ATE258603T1 - Verfahren zur herstellung von pravastatin und lovastatin - Google Patents
Verfahren zur herstellung von pravastatin und lovastatinInfo
- Publication number
- ATE258603T1 ATE258603T1 AT01114462T AT01114462T ATE258603T1 AT E258603 T1 ATE258603 T1 AT E258603T1 AT 01114462 T AT01114462 T AT 01114462T AT 01114462 T AT01114462 T AT 01114462T AT E258603 T1 ATE258603 T1 AT E258603T1
- Authority
- AT
- Austria
- Prior art keywords
- lovastatin
- pravastatin
- aspergillus
- exocellular
- producing pravastatin
- Prior art date
Links
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229960002965 pravastatin Drugs 0.000 title abstract 3
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title abstract 3
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004844 lovastatin Drugs 0.000 title abstract 2
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title abstract 2
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title abstract 2
- 241000228212 Aspergillus Species 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01114462A EP1266967B1 (de) | 2001-06-15 | 2001-06-15 | Verfahren zur Herstellung von Pravastatin und Lovastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258603T1 true ATE258603T1 (de) | 2004-02-15 |
Family
ID=8177727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01114462T ATE258603T1 (de) | 2001-06-15 | 2001-06-15 | Verfahren zur herstellung von pravastatin und lovastatin |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1266967B1 (de) |
| AT (1) | ATE258603T1 (de) |
| DE (1) | DE60101904T2 (de) |
| DK (1) | DK1266967T3 (de) |
| ES (1) | ES2210066T3 (de) |
| PT (1) | PT1266967E (de) |
| TR (1) | TR200400357T4 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009540811A (ja) * | 2006-06-22 | 2009-11-26 | ディーエスエム アイピー アセッツ ビー．ブイ． | プラバスタチンの産生 |
| WO2009077523A2 (en) * | 2007-12-18 | 2009-06-25 | Dsm Ip Assets B.V. | Improved statin production |
| JP6916482B2 (ja) * | 2016-06-23 | 2021-08-11 | 学校法人日本大学 | アスペルギルス・テレウス検出用プローブ、及びアスペルギルス・テレウスの検出方法 |
| CN112553262B (zh) * | 2020-12-31 | 2023-04-07 | 广东蓝宝制药有限公司 | 一种普伐他汀的发酵工艺 |
| CN113061536B (zh) * | 2021-03-17 | 2022-08-23 | 江南大学 | 一株高产洛伐他汀的紫色红曲菌z-27及其应用 |
| CN114958625B (zh) * | 2022-07-07 | 2023-12-19 | 福安药业集团烟台只楚药业有限公司 | 一种发酵生产洛伐他汀的土曲霉的培养与保存方法 |
| CN116925926B (zh) * | 2023-07-14 | 2024-02-02 | 中国农业大学 | 富硒红色红曲霉发酵生产洛伐他汀的方法 |
-
2001
- 2001-06-15 DK DK01114462T patent/DK1266967T3/da active
- 2001-06-15 ES ES01114462T patent/ES2210066T3/es not_active Expired - Lifetime
- 2001-06-15 PT PT01114462T patent/PT1266967E/pt unknown
- 2001-06-15 TR TR2004/00357T patent/TR200400357T4/xx unknown
- 2001-06-15 DE DE60101904T patent/DE60101904T2/de not_active Expired - Fee Related
- 2001-06-15 AT AT01114462T patent/ATE258603T1/de not_active IP Right Cessation
- 2001-06-15 EP EP01114462A patent/EP1266967B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60101904D1 (de) | 2004-03-04 |
| TR200400357T4 (tr) | 2004-03-22 |
| DK1266967T3 (da) | 2004-05-03 |
| ES2210066T3 (es) | 2004-07-01 |
| EP1266967A1 (de) | 2002-12-18 |
| DE60101904T2 (de) | 2004-07-15 |
| EP1266967B1 (de) | 2004-01-28 |
| PT1266967E (pt) | 2004-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1266967 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |