ATE258440T1 - Verwendung von neutralen gallium chelaten mit 3- hydroxy-4-pyrone verbindungen zur behandlung von krankheiten die verbessert werden können durch die hemmung der hyperproliferation von keratinocyten - Google Patents
Verwendung von neutralen gallium chelaten mit 3- hydroxy-4-pyrone verbindungen zur behandlung von krankheiten die verbessert werden können durch die hemmung der hyperproliferation von keratinocytenInfo
- Publication number
- ATE258440T1 ATE258440T1 AT97938025T AT97938025T ATE258440T1 AT E258440 T1 ATE258440 T1 AT E258440T1 AT 97938025 T AT97938025 T AT 97938025T AT 97938025 T AT97938025 T AT 97938025T AT E258440 T1 ATE258440 T1 AT E258440T1
- Authority
- AT
- Austria
- Prior art keywords
- keratinocytes
- diseases
- hydroxy
- treatment
- improved
- Prior art date
Links
- 210000002510 keratinocyte Anatomy 0.000 title abstract 2
- 230000007935 neutral effect Effects 0.000 title abstract 2
- VEYIMQVTPXPUHA-UHFFFAOYSA-N 3-hydroxypyran-4-one Chemical class OC1=COC=CC1=O VEYIMQVTPXPUHA-UHFFFAOYSA-N 0.000 title 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229910052733 gallium Inorganic materials 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000002258 gallium Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000004927 skin cell Anatomy 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/688,565 US5747482A (en) | 1996-07-30 | 1996-07-30 | Methods and compositions to inhibit keratinocyte proliferation |
| PCT/US1997/012951 WO1998004264A1 (en) | 1996-07-30 | 1997-07-30 | Methods and compositions to inhibit keratinocyte proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258440T1 true ATE258440T1 (de) | 2004-02-15 |
Family
ID=24764914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97938025T ATE258440T1 (de) | 1996-07-30 | 1997-07-30 | Verwendung von neutralen gallium chelaten mit 3- hydroxy-4-pyrone verbindungen zur behandlung von krankheiten die verbessert werden können durch die hemmung der hyperproliferation von keratinocyten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5747482A (de) |
| EP (1) | EP0959889B1 (de) |
| JP (1) | JP2000516219A (de) |
| AT (1) | ATE258440T1 (de) |
| AU (2) | AU3726797A (de) |
| DE (1) | DE69727399T2 (de) |
| ES (1) | ES2214635T3 (de) |
| WO (2) | WO1998004263A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6203822B1 (en) * | 1996-09-03 | 2001-03-20 | University Of Iowa Research Foundation | Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection |
| AU775459B2 (en) * | 1999-10-04 | 2004-08-05 | Lawrence R. Bernstein | Gallium complexes of 3-hydroxy-4-pyrones to treat infection by intracellular prokaryotes, DNA viruses and retroviruses |
| US20020160055A1 (en) * | 2000-09-18 | 2002-10-31 | Jack Stapleton | Methods for treating human immunodeficiency virus infections with gallium compositions |
| JP2004292314A (ja) * | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | ケラチノサイト増殖抑制剤 |
| JP2003267966A (ja) * | 2002-03-13 | 2003-09-25 | Pola Chem Ind Inc | フラバン誘導体、皮膚線維芽細胞増殖抑制剤および皮膚外用剤 |
| US7081247B2 (en) * | 2002-05-20 | 2006-07-25 | Nidaria Technology Ltd. | Composition and method for inhibiting polar capsule discharge and protecting a subject from nematocyst sting |
| AU2003279067A1 (en) * | 2002-09-23 | 2004-04-08 | Genta Inc. | Tri(alkylcarboxylato) gallium (iii) products and pharmaceutical compositions containing them |
| EP1993567A4 (de) | 2005-10-27 | 2011-01-26 | Lawrence Richard Bernstein | Oral verabreichbare gallium-zusammensetzungen und anwendungsverfahren |
| EP1962774B1 (de) * | 2005-11-01 | 2014-01-01 | Mount Sinai School of Medicine | Kontrolle des wachstums von oralen und oberflächlichen mikroorganismen mit gallium-verbindungen |
| EP1945273A1 (de) * | 2005-11-07 | 2008-07-23 | Titan Pharmaceuticals, Inc. | Behandlung und prävention von lebererkrankungen mit gallium |
| AU2007208169A1 (en) * | 2006-01-30 | 2007-08-02 | Lawrence R. Bernstein | Use of gallium to treat biofilm-associated infectons |
| US8168214B2 (en) | 2006-11-09 | 2012-05-01 | Bernstein Lawrence R | Local administration of gallium compositions to treat pain |
| US20080292726A1 (en) * | 2007-01-23 | 2008-11-27 | Bernstein Lawrence R | Ophthalmic gallium compositions and methods of their use |
| US20080175922A1 (en) * | 2007-01-23 | 2008-07-24 | Bernstein Lawrence R | Ophthalmic gallium compositions and methods of their use |
| PL2141996T3 (pl) * | 2007-04-02 | 2013-05-31 | Sinai School Medicine | Sposoby zapobiegania lub leczenia chorób infekcyjnych z zastosowaniem związków galu |
| ES2336995B1 (es) | 2008-10-13 | 2011-02-09 | Lipotec, S.A. | Composicion cosmetica o dermofarmaceutica para el cuidado de la piel,cuero cabelludo y uñas. |
| AU2015358910B2 (en) * | 2014-12-12 | 2019-01-24 | Dermavant Sciences GmbH | Novel method of use |
| KR102704001B1 (ko) * | 2023-09-15 | 2024-09-06 | 주식회사 함소아제약 | 개망초 추출물을 포함하는 가려움증 개선용 화장료 조성물 제조방법 및 이에 따라 제조된 화장료 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2500303A1 (fr) * | 1981-02-20 | 1982-08-27 | Meram Lab | Le chlorure de gallium, nouveau medicament anti-cancereux |
| CA1219210A (en) * | 1982-10-22 | 1987-03-17 | Warrell Raymond P., Jr. | Use of gallium salts to treat disorders of calcium homeostasis |
| US4704277A (en) * | 1985-04-30 | 1987-11-03 | Sloan-Kettering Institute For Cancer Research | Methods of treating bone disorders |
| US5258376A (en) * | 1989-11-22 | 1993-11-02 | Bernstein Lawrence R | Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones |
| ATE195424T1 (de) * | 1990-01-12 | 2000-09-15 | New York Society | Verfahren zur verbesserung der wundheilung und gewebeerneuerung |
| WO1991017751A1 (en) * | 1990-05-24 | 1991-11-28 | Fujisawa, Inc. | Orally administrable gallium compositions and methods of treatment therewith |
| US5175006A (en) * | 1990-09-21 | 1992-12-29 | The Ohio State University | Method of treating arthritis using gallium compounds |
| CA2122908C (en) * | 1991-11-12 | 2004-08-17 | Lawrence Richard Bernstein | Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones |
-
1996
- 1996-07-30 US US08/688,565 patent/US5747482A/en not_active Expired - Lifetime
-
1997
- 1997-07-15 AU AU37267/97A patent/AU3726797A/en not_active Abandoned
- 1997-07-15 WO PCT/US1997/012197 patent/WO1998004263A1/en not_active Ceased
- 1997-07-30 ES ES97938025T patent/ES2214635T3/es not_active Expired - Lifetime
- 1997-07-30 AT AT97938025T patent/ATE258440T1/de not_active IP Right Cessation
- 1997-07-30 JP JP10508959A patent/JP2000516219A/ja not_active Ceased
- 1997-07-30 EP EP97938025A patent/EP0959889B1/de not_active Expired - Lifetime
- 1997-07-30 AU AU40446/97A patent/AU740198B2/en not_active Ceased
- 1997-07-30 DE DE69727399T patent/DE69727399T2/de not_active Expired - Lifetime
- 1997-07-30 WO PCT/US1997/012951 patent/WO1998004264A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0959889B1 (de) | 2004-01-28 |
| EP0959889A1 (de) | 1999-12-01 |
| AU3726797A (en) | 1998-02-20 |
| DE69727399D1 (de) | 2004-03-04 |
| DE69727399T2 (de) | 2004-12-09 |
| US5747482A (en) | 1998-05-05 |
| AU740198B2 (en) | 2001-11-01 |
| JP2000516219A (ja) | 2000-12-05 |
| EP0959889A4 (de) | 2000-08-16 |
| AU4044697A (en) | 1998-02-20 |
| ES2214635T3 (es) | 2004-09-16 |
| WO1998004263A1 (en) | 1998-02-05 |
| WO1998004264A1 (en) | 1998-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |