns |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| RU2767410C2 (ru) | 2017-03-24 | 2022-03-17 | Интра-Селлулар Терапиз, Инк. | Новые композиции и способы |
| EP3658144B1 (de) | 2017-07-26 | 2022-01-26 | Intra-Cellular Therapies, Inc. | Pyridopyrroloquinoxalinverbindungen, deren zusammensetzungen und verwendungen in therapie |
| WO2019023062A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | ORGANIC COMPOUNDS |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| AU2019280850C1 (en) | 2018-06-06 | 2025-02-13 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| EP3801527B1 (de) | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Anellierte gamma-carboline zur akutbehandlung von angst oder depression |
| CA3240552A1 (en) | 2018-06-11 | 2019-12-19 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| WO2020047408A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| BR112021003655A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
| IL315005B2 (en) | 2018-12-17 | 2026-04-01 | Intra Cellular Therapies Inc | Synthesis of condensed gamma-carbolines and converted heterocycles |
| JP7520013B2 (ja) | 2018-12-17 | 2024-07-22 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 置換複素環縮合γ－カルボリンの合成 |
| WO2021007245A1 (en) | 2019-07-07 | 2021-01-14 | Intra-Cellular Therapies, Inc. | Novel methods |
| WO2021216496A1 (en) * | 2020-04-20 | 2021-10-28 | Tricida, Inc. | Process for the preparation of 1,3-bis(allylamino)propane |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL124467C (de) | 1963-03-27 | |||
| US3657430A (en) * | 1969-06-25 | 1972-04-18 | Merck & Co Inc | Composition and methods for treating inflammation |
| US4096185A (en) | 1976-01-08 | 1978-06-20 | E. I. Du Pont De Nemours And Company | Preparation of p-aminobenzotrifluoride |
| US4204997A (en) | 1979-03-19 | 1980-05-27 | Monsanto Company | Asymmetric amination of 1,3-dienes |
| FR2474491A1 (fr) | 1980-01-30 | 1981-07-31 | Inst Francais Du Petrole | Procede de fabrication d'imines d'aminoacides allyl-substituees convertibles notamment en a-aminoacides |
| US5739396A (en) | 1991-12-09 | 1998-04-14 | Stanford University | Asymmetric ligands useful for transition metal catalyzed bond forming reactions |
| US5919948A (en) | 1991-12-09 | 1999-07-06 | The Board Of Trustees Of The Leland Stanford Junior University | Asymmetric ligands useful for transition metal catalyzed bond forming reactions and epoxide reactions therewith |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| CZ297891B6 (cs) | 1995-07-25 | 2007-04-25 | Archimica Gmbh | Zpusob výroby vícejaderných aromatických sloucenin |
| US5767276A (en) | 1995-10-13 | 1998-06-16 | The Penn State Research Foundation | Asymmetric synthesis catalyzed by transition metal complexes with new chiral ligands |
| JPH09239275A (ja) | 1996-03-10 | 1997-09-16 | Daicel Chem Ind Ltd | イミン化合物合成用触媒、及びこれを用いたイミン化合物の製造法 |
| US5847166A (en) | 1996-10-10 | 1998-12-08 | Massachusetts Institute Of Technology | Synthesis of aryl ethers |
-
1998
- 1998-07-24 US US09/122,324 patent/US6323366B1/en not_active Expired - Lifetime
-
1999
- 1999-07-23 PT PT99937293T patent/PT1100774E/pt unknown
- 1999-07-23 CA CA002336976A patent/CA2336976A1/en not_active Abandoned
- 1999-07-23 WO PCT/US1999/016257 patent/WO2000005199A1/en not_active Ceased
- 1999-07-23 AT AT99937293T patent/ATE258163T1/de not_active IP Right Cessation
- 1999-07-23 EP EP99937293A patent/EP1100774B1/de not_active Expired - Lifetime
- 1999-07-23 JP JP2000561156A patent/JP2002521359A/ja active Pending
- 1999-07-23 DE DE69914337T patent/DE69914337T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002521359A (ja) | 2002-07-16 |
| WO2000005199A1 (en) | 2000-02-03 |
| US6323366B1 (en) | 2001-11-27 |
| DE69914337T2 (de) | 2004-11-04 |
| CA2336976A1 (en) | 2000-02-03 |
| EP1100774A1 (de) | 2001-05-23 |
| DE69914337D1 (de) | 2004-02-26 |
| EP1100774B1 (de) | 2004-01-21 |
| PT1100774E (pt) | 2004-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |